Metal organic framework for sustainable removal of heavy metals contamination from wastewater: a review by Yinglian Qin, Nidhi Singh, Sukhendra Singh, Veer Singh, Vishal Mishra, Shili Li

“…Functionalization increases the surface binding sites for the heavy metal ions. Several functionalization methods, such as amino functionalization, thiol grafting and biopolymer composite, etc, are applied. …”
Get full text

Remediation of Soil Contaminated with Heavy Metals by Plyatsuk L. D., Chernysh Y. Y., Ablieieva I. Y., Yakhnenko O. M., Bataltsev E. V., Balintova M., Hurets L. L.

“…The integration of theoretical and experimental principles in the synergy analysis of the interrelations in the system “object – subject of research” in the study of the dynamics of changes in the forms of HM finding in the soil was carried out. …”
Get full text

Should the Muslim President become a constitutional convention in Indonesia? Based on constitutional debates about Islam and state, and the constitutional practice by Mei Susanto, Susi Dwi Harijanti, Hamdan Zoelva, Ali Abdurahman

“…As a result, the convention improves Indonesia’s integration function.…”
Get full text

Leonurine (SCM-198) exerts protective effects on pancreatic β-cells in type 1 diabetes by modulating the Bax/Bcl-2/Caspase-3 signaling pathway by Zhiqi Li, XiaoRan Liu, FuJiang Wen, WenGuo Jiang, ZhenHong Xia

“…Subsequently, molecular docking simulations were employed to investigate the binding affinities of the core genes involved in SCM-198 treatment for T1DM. …”
Get full text

Eco-benign synthesis of multifunctional silver nanoparticles using leptochloa fusca for enhanced biomedical and catalytic applications by Riaz Ahmad Khan, Hidayat Ullah Khan, Shahnaz, Kamran Tahir, Moamen S Refat, Abdel Majid A Adam, Amnah Mohammed Alsuhaibani

“…These findings suggest that LF-AgNPs exhibit significant capability for integration into catalytic process of MB reduction and selected biomedical applications.…”
Get full text

A New Protein–Ligand Trapping System to Rapidly Screen and Discover Small-Molecule Inhibitors of PD-L1 from Natural Products by Yazhuo Huang, Senfeng Sun, Runxin Yin, Zongtao Lin, Daidong Wang, Wanwan Wang, Xiangyu Fu, Jing Wang, Xinyu Lei, Mimi Sun, Shizhong Chen, Hong Wang

“…Fourteen components were then identified as PD-L1 binders, and surface plasmon resonance (SPR) validation results showed that six of them—magnoflorine (<b>6</b>), nitidine (<b>22</b>), chelerythrine (<b>24</b>), jatrorrhizine (<b>13</b>), toddaculin (<b>68</b>), and toddanol (<b>45</b>)—displayed PD-L1 binding activity. Laser scanning confocal microscopy results demonstrated that these compounds effectively inhibited the binding of PD-1 to PD-L1 in a dose-dependent manner. …”
Get full text

Therapeutic Potential of Qilianxiaopi Formula: Targeting ADAM17-Mediated Chronic Inflammation in Atrophic Gastritis by Sijing Du, Tianxiang Wang, Zhiqiang Li, Ting Li, Zelong Miao, Yuling Chen, Songbiao Zhu, Wei Wei, Haiteng Deng

“…<b>Conclusions</b>: This study highlights ADAM17 as a key molecular target of QLXP and narirutin as its principal binding component. The integrated approach combining chromatography-mass spectrometry, network pharmacology, TPP, BLI, and molecular docking provides a robust framework for elucidating the mechanisms of action of TCM.…”
Get full text

LEGAL EDUCATION OF PHARMACISTS IN A CONTEXT OF SOCIETY DEMOCRATIZATION AND THE EUROPEAN STANDARDS OF EDUCATION IN UKRAINE by I. M. Alieksieieva

“…Formation of Ukraine as a democratic, legal and social state regulated by the Constitution - the Basic Law and legislation on European integration, is therefore binding. Fundamental to achieve these ideals is the formation of personality with high level of legal awareness and legal culture. …”
Get full text

Genome-wide, chromosome-naïve compartmentalization of major developmental networks tailored by modular placement of human embryo-regulatory Long Terminal Repeats by Gennadi V. Glinsky

“…Despite this physical segregation, eukaryotic genomes possess an intrinsic regulatory connectivity that facilitates remarkable chromosome-naive function-aligned integration and striking developmental precision in conveying genetic information from conception and embryogenesis to adulthood. …”
Get full text

Revolutionizing pharmacology: AI-powered approaches in molecular modeling and ADMET prediction by Irfan Pathan, Arif Raza, Adarsh Sahu, Mohit Joshi, Yamini Sahu, Yash Patil, Mohammad Adnan Raza, Ajazuddin

“…This review explores the integration of AI techniques, including machine learning (ML), deep learning (DL), and generative models with traditional computational methods such as molecular docking, quantum mechanics, and molecular dynamics simulations. …”
Get full text

