Integrated microarray analysis of HPV of Mus musculus revealed the proteasome subunit beta type 6 gene as a potential biomarker by Mallari Praveen, Somdutt Mujwar, Swanti Gupta

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DIORS: Enhancing drug-target interaction prediction via structure and signature integrated-driven approach and discovering potential targeted molecules by Yiran Tang, Shengqiao Gao, Dan Luo, Xuyong Jiang, Xueru Zhao, Wanting Hu, Yongxiang Zhang, Zhiyong Xiao, Lu Han, Wenxia Zhou

“…Drug-target interaction prediction is critical for drug development. Through the integration of structural and transcriptional signature information, molecules both binding to the target and producing therapeutic activities could be found out to improve targeted drug prediction. …”
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Integrating molecular docking and network pharmacology to reveal the molecular mechanisms of Anemarrhena asphodeloides in the treatment of non-small cell lung cancer by Xianshun Xie, Yiling Jiang, Sumei Liu, Changjun Xie

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Integrative profiling of lung cancer biomarkers EGFR, ALK, KRAS, and PD-1 with emphasis on nanomaterials-assisted immunomodulation and targeted therapy by Li Peng, Hongmei Li, Wencai Yan, Yingjie Liu, Haihao Zhu, Yingcai Hong

“…Key mutations, including EGFR T790M and KRAS G12C, were localized to ATP-binding clefts and allosteric pockets respectively, based on structural mapping using SWISS-MODEL. …”
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Integration of bioaccumulations, chemical forms and gene expression responses to understand the transformation and detoxification of inorganic arsenic, cadmium and lead in the brow... by Yanfang Zhao, Yingying Guo, Jifa Wu, Xuming Kang, Xiaofeng Sheng, Zhijun Tan

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Revealing inhibitory activity of luteolin from Vietnamese Jatropha Podagrica Hook against Staphylococcus aureus by integrating in vitro and in silico approaches by Manh Hung Tran, Phu Chi Hieu Truong, Thuy Tram Thi Le, Hong Khuyen Thi Pham, Van Ngo Thai Bich, Y Ngo Huynh Thien, Loi Huynh, Phu Tran Vinh Pham

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Cepharanthine as an effective small cell lung cancer inhibitor: integrated insights from network pharmacology, RNA sequencing, and experimental validation by Fengyun Zhao, Zhaowei Ding, Mengting Chen, Mingfang Ji, Fugui Li

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Flunarizine as a potential repurposed drug for the serotonin transporter inhibition: an integrated approach for therapeutic development against major depressive disorder by Abdelbaset Mohamed Elasbali, Abdelbaset Mohamed Elasbali, Ahmed S. Ali, Ahmed S. Ali, Taj Mohammad, Mohd Adnan, Mohd Adnan, Anas Shamsi, Md. Imtaiyaz Hassan

“…The binding affinity, structural stability, and inhibitory potential were assessed using molecular docking and molecular dynamics (MD) simulations. …”
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Potential active ingredients and mechanisms of Shufeitie ointment in the treatment of chronic obstructive pulmonary disease by integrating transdermal chemistry and network pharmac... by Jianing Sun, Jianing Sun, Di Zhang, Panpan Wang, Panpan Wang, Panpan Wang, Panpan Wang, Junhan Shi, Junhan Shi, Junhan Shi, Junhan Shi, Tan Xue, Tan Xue, Panpan Zhang, Panpan Zhang, Qi Wang, Qi Wang, Xinjing Gui, Xinjing Gui, Xinjing Gui, Xinjing Gui, Suyun Li, Suyun Li, Jiansheng Li, Jiansheng Li, Xuelin Li, Xuelin Li, Xuelin Li, Xuelin Li, Ruixin Liu, Ruixin Liu, Ruixin Liu, Ruixin Liu, Ruixin Liu, Ruixin Liu

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Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. by Shadmehr Demehri, Zhenyi Liu, Jonghyeob Lee, Meei-Hua Lin, Seth D Crosby, Christopher J Roberts, Perry W Grigsby, Jeffrey H Miner, Andrew G Farr, Raphael Kopan

“…RBP-j is the DNA binding partner of Notch, but both RBP-j-dependent and independent Notch signaling were necessary for proper epidermal differentiation and lipid deposition. …”
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A Label-Free CRISPR/Cas12a-G4 Biosensor Integrated with FTA Card for Detection of Foodborne Pathogens by Anqi Chao, Qinqin Hu, Kun Yin

