Identifying the crucial oncogenic mechanisms of DDX56 based on a machine learning-based integration model of RNA-binding proteins by Hui Jiang, Haotian Zheng, Xinjie Zhao, Yunzhi Xiang, Jiahao Li, Kai Wang, Guanghui Wang, Jiajun Du

“…Abstract RNA-binding proteins (RBPs) play a fundamental role in cellular metabolism, with their disturbance leading to large-scale transcriptomic dysregulation. …”
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PIONet: A Positional Encoding Integrated Onehot Feature-Based RNA-Binding Protein Classification Using Deep Neural Network by Mahmood A. Rashid, Mayank Chaturvedi, Kuldip K. Paliwal

“…RNA-binding proteins (RBPs) are pivotal in regulating various biological processes, including RNA splicing and protein translation. …”
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Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis. by Madushi Wanaguru, David J Barry, Donald J Benton, Nicola J O'Reilly, Kate N Bishop

“…We and others hypothesised that p12 tethers the pre-integration complex (PIC) to host chromatin ready for integration. …”
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Reverse Vaccinology Integrated with Biophysics Techniques for Designing a Peptide-Based Subunit Vaccine for Bourbon Virus by Taghreed N. Almanaa

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An Integrated Approach to Develop a Potent Vaccine Candidate Construct Against Prostate Cancer by Utilizing Machine Learning and Bioinformatics by Aqel Albutti

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Binding memory of liquid molecules by Shiyi Qin, Zhi Yang, Huimin Liu, Xiaoli Wang, Bing Miao, Shangguo Hou, Kai Huang

“…Here, we integrate large scale computer simulation, scaling theory, and real-time single particle tracking microscopy with high spatiotemporal precision to unveil a universal memory effect in the binding dynamics of liquid molecules. …”
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Interpretable protein-DNA interactions captured by structure-sequence optimization by Yafan Zhang, Irene Silvernail, Zhuyang Lin, Xingcheng Lin

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How allosteric mutations control ligand binding in Lipocalin protein: odorant binding protein as a test case by Maxence Lalis, Lucie Moitrier, Miriam Jäger, Cornelia Meinert, Marine Brulé, Christine Belloir, Nykola C. Jones, Søren V. Hoffmann, Sébastien Fiorucci, Steffen Wolf, Loïc Briand, Jérémie Topin

“…Using an integrative approach combining numerical modelling and experimental validation, we identified key structural regions that regulate the entry of molecules into the binding pocket. …”
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Integrative computational approaches identify haptoglobin inhibitors to modulate erythrocyte sedimentation rate in trauma-linked inflammatory and haematological malignancies by Abdulaziz H. Al Khzem, Shaban Ahmad

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High resolution genome wide binding event finding and motif discovery reveals transcription factor spatial binding constraints. by Yuchun Guo, Shaun Mahony, David K Gifford

“…To discover novel transcription factor spatial binding constraints in vivo, we developed a new integrative computational method, genome wide event finding and motif discovery (GEM). …”
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SHAPING EU LAW THROUGH THE PRELIMINARY RULING PROCEDURE - THE UNITED KINGDOM’S CONTRIBUTION by Maria-Cristina SOLACOLU

Subjects: “…judicial integration…”
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Correction: Integrative computational approaches identify haptoglobin inhibitors to modulate erythrocyte sedimentation rate in trauma-linked inflammatory and haematological maligna... by Abdulaziz H. Al Khzem, Shaban Ahmad

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Ensemble-Based Binding Free Energy Profiling and Network Analysis of the KRAS Interactions with DARPin Proteins Targeting Distinct Binding Sites: Revealing Molecular Determinants a... by Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Gennady Verkhivker

“…KRAS residues I36, Y40, M67, and H95 consistently emerge as critical contributors to binding stability. Binding free energy computations show that, despite similar binding modes, K27 relies heavily on electrostatic contributions from major binding hotspots while K55 exploits a dense hydrophobic cluster enhancing its effector-mimetic signature. …”
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Habituation in Predictability-Modulations of Stimulus-Response Binding by Philip Schmalbrock, Jan Theeuwes, Christian Frings

“…In the action control literature, this integrated representation is often called event file and is measured in so-called stimulus-response binding effects. …”
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Structure, Binding Characteristics, and 3D Model Prediction of a Newly Identified Odorant-Binding Protein from the Cotton Bollworm, Helicoverpa armigera (Hübner) by Tian-tao ZHANG, Wei-xuan WANG, Shao-hua GU, Zi-ding ZHANG, Kong-ming WU, Yong-jun ZHANG, Yu-yuan GUO

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Real-Time SPR Biosensing to Detect and Characterize Fast Dissociation Rate Binding Interactions Missed by Endpoint Detection and Implications for Off-Target Toxicity Screening by William Martelly, Rebecca L. Cook, Chidozie Victor Agu, Lydia R. Gushgari, Salvador Moreno, Sailaja Kesiraju, Mukilan Mohan, Bharath Takulapalli

“…We highlight the importance of choosing reagents well suited to the selected assay, as well as the importance of considering binding kinetics and protein ligand conformational states when interpreting results from binding assays, especially for applications as critical as the off-target screening of therapeutics.…”
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Inhibition potential of margolonone and isomargolonone against the dengue virus protease using molecular modeling approaches by Gourav Choudhir, Faiza Iram, Israil, Mohammad Shahid, Anas Shamsi, Md Imtaiyaz Hassan, Asimul Islam

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Multiscale End-point Screening with Extended Tight-binding Hamiltonians by Xiaohui Wang, Sai Li, Zuoyuan Zhang, Linqiong Qiu, Zhaoxi Sun

“…Background: Extended tight-binding (xTB) methods offer a computationally efficient alternative to classical force fields and ab initio quantum methods in modeling molecular systems. …”
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PxBLAT: an efficient python binding library for BLAT by Yangyang Li, Rendong Yang

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Solid-Binding Peptide for Enhancing Biocompatibility of Metallic Biomaterials by Satoshi Migita

“…Solid-binding peptides (SBPs) are a powerful tool for surface modification of metallic biomaterials which improve the biocompatibility and functionality of medical devices. …”
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