Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis by Yue-Jie Xu, Cai-Zhi Liu, Ying Chen, Lan-Xin Li, Bo Xu, Ling-Xin You, Mei-Yao Meng, Xin Li, Hong Zhang, Qiu-Rong Ding, Rong Zhang, Xin-Ran Ma, Xiao-Hua Chen, Cheng Hu

“…Serum fibroblast growth factor binding protein 1 (FGFBP1) protein levels in ALI patients were assessed via enzyme-linked immunosorbent assay. …”
Get full text

Integrating Strategy of Network Pharmacology, Molecular Dynamics Simulation, and Experimental Verification to Investigate the Potential Mechanism of <i>Gastrodia elata</i> Against... by Peiyuan Sun, Ruohan Zhang, Xuanyou Li, Dengwang Yang, Shunfeng Ji, Lei Peng, Jun Sheng, Jing Wang

Get full text

Electrochemically reduced graphene oxide integrated with carboxylated-8-carboxamidoquinoline: A platform for highly sensitive voltammetric detection of Zn(II) ion by screen-printed... by Ling Ling Tan, Nur Syamimi Mohamad, Nurul Izzaty Hassan, Choo Ta Goh

Get full text

Unraveling anti-inflammatory components and mechanisms in decoction derived from Allium ascalonicum L. Bulbs and Sojae Semen Praeparatum via UPLC-MS/MS integrated with bioinformati... by Yuanyuan Jiang, Junya Wen, Wenfeng Wei, Jinhai Huo, Yingying Yang, Weiming Wang

Get full text

Plant Compounds Inhibit the Growth of W12 Cervical Precancer Cells Containing Episomal or Integrant HPV DNA; Tanshinone IIA Synergizes with Curcumin in Cervical Cancer Cells by Linda Saxe Einbond, Jing Zhou, Kunhui Huang, Mario R. Castellanos, Emeka Mbazor, Michael Balick, Hongbao Ma, James A. DeVoti, Stephen Redenti, Hsan-au Wu

“…Molecular docking studies suggested tanshinone IIA and curcumin bind to the Na⁺/K⁺-ATPase ion channel, with curcumin binding with higher affinity. …”
Get full text

RsWRKY40 coordinates the cold stress response by integrating RsSPS1-mediated sucrose accumulation and the CBF-dependent pathway in radish (Raphanus sativus L.) by Sen Chen, Liang Xu, Yan Wang, Baozhen Mao, Xiaoli Zhang, Qiyu Song, Feng Cui, Yingbo Ma, Junhui Dong, Kai Wang, Hongyu Bi, Liwang Liu

“…Together, a transcription module of RsWRKY40 orchestrated cold stress response by integrating sucrose accumulation and the CBF-dependent pathway was uncovered. …”
Get full text

TNFRSF13B VARIANTS ACT AS MODIFIERS TO CLINICAL PHENOTYPES IN COMMON VARIABLE IMMUNE DEFICIENCY DISORDERS by Sinem Fırtına, Aslı Kutlu, Begüm Işıkgil, Medinenur Yozlu, Beyza Nur Cepeci, Hülya Yılmaz, Yuk Yin Ng, Özden Hatırnaz Ng, Ayça Kıykım, Esra Özek Yücel, Elif Karakoç Aydıner, Safa Barış, Ahmet Oğuzhan Özen, Serdar Nepesov, Yıldız Çamcıoğlu, İsmail Reisli, Muhlis Cem Ar, Müge Sayitoğlu

“…Besides the disease-causing variants of this gene, its different isoforms are associated with strong and weak TNFRSF13B expression that leads to an unbalanced B cell response.Materials and Methods: The study detected 26 variants (three synonymous, five missenses, eleven UTR, and seven intronic variants) in the TNFRSF13B gene by screening 68 CVID patients with targeted next generation sequencing. An integrative bioinformatics approach was utilized to provide a plausible explanation for CVID associations from different perspectives and to investigate the associations from the clinical findings.Results: Fifty-eight percent (15/26) of the detected variants were altered regulatory elements, such as transcription factor binding, miRNA binding sites, splice site regions or the thermodynamic impact on protein. …”
Get full text

Integrated approach of network pharmacology, molecular docking, and clinical observations in evaluating the efficacy and safety of Bufei Huoxue capsules for pulmonary hypertension... by Wenjun He, Chunli Liu, Xuanyi Li, Bihua Zhong, Qian Jiang, Ning Lai, Yuanhui Xiong, Weici Feng, Yilin Chen, Dansha Zhou, Defu Li, Wenju Lu, Jurjan Aman, Harm Jan Bogaard, Jian Wang, Yuqin Chen

Get full text

Disordered regions and folded modules in CAF-1 promote histone deposition in Schizosaccharomyces pombe by Fouad Ouasti, Maxime Audin, Karine Fréon, Jean-Pierre Quivy, Mehdi Tachekort, Elizabeth Cesard, Aurélien Thureau, Virginie Ropars, Paloma Fernández Varela, Gwenaelle Moal, Ibrahim Soumana Adamou, Aleksandra Uryga, Pierre Legrand, Jessica Andreani, Raphaël Guerois, Geneviève Almouzni, Sarah Lambert, Francoise Ochsenbein

“…Genome and epigenome integrity in eukaryotes depends on the proper coupling of histone deposition with DNA synthesis. …”
Get full text