“…To tackle this problem, we have developed a label-free, equipment-free platform integrating FTA card-based extraction, CRISPR/Cas12a, and pre-folded G-quadruplex (G4)–Thioflavin T (ThT) signal reporter. …”
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Integrating Molecular Dynamics, Molecular Docking, and Machine Learning for Predicting SARS-CoV-2 Papain-like Protease Binders by Ann Varghese, Jie Liu, Tucker A. Patterson, Huixiao Hong

“…Our findings demonstrate the power of integrating computational modeling with machine learning to accelerate drug repurposing against emerging viral targets.…”
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Integrated transcriptomics and proteomics revealed that exogenous spermidine modulated signal transduction and carbohydrate metabolic pathways to enhance heat tolerance of lettuce by Yipei Duan, Wenjing Sun, Qian Wang, Lingling Cao, Huiyu Wang, Jinghong Hao, Yingyan Han, Chaojie Liu

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Integrated metabolome and transcriptome analyses provide comprehensive insight into dark- and light-responsive mechanisms in Althaea officinalis hairy root cultures by Yun Ji Park, Jae Kwang Kim, Nam Su Kim, Young Jin Park, Ramaraj Sathasivam, Sang Un Park

“…Moreover, light-responsive genes, such as ribulose bisphosphate carboxylase, photosystem II, and chlorophyll A-B binding family protein, were upregulated. Conclusions These findings emphasise that exposure of A. officinalis hairy root culture to light conditions is a useful method for enhancing most of the primary and secondary metabolites. …”
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Integrative in silico and in vivo Drosophila model studies reveal the anti-inflammatory, antioxidant, and anticancer properties of red radish microgreen extract by Trina Ekawati Tallei, Nova Hellen Kapantow, Nurdjannah Jane Niode, Sofia Safitri Hessel, Maghfirah Savitri, Fatimawali Fatimawali, Sojin Kang, Moon Nyeo Park, Muhammad Raihan, Widya Hardiyanti, Firzan Nainu, Bonglee Kim

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Integrative Analysis of Whole-Genome and Transcriptomic Data Reveals Novel Variants in Differentially Expressed Long Noncoding RNAs Associated with Asthenozoospermia by Maria-Anna Kyrgiafini, Maria Katsigianni, Themistoklis Giannoulis, Theologia Sarafidou, Alexia Chatziparasidou, Zissis Mamuris

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Integrated single-cell and bulk RNA dequencing to identify and validate prognostic genes related to T Cell senescence in acute myeloid leukemia by Mengyao Sha, Jun Chen, Haifeng Hou, Huaihui Dou, Yan Zhang

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Integrative network pharmacology, transcriptomics, and proteomics reveal the material basis and mechanism of the Shen Qing Weichang Formula against gastric cancer by Yi Wang, Xiaoyu Sun, Mingming Ren, Fangqi Ma, Ruohan Zhao, Xiaohong Zhu, Yan Xu, Nida Cao, Yuanyuan Chen, Yongfu Pan, Aiguang Zhao

“…A comprehensive strategy integrating mass spectrometry, network pharmacology, omics analysis, and bioinformatic methods was adopted to explore the core components, key targets, and potential mechanism of SQWCF in treating GC. …”
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Identification of the Casparian strip integrity factor (CIF) gene family in Brassica napus and functional prediction of mature CIF small peptides by Miao Cheng, Hanbing Hu, Rui Chen, Ling He, Shanshan Wang, Yuling Zheng, Jiten Yadav, Hosam O. Elansary, Nisha Jaswal, Deepak Bhanot, Changli Zeng, Xiaoyun Liu

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Integrated functional genomic analysis identifies regulatory variants underlying a major QTL for disease resistance in European sea bass by Robert Mukiibi, Serena Ferraresso, Rafaella Franch, Luca Peruzza, Giulia Dalla Rovere, Massimiliano Babbucci, Daniela Bertotto, Anna Toffan, Francesco Pascoli, Sara Faggion, Carolina Peñaloza, Costas S. Tsigenopoulos, Ross D. Houston, Luca Bargelloni, Diego Robledo

“…RNA sequencing revealed a clear association between the QTL genotype and the expression of two of the IFI27L2A genes, and the IFI27L2 gene. Integration with chromatin accessibility and histone modification data pinpointed two SNPs in active regulatory regions of two of these genes (IFI27L2A and IFI27L2), and transcription factor binding site gains for the resistant alleles were predicted. …”
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