High-performance hydrogen energy generation via innovative metal-organic framework catalysts and integrated system design by Kenzhebatyr Zh. Bekmyrza, Kairat A. Kuterbekov, Asset M. Kabyshev, Marzhan M. Kubenova, Aliya A. Baratova, Nursultan Aidarbekov, Mesfin Diro Chaka, Natei Ermias Benti

“…Electrochemical performance was analyzed in 1.0 M KOH. A custom-designed integrated electrolysis system at 75 °C assessed practical performance. …”
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Integrating Network Pharmacology and in vivo Validation to Explore the Mechanisms of Buyang Huanwu Decoction in Myocardial Ischemia-Reperfusion Injury by Luo Y, Hu W, Li Z, Zhang X, Chen S, Yang Q, Hu B, Zou X

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FICD (FIC Domain Protein Adenylyl Transferase) Deficiency Protects Mice From Hypertrophy‐Induced Heart Failure and Promotes BiP (Binding Immunoglobulin Protein) ‐Mediated Activatio... by Shannon M. Lacy, Rebecca J. Taubitz, Nicholas D. Urban, Samantha N. Turowski, Eric N. Primack, Eric D. Smith, Adam S. Helms, Daniel E. Michele, Matthias C. Truttmann

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Exploring the inhibitory effect and mechanism of 3,4,5-trihydroxybiphenyl on α-glucosidase: an integrated experimental and computational approach by Ruofan Guo, Ruofan Guo, Guohua Yu, Yuan Li, Youyou Wang, Youyou Wang, Huixia Fan, Shuo Zhang, Chen Wang, Junhui Zhou, Junhui Zhou, Jian Yang, Jian Yang, Feng Gao, Feng Gao, Zhiqiang Luo

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Psychoactive Plant Database: a phytochemical resource for neurological drug discovery by Harjot Kaur, Harjot Kaur, Monika Gupta, Monika Gupta, Zabeer Ahmed, Zabeer Ahmed, Amit Nargotra, Amit Nargotra

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Xist condensates: perspectives for therapeutic intervention by Irene Perotti, Laura Broglia, Gian Gaetano Tartaglia, Andrea Cerase

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LncRNA–Protein Interactions: A Key to Deciphering LncRNA Mechanisms by Zuoneng Wang, Muhammad Aftab, Zigang Dong, Yanan Jiang, Kangdong Liu

“…Here, we delve into the interactions between lncRNAs and RNA-binding proteins (RBPs), explore their implications in cellular processes, and examine bioinformatic and experimental approaches for characterizing these interactions. …”
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Integrated SegFlow, µSIA, and UPLC for Online Sialic Acid Quantitation of Glycoproteins Directly from Bioreactors by Letha Chemmalil, Tanmay Kulkarni, Mathura Raman, Priya Singh, Yueming Qian, Chris Chumsae, Kyle McHugh, Zhuangrong Huang, Eric Hodgman, Michael C. Borys, Julia Ding, Gloria Li, Anthony Leone

“…This work demonstrates the utility of an integrated PAT system for near real‐time online sialic acid measurements. …”
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Unraveling ScAPD1-mediated resistance mechanism to Verticillium dahliae through integrated host-pathogen transcriptomics by Qilin Yang, Ruirui Yang, Huan Zhang, Fangliu Yin, Leyi Wang, Daoyuan Zhang, Xiaoshuang Li

“…EMSAs demonstrated that ScAPD1 directly binds to promoter regions of key photosynthesis genes PsbQ1 and PsbO1, providing a direct mechanistic link to this preserved primary metabolism. …”
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Integrated oral-gut microbiota therapy: a novel perspective on preventing bacterial translocation for systemic disease management by Jie Zhu, Ziyi Jiang, Fangli Yu, Linglin Gao, Xiaomei Wang, Qiang Wang

“…It particularly highlights the translational value of integrating oral and gut microbiota research, offering novel insights for the prevention and precision treatment of systemic disorders. …”
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Screening and identification of vascular endothelial cell targeting peptide in gastric cancer through novel integrated in vitro and in vivo strategy by Yan-ting Zhang, Sheng-hui Wang, Li Zhao, Hui-min Wang, Lin Wang, Rong-rong Shi, Si-chao Liang, Bao-feng Li, Bei Chen

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Spatial transcriptomics unravels the interactive network of aflatoxin B1-driven gastric cancer: Multi-omics integration of transcriptome and mendelian randomization by Yong-Le Li, Cong Liu, Meng Tang, Wan-Shou Wei, Xiao-Mei Xie, Yuan Gan, Xuan-Hua Chen, Shan-Shan Dong, Li-He Jiang

