Global and local effects in lipid-mediated interactions between peripheral and integral membrane proteins by Tatiana K. Rostovtseva, David P. Hoogerheide, William A. Milhizer, Sergey M. Bezrukov

“…When an AP interacts with a membrane containing an integral membrane protein, a ternary protein-lipid-protein system is created. …”
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HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency. by Torsten Schaller, Karen E Ocwieja, Jane Rasaiyaah, Amanda J Price, Troy L Brady, Shoshannah L Roth, Stéphane Hué, Adam J Fletcher, KyeongEun Lee, Vineet N KewalRamani, Mahdad Noursadeghi, Richard G Jenner, Leo C James, Frederic D Bushman, Greg J Towers

“…Inhibition of CypA reduced dependence on Nup358 and the nuclear basket protein Nup153, suggesting that CypA regulates the choice of the nuclear import machinery that is engaged by the virus. HIV-1 cyclophilin-binding mutants CA G89V and P90A favored integration in genomic regions with a higher density of transcription units and associated features than wild type virus. …”
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An integrated approach to the characterization of immune repertoires using AIMS: An Automated Immune Molecule Separator. by Christopher T Boughter, Martin Meier-Schellersheim

“…The adaptive immune system employs an array of receptors designed to respond with high specificity to pathogens or molecular aberrations faced by the host organism. Binding of these receptors to molecular fragments-collectively referred to as antigens-initiates immune responses. …”
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Integrative network pharmacology and experimental validation of anti-inflammatory triterpenoids from hawthorn leaves by Zhixing Liu, Jihua Liu

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Integrative analysis identifies shared therapeutic pathways in thyroid eye disease and diabetes mellitus by Yifei Wang, Hui Li

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Integrating in vitro and in silico approaches for exploring antidiabetic potential of dimethyl and thiomethyl indolinone derivatives. by Kashif Ali, Ahmed A Elhenawy, Waqas Alam, Khalaf F Alsharif, Khalid J Alzahrani, Haroon Khan, Long Chiau Ming, Rahul G Ingle

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Optogenetic induction of TDP-43 aggregation impairs neuronal integrity and behavior in Caenorhabditis elegans by Kyung Hwan Park, Euihyeon Yu, Sooji Choi, Sangyeong Kim, Chanbin Park, J. Eugene Lee, Kyung Won Kim

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Identification of exosome-related genes in NSCLC via integrated bioinformatics and machine learning analysis by Zhenjie Sun, Tianyu Du, Guosheng Yang, Yinghuan Sun, Xuyang Xiao

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The KdpD/KdpE two-component system: integrating K⁺ homeostasis and virulence. by Zoë N Freeman, Steve Dorus, Nicholas R Waterfield

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Integrative analysis reveals key molecular mechanisms and prognostic model for Ethylnitrosourea-induced gliomagenesis by Bo Tan, Tao Chen, Peng Song, Feng Lin, Shuangyin He, Shiyuan Zhang, Xiaohong Yin

“…Molecular docking suggested strong binding affinities of ENU with MGMT and CA12. Conclusion Our integrative analysis identified key genes and pathways implicated in ENU-induced gliomagenesis. …”
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Corchorus olitorius exhibits antiproliferative potential supported by metabolic profiling and integrative biological analyses by Salma Sameh, Maha R. A. Abdollah, Ahmed M. Elissawy, Eman Al-Sayed, Rola M. Labib, Lan Ye, Fang-Rong Chang, Abdel Nasser B. Singab

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In Silico Evaluation of Potential NDM-1 Inhibitors: An Integrated Docking and Molecular Dynamics Approach by Eduvan Valencia, Mauricio Galvis, Jorge Nisperuza, Vladimir Ballesteros, Fredy Mesa

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Identification of Hub Genes Related to Carcinogenesis and Prognosis in Colorectal Cancer Based on Integrated Bioinformatics by Benjiao Gong, Yanlei Kao, Chenglin Zhang, Fudong Sun, Zhaohua Gong, Jian Chen

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Integrated analysis of differential expression profile of miRNA in the uterus of seasonal estrus sheep by Fan Yang, Jiannan Liu, Yongfu La, Ran Di, Xiaoyun He, Pingqing Wang, Yufang Liu, Mingxing Chu

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Citrus aurantifolia essential oil: antiaging potential through integrated in vitro and in silico studies by Yasmin A. Elkhawas, Mahmoud A. El Hassab, Omkulthom Al kamaly, Ahmed T. Negmeldin, Ahmed T. Negmeldin, Taghreed A. Majrashi, Wagdy M. Eldehna, Nada M. Mostafa

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Single neurons and networks in the mouse claustrum integrate input from widespread cortical sources by Andrew M Shelton, David K Oliver, Ivan P Lazarte, Joachim S Grimstvedt, Ishaan Kapoor, Jake A Swann, Caitlin A Ashcroft, Simon N Williams, Niall Conway, Selma Tir, Amy Robinson, Stuart Peirson, Thomas Akam, Clifford G Kentros, Menno P Witter, Simon JB Butt, Adam Max Packer

“…These findings support the view that the claustrum is a fundamentally integrative structure, consolidating information from around the cortex and redistributing it following local computations.…”
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Development and application of a customized online affinity selection mass spectrometry screening platform by Jun Zhang, Jerry Barney, Qingqing Shen, Anthony Paiva, Wilson Shou, Chris Barbieri, Nancy Huynh, Heidi L. Perez, Andrew F. Donnell, Cullen L. Cavallaro

“…To meet the ever-increasing demand for binding screens, the ASMS platform requires continuous enhancements in efficiency and scalability. …”
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Integrative computational analysis of anti-influenza potential in Caesalpinia mimosoides Lamk hydroethanolic extract by Anuwatchakij Klamrak, Shaikh Shahinur Rahman, Napapuch Nopkuesuk, Jaran Nabnueangsap, Jaraspim Narkpuk, Piyapon Janpan, Yutthakan Saengkun, Thananya Soonkum, Supawadee Sriburin, Samaporn Teeravechyan, Poramet Sitthiwong, Nisachon Jangpromma, Sirinan Kulchat, Kiattawee Choowongkomon, Rina Patramanon, Arunrat Chaveerach, Jureerut Daduang, Sakda Daduang

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Machine learning analysis of ARVC informed by sodium channel protein-based interactome networks by Yanan Zhu, Hui Zhang, Xuan Zhao, Xin Wang, Lina Xing, Sijie Yao, Xiao Jin, Tingting Li, Ting Dai, Xinyue Ding, Zhen Qi, Zongjun Liu

“…By integrating ML modeling with organoid validation, our platform provides valuable support in addressing the public health challenges posed by ARVC, with broad application prospects. …”
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Decoding RNA–Protein Interactions: Methodological Advances and Emerging Challenges by Wenkai Yi, Jian Yan

“…Protein‐centric strategies, such as immunoprecipitation‐based CLIP‐seq, and emerging proximity‐tagging methods, map RNA interactomes of RNA‐binding proteins with nucleotide precision. This study evaluates key innovations like LACE‐seq and ARTR‐seq, which minimize cell input requirements, and HyPro‐MS, which bypasses genetic modifications. …”
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