Potential shared mechanisms in atopic dermatitis and type 2 diabetes identified via transcriptomic and machine learning approaches by Yang Zhang, Qiangman Wei, Qianzhi Chen

“…Furthermore, virtual screening revealed that Dioscin, Camptothecin, and Albamycin exhibit strong affinity for the CCR1 binding site, indicating their potential as therapeutic candidates. …”
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Stability studies of titanium–carboxylate complexes: A multi-method computational approach by Omar Abdalazeem A., Elmarassi Yasser R. M., Saadawy M., Musa Abdallah Bashir, Mahmoud Nesrine M. R.

“…A multi-method computational approach was employed, integrating point-wise calculation, half-integral, linear plot, and least-squares methods to enhance the accuracy and reproducibility of proton–ligand dissociation constants (pK a) and metal–ligand formation constants (log K). …”
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Unveiling Key Biomarkers and Mechanisms in Septic Cardiomyopathy: A Comprehensive Transcriptome Analysis by Zhao D, Zhuang J, Wang L, Wu L, Xu W, Zhao L, Hong J, Jin W, Miao C

“…Functional enrichment highlighted chemokine activity and receptor binding, with KEGG pathways revealing significant involvement of the TNF and IL-7 signaling pathways. …”
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Jian Pi Hua Tan Fang Reverses Trastuzumab Resistance of HER2‐Positive Gastric Cancer Through PI3K/AKT/mTOR Pathway: Integrating Network Pharmacology, Molecular Docking and Experime... by Jia Hu, Wenjing Bu, Yongfang Ding, Xin Li, Bo Zhang, Bo Shen, Cong Wu, Youqi Xu, Xiaoyang Zhang

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Integration of Untargeted Metabolomics, Network Pharmacology, Single-Cell RNA Sequencing, and Molecular Dynamics Simulation Reveals GOT1, CYP1A2, and CA2 as Potential Targets of Hu... by Tiegang Li, Zheng Yan, Mingxuan Zhou, Wenyi Zhao, Fang Zhang, Silin Lv, Yufang Hou, Zifan Zeng, Liu Yang, Yixin Zhou, Zengni Zhu, Xinyi Ren, Min Yang

“…<b>Methods:</b> This study integrates metabolomics from a mouse model and network pharmacology to screen potential targets and bio-active ingredients of HQD. …”
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Staphylococcus epidermidis ST2 strains associated with bloodstream infections contain a unique mobile genetic element encoding a plasmin inhibitor by Amy A. Gomez, Clara Kjerfve, Minseo Choi, Wen Liu, Kelly Churion, Sheila Thomas, Holger Rohde, Sam Shelburne, Jon T. Skare, Magnus Hook, Srishtee Arora

“…In this study, we identified a novel putative integrated conjugative element, pICE-Sepi-ST2, unique to the genomes of S. epidermidis ST2. …”
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ABCE1 facilitates tumour progression via aerobic glycolysis and inhibits cell death in human colorectal cancer cells through the p53 signalling pathway by Sathan Raj Natarajan, Rajapandiyan Krishnamoorthy, Mohammad A Alshuniaber, Tawfiq S Alsulami, Mansour K. Gatasheh, Ponnulakshmi Rajagopal, Chella Perumal Palanisamy, Ramajayam Govindan, Vishnu Priya Veeraraghavan, Selvaraj Jayaraman

“…This study explores ABCE1 (ATP-binding cassette subfamily E member 1) as a potential biomarker for CRC and delves into its intricate molecular mechanisms. …”
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Global changes in synthesis rates and mRNA stabilities during adaptive responses to cell wall stress in yeast by José García-Martínez, Jose M. Rodríguez-Peña, José E. Pérez-Ortín, Javier Arroyo, Raúl García

