A modular protein language modelling approach to immunogenicity prediction. by Hugh O'Brien, Max Salm, Laura T Morton, Maciej Szukszto, Felix O'Farrell, Charlotte Boulton, Laurence King, Supreet Kaur Bola, Pablo D Becker, Andrew Craig, Morten Nielsen, Yardena Samuels, Charles Swanton, Marc R Mansour, Sine Reker Hadrup, Sergio A Quezada

“…Compared with state-of-the-art models for each task, ImmugenX's encoding module performs comparably or better on pMHC binding affinity, eluted ligand prediction and stability tasks. …”
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Leveraging machine learning and molecular docking techniques to predict novel melanocortin-4 receptor agonists by Stavroula Giakoumopoulou, Paris Christodoulou, Minos-Timotheos Matsoukas, Vasilis Panagiotopoulos, Dionisis Cavouras, Eftichia Kritsi

“…Integration of the predictive model with molecular docking simulations reinforced these findings, illustrating the complementary roles of data-driven insights and structural assessments in pinpointing viable hit compounds. …”
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Development of PowerMag System II for Isolation of Circulating Tumor Cells with Improved Purity by Cheng-Rou Ho, Hui-Ju Tsai, Jin-Ru Wang, Chia-Te Wang, Chiuan-Chian Chiou, Ju-Chien Cheng, Sum-Fu Chiang, Ching-Ping Tseng

“…<b>Results</b>: The EpCAM⁻CD45⁻ cells were defined as apoptotic cells, which displayed apoptotic body-like morphology and elicited AnxV binding activity. AnxV beads developed in-house can effectively bind and remove EpCAM⁻CD45⁻ cells from the cell filtrates. …”
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Network Pharmacology, Molecular Docking and Experimental Verification to Explore the Mechanism of Chicoric Acid against Hepatocellular Carcinoma by Wenqian XU, Liangliang ZHANG, Yiping ZHAO, He QIAN, Jianguo XU

“…Molecular docking results showed that CA had good binding activity with the key targets PI3K and AKT. …”
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Here and there: the double-side transgene localization by P. A. Salnikov, A. A. Khabarova, G. S. Koksharova, R. V. Mungalov, P. S. Belokopytova, I. E. Pristyazhnuk, A. R. Nurislamov, P. Somatich, M. M. Gridina, V. S. Fishman

“…Random transgene integration is a powerful tool for developing new genome-wide screening approaches. …”
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Development and validation of optimized lentivirus-like particles for gene editing tool delivery with Gag-Only strategy by Jinlin Jia, Yanzhe Hao, Lu Zhang, Xiaofang Cao, Lisha An, Hu Wang, Qi Ma, Xiaohua Jin, Xu Ma

“…Methods We implemented a Gag-Only strategy, constructing LVLPs with HIV-Gag protein, thereby eliminating the integration risks linked to Pol. By leveraging the interactions between MS2-MCP (MS2 coat protein), PP7 and PP7 BP (PP7 binding protein), and the psi (HIV packaging signal) with HIV-Gag, we encapsulated PAMless andesine base editor (CE-8e-SpRY) mRNA and sgRNA targeting the PD1 start codon (ATG) into the LVLP. …”
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Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir by Lorenzo Briganti, Arun S. Annamalai, Stephanie M. Bester, Guochao Wei, Jonathan R. Andino-Moncada, Satya P. Singh, Alex B. Kleinpeter, Meghna Tripathi, Binh Nguyen, Rajalingam Radhakrishnan, Parmit K. Singh, Juliet Greenwood, Lauren I. Schope, Reed Haney, Szu-Wei Huang, Eric O. Freed, Alan N. Engelman, Ashwanth C. Francis, Mamuka Kvaratskhelia

“…Here we investigated structural and mechanistic bases for how the M66I change affects LEN binding to CA and viral replication. The high-resolution X-ray structure of the CA(M66I) hexamer revealed that the β-branched side chain of Ile66 induces steric hindrance specifically to LEN, thereby markedly reducing the inhibitor binding affinity. …”
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Molecular Markers of Occult Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma (HNSCC) Patients by Piero Giuseppe Meliante, Sofia Pizzolante, Luca Perna, Chiara Filippi, Giorgio Bandiera, Christian Barbato, Antonio Minni, Marco de Vincentiis, Edoardo Covelli

