The Emerging Role of Filamin A and FLNA Gene in Central Nervous System Functions: Insights into Neurodevelopment and Disease by Nikita I. Golushko, Anton D. Shevlyakov, Daniil D. Martynov, Longen Yang, Murilo S. de Abreu, Allan V. Kalueff

Get full text

The role of the transcription factor NAC17 in enhancing plant resistance and stress tolerance in Vitis quinquangularis by Xiaolin Liu, Jie Zhu, Ruixiang Li, Yang Feng, Qian Yao, Dong Duan

Get full text

The homeodomain transcription factor VvOCP3 negatively regulates white rot resistance in grape by Zhen Zhang, Cui Chen, Changyue Jiang, Hong Lin, Yuhui Zhao, Yinshan Guo

Get full text

Transcriptomic analysis elucidates the enhanced skeletal muscle mass, reduced fat accumulation, and metabolically benign liver in human follistatin-344 transgenic pigs by Ke-ren LONG, Xiao-kai LI, Ruo-wei ZHANG, Yi-ren GU, Min-jie DU, Xiang-yang XING, Jia-xiang DU, Miao-miao MAI, Jing WANG, Long JIN, Qian-zi TANG, Si-lu HU, Ji-deng MA, Xun WANG, Deng-ke PAN, Ming-zhou LI

Get full text

Magnaporthe Rab5 homologs show distinct functions in nerve growth factor (NGF)-mediated neurite outgrowth and cell differentiation by Yao-yao QI, Zhi-min LIANG, Jie ZHOU, Zong-hua WANG, Guo-dong LU, Guang-pu LI

Get full text

Network pharmacology-based study on the mechanism of Yiwei Decoction in chronic atrophic gastritis and experimental assessment by Zepeng Zhang, Ju Liu, Yi Wang, Xiwen Li, Manman Guo, Menglei Ding, Tongtong Zhu, Lei Zhang

Get full text

IRISIN, OBESITY AND TYPE II DIABETES MELLITUS by Zainab Fathi, Jehan A Mohammad, Mayadah H.Al Jammas, Ban Ali

Get full text

Pharmacoinformatics in identifying therapeutically important chemical species from Ayurvedic formulations employed in treating COVID-19 patients by Akash G. Kendre, Akash Dey, Ramadas Maganti, Sumit Srivastava, Sanjay M. Jachak, Prasad V. Bharatam

Get full text

Genome-wide determinants of proviral targeting, clonal abundance and expression in natural HTLV-1 infection. by Anat Melamed, Daniel J Laydon, Nicolas A Gillet, Yuetsu Tanaka, Graham P Taylor, Charles R M Bangham

“…First, that binding sites for transcription factors and chromatin remodelling factors in the genome flanking the proviral integration site of HTLV-1 are associated with integration targeting, spontaneous proviral expression, and in vivo clonal abundance. …”
Get full text

Structure-guided engineering of type I-F CASTs for targeted gene insertion in human cells by George D. Lampe, Ashley R. Liang, Dennis J. Zhang, Israel S. Fernández, Samuel H. Sternberg

“…We recently leveraged a type I-F CRISPR-associated transposase, PseCAST, for DSB-free DNA integration in human cells, albeit at low efficiencies; multiple lines of evidence suggest DNA binding may be a bottleneck for higher efficiencies. …”
Get full text

Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly. by Amanda J Price, David A Jacques, William A McEwan, Adam J Fletcher, Sebastian Essig, Jason W Chin, Upul D Halambage, Christopher Aiken, Leo C James

“…The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration site selection, and is the target of multiple host cell and pharmacologic ligands. …”
Get full text

Interrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinity. by Daniel J Cole, Eeson Rajendra, Meredith Roberts-Thomson, Bryn Hardwick, Grahame J McKenzie, Mike C Payne, Ashok R Venkitaraman, Chris-Kriton Skylaris

“…Our computational approaches encompass a range of techniques designed to link sequence variation with binding free energy. They include MM-PBSA and thermodynamic integration, which are based on classical force fields, and a recently developed approach to computing binding free energies from large-scale quantum mechanical first principles calculations with the linear-scaling density functional code onetep. …”
Get full text

National Minorities in the Law of the EC/EU by Daniel Šmihula

“…But in the 1990s there began a process of „de-economisation of the European integration” and the importance of national minorities became higher. …”
Get full text

Biology and utilization of R2 retrotransposons by Shengqiu Luo, Qicheng Chen, Yangcan Chen, Wei Li

“…Each R2 element contains a single open reading frame (ORF) encoding a multifunctional protein with nucleic acid-binding, reverse transcriptase, and endonuclease activities, enabling specific genomic integration via a mechanism called target-primed reverse transcription (TPRT). …”
Get full text

The Path to Euro Adoption: a Case Study of Slovenia and Slovakia by DORINA CLICHICI

“…By the terms of their treaties of accession, the financial integration and the adoption of the euro became binding on all new Member States of the European Union. …”
Get full text

Footprinting of Inhibitor Interactions of In Silico Identified Inhibitors of Trypanothione Reductase of Leishmania Parasite by Santhosh K. Venkatesan, Vikash Kumar Dubey

“…The method provides scope for automation and integration into the virtual screening process employing docking softwares, for clustering the small molecule inhibitors based upon protein-ligand interactions.…”
Get full text

Identification of Praziquantel derivatives to target serpin for inhibiting Schistosoma infection in human: using molecular docking and network pharmacology approach by Esam S. Al-Malki

“…ADMET and molecular docking predict the preferred binding orientation of drug candidates, like Mol4, with target proteins. …”
Get full text

Mitochondrial transcription terminator family members mTTF and mTerf5 have opposing roles in coordination of mtDNA synthesis. by Priit Jõers, Samantha C Lewis, Atsushi Fukuoh, Mikael Parhiala, Simo Ellilä, Ian J Holt, Howard T Jacobs

“…We have investigated the roles in this process of the mTERF (mitochondrial transcription termination factor) family members mTTF and mTerf5 in Drosophila melanogaster. The two mTTF binding sites in Drosophila mtDNA, which also bind mTerf5, were found to coincide with major sites of replication pausing. …”
Get full text

Structure-Based Identification of Natural MTH1 Inhibitors for Breast Cancer Therapy via Molecular Docking and Dynamics Simulations by Abdullah S. Alawam, Mubarak A. Alamri

“…This protein ensures the integrity of the nucleotide pool by preventing the integration of oxidized 2′-deoxynucleoside triphosphates (dNTPs) during DNA replication. …”
Get full text

Dishevelled-1 regulates global transcriptomic changes and associates with ETS1 transcription factor by Dalia Martinez-Marin, Monica Sharma, Jenna C. van Wunnik, Flávia Sardela de Miranda, Geetha Priya Boligala, Ella C. Jull, Grace C. Stroman, Rachel L. Babcock, Kevin Pruitt

“…Integration of RNA-sequencing and ChIP-sequencing further revealed ETS1 as a transcription factor binding partner which targets nuclear DVL1 to specific genomic loci. …”
Get full text