Integrative scRNA-seq and transcriptomic analysis initially reveals monocyte/macrophage activation drives EV-A71-induced immune dysregulation and neural injury in severe HFMD by Muqi Wang, Meng Zhang, Huiling Deng, Yufeng Zhang, Chenrui Liu, Yuan Chen, Chuting Zhang, Wen Zhang, Xiaoli Jia, Shuangsuo Dang, Yaping Li

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An integrated approach based on FDA adverse event reporting system, network pharmacology, molecular docking, and molecular dynamics simulation analysis to study the cardiac adverse... by Wenjuan Wang, Hong Liu, Yongqing Wen, Yanhua Zhang, Xu Ma

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<i>Syzygium aromaticum</i> Phytoconstituents Target SARS-CoV-2: Integrating Molecular Docking, Dynamics, Pharmacokinetics, and <i>miR-21 rs1292037</i> Genotyping by Mustafa Ahmed Muhmood, Faiza Safi, Mohammed Mukhles Ahmed, Safaa Abed Latef Almeani

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Molecular docking study and pharmacokinetic insights of rifampicin in pure and capsule dosage forms by Nahla A. Alassaf, Azhar S. Hamody, Majid S. Jabir, Suresh Ghotekar, Ayman A. Swelum

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An Environmentally-Friendly RNAi Yeast-Attractive Targeted Sugar Bait Turns off the <i>Drosophila suzukii Rbfox1</i> Gene by Keshava Mysore, Jackson Graham, Saisuhas Nelaturi, Teresia M. Njoroge, Majidah Hamid-Adiamoh, Akilah T. M. Stewart, Longhua Sun, Molly Duman-Scheel

“…Rbfox.687 yeast delivered in ATSB feeders may one day be a useful component of integrated SWD control programs.…”
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Integrating Widely Targeted Metabolomics，Network Pharmacology，and Molecular Docking to Investigate the Protective Mechanisms of from Styphnolobium japonicum cv. Jinhuai's Flower Bu... by Leilei ZUO, Lin HUANG, Huanan SUN, Xiao MENG, Dayi CHEN, Juan WANG, Jiali ZHAO, Fanfan SHI, Yao WANG, Rundong MENG

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SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPL by Xinyuan Xiong, Yang Zhi, Nan Yang, Wenzhen Zhao, Shu Wang, Huiqin Zhu, Jieting Tang, Jing Yi, Xuxu Sun, Jie Yang

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Optimized Microfluidic Biosensor for Sensitive C-Reactive Protein Detection by Amirmahdi Tavakolidakhrabadi, Matt Stark, Alexander Küenzi, Sandro Carrara, Cédric Bessire

“…Lateral flow immunoassays (LFIAs) were integrated into microfluidic chips and tested to enhance point-of-care testing (POCT), with the aim of improving sensitivity and expanding the range of CRP detection. …”
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Prospects of using C3435T polymorphism in the <i>ABCB1</i> gene encoding P-glycoprotein in personalised medicine by R. E. Kazakov, V. A. Evteev, O. V. Muslimova, I. A. Mazerkina, E. Yu. Demchenkova, E. V. Shikh

“…The article reviews scientific literature on C3435T polymorphism in the ABCB1 gene which encodes P-glycoprotein (an ATP-binding cassette transporter which is responsible for energy-dependent transport of substrates across cellular membranes and whose primary role consists in the prevention of penetration of various substances, such as xenobiotics, through biological barriers. …”
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20(S)-Ginsenoside Rh2 overcomes gemcitabine resistance in pancreatic cancer by inhibiting LAMC2-Modulated ABC transporters by Yulin Wu, Juan Zhang, Yuanyang Tian, William Chi Shing Cho, Hong-Xi Xu, Zhi-Xiu Lin, Yan-Fang Xian

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Identification of Potentially Functional Circular RNA/Long Noncoding RNA-MicroRNA-mRNA Regulatory Networks Associated with Vascular Injury in Type 2 Diabetes Mellitus by Integrated... by Yi Leng, Ming-zhu Wang, Kang-ling Xie, Ying Cai

