Engineering tripartite gene editing machinery for highly efficient non-viral targeted genome integration by Hangu Nam, Keqiang Xie, Ishita Majumdar, Jiao Wang, Shaobo Yang, Jakob Starzyk, Danna Lee, Richard Shan, Jiahe Li, Hao Wu

“…Here, we introduce enGager, an enhanced GATALYST associated genome editor system that increases transgene integration efficiency by tethering cssDNA donors to nuclear-localized Cas9 fused with single-stranded DNA binding peptide motifs. …”
Get full text

Altered multisensory integration in pilots: Examining susceptibility to fission and fusion sound-induced flash illusions by Xing Peng, Yaowei Liang, Xiuyi Li, Jiaying Sun, Xiaoyu Tang, Aijun Wang, Chengyi Zeng

“…In the fission condition, the group difference was primarily driven by visual sensitivity, whereas in the fusion condition it also likely reflected pilots’ distinct multisensory integration mechanisms. Two alternative possibilities are discussed to explain the group differences and the different multisensory integration patterns in fission and fusion conditions.…”
Get full text

Amyloid fibrils of the myelin basic protein are an integral component of myelin in the vertebrate brain by Evgeniy I. Sysoev, Aleksandr A. Shenfeld, Tatyana A. Belashova, Anna A. Valina, Sergey P. Zadorsky, Alexey P. Galkin

Get full text

Investigating the potential risk of cadmium exposure on Osteoporosis: An integrated multi-omics approach by Yiwei Li, Xuezhen Liang, Yifa Rong, Kai Jiang, Jiahao Zhang, Gang Li

Get full text

Hiding in plain sight: the biomolecular identification of pinniped use in medieval manuscripts by Élodie Lévêque, Matthew D. Teasdale, Sarah Fiddyment, Maiken Hemme Bro-Jørgensen, Luke Spindler, Ruairidh Macleod, François Bougard, Morten Tange Olsen, Matthew Collins

“…The survival of medieval manuscripts in their original bindings remains a rare occurrence. Taking advantage of the diversity of bindings in Cistercian libraries such as Clairvaux and its daughter abbeys during the twelfth and thirteenth centuries, this study focuses on the biocodicological analysis of medieval manuscript bindings, with particular emphasis on the use of sealskins. …”
Get full text

The mRNA Expression and Methylation Status in Imprinting Control Region of H19 Gene Between Cattle-Yak and Their Parents by Ming-gui LI, Zhen-shan LIU, Zeng-xiang PAN, Hua LUO, Zhuang XIE, Qi-fa LI

Get full text

Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration. by Lihong Zhou, Elena Sokolskaja, Clare Jolly, William James, Sally A Cowley, Ariberto Fassati

“…Here we show that the karyopherin Transportin 3 (Tnp3) promotes HIV-1 integration in different cell types. Furthermore Tnp3 binds the viral capsid proteins and tRNAs incorporated into viral particles. …”
Get full text

Synergy and antagonism in the integration of BCR and CD40 signals that control B-cell population expansion by Helen Huang, Haripriya Vaidehi Narayanan, Mark Yankai Xiang, Vaibhava Kesarwani, Alexander Hoffmann

“…B-cells are instructed via B-cell receptor (BCR), which binds antigen, and CD40 receptor by antigen-recognizing T-cells. …”
Get full text

Single-Cell Sequencing and Machine Learning Integration to Identify Candidate Biomarkers in Psoriasis: INSIG1 by Zhou X, Ning J, Cai R, Liu J, Yang H, Bai Y

“…Bulk transcriptome and scRNA-seq data were integrated to identify differentially expressed genes (DEGs). …”
Get full text

Ultrasensitive gene regulation by positive feedback loops in nucleosome modification by Kim Sneppen, Mille A Micheelsen, Ian B Dodd

“…In addition, the system provides a simple means by which the activities of many TFs could be integrated at a promoter.…”
Get full text