Eucommia Ulmoides Gum Soft‐Hard Gradient Composite Materials with Shape Memory Property by Furao Wang, Jinjian Lin, Tao Liao, Kexu Bao, Rongzhen Fu, Ruifeng Zhao, Jichuan Zhang

Get full text

Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission Ex Vivo by Flora Mikaeloff, Marco Gelpi, Alejandra Escós, Tianqi Wang, Soham Gupta, Anna Olofsson, Sara Svensson Akusjärvi, Sabrina Schuster, Prajakta Naval, Vikas Sood, Negin Nikouyan, Andreas D. Knudsen, Beate Vestad, Julie Høgh, Johannes R. Hov, Thomas Benfield, Marius Trøseid, Vinay Pawar, Marijana Rucevic, Rui Benfeitas, Ákos Végvári, Liam O'Mahony, Rajkumar Savai, Niklas K. Björkström, Magda Lourda, João Pedro deMagalhães, Siegfried Weiss, Adil Mardinoglu, Mukesh Kumar Varshney, Annika C. Karlsson, Yasir Ahmed Syed, Susanne D. Nielsen, Ujjwal Neogi

“…A personalized medicine approach integrating blood cell transcriptomics, plasma proteomics, and metabolomics is employed to identify the mechanisms of immunometabolic complications in prolonged treated PWH from the COCOMO cohort. …”
Get full text

Exploring chemical constituents and anti-inflammatory mechanisms of Semiaquilegiae Radix via an integrated strategy combining UHPLC-Q-TOF–MS analysis, network pharmacology and mole... by Gengyi Shang, Xun Gao, Rong Guo, Ying Zhang, Chenfeng Zhang, Yun Shi, Kunming Qin

Get full text

Integrated systems biology and structural approaches to discover novel biomarkers and small molecule inhibitors using the gene expression data from drug-resistant breast cancer cel... by Suad A. Alghamdi, Mohammed Alissa, Muhammad Suleman

Get full text

INFODORADCA+ project from the perspective of the management team by Jarosław ZYSNARSKI, Monika Dryl

Get full text

Clinical efficacy and regulatory mechanisms of Shi Pi Zeng Ye formula in treating functional constipation comorbid with depression: integrating clinical observation, mass spectrome... by Ling Yao, Xiaoqiang Jia, Yufei Li, Haixia Li, Zhuhui Zhang, Longfang Quan, Qiuling Liu, Jie Dai, Xuedi Lei, Huashang Li, Yonghai Li

Get full text

Repurposing terfenadine and domperidone for inhibition of apoptotic gene association in colorectal cancer: A system pharmacology approach integrated with molecular docking, MD simu... by Pushpaveni C, Hemavathi S, Santosh Prasad Chaudhary Kurmi, Biswa Ranjan Patra, V Angelin Esther, Chandrajeet Kumar Yadav, Mahalakshmi Suresha Biradar, Shankar Thapa

“…Molecular docking studies demonstrated high binding affinities of both terfenadine and domperidone against all selected targets (−7.1 to −11.5 kcal/mol), with the strongest interaction observed with DRD2, where both compounds exhibited a binding affinity of −11.5 kcal/mol. …”
Get full text

Berberine Mitigates Sepsis-Associated Acute Kidney Injury in Aged Rats by Preserving Mitochondrial Integrity and Inhibiting TLR4/NF-κB and NLRP3 Inflammasome Activations by Ruedeemars Yubolphan, Anongporn Kobroob, Apisek Kongkaew, Natthakarn Chiranthanut, Natthanicha Jinadang, Orawan Wongmekiat

“…BBR pretreatment substantially mitigated these adverse effects, suggesting that it protects against SA-AKI in aged rats by reducing oxidative stress, preserving mitochondrial integrity, and inhibiting key inflammatory pathways. …”
Get full text

Integrated approach with UHPLC-Q-Exactive-tandem mass spectrometry, network analysis, and molecular docking to determine potential active compounds and mechanisms of Rhizoma Musae... by Jian Zhang, Wanyan Shen, Fanzhi Liu, Hehe He, Shuquan Han, Lina Luo

“…Molecular docking studies showed significant binding affinity between the core targets and key components. …”
Get full text

Integrated multi-omics analysis identifies TLR4-mediated mechanisms in ATBC-induced ovarian dysfunction and female infertility: A network toxicology, transcriptomic, and Mendelian... by Jinfa Huang, Lingling Zeng, Qian Yang, Kaixian Deng

“…This study employs an integrative computational framework to elucidate ATBC-associated targets and pathways, with validation through genetic epidemiology and molecular docking. …”
Get full text

An integrated in vitro and in silico approach to assess targeted cytotoxicity against MDA-MB-231 triple-negative breast cancer cells with Psidium guajava peel-derived chitosan nano... by Vino Udappusamy, Rajan Thinagaran, Vijayakumar Mayakrishnan, Janani Balakarthikeyan, Priya Kannappan, Sameer Al-Ghamdi, Naif Abdurhman Alrudian, Mohammed Saad Alqahtani, Khalid Albasheer, Chandrabose Sureka, Mahmoud H. El-Bidawy, Nesreen Alsanousi, Sahar Gamil, Thiyagarajan Ramesh

Get full text