Identification of as a Susceptibility Locus for Kawasaki Disease in Patients Younger than 6 Months of Age by Hea-Ji Kim, Sin Weon Yun, Jeong Jin Yu, Kyung Lim Yoon, Kyung-Yil Lee, Hong-Ryang Kil, Gi Beom Kim, Myung-Ki Han, Min Seob Song, Hyoung Doo Lee, Kee Soo Ha, Sejung Sohn, Ryota Ebata, Hiromichi Hamada, Hiroyuki Suzuki, Yoichiro Kamatani, Michiaki Kubo, Kaoru Ito, Yoshihiro Onouchi, Young Mi Hong, Gi Young Jang, Jong-Keuk Lee

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Revolutionizing diabetes treatment: computational insights into 4-hydroxy isoleucine derivatives and advanced molecular screening for antidiabetic compounds by Lakshmi Mounika Kelam, Manjinder Singh Gill, M. Elizabeth Sobhia

“…Conclusions: The study highlights 4HILe derivatives as promising inhibitors for diabetes-associated enzymes, demonstrating robust binding and dynamic stability. Integrating molecular dynamics, free energy calculations, and AI-driven generative modeling provides a strong framework for accelerating antidiabetic drug discovery. …”
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Antibacterial and antibiofilm activity of peptide PvGBP2 against pathogenic bacteria that contaminate Auricularia auricular culture bags by Shen Yang, Zijin Yuan, Jude Juventus Aweya, Shanggui Deng, Wuyin Weng, Yueling Zhang, Guangming Liu

“…Transmission electron microscopy (TEM) revealed that PvGBP2 kills bacteria by perforating the cell wall, destroying membrane integrity and resulting in the leakage of intracellular solutes. …”
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Participatory Action Research: Engaging Communities in Mental Health by Sandra Janashak, Cadena

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Integrated multi-omics analyses of molecular pathways underlying microcystin-LR toxicity in the earthworm Eisenia fetida by Xiang Liu, Wen-Hua Zhai, Rao Liu, Bai-Lin Liu, Rong-Jun Gao, Yan-Wen Li, Lei Xiang, Quan-Ying Cai, Hai-Ming Zhao, Ce-Hui Mo

“…Proteomic analysis showed that MC-LR affected distinct pathways, particularly those associated with nucleotide binding, calcium ion binding, ATP binding, cytoskeleton, and actin filament binding. …”
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Integrating network pharmacology, molecular docking, and molecular dynamics to explore the antidiabetic mechanism of Physalis angulata L. by Sri Peni Fitrianingsih, Neng Fisheri Kurniati, Taufik Muhammad Fakih, I Ketut Adnyana

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Discovery of Novel CRK12 Inhibitors for the Treatment of Human African Trypanosomiasis: An Integrated Computational and Experimental Approach by Qin Li, Jiayi Luo, Chenggong Fu, Wenqingqing Kang, Lingling Wang, Henry Tong, Zhaorong Lun, Qianqian Zhang, Dehua Lai, Huanxiang Liu

“…The top four hits, F733-0072, F733-0407, L368-0556, and L439-0038, exhibited IC₅₀ values of 1.11, 1.97, 0.85, and 1.66 µM, respectively. Binding free energy and energy decomposition analyses identified ILE335, VAL343, PHE430, ALA433, and LEU482 as hotspot residues for compound binding. …”
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An integrated bioinformatics and immunoinformatics approach to design a multi-epitope-based vaccine against Langya henipavirus by Saurav Kumar Mishra, Gyan Prakash Rai, Neeraj Kumar, Asheesh Shanker, John J. Georrge

“…The 3D structure was anticipated and verified, and a docking study with toll-like receptors (TLR2, TLR3, TLR8 and TLR9) indicates significant binding with TLR3 and TLR9 based on the highest molecular interaction and high binding affinity score of − 25.2 and − 24.2 kcal mol−1. …”
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Integrating Biochemical and Computational Approaches Reveal Structural Insights in Trastuzumab scFv-Fc Antibody Engineering by Olga Bednova, Jessica Pougoue Ketchemen, Hazem Mslati, Mark Barok, Heikki Joensuu, Natalie Zeytuni, Francesco Gentile, Leon Sanche, Humphrey Fonge, Jeffrey Victor Leyton

