Integrated ATAC‐seq and RNA‐seq analysis identifies key regulatory elements in NK cells activated with feeder cells and IL‐2 by Pedram Motallebnejad, Zion Lee, Jennifer L. One, Frank Cichocki, Wei‐Shou Hu, Samira M. Azarin

Get full text

Multi-omics network toxicology reveals the role of benzo[a]pyrene in ovarian cancer: Integrating gut microbiota dynamics and Mendelian randomization by Jinfa Huang, Qian Yang, Lingling Zeng, Kaixian Deng

“…This study elucidates the role and molecular mechanisms of the environmental carcinogen benzo[a]pyrene (BaP) in the pathogenesis of ovarian cancer by employing an integrative approach that combines multi-omics networks, gut microbiota analysis, and Mendelian randomization. …”
Get full text

Integrating network pharmacology, molecular docking, and animal studies to investigate the protective effect of astragalus polysaccharide on fluoride-induced renal injury in rats by Xiaoyue Zhang, Qianda Yan, Yuanyuan Xiao, Xingyan Du, Xuehua Zhang, Didong Lou, Fang Peng, Daiyong Chen, Wenchao Tang

Get full text

Aptamer-based dual-enzyme, amplification-free biosensor integrating CRISPR-Cas12a and Exo III for sensitive detection of ATP by Baolin Li, Yaxin Huang, Zixin Zhu, Min Zhong, Guangrong Li, Jinbo Liu

Get full text

Integrated 4D label-free proteome and SUMOylated proteome in glioma uncover novel pathological mechanisms and pave the way for precision therapy by Jiazheng Wang, Zhuo Li, Kaijie Mu, Qichao Qi, Zeli Zhang, Can Yan, Xukai Jiang, Anjing Chen

“…Bioinformatics analysis was applied to identify differentially expressed proteins (DEPs) and differentially SUMOylated proteins, elucidating their functions and interactions. By integrating proteomics and transcriptomics data, we pinpointed core proteins with consistent upregulation and assessed their potential as drug targets in glioma through virtual screening of eight cytoplasmic proteins with small molecule binding cavities. …”
Get full text

Stress resilience in Coffea arabica and Coffea canephora under harsh drought and/or heat conditions: selected genes, proteins, and lipid integrated responses by José C. Ramalho, José C. Ramalho, Isabel Marques, Isabel P. Pais, Isabel P. Pais, Jean Armengaud, Duarte Gouveia, Ana P. Rodrigues, Danielly Dubberstein, Danielly Dubberstein, Danielly Dubberstein, António E. Leitão, António E. Leitão, Miroslava Rakočević, Paula Scotti-Campos, Paula Scotti-Campos, Sónia Martins, Sónia Martins, Magda C. Semedo, Magda C. Semedo, Fábio L. Partelli, Fernando C. Lidon, Fábio M. DaMatta, Ana I. Ribeiro-Barros, Ana I. Ribeiro-Barros

Get full text

Fh15 Reduces Colonic Inflammation and Leukocyte Infiltration in a Dextran Sulfate Sodium-Induced Ulcerative Colitis Mouse Model by María Del Mar Figueroa-Gispert, Claudia M. Ramos-Lugo, Carlimar Ocasio-Malavé, Rizaldy P. Scott, Jared T. Ahrendsen, Mercedes Gomez-Samblas, Antonio Osuna, Stephanie M. Dorta-Estremera, Ana M. Espino

“…This study evaluates the anti-inflammatory potential of Fh15, a recombinant <i>Fasciola hepatica</i> fatty acid binding protein, in a DSS-induced UC mouse model. …”
Get full text

Biological potential of Lophosoria quadripinnata fern extract: integration of UHPLC/ESI/QToF/MS analysis, antioxidant activity, molecular docking and molecular dynamics simulation by Alfredo Torres-Benítez, José Erick Ortega-Valencia, Juan Rodrigo Salazar, Jaqueline Ley-Martínez, Javian Gallardo-Valdivia, Marta Sánchez, María Pilar Gómez-Serranillos, Gabriel Vargas-Arana, Gabriel Vargas-Arana, Mario J. Simirgiotis

Get full text

Neuropathological stages of neuronal, astrocytic and oligodendrocytic alpha-synuclein pathology in Parkinson’s disease by Maria Otero-Jimenez, Marcelina J. Wojewska, Lawrence P. Binding, Simona Jogaudaite, Sandra Gray-Rodriguez, Alexandra L. Young, Steve Gentleman, Javier Alegre-Abarrategui

Get full text

Integrating single-cell RNA-Seq and bulk RNA-Seq data to explore the key role of fatty acid metabolism in hepatocellular carcinoma by Hua Dai, Xin Tao, Yuansen Shu, Fanrong Liu, Xiaoping Cheng, Xiushen Li, Bairui Shu, Hongcheng Luo, XuXiang Chen, Zhaorui Cheng