Multi-scale computational analysis of Melanin’s therapeutic potential in skin cancer by Shilpa Valiyaparambil, Janakiraman Kunchithapatham, Muddukrishnaiah Kotakonda, Kamal Yoonus Thajudeen, Saad Ali Alshehri, Mohammed Muqtader Ahmed

“…We used molecular docking, binding free energy analysis, MD simulations, and DFT to explore. …”
Get full text

Phosphorylcholine allows for evasion of bactericidal antibody by Haemophilus influenzae. by Sarah E Clark, Julian Snow, Jianjun Li, Tracey A Zola, Jeffrey N Weiser

“…Moreover, ChoP-mediated protection against antibody binding correlated with increased resilience of outer membrane integrity. …”
Get full text

Design and preparation of a fluorescent molecularly imprinted membrane for the selective detection of pepsin enzyme as a biomarker for gastroesophageal reflux disease by Aya M. Mostafa, Stephen J. Barton, Stephen P. Wren, James Barker

“…Furthermore, comprehensive characterisation of both FMIM and FNIM was conducted using various analytical techniques to ensure their structural integrity and functionality. Ultimately, the developed FMIM exhibited effective binding of pepsin in standard solutions and samples, enabling enrichment and visual detection of the biomarker enzyme.…”
Get full text

Evidence for Fgf and Wnt regulation of Lhx2 during limb development via two limb-specific Lhx2-associated cis-regulatory modules by Jessica C. Britton, Anett Somogyi-Leatigaga, Billy A. Watson, Endika Haro, Cassidy G. Mulder, Kari D. Kennedy, Allen M. Cooper, Kristen L. Whitley, Ruth-Love Yeboah, Jeanyoung Kim, Micah C. Yu, Micah C. Yu, Jairo D. Campos, Jairo D. Campos, Japhet Amoah, Japhet Amoah, Shimako Kawauchi, Eunyoung Kim, Charmaine U. Pira, Kerby C. Oberg

“…IntroductionIn vertebrate limb morphogenesis, wingless-related integration site (Wnt) proteins and fibroblast growth factors (Fgfs) secreted from the apical ectodermal ridge (AER) coordinate proximodistal outgrowth. …”
Get full text

Strategy for Development of Modern Protective Equipment Based on Organometallic Complexes with Desired Properties by V. V. Zavyalov, N. V. Zavyalova, V. I. Kholstov, V. K. Gorelenkov, G. A. Frolov, I. V. Lyagin, E. N. Efremenko

“…The review provides the details of the use of biomolecules for integration with MOF by pore encapsulation, surface attachment, covalent binding, in situ encapsulation of biomolecules in MOF, and the creation of bio-MOFs. …”
Get full text

HEATR2 plays a conserved role in assembly of the ciliary motile apparatus. by Christine P Diggle, Daniel J Moore, Girish Mali, Petra zur Lage, Aouatef Ait-Lounis, Miriam Schmidts, Amelia Shoemark, Amaya Garcia Munoz, Mihail R Halachev, Philippe Gautier, Patricia L Yeyati, David T Bonthron, Ian M Carr, Bruce Hayward, Alexander F Markham, Jilly E Hope, Alex von Kriegsheim, Hannah M Mitchison, Ian J Jackson, Bénédicte Durand, Walter Reith, Eamonn Sheridan, Andrew P Jarman, Pleasantine Mill

“…Functional conservation of closely arranged RFX-FOX binding sites upstream of HEATR2 orthologues may drive higher cytoplasmic expression of HEATR2 during early motile ciliogenesis. …”
Get full text

KeyVisor – A Lightweight ISA Extension for Protected Key Handles with CPU-enforced Usage Policies by Fabian Schwarz, Jan Philipp Thoma, Christian Rossow, Tim Güneysu

“…KeyVisor’s direct CPU integration enables fast crypto operations and hardware-enforced key usage restrictions, e.g., keys usable only for de-/encryption, with a limited lifetime, or with a process binding. …”
Get full text

Modeling an evolutionary conserved circadian cis-element. by Eric R Paquet, Guillaume Rey, Felix Naef

“…Taken together, we built a predictive model for CLK/CYC or CLOCK/BMAL1-bound cis-enhancers through the integration of comparative and functional genomics data. …”
Get full text

Berries as Nature’s Therapeutics: Exploring the Potential of <i>Vaccinium</i> Metabolites in Gastric Cancer Treatment Through Computational Insights by Angelica Rachel Carpio, Nicholas Dale Talubo, Po-Wei Tsai, Bor-Yann Chen, Lemmuel L. Tayo

“…Furthermore, molecular dynamics simulations of the HSP90AA1-C3G complex demonstrated stable binding and structural integrity, suggesting that C3G may inhibit HSP90AA1, a protein involved in cancer progression. …”
Get full text

Evaluating interhemispheric connectivity during midline object recognition using EEG. by Anwesha Das, Alexandra Mandel, Hitoshi Shitara, Traian Popa, Silvina G Horovitz, Mark Hallett, Nivethida Thirugnanasambandam

“…Functional integration between two hemispheres is crucial for perceptual binding to occur when visual stimuli are presented in the midline of the visual field. …”
Get full text