Binding mechanism and distant regulation of histone deacetylase 8 by PCI-34051 by Yuxiang Luo, Zhaoyue Yan, Xiakun Chu, Ying Zhang, Yufan Qiu, Huilin Li

“…Our results revealed that PCI-34051 engages with an expanded set of residues and conforms more aptly to the binding channel of hHDAC8, stabilizing the flexible loops surrounding the binding channel. …”
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The Regulatory Roles of RNA-Binding Proteins in Plant Salt Stress Response by Tangying Wang, Kaiyuan Meng, Zilin Zhu, Linxuan Pan, Thomas W. Okita, Laining Zhang, Li Tian

“…Complementing transcriptional mechanisms, post-transcriptional regulation performed by RNA-binding proteins provides an additional layer of control through sophisticated molecular machinery. …”
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Coordinated subdomain movements of MlaC regulate ligand binding and transport by Angshu Dutta, Smit Patel, Shankar Prasad Kanaujia

“…MlaC is constituted by two domains, viz. nuclear transport factor 2-like and phospholipid-binding protein. These unique structural properties contribute to a novel ligand binding process and a diverse conformational landscape, which still remains a marginally investigated subject. …”
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The Role of Cellulose Binding Heptapeptide in Immobilizing Glucose Oxidase to Cellulosic Surfaces by Nastaran Rezaeepour, Sayyed Shahryar Rahpeyma, Mohammad Javad Mehdipour Moghaddam, Ali Asghar Karkhane, Bijan Bambai, Jamshid Raheb

“…Enzyme immobilization was accomplished by adding WHWTYYW heptapeptide, which tends to bind to cellulosic and nitrocellulose surfaces, to bind the enzyme to the above-mentioned surfaces. …”
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Multifaceted roles of Galectins: from carbohydrate binding to targeted cancer therapy by Nan Zhang, Qiao Liu, Daihan Wang, Xiaoyun Wang, Zhaoping Pan, Bo Han, Gu He

“…This review offers a comprehensive overview of the structural characteristics, ligand-binding properties, and interacting proteins of Galectins. …”
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Integrative Computational Modeling of Distinct Binding Mechanisms for Broadly Neutralizing Antibodies Targeting SARS-CoV-2 Spike Omicron Variants: Balance of Evolutionary and Dynamic Adaptability in Shaping Molecular Determinants of Immune Escape by Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Gennady Verkhivker

“…Using integrative computational modeling that combined all-atom molecular dynamics (MD) simulations, mutational scanning, and MM-GBSA binding free energy calculations, we elucidated the structural, energetic, and dynamic determinants of antibody binding. …”
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The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication. by Alan Engelman, Peter Cherepanov

“…In particular, recent results have highlighted an important role for the integrase-interactor lens epithelium-derived growth factor (LEDGF)/p75 in lentiviral integration. Cells engineered to over-express fragments of LEDGF/p75 containing its integrase-binding domain but lacking determinants essential for chromatin association are refractory to HIV-1 infection. …”
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Response–Response Binding: New Evidence from Event-Related Potentials Data by Biye Wang, Lu Wang, Tao Tao, Wei Guo

“…Background: Response–response (RR) binding, involving the integration of independently planned and executed responses, presents a novel perspective on action control. …”
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Induction of hepatitis B core protein aggregation targeting an unconventional binding site by Vladimir Khayenko, Cihan Makbul, Clemens Schulte, Naomi Hemmelmann, Sonja Kachler, Bettina Böttcher, Hans Michael Maric

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Exploring RNA binding proteins in hepatocellular carcinoma: insights into mechanisms and therapeutic potential by Xing Ren, Wenna Yang, Xiuli Yan, Hui Zhang

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Dynamic transitions of initiator binding coordinate the replication of the two chromosomes in Vibrio cholerae by Théophile Niault, Ariel Talavera, Eric Le Cam, Sonia Baconnais, Ole Skovgaard, Florian Fournes, Léa Wagner, Hedvig Tamman, Andrew Thompson, Dannele Echemendia-Blanco, Noa Guzzi, Abel Garcia-Pino, Didier Mazel, Marie-Eve Val

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Documentation and Evaluation of an Ancient Paper Manuscript with Leather Binding Using Spectrometric Methods by Rushdya Rabee Ali Hassan, Mona F. Ali, Abdel-Gawaad A. Fahmy, Hayssam M. Ali, Mohamed Z. M. Salem

“…The present study presented an integrated analytical approach to the Qur’anic manuscript with leather binding; the multianalyses revealed the degree of degradation for paper and leather in the current manuscript under the study, causing the mapping of treatment. …”
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A Folding-Docking-Affinity framework for protein-ligand binding affinity prediction by Ming-Hsiu Wu, Ziqian Xie, Degui Zhi

“…We anticipate that our proposed framework serves as a starting point for integrating binding structures for more accurate binding affinity prediction.…”
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DNA polymerase actively and sequentially displaces single-stranded DNA-binding proteins by Longfu Xu, Shikai Jin, Mia Urem, Seung-Joo Lee, Meindert H. Lamers, Xun Chen, Peter G. Wolynes, Gijs J. L. Wuite

“…Abstract Single-stranded DNA-binding proteins (SSBs) protect transiently exposed ssDNA, yet how DNA polymerase (DNAp) displaces them during replication remains unclear. …”
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Single Nucleotide Polymorphisms in MicroRNA Binding Sites: Implications in Colorectal Cancer by Panchalee Bhaumik, Chandrasekhar Gopalakrishnan, Balu Kamaraj, Rituraj Purohit

“…Mutations occurring in miRNA binding regions can alter the miRNA, mRNA combination, and can alter gene expression drastically. …”
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Force transduction and lipid binding in MscL: a continuum-molecular approach. by Juan M Vanegas, Marino Arroyo

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A model of thalamo-cortical interaction for incremental binding in mental contour-tracing. by Daniel Schmid, Heiko Neumann

“…In this work, we propose a neural dynamical model of incremental binding that provides a mechanistic account for these findings. …”
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Role of the CTCF binding site in Human T-Cell Leukemia Virus-1 pathogenesis. by Ancy Joseph, Xiaogang Cheng, John Harding, Jacob Al-Saleem, Patrick Green, Malachi Griffith, Deborah Veis, Daniel A Rauch, Lee Ratner

“…During HTLV-1 infection, the virus integrates into the host cell genome as a provirus with a single CCCTC binding protein (CTCF) binding site (vCTCF-BS), which acts as an insulator between transcriptionally active and inactive regions. …”
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The evaluation of transcription factor binding site prediction tools in human and Arabidopsis genomes by Dinithi V. Wanniarachchi, Sameera Viswakula, Anushka M. Wickramasuriya

“…Abstract Background The precise prediction of transcription factor binding sites (TFBSs) is pivotal for unraveling the gene regulatory networks underlying biological processes. …”
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Identification of RNA binding protein genes associated with colorectal cancer by bioinformatics analysis by Rong-Chao He, Haibo Wang, Jun He, Hou-Dong Wang, Zhong Shen

“…Abstract Colorectal cancer (CRC) is a prevalent malignant neoplasm on a global scale, with tumor heterogeneity driving therapeutic resistance and poor prognosis. RNA-binding proteins (RBPs), which are involved in regulating post-transcriptional processes, are becoming more recognized for their involvement in the advancement of cancer. …”
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