“…While various environmental stress responses are well studied in yeast, the effects of cell wall stress, primarily mediated by the Cell Wall Integrity (CWI) pathway, on mRNA dynamics remain less understood. …”
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Integrated computational and experimental identification of N-[(1H-1,2,4-triazol-3-yl)phenyl]-1-(1H-pyrazolo[3,4-b]pyridin-3-yl)methanamide as a potent and selective TIM-3 inhibito... by Xinxin Ying, Yangyong Lou, Yueming Wu, Weiwei Hu

“…MMGBSA binding free energy calculations and metadynamics further confirmed its potent binding. …”
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Mycobacterial PstP impairs host RNA alternative splicing by dephosphorylation of spliceosome RBMX at S189 by Tianxian Liu, Jun‐Yu Xu, Lei Zhao, Yameng Fan, Shuyu Xie, Ke Ma, Ying Zhou, Minjia Tan, Bang‐Ce Ye

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Stability-based approaches in chemoproteomics by Amy L. George, Maria Emilia Dueñas, José Luis Marín-Rubio, Matthias Trost

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Designing an optimized theta-defensin peptide for HIV therapy using in-silico approaches by Mosalanejad Zahra, Faraji Seyed Nooreddin, Rahbar Mohammad Reza, Gholami Ahmad

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Exercise Leads to Brain Glucose Metabolism Activation, Increased Dopamine D1 Receptor Levels and is Negatively Correlated with Social Behavior by Michael Bobick, Colin Hanna, John Tyler, Patrick Mohr, Huy Lu, Aidan Powell, Kenneth Blum, David Baron, Kai-Uwe Lewandrowski, Igor Elman, Albert Pinhasov, Mark S. Gold, Panayotis K. Thanos

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Tissue-specific expression and correlation with promoter DNA methylation of the LBP gene in pigs by Yue CAO, Zhong-cheng GAO, Zheng-chang WU, Hai-fei WANG, Wen-bin BAO

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Muscone Protects Against Ferroptosis-Induced Injury in Models of Acute Ischemic Stroke by Modulating Snap25 Protein by Ruijia You, Bin Sun, Jing Luo, Guanhua Hu, Nan Shao, Wenwen Si

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H5N1 avian influenza virus PB2 antagonizes duck IFN-β signaling pathway by targeting mitochondrial antiviral signaling protein by Zuxian Chen, Bingbing Zhao, Yingying Wang, Yuqing Du, Siyu Feng, Junsheng Zhang, Luxiang Zhao, Weiqiang Li, Yangbao Ding, Peirong Jiao

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Numerical Cohesive Zone Modeling (CZM) of Self-Anchoring AM Metal-CFRP joints by Fikret Enes Altunok Politecnico di Torino, Italy, Giorgio De Pasquale

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Serine protease inhibitors LmSPN2 and LmSPN3 co-regulate embryonic diapause in Locusta migratoria manilensis (Meyen) via the Toll pathway by Shi-qian FENG, Neng ZHANG, Jun CHEN, Dao-gang ZHANG, Kai-hui ZHU, Ni CAI, Xiong-bing TU, Ze-hua ZHANG

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Advances in Drug Delivery Systems for Osteochondral Tissue Regeneration by Jun Shang, Jianping Zhang, Linhong Liu, Wenjuan Kou, Pingping Zhang, Guangwei Sun, Huishuang Zhou, Weihan Shi, Yaning Zhang, Chaozong Liu, Bin Li

“…A desirable drug delivery system should be able to penetrate cartilage tissue before the drug is cleared by synovial capillaries and lymphatic vessels, and bind to components of the cartilage extracellular matrix to reduce the physical deformation of cartilage during locomotion, resulting in a cartilage-specific drug pool. …”
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Fluorescent competitive assay for melamine using dummy molecularly imprinted polymers as antibody mimics by Xin-wei DU, Yan-xin ZHANG, Yong-xin SHE, Guang-yang LIU, Feng-nian ZHAO, Jing WANG, Shan-shan WANG, Fen JIN, Hua SHAO, Mao-jun JIN, Lu-fei ZHENG

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