“…Molecular docking simulations demonstrate significant binding activity between AFB1 and the core targets, with MAPK3 exhibiting the optimal binding affinity as evidenced by the most favorable binding free energy. …”
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Integrated Assessment of Antibacterial Activity, Polyphenol Composition, Molecular Docking, and ADME Properties of Romanian Oak and Fir Honeydew Honeys by Calin Hulea, Diana Obistioiu, Anca Hulea, Mukhtar Adeiza Suleiman, Doris Floares (Oarga), Ersilia Alexa, Ilinca Merima Imbrea, Alina-Georgeta Neacșu, Marius Pentea, Cosmin Alin Popescu, Florin Imbrea

“…The docking outcomes showed rutin, rosmarinic acid, beta resorcylic acid, quercetin, ferulic acid, and p-coumaric acid have high inhibitory activities characterised by binding affinities and binding interactions against shiga toxin, riboflavin synthase, ATP-binding sugar transporter-like protein, undecaprenyl diphosphate synthase, putative lipoprotein, sortase A, and immunity protein, making them key contributors to the honey’s antimicrobial activity. …”
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Respiratory toxicity mechanism of 6PPD and 6PPD-quinone: An integrated study based on network toxicology and molecular docking by Gang Li, Dan Li, Weibin Zhai, Chang Liu, Mengying Chen, Qingqiang Xu, Yuanlan Huang

“…Molecular docking and molecular dynamics simulations confirmed that both compounds showed high affinity binding to key toxicity targets (binding energy <-20.92 kJ/mol), and revealed the interaction mode of these two compounds with the key target CYCS. …”
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Identification of Therapeutic Potential of Hydroxychavicol Against Alzheimer’s Disease: An Integrated Network Pharmacology, Molecular Docking, and Dynamic Simulation Study by Priyank Upadhayay, Saurabh K. Sinha, Neeraj Kumar, Shashi Kant Singh, Preet Jain, Sunita Panchawat, Nitish Rai

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Integrating In Situ Non-Destructive Techniques and Colourimetric Analysis to Evaluate Pigment Ageing and Environmental Effects on Tibetan Buddhist Murals by Xiyao Li, Erdong She, Jingqi Wen, Yan Huang, Jianrui Zha

“…Initial cleaning efforts proved effective. The integrated approach adopted in this study provides a replicable model for mural diagnostics and conservation under complex environmental conditions.…”
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In Silico Discovery and Sensory Validation of Umami Peptides in Fermented Sausages: A Study Integrating Deep Learning and Molecular Modeling by Haochen Geng, Chunming Xu, Huijun Ma, Youxu Dai, Ziyou Jiang, Mingyue Yang, Danyang Zhu

“…Subsequently, molecular docking was performed to assess the binding stability of these peptides with the umami receptor T1R1/T1R3, selecting the three peptides DDSMAATGL, DGEEDASM, and DEEEVDI with the most stable binding for further study. …”
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Integrative Mendelian randomization and multi-omics analysis identifies anti-allergic drug targets associated with cardiovascular disease risk by Huilin Lian, Dai Li, Youjie Zeng, Yi Meng, Ruifang Chen, Ren Guo

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Discovery of Novel Natural Inhibitors of H5N1 Neuraminidase Using Integrated Molecular Modeling and ADMET Prediction by Afaf Zekri, Mebarka Ouassaf, Shafi Ullah Khan, Kannan R. R. Rengasamy, Bader Y. Alhatlani

“…Three lead compounds (C1: CID 102209473, C2: CID 85692821, and C3: CID 45379525) demonstrated strong binding affinity toward NA. Their ADMET profiles predicted favorable bioavailability and low toxicity. …”
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Integrating network pharmacology, IPA, and molecular docking to reveal the anti-osteoporosis effects of EA and EB via the FAK pathway by Ziheng Wei, Ziheng Wei, Fei You, Henghui Li, Si Wu, Fen Tang, Xiangyang Wan, Huizhong Dong, Wenxuan Huang, Songyan Gao, Bo Cai, Xiongsheng Chen, Xiongsheng Chen, Xin Dong

“…Molecular docking studies using Autodock confirmed the binding of EA and EB to FAK1 (binding free energy: −13.012 kJ/mol and −14.0164 kJ/mol) and FAK2 (binding free energy: −5.815 kJ/mol and −6.4852 kJ/mol). qPCR analysis further demonstrated that EA and EB significantly inhibited FAK1 and FAK2 gene expression in osteoclasts while promoting their expression in osteoblasts at very high doses. …”
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