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Integrative analysis of m6A-SNPs and single-cell RNA sequencing reveals key drivers of endocrine combined with CDK4/6 inhibitor therapy resistance in ER+ breast cancer by Ruijie Ming, Ruijie Ming, Han Zhang, Huan Wu, Fangbiao Zhan, Fangbiao Zhan, Xiaoping Huang, Xiaoping Huang, Huawen Liu, Huawen Liu

“…This study explores the role of N6-methyladenosine (m6A) modifications, influenced by m6A-SNPs, in shaping therapy resistance, utilizing single-cell RNA sequencing to delineate the underlying molecular mechanisms.MethodsWe integrated genome-wide association study data with single-cell transcriptomic profiles from ER+ breast cancer patients, focusing on differences between resistant and sensitive responses to CDK4/6 inhibitors. m6A-SNPs were identified and analyzed for their impact on gene expression and interactions with RNA-binding proteins, with a particular focus on their roles within key cellular pathways.ResultsThe study identified crucial m6A-SNPs associated with therapy resistance. …”
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<i>Gallic</i>, <i>Aconitic</i>, and <i>Crocetin</i> Acids as Potential TNF Modulators: An Integrated Study Combining Molecular Docking, Dynamics Simulations, ADMET Profiling, and G... by Adolat Manakbayeva, Andrey Bogoyavlenskiy, Timur Kerimov, Igor Yershov, Pavel Alexyuk, Madina Alexyuk, Vladimir Berezin, Vyacheslav Dushenkov

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Transcription factor Krüppel‐like factor 4 upregulated G protein‐coupled receptor 30 alleviates intestinal inflammation and apoptosis, and protects intestinal integrity from intest... by Jie Yin, Xiaoli Xie, Jinfeng Yao, Xiaoxu Jin, Huiqing Jiang, Chenguang Ji

“…It was evidenced that Krüppel‐like factor 4 (KLF4) could directly bind to GPR30 promoter and positively regulate GPR30 expression. …”
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TRIF-TAK1 signaling suppresses caspase-8/3-mediated GSDMD/E activation and pyroptosis in influenza A virus-infected airway epithelial cells by Yuling Sun, Huidi Yu, Zhihao Zhan, Wei Liu, Penggang Liu, Jing Sun, Pinghu Zhang, Xiaoquan Wang, Xiufan Liu, Xiulong Xu

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Anticancer activity of Stemona tuberosa (wild asparagus) against type-II human lung adenocarcinoma (A549) cells and identification of SRC inhibitor using integrated network pharmac... by C. Lalmuansangi, Lalfakawmi, Fanai Nghakliana, Hmingremhlua Sailo, Lalchhandami Tochhawng, Amit Kumar Trivedi, Kiran R. Kharat, Balachandar Vellingiri, Nachimuthu Senthil Kumar, Zothan Siama

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Evaluation of Fifteen 5,6-Dihydrotetrazolo[1,5-<i>c</i>]quinazolines Against <i>Nakaseomyces glabrata</i>: Integrating In Vitro Studies, Molecular Docking, QSAR, and In Silico Toxi... by Lyudmyla Antypenko, Oleksii Antypenko, Alina Fominichenko, Iryna Karnaukh, Serhii Kovalenko, Mieko Arisawa

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Integrated analysis of tyrosine-induced MiRNA and mRNA expression profiles in melanocytes reveals the regulatory role of miR-1560-3p in melanin deposition in Xichuan black-bone chi... by Zhiyuan Zhang, Pengwei Zhang, Fumin He, Yingdong Hou, Xiaowen Geng, Ruilong Xu, Ruiting Li, Yadong Tian, Wenting Li, Guirong Sun, Ruirui Jiang, Xiaojun Liu, Ruili Han, Guoxi Li, Xiangtao Kang, Donghua Li

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Identification and evaluation of bioactive compounds from Azadirachta indica as potential inhibitors of DENV-2 capsid protein: An integrative study utilizing network pharmacology,... by Md. Ahad Ali Khan, Md. Nazmul Hasan Zilani, Mahedi Hasan, Nahid Hasan

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Estimating Efficiency of Business Ecosystem Functioning in Digital Economy by O. E. Kalenov

“…The article proposes to study ecosystems without binding to any concrete type of activity, for instance, banking, telecommunication, etc. …”
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