Get full text

Evaluation and optimization simulation of land suitability for village construction in the urban rural integration zone empirical test based on 49 administrative villages in Chuzho... by Shuping Fan, Yuntao Zhu, Huimin Guo, Qi Wang, Yishi Mi, Xin Gao, Yangbing Liu, Zihao Su

Get full text

Integrated analysis of bioinformatics, mendelian randomization, and experimental validation reveals novel diagnostic and therapeutic targets for osteoarthritis: progesterone as a p... by Ziyu Weng, Chenzhong Wang, Bo Liu, Yi Yang, Yueqi Zhang, Chi Zhang

Get full text

In silico exploration of novel EGFR-targeting compounds: integrative molecular modeling, docking, pharmacokinetics, and MD simulations for advancing anti-cervical cancer therapeuti... by Auwal Salisu Isa, Adamu Uzairu, Umar Meleh Umar, Muhammad Tukur Ibrahim, Abdullahi Bello Umar, Kamal Tabti, Abdussamad Mukhtar Mohammed

Get full text

Integrative bioinformatics and machine learning approaches reveal oxidative stress and glucose metabolism related genes as therapeutic targets and drug candidates in Alzheimer’s di... by Fatima Noor, Sidra Aslam, Ignazio S. Piras, Cecilia Tremblay, Thomas G. Beach, Geidy E. Serrano

“…We discovered drug candidates with strong binding affinities, offering new avenues for effective AD treatment strategies.…”
Get full text

Integrative multi-omics analysis of IFNγ-induced macrophages and atherosclerotic plaques reveals macrophage-dependent STAT1-driven transcription in atherosclerosis by Mahdi Eskandarian Boroujeni, Natalia Lopacinska, Aleksandra Antonczyk, Katarzyna Kluzek, Joanna Wesoly, Hans A. R. Bluyssen

“…Comparative MØ-dependent expression analysis in aortic lesions from LDLr-/- and ApoE-/- high fat diet mouse models substantiated overlap between human and mouse atherosclerosis and identified 24 MØ-specific commonly expressed STAT1-dependent integrated genes. Collectively, we provide detailed insights into MØ-specific IFNγ-activated transcriptional changes, mediated by STAT1-PU.1 co-binding and associated epigenetic changes, and offer the identification of new biomarkers and therapeutic targets in atherosclerosis. …”
Get full text

Changes in chromatin accessibility are not concordant with transcriptional changes for single‐factor perturbations by Karun Kiani, Eric M Sanford, Yogesh Goyal, Arjun Raj

Get full text

Valproate-vitamin E co-treatment preserved cortico-callosal white matter integrities in cypermethrin co-exposed pentylene tetrazole induced seizure by Aminu Imam, Oluwadamilola Eunice Ajibola, Aalimah Akinosho Akorede, Omamuyovwi Meashack Ijomone, Moyosore Salihu Ajao

“…This study investigates the effects of Cypermethrin (CPM) on Pentylenetetrazole (PTZ)-induced seizures and the Vitamin E (Vit E) and valproate (VAP) co-interventions on myelin and glial integrity. Methods Histochemical and immunohistochemical analyses for hematoxylin and eosin (H&E), myelin basic protein (MBP), ionized calcium-binding adaptor molecule 1 (IBA1), glial fibrillary acidic protein (GFAP), and oligodendrocyte transcription factor 2 (OLIG-2) were conducted on cerebral white matter and corpus callosum tissues. …”
Get full text

Past, present and (possible) future of biofouling regulatory instruments within the international marine environmental protection framework by Mar Santos-Simón, Ainhoa Fernández-García de la Yedra, Maren Ortiz-Zarragoitia, Agnese Marchini

“…Finally, the main gaps and challenges for the development of a regulatory framework on biofouling are identified and listed, along with the major learnings and proposals derived from the experimental outcomes of recent works, to provide an integrative tool for suitable antifouling selection.…”
Get full text

Homogeneous electrochemical detection of carcinoembryonic antigen based on target-controlled catalytical reaction of platinum/UiO-66 MOFs nanozyme integrated with aptamer by Jie Zhang, Yuanying Shi, Liming Liu, Bin Qiu, Yue Tian, Guodong Guo

“…The presence of CEA induces specific Apt-CEA binding, resulting Apt away from the nanozyme surface and restoring catalytic activity in a concentration-dependent manner. …”
Get full text

The crucial role of mitochondrial/chloroplast-related genes in viral genome replication and host defense: integrative systems biology analysis in plant-virus interaction by Amir Ghaffar Shahriari, Aminallah Tahmasebi, Mohamad Hamed Ghodoum Parizipour, Zahra Soltani, Ahmad Tahmasebi, Muhammad Shafiq Shahid

“…Promoter analysis revealed that AP2/EREBP, DOF, and C2H2 zinc finger factors included the most frequent binding sites and played a more important role in plant-viral interactions. …”
Get full text