Integrated computational and in vivo approaches for promoter editing in SWEET genes to enhance sheath blight resistance in rice by Vignesh Ponnurangan, David Jesudoss, Varanavasiappan Shanmugam, R. K. Mohana Pradeep, Krish K. Kumar, Jayakanthan Mannu, Prakasam Vellaichamy, Paranidharan Vaikuntavasan

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Integrated transcriptomics and metabolomics reveal multi-target mechanisms of tannins against Clostridium perfringens and necrotic enteritis by Huiping Xu, Lu Gong, Yuming Guo

“…Objective This study integrated transcriptomics and metabolomics to systematically investigate the mechanism by which tannins, specifically pentagalloylglucose (PGG) and tannic acid (TA), inhibit C. perfringens and potential pathways to alleviate infection in vivo. …”
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Integrated metabolomics and network pharmacology analysis to reveal the mechanisms of Wenshenyang decoction in the treatment of chronic kidney disease by Ge Jin, Zongjiang Zhao

“…However, its mechanism remains unclear.AimsThis study aimed to integrated metabolomics and network pharmacology analysis combined with in vitro experiments to reveal the mechanisms.Materials and methodsPatients were selected from a clinical trial. …”
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Integrative Bioinformatics Analysis Unravel the Association between Intracerebral Hemorrhage and Cellular Apoptosis through Immune Infiltration by Pandi Chen, Gengfan Ye, Jia Li, Kuan Feng, Guangyao Zhu, Maosong Chen, Wei Chen

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Identification and evaluation of pyrimidine based CDK6 inhibitors against glioblastoma using integrated computational approaches by Hina Manzoor, Muhammad Umer Khan, Raima Rehman, Chaudhry Ahmed Shabbir, Muhammad Ikram Ullah, Heba Bassiony Ghanem, Ayman Ali Mohammed Alameen, Muhammad Arshad Javed, Qurban Ali, Nazima Haider

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Unveiling pharmacological targets of Rihimaside C for radiation-induced lung injury: An in silico and experimental integrated approach by Youyi Liu, Jingrou Guo, Chuang Liu, Xingyi Chen, Yifei Tang, Minchen Wu, Jianfeng Huang

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Integrating single-cell RNA sequencing, WGCNA, and machine learning to identify key biomarkers in hepatocellular carcinoma by Gang Wang, Jiaxing Zhang, Yirong Li, Yuyu Zhang, Weiwei Dong, Hengquan Wu, Jinglan Wang, Peiqing Liao, Ziqiang Yuan, Tao Liu, Wenting He

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Perovskite‐Graphene Heterostructure Biosensor Integrated with Biotunable Nanoplasmonic Ternary Logic Gate for Ultrasensitive Cytokine Detection by Jiaxing Sun, Lin Zhou, Zening Li, Guolin He, Hongju Mao, Jianlong Zhao, John A. Hunt, Xianfeng Chen

“…Abstract The integration of 2D‐materials and optoelectronic devices has attracted great attention for advanced applications. …”
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A glimpse into the future: Integrating artificial intelligence for precision HER2‐positive breast cancer management by Xinpei Deng, Yixuan Yan, Zekai Zhan, Jindong Xie, Hailin Tang, Yutian Zou, Jian Tu, Peng Liu

“…We also proposed future directions for integrating AI in assessing and managing anti‐HER2 therapy. …”
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ZFHX3 is integral to androgen/AR signaling involving protein association with AR in prostate cancer cells by Xing Fu, Zhiqian Zhang, Rui Chen, Jun A, Na An, Xinxin Tian, Jin-Tang Dong

“…Biochemically, ZFHX3’s absence weakened AR’s transactivity, including AR’s binding to target gene promoters. These findings suggest that ZFHX3 is integral for AR signaling in prostate epithelial cells. …”
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Integrating pharmacokinetics and network pharmacology to decipher the efficacy of Fufang Qinlan oral liquid on post infectious cough by Leyi Huang, Yangyang Wang, Xinyi Yue, Fangfang Yu, Tong Wu, Yimeng Ge, Chunmiao Wang, Meihong Tong

