Anticancer and Antimalarial Assays of Xanthone-Fatty Acid Hybrids: Integrative <i>In Vitro</i> and <i>In Silico</i> Evaluation by Yehezkiel Steven Kurniawan, Harizal Harizal, Ervan Yudha, Kasta Gurning, Harno Dwi Pranowo, Eti Nurwening Sholikhah, Jumina Jumina

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Combined Effects of Particulate Matter Exposure and Exercise Training on Neuroplasticity-Related Growth Factors and Blood–Brain Barrier Integrity by Su-Youn Cho, Hee-Tae Roh

“…Exercise training mitigates these adverse effects by enhancing antioxidant activity, reducing inflammation, upregulating neuroplasticity-related growth factors, and preserving BBB integrity. However, the protective effects of exercise may be partially diminished under conditions of PM exposure.…”
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BPP43_05035 is a Brachyspira pilosicoli cell surface adhesin that weakens the integrity of the epithelial barrier during infection by Anandi Rajan, Pablo Gallego, Brendan Dolan, Piyush Patel, Chinmay Dwibedi, Ana S. Luis, Sergio Trillo-Muyo, Liisa Arike, Sjoerd van der Post, Magnus Simrén, Thaher Pelaseyed

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Integrated Immuno and bioinformatics assisted novel epitope vaccine against HIV infection: a study based on complete genome by Saurav Kumar Mishra, Abdelkrim Guendouzi, Neeraj Kumar, Ganesh Sharma, Taha Alqahtani, Magdi E. A. Zaki, Md. Abdullah Al mashud, Yewulsew Kebede Tiruneh, John J. Georrge

“…Therefore, we utilize integrated immuno and bioinformatics approaches in this study to design a peptide vaccine against HIV infection by targeting its complete genome. …”
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Integrated bioinformatics and network pharmacology to identify and validate macrophage polarization related hub genes in the treatment of osteoarthritis with Astragalus membranaceu... by Hui Zang, Liuyan Wang, Yang Wu, Junfei Chang, Wanjun Liu

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Integrated network pharmacology, transcriptomics, and experimental validation to explore the mechanism of Qihuang Jianpi Zishen granules against Sjögren’s syndrome by Haikun Wang, Zichuang Ma, Na Wu, Xin Wang, Xinmeng Yang

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Integrating network pharmacology and molecular docking to reveal the mechanism of Baihu Decoction in alleviating myocardial injury of heat stressed chicks by Mingyue Sun, Cuiyan Liu, Pengju Zhang, Hao Zhang, Hong Zhang, Tao Zhang, Chunyang Han

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Integrated Transcriptomic and Proteomic Analyses Reveal CsrA-Mediated Regulation of Virulence and Metabolism in <i>Vibrio alginolyticus</i> by Bing Liu, Huizhen Chen, Kai Sheng, Jianxiang Fang, Ying Zhang, Chang Chen

“…Increasing evidence suggests that post-transcriptional regulation by RNA-binding proteins and small RNAs (sRNAs) plays a crucial role in bacterial adaptation and metabolism. …”
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Female-specific associations of serum perfluoroalkyl and polyfluoroalkyl substances with sex hormonal/insulin dysregulation: An integrated population-based study by Le-Xin Yang, Junyu Zhai, Zi-Jiang Chen, Yanzhi Du

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Integrating network pharmacology and experimental validation to explore the mechanism of action of BushenQiangxin Formula for the treatment of chronic heart failure by Jinhua Pang, Jiejun Hou, Jinyi Chen, Wenchu Zhao, Tiantian Tang, Taotao Li, Ding Liu, Jinkai Li, Xuan Wang

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Integrating network pharmacology and molecular modeling to decipher the anti-esophageal squamous cell carcinoma mechanisms of Bidens pilosa L by Zhenzhen Yang, Cheng Chang, Na Gao, Pan Gao, Yinsen Song, Ruiting Feng, Jingjie Meng, Chen Wang, Haozhe Zhang, Tianli Fan

