Integrated mRNA and miRNA Omics Analyses Reveal Transcriptional Regulation of the Tolerance Traits by <i>Aquatica leii</i> in Response to High Temperature by Chao Liu, Jiapeng Li, Lihong Yan, Yuting Zhu, Zikun Li, Chengquan Cao, Yiping Wang

“…This study performed an integrated miRNA and mRNA analysis on <i>Aquatica leii</i> larvae exposed to temperatures of 20 °C, 24 °C, 28 °C, and 32 °C. …”
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Integrative multi-omics identifies AP-1 transcription factor as a targetable mediator of acquired osimertinib resistance in non-small cell lung cancer by Bengisu Dayanc, Sude Eris, Nazife Ege Gulfirat, Gulden Ozden-Yilmaz, Ece Cakiroglu, Ozlem Silan Coskun Deniz, Gökhan Karakülah, Serap Erkek-Ozhan, Serif Senturk

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Identification of Immune-Related Genes and Small-Molecule Drugs in Interstitial Cystitis/Bladder Pain Syndrome Based on the Integrative Machine Learning Algorithms and Molecular Do... by Yiheng Jiang, Xinqing Zhu, Abdullah Y. Al-danakh, Qiwei Chen, Deyong Yang

“…When compared to the normal control group, the IC/BPS cohort had significantly more immune cell infiltration. Integrative machine learning methods discovered 5 IC/BPS characteristic genes (RASGRP1, PPBP, RBP4, CR2, and PROS2) that may predict IC/BPS diagnosis and immune cell infiltration. …”
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Integrative investigation on Hippocratea africana root: insights from cardio-protective, anti-oxidative stress activities, isolation, GC/MS, and pharmacological significance profil... by Edet Effiong Asanga, Kufre Uyo Noah, Jude Efiom Okokon, Chinedum Martins Ekeleme, Imaobong Etima Udoh, Augustine Bassey, Martin Osita Anagboso, Aniekeme Ndisa Inyang

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Annonacin induces apoptosis and modulates programmed death-ligand 1 and interferon-gamma expression in triple-negative breast cancer: Integrated in silico and in vitro analysis by Retina Yunani, Sri Agus Sudjarwo, Mustofa Helmi Effendi, Rochmah Kurnijasanti, Nurul Hidayah

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Identification of potential key targets and mechanisms underlying cleft palate induced by tobacco smoke exposure through multi-omics integrated Mendelian randomization analysis by Yuxin Lin, Xiaoping Zhong, Zhengyuan Chi, Hui Li, Rui Han, Hao Li, Shukai Zheng, Shijie Tang, Jiasheng Chen

“…Although the mechanisms underlying TS-induced CP remain incompletely understood, this study provides novel insights by integrating multi-omics with Mendelian Randomization (MR) analyses. …”
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Identification and characterization of CmPP2C31 playing a positive role in the abiotic stress resistance of Chinese chestnut via an integrated strategy by Xuan Wang, Xuan Wang, Wenli Shang, Wenli Shang, Mingyuan Li, Fei Cao, Fei Cao, Dongsheng Wang, Meng Wang, Yi Lu, Haie Zhang, Fei Shen, Jing Liu

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Mechanistic Exploration of Yiqi Zengmian in Regulating the Microenvironment as an Immunopotentiator with the Beijing Bio-Institute of Biological Products Coronavirus Vaccine Based... by Zeyue Yu, Yudong Wang, Jianhui Sun, Xiaotong Zheng, Liyu Hao, Yurong Deng, Jianliang Li, Zongyuan Li, Zhongchao Shan, Weidong Li, Yuling Qiao, Ruili Huo, Yibai Xiong, Hairu Huo, Hui Li, Longfei Lin, Hanhui Huang, Guimin Liu, Aoao Wang, Hongmei Li, Luqi Huang

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Identification of key genes associated with residual feed intake in small-sized meat ducks through integrated analysis of mRNA and miRNA transcriptomes by Dandan Geng, Chunyou Yuan, Xiaofan Li, Chenxiao Wang, Qixin Guo, Yong Jiang, Zhixiu Wang, Guohong Chen, Guobin Chang, Hao Bai