“…All 6 compounds had potently binding activity to core targets in molecular docking. …”
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Integrating bioinformatics and machine learning to identify glomerular injury genes and predict drug targets in diabetic nephropathy by Li Zhang, ZhenPeng Sun, Yao Yuan, Jie Sheng

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Integrated bioinformatic analysis of dysregulated microRNA‐mRNA co‐expression network in ovarian endometriosis by Yong Liu, Linyuan Fan, Lingge Jin, Chang Lu, Ting Li, Zhan Zhang, Chengmao Xie, Shenghui Li, Yudi Zhang, Jian Ren, Dan Lu

“…This study aims to identify key miRNAs in ovarian endometriosis by using integrated bioinformatic analysis of a dysregulated miRNA‐mRNA co‐expression network. …”
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Network pharmacology, experimental validation and pharmacokinetics integrated strategy to reveal pharmacological mechanism of goutengsan on methamphetamine dependence by Han-Cheng Li, Han-Cheng Li, Jie-Yu Li, Xing-Chen Wang, Xing-Chen Wang, Ming Zeng, Yang-Kai Wu, Yi-Ling Chen, Cai-Hua Kong, Cai-Hua Kong, Ke-Lin Chen, Jie-Ru Wu, Zhi-Xian Mo, Jia-Xuan Zhang, Chang-Shun Liu, Chang-Shun Liu

“…The network pharmacology, experimental validation and pharmacokinetics integrated strategy is efficient in discovering the key pharmacological mechanism of herbal formulae.…”
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Programming gene expression with combinatorial promoters by Robert Sidney Cox, Michael G Surette, Michael B Elowitz

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Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis by Jiaqi Yao, Yuhong Jiang, Pengcheng Zhang, Yifan Miao, Xiajia Wu, Hang Lei, Zhijun Xie, Yong Tian, Xianlin Zhao, Juan Li, Lv Zhu, Meihua Wan, Wenfu Tang

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Moldina: a fast and accurate search algorithm for simultaneous docking of multiple ligands by Radek Halfar, Jiří Damborský, Sérgio M. Marques, Jan Martinovič

“…By integrating Particle Swarm Optimization into the established AutoDock Vina framework, we provided a powerful tool capable of accelerating drug discovery, and computational enzymology. …”
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Polymicellar-based drug delivery systems for use in nanodentistry, oral and cranio-maxillo-facial oncology by Ziyad S Haidar

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Temporal evolution of microstructural integrity in cerebellar peduncles in Parkinson’s disease: Stage-specific patterns and dopaminergic correlates by Chentao He, Rui Yang, Siming Rong, Piao Zhang, Xi Chen, Qi Qi, Ziqi Gao, Yan Li, Hao Li, Frank-Erik de Leeuw, Anil M. Tuladhar, Marco Duering, Rick C. Helmich, Rick van der Vliet, Sirwan K.L. Darweesh, Zaiyi Liu, Lijuan Wang, Mengfei Cai, Yuhu Zhang

“…We also examined the relationships between microstructural integrity in CP, striatal dopamine transporter specific binding ratio (SBR), and clinical symptoms. …”
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Integrity of Narrow Epithelial Tubes in the C. elegans Excretory System Requires a Transient Luminal Matrix. by Hasreet K Gill, Jennifer D Cohen, Jesus Ayala-Figueroa, Rachel Forman-Rubinsky, Corey Poggioli, Kevin Bickard, Jean M Parry, Pu Pu, David H Hall, Meera V Sundaram

“…Structure/function and fluorescence recovery after photobleaching studies revealed that LET-653 exists in two separate luminal matrix pools, a loose fibrillar matrix in the central core of the lumen, to which it binds dynamically via its PAN domains, and an apical-membrane-associated matrix, to which it binds stably via its ZP domain. …”
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