Enhancing aptamer selection in alzheimer’s disease: integrating structure prediction and molecular dynamics simulations by Benedikt Jakob Lohnes, Aaron John Goff, Udo Frank Hartwig, Nitesh Kumar Poddar

Get full text

Entre la unión y la desunión: alcances y limitaciones de la integración centroamericana by Josette Altmann Borbón

“…Finally, at the regional level, ALBA, and more specifically the Petrocaribe program, has gained the support of several Central American countries.To conclude, the author presents the main challenges that Central America will have to face to reinforce the regional integration process and strengthen its ties with the rest of the world: 1) the persistence of asymmetries between and within Central American countries; 2) the absence of regional cohesion funds that might reduce these inequalities; 3) the lack of political will, along with the weakness of current regional institutions and the absence of binding decisions. …”
Get full text

Identification of RC3H1 as antiviral host factor binding to the non-structural protein 1 of Influenza A virus via a 3-stage computational pipeline and cell-based analysis by Swee Teng Teo, Shamima Rashid, Kong Yen Liew, Kah Man Lai, Teng Ann Ng, Jifeng Jiao, Chee Keong Kwoh, Yee-Joo Tan

“…Abstract To complete its life-cycle in the infected host, Influenza A virus (IAV) hijacks host machineries by expressing multiple viral proteins to bind to specific host proteins. In the era of integrative genomics, there is an opportunity to develop computational techniques to accurately and quickly predict host-pathogen protein-protein interactions (HP-PPI). …”
Get full text

Myotonic dystrophy-related CDC42-binding kinase alpha (MRCKα) mediates methionine- and leucine-stimulated β-casein synthesis in bovine mammary epithelial cells via targeting mTOR by Fang Wang, Jürgen van Baal, Lu Ma, Xuejun Gao, Jan Dijkstra, Dengpan Bu

Get full text

Integrated bioinformatics analysis identifies CHAD association with osteoporosis and in vitro chondrogenic effects of Wogonin by Keng-Fu Lan, Wei-Hsiang Su, Yongjin Zhong, Yan Wu, Siqi Ye, Dan He, Yancheng Lai, Charles C. N. Wang, Anchun Mo

“…Molecular docking predicted binding affinities of several TCM compounds to CHAD and COL2A1, with tetrandrine and wogonin showing the highest binding affinities. …”
Get full text

TAR RNA Mimicry of INI1 and Its Influence on Non-Integration Function of HIV-1 Integrase by Ganjam V. Kalpana, Emilie Ernst, Swati Haldar

“…Several factors influence these non-integration functions, including the ability of IN to bind to viral RNA. …”
Get full text

Integrated analyses to explore the mechanism of Gancao Renshen Zhixue Decoction in treating liver cirrhosis by Junwei Pan

Get full text

Identifying RAGE inhibitors as potential therapeutics for Alzheimer’s disease via integrated in-silico approaches by Inderjeet Bhogal, Vaishali Pankaj, Sudeep Roy

Get full text

ALDH18A1 has carcinogenic functions and regulates alternative splicing events of DNA repair-related genes in esophageal carcinoma cells by Wang Yongkang, Maimaiti Yisireyili, Kelimu Abudureyimu, Atsushi Enomoto

“…ALDH18A1, a potential RNA binding protein (RBP), is significantly overexpressed as in ESCA, while its functions and mechanism is unclear. …”
Get full text

Cullin-3 and Regulatory Biomolecules Profiling in Vitiligo: Integrated Docking, Clinical, and In Silico Insights by Hidi A. A. Abdellatif, Mohamed Azab, Eman Hassan El-Sayed, Rwan M. M. M. Halim, Ahmad J. Milebary, Dhaifallah A. Alenizi, Manal S. Fawzy, Noha M. Abd El-Fadeal

“…Docking revealed a strong binding of vitexin to Keap1 (RMSD: 0.23 Å), mirroring the binding of the control ligand CDDO-Im. …”
Get full text