Suggested Topics within your search.
Suggested Topics within your search.
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RNA binding proteins (RBPs) on genetic stability and diseases
Published 2025-03-01“…RNA-binding proteins (RBPs) are integral components of cellular machinery, playing crucial roles in the regulation of gene expression and maintaining genetic stability. …”
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42
Deep Learning for Predicting Biomolecular Binding Sites of Proteins
Published 2025-01-01“…The rapid evolution of deep learning has markedly enhanced protein–biomolecule binding site prediction, offering insights essential for drug discovery, mutation analysis, and molecular biology. …”
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43
DNA–Protein Binding is Dominated by Short Anchoring Elements
Published 2025-05-01“…This method allows for the direct identification of the dominant role of AEs from experimental data. Moreover, when integrated with genomic data, it reveals an energetic funnel around transcription factor binding sites (TFBSs), which is directly correlated with the density of AEs (AED). …”
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44
The next generation of transcription factor binding site prediction.
Published 2013-01-01“…Moreover, using available TF-DNA affinity measurements for the Max TF, we demonstrate that TFFMs constructed from ChIP-seq data correlate with published experimentally measured DNA-binding affinities. Finally, TFFMs allow for the straightforward computation of an integrated TF occupancy score across a sequence. …”
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Ensembling methods for protein-ligand binding affinity prediction
Published 2024-10-01Get full text
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47
Global analysis of small molecule binding to related protein targets.
Published 2012-01-01“…We report on the integration of pharmacological data and homology information for a large scale analysis of small molecule binding to related targets. …”
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48
Selective Enrichment of Hypermethylated DNA by a Multivalent Binding Platform
Published 2022-12-01“…In the here proposed method, a methyl binding domain (MBD) protein immobilized at a surface is used as a receptor for (hyper)methylated DNA. …”
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Allosteric binding sites in Rab11 for potential drug candidates.
Published 2018-01-01“…Although they are medically important, no previous study has found Rab11 allosteric binding sites where potential drug candidates can bind to. …”
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51
Proteome-wide determinants of co-translational chaperone binding in bacteria
Published 2025-05-01“…Here, by integrating genome-wide selective ribosome profiling, single-molecule tools, and computational predictions using AlphaFold we show that the binding of the main E. coli chaperones involved in co-translational folding, Trigger Factor (TF) and DnaK correlates with “unsatisfied residues” exposed on nascent partial folds – residues that have begun to form tertiary structure but cannot yet form all native contacts due to ongoing translation. …”
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52
Competitive dCas9 binding as a mechanism for transcriptional control
Published 2021-11-01“…Natural promoters use overlapping binding sites as a mechanism for signal integration, where the binding of one can block, displace, or augment the activity of the other. …”
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Odors drive feeding through gustatory receptor neurons in Drosophila
Published 2025-08-01Subjects: “…odor-taste multisensory integration…”
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A quantitative analysis of ligand binding at the protein-lipid bilayer interface
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55
Model of Organizational Structure for University Institutes Binding with the Venezuelan Socioeconomic Reality
Published 2014-01-01“…The present study is aimed at proposing a model of organizational structure for university institutes binding with the Venezuelan socioeconomic reality. …”
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Intra‐ and inter‐chromosomal interactions correlate with CTCF binding genome wide
Published 2010-11-01“…In this report, we use chromatin immunoprecipitation (ChIP) data that map protein‐binding sites on the genome, and Hi‐C data that map interactions between DNA fragments in the genome in an integrative approach. …”
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Binding the flows: Why trade is central for a global plastics treaty
Published 2025-01-01Get full text
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58
Identification of druggable binding sites and small molecules as modulators of TMC1
Published 2025-05-01“…Our pipeline successfully identified three potential drug-binding sites within the TMC1 pore, phospholipids, and key amino acids involved in the binding of several compounds, as well as FDA-approved drugs that reduced dye uptake in cultured cochlear explants. …”
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A Beautiful Bind: Phage Display and the Search for Cell-Selective Peptides
Published 2025-07-01“…Phage display has advanced the discovery of peptides that selectively bind to a wide variety of cell surface molecules, offering new modalities to modulate disease-related protein–protein interactions (PPIs). …”
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POT1 stability and binding measured by fluorescence thermal shift assays.
Published 2021-01-01“…The results from these assays provide thermodynamics details of POT1 folding, the sequence selectivity of its DNA binding and the thermodynamic profile for its binding to its preferred DNA binding sequence. …”
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