IntAct: A nondisruptive internal tagging strategy to study the organization and function of actin isoforms. by Maxime C van Zwam, Anubhav Dhar, Willem Bosman, Wendy van Straaten, Suzanne Weijers, Emiel Seta, Ben Joosten, Jeffrey van Haren, Saravanan Palani, Koen van den Dries

“…Furthermore, IntAct β-actin remains associated with common actin-binding proteins (ABPs) and can be targeted in living cells. …”
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Circular RNA: functions, applications and prospects by Minghon Lu

“…Abstract Following improvement and integration of novel genome sequencing techniques, a new stage light has been shone upon circular RNAs (circRNA) in regard to their structure and functionality. …”
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Tuning the transcription and translation of L-amino acid deaminase in Escherichia coli improves α-ketoisocaproate production from L-leucine. by Yang Song, Jianghua Li, Hyun-Dong Shin, Long Liu, Guocheng Du, Jian Chen

“…The highest KIC titers reached 76.47 g·L-1, 80.29 g·L-1, and 81.41 g·L-1, respectively. Additionally, the integration of these three engineering strategies achieved an even higher KIC production of 86.55 g·L-1 and a higher l-leucine conversion rate of 94.25%. …”
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Accelerating fragment-based drug discovery using grand canonical nonequilibrium candidate Monte Carlo by William G. Poole, Marley L. Samways, Davide Branduardi, Richard D. Taylor, Marcel L. Verdonk, Jonathan W. Essex

“…Computational tools are integral to these campaigns, providing a route to library design, virtual screening, the identification of putative small-molecule binding sites, the elucidation of binding geometries, and the prediction of accurate binding affinities. …”
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MyμAlbumin: A Cutting-Edge Immunoturbidity-Based Device with Real-Time and Seamless Data Transmission for Early Detection of Chronic Kidney Disease at the Point of Care by Wanna Chaijaroenkul, Napaporn Youngvises, Artitaya Thiengsusuk, Tullayakorn Plengsuriyakarn, Jakkrapong Suwanboriboon, Kridsada Sirisabhabhorn, Wanchai Meesiri, Kesara Na-Bangchang

“…Additionally, the device supports real-time, seamless data transmission, making it ideal for integration into remote healthcare settings.…”
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LRMAHpan: a novel tool for multi-allelic HLA presentation prediction using Resnet-based and LSTM-based neural networks by Xue Mi, Shaohao Li, Zheng Ye, Zhu Dai, Bo Ding, Bo Sun, Yang Shen, Yang Shen, Zhongdang Xiao, Zhongdang Xiao

“…Our approach is based on a novel pHLA encoding method that enables the integration of neoantigen prediction tasks into computer vision methods. …”
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Imatinib detection by memristive biosensors for therapeutic drug monitoring by Junrui Chen, Lavinia Alberi, Yuan Pétermann, Thierry Buclin, Monia Guidi, Sandro Carrara

“…Kinetic analysis reveals that the analysis time for achieving binding equilibrium and measurement is within 10 min. …”
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ATF3-mediated inhibition of Trem2 by Toxoplasma gondii contributes to adverse pregnancy outcomes by Xiaoyu Geng, Tiankun Yao, Xinyue Wang, Jianan Wang, Tongrui Zhang, Tianmei Qian, Chun Liu, Jinling Chen

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Selective Co‐Assembly of Water‐Soluble Conjugated Polyelectrolyte with Discernable Fluorescence Modulation for Antibiotic Detection by Hyena Ji, Yesica Fernanda Florez‐Villabona, Youngsun Kim, Yerim Kim, Yongju Kim, Seungyun Baik, Young Hun Seo, Sehoon Kim

“…PQx‐Ph exhibits remarkable selectivity toward KAN, demonstrating strong binding with minimal interference from various competing substances. …”
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Foliar Fe2O3 nanoparticles enhance cadmium tolerance in Amaranthus hypochondriacus by modulating cell wall immobilization and antioxidant defenses by Yanfeng Hu, Jia You, Yue Xiang, Runze Tian, Jianli Wang, Zhongbao Shen, Yansheng Li