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Integrated bioinformatics analysis of expression and gene regulation network of COL12A1 in colorectal cancer by Yibin Wu, Ye Xu

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Integrative UHPLC-HRMS and computational biology reveal ferroptosis and anoikis targeting by Wenpitongluo decoction in cardiorenal syndrome by Xinxin Mao, Shuqing Shi, Chunmei Chen, Yumeng Li, Bingxuan Zhang, Qingqiao Song

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Integrating multi-dimensional data to reveal the mechanisms and molecular targets of baikening granules for treatment of pediatric influenza by Zhaoyuan Gong, Qianzi Che, Mingzhi Hu, Tian Song, Lin Chen, Haili Zhang, Ning Liang, Huizhen Li, Guozhen Zhao, Lijiao Yan, Xuefei Zhang, Bin Liu, Jing Guo, Nannan Shi

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Directed evolution and modular integration of a high-affinity ICOS-L variant for potent T cell–mediated tumor elimination by Ji Yeon Ha, Tae Wook Song, Petrina Jebamani, Sun-Gu Lee, Sang Taek Jung

“…Abstract Background Advancing cancer immunotherapy requires engineering synthetic immunomodulators that integrate precise receptor targeting, tunable activity, and compatibility with modular biologic formats. …”
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Engineering a probiotic Bacillus subtilis for acetaldehyde removal: A hag locus integration to robustly express acetaldehyde dehydrogenase. by Chandler Hassan-Casarez, Valerie Ryan, Bentley M Shuster, John W K Oliver, Zachary D Abbott

“…We demonstrate constitutive gene expression in relevant conditions driven by the endogenous hag promoter, following a deletion of the gene encoding a post-translational regulator of σD, FlgM, and a point mutation to abrogate the binding of the translational inhibitor CsrA. Reporter constructs demonstrate activity at the hag locus after germination, with a steady increase in heterologous expression throughout outgrowth and vegetative growth. …”
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Final pre-40S maturation depends on the functional integrity of the 60S subunit ribosomal protein L3. by Juan J García-Gómez, Antonio Fernández-Pevida, Simon Lebaron, Iván V Rosado, David Tollervey, Dieter Kressler, Jesús de la Cruz

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Dissecting the calcium-induced differentiation of human primary keratinocytes stem cells by integrative and structural network analyses. by Kiana Toufighi, Jae-Seong Yang, Nuno Miguel Luis, Salvador Aznar Benitah, Ben Lehner, Luis Serrano, Christina Kiel

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HybTrans: A Molecular Generation and Optimization Model Integrating Protein Pocket Sequence and Structural Information by Chen Yinghao, Liu Hongde, Sun Xiao

“…However, there is a lack of models that integrate both protein pocket sequence and structural information for molecular generation. …”
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Integrated Computational Approach to Rational Drug Design Targeting SIK2/3: From Theory to Practice by Eid Youssef Eid Rashed, Alisa Gorislav

“…This study presents a comprehensive approach to designing and optimizing small molecule inhibitors targeting Salt-Inducible Kinases 2 and 3 (SIK2 and SIK3), crucial regulators of cellular signaling pathways implicated in various diseases, including cancer, inflammation, and metabolic disorders. By integrating advanced computational methods and expert-driven chemical synthesis, we generated a diverse library of potential inhibitors and meticulously evaluated their pharmacological properties and binding affinities to SIK2. …”
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Unlocking precision medicine: clinical applications of integrating health records, genetics, and immunology through artificial intelligence by Yi-Ming Chen, Tzu-Hung Hsiao, Ching-Heng Lin, Yang C. Fann

“…Abstract Artificial intelligence (AI) has emerged as a transformative force in precision medicine, revolutionizing the integration and analysis of health records, genetics, and immunology data. …”
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Integrated network pharmacology, molecular docking and experimental validation to investigate the mechanism of tannic acid in nasopharyngeal cancer by Meiwei Wang, Longmei He, Pan Yan

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