“…Molecular docking demonstrated high-affinity binding of (2E)-2-(3,4-Dihydroxybenzylidene)-6,7-Dihydroxy-Benzofuran-3-One (− 10.4 kcal/mol), Luteolin (− 10.1 kcal/mol), and Okanin (− 9.7 kcal/mol) to matrix metalloproteinase-9 (MMP9), specifically targeting catalytic residues GLU227 and TYR245. …”
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Identification and validation of shared biomarkers and drug repurposing in psoriasis and Crohn’s disease: integrating bioinformatics, machine learning, and experimental approaches... by Xiaolong Li, Xiaolong Li, Hui Cao, Mutian Niu, Mutian Niu, Qingbo Liu, Bin Liang, Junfeng Hou, Junfeng Hou, Jian Tu, Jian Tu, Jintao Gao, Jintao Gao

“…Molecular docking simulations were performed to assess the binding affinity of the drugs to key target proteins. …”
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Linking PFOS exposure to chronic kidney disease: A multimodal study integrating epidemiology, network toxicology, and experimental validation by Xulei Zuo, Shiyi Tan, Yuxi Zhang, Cong Zhang, Li Ma, Xiaoyu Hou, Wei Wang, Rongli Sun, Lihong Yin, Yuepu Pu, Juan Zhang

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DDX41 resolves G-quadruplexes to maintain erythroid genome integrity and prevent cGAS-mediated cell death by Honghao Bi, Kehan Ren, Pan Wang, Ermin Li, Xu Han, Wen Wang, Jing Yang, Inci Aydemir, Kara Tao, Renee Ma, Lucy A. Godley, Yan Liu, Vipul Shukla, Elizabeth T. Bartom, Yuefeng Tang, Lionel Blanc, Madina Sukhanova, Peng Ji

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Integrative in silico and Petra/Osiris/Molinspiration (POM) analysis of baicalein: identification of therapeutically relevant pharmacophores against keloid pathology by Abhay Mishra, Anothai Tangsumranjit, Manisha Nigam, Harish Chandra, Faisal A. Almalki, Taibi Hadda, Neti Waranuch

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Discovery of ROCK2 inhibitors through computational screening of ZINC database: Integrating pharmacophore modeling, molecular docking, and MD simulations. by Abdullah R Alanzi, Abdelaaty A Shahat, Bayan Abdullah Alhaidhal, Raghad Mohammad Aloatibi

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Computational modeling of cyclotides as antimicrobial agents against Neisseria gonorrhoeae PorB porin protein: integration of docking, immune, and molecular dynamics simulations by Muzamal Hussain, Muzamal Hussain, Nazia Kanwal, Alishba Jahangir, Nouman Ali, Nimra Hanif, Obaid Ullah

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Effects of multisensory simultaneity judgment training on the comprehension and cortical processing of speech in noise: a randomized controlled trial by Ansley J. Kunnath, Hannah S. Bertisch, Andrew S. Kim, René H. Gifford, Mark T. Wallace

“…Abstract Understanding speech in noise can be facilitated by integrating auditory and visual speech cues. Audiovisual temporal acuity, which can be indexed by the temporal binding window (TBW), is critical for this process and can be enhanced through simultaneity judgment training. …”
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Systems Biology-Driven Discovery of Host-Targeted Therapeutics for Oropouche Virus: Integrating Network Pharmacology, Molecular Docking, and Drug Repurposing by Pranab Dev Sharma, Abdulrahman Mohammed Alhudhaibi, Abdullah Al Noman, Emad M. Abdallah, Tarek H. Taha, Himanshu Sharma

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Electrochemical Impedance Spectroscopy-Based Biosensors for Label-Free Detection of Pathogens by Huaiwei Zhang, Zhuang Sun, Kaiqiang Sun, Quanwang Liu, Wubo Chu, Li Fu, Dan Dai, Zhiqiang Liang, Cheng-Te Lin

“…Key challenges—including non-specific binding, matrix effects, the inherently low ΔR_ct/decade sensitivity of impedance transduction, and long-term stability—are critically evaluated alongside recent breakthroughs. …”
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