“…We divided the results by subsite for markers: lymph node analysis (microRNAs, myosin-5a (MYO5A), ring finger protein 145 (RNF145), F-box only protein 32 (FBXO32), CTONG2002744, cytokeratin 14 (CK14), eukaryotic initiation factor 4E (eIF4E), desmoglein-3 (DSG3), microsatellite D9S171, squamous cell carcinoma antigen, cytokeratin, tumor budding score, human papillomavirus-DNA (HPV-DNA), tumor infiltrating lymphocytes, sentinel lymph node analysis techniques, single fiber reflectance spectroscopy, radiological techniques), tumor tissue analysis (activin A, carcinoma-associated fibroblasts, cyclins, β-catenin, histopathology, genetic amplifications, DNA methylation, ecotropic viral integration site 1, CC-chemokine receptor 7, melanoma associated-A antigens, vascular endothelial growth factor-C (VEGF-C), panitumumab, epidermal growth factor receptor (EGFR), cornulin, total protein analysis, CD133, NANOG homeobox, neurogenic locus notch homolog protein 1 (NOTCH1), metastasis-associated protein 1, 14-3-3-zeta, E-cadherin, focal adhesion kinase, p-epithelial-mesenchymal transition (EMT), small proline rich protein 1B (SPRR1B), transcription factor NKX3-1, DNA copy number aberrations, microfibril-associated protein 5 (MFAP5), troponin C1, slow skeletal and cardiac type (TNNC1), matrix Gla protein (MGP), fibroblast growth factor binding protein 1 (FBFBP1), F-box protein 32 (FBXO32), fatty acid binding protein 5, B cell-specific Moloney murine leukemia virus integration site 1, podoplanin, p53, Bcl-2, epidermal growth factor receptor (EGFR), Ki67, cyclin D1, cox-2, semaphorin-3F, neuropilin-2, histologic features, cellular dissociation grade, prospero homeobox protein 1, radiologic features, Ki-67, poly (ADP-ribose) polymerase (PARP), Bcl-2 associated agonist of cell death (BAD), caspase-9, vascular endothelial growth factor A (VEGF-A), HPV, p16, methylation status of long interspersed element 1 (LINE-1) and Alu elements, mesenchymal-epithelial transition (MET), gene expression analyses, molecular subtypes) and blood markers (standard blood analysis indexes and ratios, circulating tumor cells, HPV-DNA, CD-31, bone marrow analysis). …”
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Characterization of multi-targeted insulin-mimetic antidiabetic peptides using in silico approaches. by Anas Bilal, Ghulam Mustafa

“…The peptides P2 and P6 showed best haddock scores and binding pattern against target receptors. The P2 showed strong interactions with maltase-glucoamylase (binding energy of -108.7 + /- 9.3 kcal/mol and with six hydrogen bonds), glucose transporter 1 (GLUT1) (binding energy of -85.3 + /- 1.4 kcal/mol and with three hydrogen bonds). …”
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Recent Advances in Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-Associated Proteins System-Based Biosensors by Xianglin Xin, Jing Su, Haoran Cui, Lihua Wang, Shiping Song

“…They exhibit two key cleavage behaviors: precise ON-target cleavage guided by specific protospacers, which ensures accurate target recognition, and bystander cleavage activity triggered upon target binding, which enables robust signal amplification. …”
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Uniformity of Refugee Status in EU law and Secondary Movements: Insights from QY v Germany and A. v Generalstaatsanwaltschaft Hamm by Vladislava Stoyanova

“…(Series Information) European Papers - A Journal on Law and Integration, 2025 10(1), 45-53 | Article | (Table of Contents) 1. …”
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Label-free optical biosensors in the pandemic era by Nava Giovanni, Zanchetta Giuliano, Giavazzi Fabio, Buscaglia Marco

“…The adaptability to any molecular recognition or conformational process facilitates the integration of DNA nanostructures carrying novel functions. …”
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Automated and Efficient Sampling of Chemical Reaction Space by Minhyeok Lee, Umit V. Ucak, Jinyoung Jeong, Islambek Ashyrmamatov, Juyong Lee, Eunji Sim

“…Open‐source code is provided for the entire workflow, facilitating the integration of the approach into existing MLIP development pipelines.…”
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Germanium in the environment: Current knowledge and identification of gaps by Montserrat Filella, Juan Carlos Rodríguez-Murillo

“…The collected data on environmental compartments are provided ready for use, which will facilitate the completion of the collection and integration of new data.…”
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Boltzmann energy-based image analysis demonstrates that extracellular domain size differences explain protein segregation at immune synapses. by Nigel J Burroughs, Karsten Köhler, Vladimir Miloserdov, Michael L Dustin, P Anton van der Merwe, Daniel M Davis

“…Here, we address this challenge, developing a new methodology for analysing and quantifying image data and its integration with biophysical models. Specifically we fit a binding kinetics model to 2 colour fluorescence data for cytoskeleton independent synapses (2 and 3D) and test whether the observed inverse correlation between fluorophores conforms to size dependent exclusion, and further, whether patterned states are predicted when model parameters are estimated on individual synapses. …”
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Machine learning-driven insights into self-healing silicon-based anodes for high-performance lithium-ion batteries by Mahta Moazzenzadeh, Mahmoud Samadpour

“…To tackle this issue, researchers are investigating the integration of self-healing polymers as binding agents in the anode structure through trial-and-error approaches, which is both time-consuming and expensive. …”
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Dissecting the dual role of OTU family proteins in tumor progression and immune escape by Xiaolong Tang, Yadan Li, Yongshuo Liu

“…The Ovarian tumor domain (OTU) family, a vital subclass of deubiquitinating enzymes, comprises 16 members that mediate ubiquitin binding and hydrolysis through their characteristic OTU domain. …”
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Metallothionein as an Anti-Inflammatory Mediator by Ken-ichiro Inoue, Hirohisa Takano, Akinori Shimada, Masahiko Satoh

“…The integration of knowledge concerning the regulation of MT, a highly conserved, low molecular weight, cystein-rich metalloprotein, on its proposed functions is necessary to clarify how MT affects cellular processes. …”
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Generative AI for drug discovery and protein design: the next frontier in AI-driven molecular science by Uddalak Das

“…., DiffDock), end-to-end binding affinity prediction, and quantum chemistry-informed neural potentials. …”
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Choice of Law in International Contracts Based on the Hague Principles 2015: Indonesian Positive Law Perspective by Geofani Lingga Meryadinata, Shihaf Ismi Salman Najib, Ahmad Bastomi

“…Integration into Indonesia's legal system is recommended to enhance legal certainty, support cross-border trade, and guide judges, practitioners, and scholars in resolving international contract disputes.…”
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