“…The integration of nanotechnology with high biomass plants offers a sustainable strategy for rehabilitating cadmium (Cd)-contaminated lands. …”
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Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ by Jinsai Shang, Douglas J Kojetin

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The GATA1-HS2 enhancer allows persistent and position-independent expression of a β-globin transgene. by Annarita Miccio, Valentina Poletti, Valentina Poletti, Francesca Tiboni, Claudia Rossi, Antonella Antonelli, Fulvio Mavilio, Giuliana Ferrari

“…Transcriptional enhancers binding chromatin-remodeling and modifying complexes may play a role in shielding transgenes from repressive chromatin effects. …”
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A multi-omics approach to Epstein-Barr virus immortalization of B-cells reveals EBNA1 chromatin pioneering activities targeting nucleotide metabolism. by R Jason Lamontagne, Samantha S Soldan, Chenhe Su, Andreas Wiedmer, Kyoung Jae Won, Fang Lu, Aaron R Goldman, Jayamanna Wickramasinghe, Hsin-Yao Tang, David W Speicher, Louise Showe, Andrew V Kossenkov, Paul M Lieberman

“…Focusing on EBNA1 revealed enhancer-binding activity at gene targets involved in nucleotide metabolism, supported by metabolomic analysis which indicated that adenosine and purine metabolism are significantly altered by EBV immortalization. …”
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Recent Advances in Aptamers-Based Nanosystems for Diagnosis and Therapy of Cardiovascular Diseases: An Updated Review by Yu H, Yu J, Yao G

“…When integrated into nanosystems, aptamers enhance the delivery, bioavailability, and stability of diagnostic and therapeutic agents, addressing challenges of solubility and degradation. …”
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Accelerating density of states prediction in Zn-doped MgO nanoparticles via kernel-optimized weighted k-NN by Hasan Kurban, Parichit Sharma, Mehmet M. Dalkilic, Mustafa Kurban

“…Abstract This study presents an integrated approach combining Density Functional based Tight Binding (DFTB) calculations with machine learning (ML) techniques to predict the density of states (DOS) in pristine and Zn-doped MgO nanoparticles (NPs). …”
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Artificial Intelligence and Machine Learning Approaches for Target-Based Drug Discovery: A Focus on GPCR-Ligand Interactions by M. O. Otun

“…This review explores the integration of AI and ML techniques in GPCR-targeted drug discovery, highlighting their potential to accelerate lead identification, optimize ligand binding predictions, and improve structure-activity relationship modeling. …”
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Uncovering the role of directed connectivity in alpha and theta band activity for sustaining perception-action links by Elena Eggert, Astrid Prochnow, Nasibeh Talebi, Christian Frings, Alexander Münchau, Christian Beste

“…Abstract Central to the process of efficient response selection, the integration of perception and action remains a primary focus in neuroscience. …”
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A brief review on utilizing natural adsorbents for microplastic removal from wastewater: A sustainable approach to environmental protection by Esmaeil Allahkarami, Ebrahim Allahkarami, Bahram Rezai

“…., electrostatic interactions, hydrophobic binding, and pore entrapment) are critically examined. …”
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Innovative Techniques for Enhancing the Reliability of Machine Learning Classifiers in Protein-Protein Interaction Hotspot Prediction by M. O. Otun

“…Key approaches include advanced feature engineering, integration of multi-omics data, ensemble learning methods, and the application of deep learning architectures. …”
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Structure–Function Relationship of Novel Tetrakis (Mercapto-Terphenyl)Benzene Cobalt (II) Phthalocyanines: Synthesis and Computational Evaluation by Sevil Sener, Nursel Acar-Selcuki

“…This study introduces a newly synthesized Co(II) phthalocyanine complex (Co-Pc, <b>4</b>) incorporating two (mercapto-terphenyl)thio-dione substituents, along with a detailed exploration of its structural, spectroscopic, and binding characteristics. The key precursor, 4-[(4′′-mercapto-[1,1′:4′,1′′-terphenyl]-4-yl)thio]phthalonitrile (compound <b>3</b>), was first obtained and subsequently used to construct the phthalocyanine macrocycle through cyclotetramerization in the presence of cobalt and zinc salts under heat and vacuum in dimethylformamide. …”
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