Glioblastoma Cell Migration, Invasion and Vasculogenic Mimicry Downmodulated by Novel uPAcyclin Derivatives by Federica Santoro, Francesco Merlino, Diego Brancaccio, Iolanda Camerino, Stefania Belli, Amelia Cimmino, Paolo Grieco, Luca Colucci-D’Amato, Maria Patrizia Stoppelli, Paola Franco, Alfonso Carotenuto

“…The integration of these results with conformational studies led to the design of the di-substituted variant uPAcyclin. …”
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The SOX11:SMARCA4 complex is a driver of oncogenic transcriptional programs in mantle cell lymphoma by Anna De Bolòs, Maria Carreras-Caballé, Marta Sureda-Gómez, Marta-Leonor Rodríguez, Stella Charalampopoulou, Robert Albero, Alba Maiques-Diaz, Heribert Playa-Albinyana, Guillem Clot, Cristina López, Dolors Colomer, José I Martin-Subero, Elías Campo, David Reverter, Josep Villanueva, Virginia Amador

“…SMARCA4 expression is directly regulated by SOX11, and its upregulation significantly associates with worse outcomes of patients. Integration of global DNA-binding and transcriptomic profiles revealed that SOX11 and SMARCA4 share binding sites enriched in open chromatin and active promoters and regulate common key oncogenic pathways crucial for MCL progression and aggressiveness. …”
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Local leadership «beyond city hall»: Analysis of the public communication of Ahmed Aboutaleb, mayor of Rotterdam by Warda Belabas, Jurian Edelenbos

“…Aboutaleb’s public communication on migrant integration, radicalization, and terrorism takes a strong visionary approach that deviates from the non-political and less partisan Dutch way of leadership. …”
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Research and Investigation on Biosensors Using Conversion Enzymes as Mediators by Liu Kewei

“…By utilizing the signal amplification effect of convertase and the specific binding properties of DNA aptamers to target substances, the convertase was linked to DNA, successfully achieving quantitative detection of test substances with low target content. …”
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Soft Law Strategy in the ASEAN Charter Framework by Didi Jubaidi, Dyah Ersita Yustanti

“…Soft law, which refers to nonlegally binding agreements, principles, and declarations, is an important instrument in directing the behavior of ASEAN member states and shaping regional norms. …”
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Introduction of ferritin gene into rice and the functional analysis of transgenic plants by XU Xiao-hui, GUO Ze-jian, CHENG Zhi-qiang, LI Jun-ying, LI De-bao

“…The integration of Fer gene into rice genome was confirmed by PCR and Southern blot techniques. …”
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Electrosorption of uranium from aqueous solutions: Mechanisms, electrode materials, and applications in in-situ leaching by Halimov Ilhom, Karimov Nurxan, Khamidov Suxrob, Sunnatullayev Shokir, Sharopov Qodir

“…This review presents the fundamental principles of electrosorption, recent advances in electrode materials, insights into binding mechanisms, and the integration potential of electrosorption units into ISL circuits. …”
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Gut microbiota and urine metabolomics signature in autism spectrum disorder children from Southern China by Ziyu Huang, Ailing Wei, Hai Yuan, Shiqin Huang, Xiaolan Chen, Yunli Han, Xing Li

“…In addition, functional analysis of the gut microbiota revealed that the ATP-binding cassette and ABC-2 type transport system ATP-binding protein were closely associated with ASD. …”
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NetMHCpan-4.2: improved prediction of CD8+ epitopes by use of transfer learning and structural features by Jonas Birkelund Nilsson, Jason Greenbaum, Bjoern Peters, Bjoern Peters, Morten Nielsen

“…MethodsTo further investigate this, we here develop an enhanced MHC class I (MHC-I) antigen presentation predictor by integrating newly curated binding affinity and eluted ligand datasets, expanding MHC allele coverage, and incorporating novel input features related to the structural constraints of the MHC-I peptide-binding cleft. …”
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Exploring transposons in macroalgae: LTR elements and neighboring genes in red seaweeds by Pilar Garcia-Jimenez, Rafael R. Robaina

“…Notably, these included LTR-specific enzymes such as ribonuclease H, as well as nucleic acid–binding proteins and cation-binding proteins like CCHC-type zinc-finger proteins and haem peroxidase superfamily members, which are involved in stress response pathways.DiscussionThe co-localization of LTRs with stress-responsive protein-coding genes raises intriguing questions about the potential regulatory interplay between TEs and stress adaptation. …”
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Surface Functionalization of Nanoparticles for Enhanced Electrostatic Adsorption of Biomolecules by Marks Gorohovs, Yuri Dekhtyar

“…Various functionalization strategies—including covalent modification, polymer coatings, and layer-by-layer assembly—have been employed to enhance electrostatic binding; however, each presents trade-offs in terms of stability, complexity, and specificity. …”
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Refining Georgia’s Legal Framework for Enforcing Constitutional Court Judgements by George Khazalia, Nino Chochia

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Phosphorylation-Mediated Regulation of Alternative Splicing in Cancer by Chiara Naro, Claudio Sette

“…The kinases and phosphatases involved in these posttranslational modifications significantly contribute to AS regulation and to its integration in the complex regulative network that controls gene expression in eukaryotic cells. …”
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Functional Characterization of <i>MaSPL8</i> Reveals Its Different Roles in Biotic and Abiotic Stress Responses in Mulberry by Longyan Zheng, Wenhao Zhang, Liuqing Wei, Mengqi Li, Li Liu

“…The Squamosa promoter-binding protein-like (SPL) family proteins plays pivotal roles in plant development and stress adaptation. …”
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S‐ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide‐Induced Depression Via Targeting SIRT2 by Cong Lin, Xiaoxuan Zhou, Mingqi Li, Cong Zhang, Haojiang Zhai, Haohong Li, Hongshuang Wang, Xiaohui Wang

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IMMUNOTHERAPY IN ALL: MONOCLONAL ANTIBODIES AND BEYOND by Fatma Arıkan

“…It is designed to include binding regions that target two different antigens simultaneously. …”
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N-terminally truncated POM121C inhibits HIV-1 replication. by Hideki Saito, Hiroaki Takeuchi, Takao Masuda, Takeshi Noda, Shoji Yamaoka

“…This truncated protein is predominantly localized in the cytoplasm, does not bind to CA, does not affect viral cDNA synthesis, reduces the formation of 2-LTR and diminished the amount of integrated proviral DNA. …”
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Zinc finger recombinases with adaptable DNA sequence specificity. by Chris Proudfoot, Arlene L McPherson, Andreas F Kolb, W Marshall Stark

“…Asymmetric Z-sites were recombined by the concomitant action of two ZFRs with different zinc finger DNA-binding specificities, and could be recombined with a heterologous site in the presence of a third recombinase. …”
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Epigenetic Modulations of Non-Coding RNAs: A Novel Therapeutic Perspective in Sjӧgren’s Syndrome by Margherita Sisto, Sabrina Lisi

“…In the autoimmune field, non-coding RNA molecules (nc-RNA), which regulate gene expression by binding to mRNAs and could have a therapeutic value, have aroused great interest. …”
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Bispecific antibodies and CLEM: an analytical approach to advanced cell imaging for therapeutic strategies by Han-ul Kim, Young Kwan Kim

“…This synergy not only deepens our understanding of BsAbs’ mechanisms of action but also provides critical insights into their spatial distribution, binding kinetics, and functional dynamics in live cells. …”
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