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Integrative Transcriptome‐Wide Association Study With Expression Quantitative Trait Loci Colocalization Identifies a Causal VAMP8 Variant for Nasopharyngeal Carcinoma Susceptibilit... by Yan Liang, Xiang‐Yu Xiong, Guo‐Wang Lin, Xiaomeng Bai, Fugui Li, Josephine Mun‐Yee Ko, Yun‐He Zhou, An‐Yi Xu, Shu‐Qiang Liu, Shuai He, Pan‐Pan Wei, Qiu‐Yan Chen, Lin‐Quan Tang, Vivien Ya‐Fan Wang, Hai‐Qiang Mai, Chun‐Ling Luo, Yanni Zeng, Maria Li Lung, Mingfang Ji, Jin‐Xin Bei

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Unveiling Pharmacological Mechanisms of <i>Bombyx mori</i> (Abresham), a Traditional Arabic Unani Medicine for Ischemic Heart Disease: An Integrative Molecular Simulation Study by Doni Dermawan, Nasser Alotaiq

“…The MD-based MM/PBSA calculations revealed the binding free energy values of Menaquinone-7 (−35.12 kcal/mol), Quercetin (−29.38 kcal/mol), and Behenic acid (−27.76 kcal/mol), confirming their strong binding affinity. …”
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Evaluating the inhibitory efficacy of Oxalis phytocompounds on monoamine oxidase B: An integrated approach targeting age related neurodegenerative diseases through molecular dockin... by Ram Lal Swagat Shrestha, Shiva M C, Ashika Tamang, Manila Poudel, Nirmal Parajuli, Aakar Shrestha, Timila Shrestha, Samjhana Bharati, Binita Maharjan, Bishnu P Marasini, Jhashanath Adhikari Subin

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Enhancing Security and Authenticity in Immersive Environments by Rebecca Acheampong, Dorin-Mircea Popovici, Titus Balan, Alexandre Rekeraho, Manuel Soto Ramos

“…The system employs RSA-2048 for signing and SHA-256 hashing for binding the digital signature to the asset’s data to prevent tampering and forgery. …”
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Revealing the Multi-Target Mechanisms of Fespixon Cream in Diabetic Foot Ulcer Healing: Integrated Network Pharmacology, Molecular Docking, and Clinical RT-qPCR Validation by Tianbo Li, Dehua Wei, Jiangning Wang, Lei Gao

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Integrated In Silico, In Vitro, and In Vivo Studies Reveal Mangiferin as a Promising Antiviral Agent Against H1N1/pdm2009 Influenza Virus by Yinde Gan, Fucheng Guo, Ayan Roy, Xiao Wang, Yongyi Shen

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Integrated multi-omics profiling to establish an IGFBP-based prognostic score for pancreatic ductal adenocarcinoma: unraveling prognostic biomarkers, immune microenvironment crosst... by Xiao Guan, Yongrun Mu, Xin Jin, Chengfeng Wang

“…Clinical manifestations such as hyperglycemia and insulin resistance are common and have been linked to aberrant expression of insulin-like growth factor-binding proteins (IGFBPs). However, the specific roles and mechanisms of IGFBP family genes in PDAC remain unclear.MethodWe conducted a multi-dimensional integrative analysis using publicly available PDAC cohorts, stratifying patients based on IGFBP gene expression profiles. …”
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Integrative proteomics and metabolomics analyses reveals the regulation of autophagy and ferroptosis by RAB10 through Slc37a2/mTOR pathway in breast cancer by Yuxin Ji, Ruonan Li, Guohui Tang, Yuhan Xiao, Ruyin Ye, Jiwen Shi, Chenchen Geng, Ruorong Ran, Chengle Zhu, Wenrui Wang, Changjie Chen, Qingling Yang

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Uncovering the mechanistic basis of Rheum palmatum L. (rhubarb) in the treatment of chronic kidney disease: an integrative approach using network pharmacology, molecular docking, a... by Wenjing He, Zhen Wei, Siwei Li, Songji Han, Jing Ma, Lei Wu, Dan Lu, Guang Ta

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Network pharmacology integrated with molecular docking and experimental validation elucidates the therapeutic potential of Forsythiae Fructus extract against hepatitis B virus-rela... by Fuqing Chen, Yifan Cai, Changzhou Chen, Jianyin Zhou

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Deep learning algorithm reveals probabilities of stage‐specific time to conversion in individuals with neurodegenerative disease LATE by Xinxing Wu, Chong Peng, Peter T. Nelson, Qiang Cheng

“…Abstract Introduction Limbic‐predominant age‐related TAR DNA‐binding protein 43 (TDP‐43) encephalopathy (LATE) is a recently defined neurodegenerative disease. …”
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