Profilin Pfy1 is critical for cell wall integrity and virulence in Candida albicans by Xun Sun, Yueqing Wang, Xiaomin Yang, Xi Xiang, Lili Zou, Xiaowen Liu, Gang Luo, Qi Han

“…ABSTRACT Profilin is a small actin-binding protein that plays an important role in actin polymerization. …”
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Integrated network pharmacology reveals the mechanism of action of Xianlinggubao prescription for inflammation in osteoarthritis by Jingyi Hou, Yubo Li, Yu Zhang, Ning Yang, Bin Chen, Guiyun Ma, Naiqiang Zhu

“…Molecular simulations indicated strong binding affinities between bioactive compounds in XLGB and these critical targets. …”
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Integrating TSPO-PET imaging with metabolomics for enhanced prognostic accuracy in multiple sclerosis by Jens Kuhle, Laura Airas, Daniel C Anthony, David Leppert, Eline Willemse, Fay Probert, Johanna Oechtering, Markus Matilainen, Marcus Sucksdorff, Daniel E Radford-Smith, Abi G Yates, Tereza Kacerova, Marjo Nylund, Aleksandra Maleska Maceski

“…Serum metabolomics was performed to identify biomarkers associated with TSPO binding and disease progression.Results Greater TSPO availability in the normal-appearing white matter and perilesional regions correlated with higher EDSS. …”
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Integrating Disaster Risk Management and Archival Frameworks for Safeguarding Citizens' Vital Records by Martino Martino

“…Citizen’s vital records contain information value, proof of important life events, and legal and binding ownership of assets. Disaster risk management rarely calculates damage and loss of vital records due to disasters. …”
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Moesin integrates cortical and lamellar actin networks during Drosophila macrophage migration by Besaiz J. Sánchez-Sánchez, Stefania Marcotti, David Salvador-Garcia, María-del-Carmen Díaz-de-la-Loza, Mubarik Burki, Andrew J. Davidson, Will Wood, Brian M. Stramer

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Surface-Modified Carbon Dots for Cancer Therapy: Integrating Diagnostic and Therapeutic Applications by González M, Romero MP

“…Advances in modalities of surface modification that include ligand binding and metal doping have significantly improved CDs’ biocompatibility and targeting precision. …”
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The Caenorhabditis elegans Myc-Mondo/Mad complexes integrate diverse longevity signals. by David W Johnson, Jesse R Llop, Sara F Farrell, Jie Yuan, Lindsay R Stolzenburg, Andrew V Samuelson

“…Additionally, we find that Myc family members are regulated by distinct mechanisms, which would allow for integrated control of gene expression from diverse signals of metabolic status. …”
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Exploring pesticide risk in autism via integrative machine learning and network toxicology by Ling Qi, Jingran Yang, Qiao Niu, Jianan Li

“…Molecular docking analysis further validated stable binding affinities between these pesticides and the hub targets. …”
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Integrating in vitro and in silico techniques for evaluating the antioxidant activity of Chrysanthemum indicum L by Fatimawali, Billy J. Kepel, Linda W. A. Rotty, Trina E. Tallei, Fahrul Nurkolis

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Integration of phytochemical profiling and computational approaches to evaluate the neuroprotective potential of Nardostachys jatamansi in Alzheimer's disease by Abdul Jalil Shah, Mohammad Younis Dar, Mohd Adnan, Tanmaykumar Varma, Dhairiya Agarwal, Prabha Garg, Reyaz Hassan Mir, Rampratap Meena, Mubashir Hussain Masoodi

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Mechanisms of Microctis Folium in Hyperlipidemia: Integrating Serum Pharmacochemistry, Network Pharmacology, and Transcriptomics by Xiao G, Wu G, Liu Y, Chen W, Zeng Z, Li S, Li Y, Bi X

“…Molecular docking further validated the binding affinities of MF key compounds (rutin and isovitexin) to AKT1, mTOR, and NF-κB. …”
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Investigating MerR’s Selectivity: The Crosstalk Between Cadmium and Copper Under Elevated Stress Conditions by Anne Soisig Steunou, Anne Durand, Sylviane Liotenberg, Marie-Line Bourbon, Soufian Ouchane

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Molecular basis of ligand-dependent Nurr1-RXRα activation by Xiaoyu Yu, Jinsai Shang, Douglas J Kojetin

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Integrative bioinformatic approach reveals novel melatonin-related biomarkers for Alzheimer’s disease by Hua-xiong Zhang, Dilmurat Hamit, Qing Li, Xiao Hu, San-feng Li, Fu Xu, Ming-yuan Wang, Guo-qing Bao, Hong-yan Li

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Transcription factor occupancy limits DNA methylation and determines ICAM1 expression in breast cancer by Chen Mingcang, Zhou Ying, Fu Zhengwei, Wu Chunyu

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Molecular docking and molecular dynamics simulations reveal the clinical resistance of the gatekeeper mutation V564F of FGFR2 against Infigratinib by Guodong Zheng, Wuxia Liu, Qian Zhang, Tuo Shen, Jingfeng Zhang, Lei Jiang, Wenqi Liang, Bin Zhou, Ling Liu, Shenqian Xu, Minyu Li

“…In this study, the protein − ligand interactions between FGFR2 kinase domain (wild-type and V564F) and Infigratinib were compared through an integrated computational method. The multiple, large-scale molecular dynamics (MD) simulations, together with dynamic cross-correlation analysis and binding free energy calculations suggested that the resistant mutation may not trigger the conformational changes of the FGFR2 kinase domain. …”
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PABPN1 Couples the Polyadenylation and Translation of Maternal Transcripts to Mouse Oocyte Meiotic Maturation by Xing‐Xing Dai, Yu‐Ke Wu, Shuai‐Bo Pi, Feng‐Jie Hu, Yun‐Wen Wu, Hang Qi, Zhiyi Li, Zhi‐Yan Jiang, Long‐Wen Zhao, Heng‐Yu Fan

“…This study highlighted the physiological importance of cytoplasmic PABPN1 in mammalian oocyte maturation by integrating maternal transcript polyadenylation, translation, and degradation.…”
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Galectin-3: a novel antimicrobial host factor identified in goat nasal mucus by Yichao Ma, Xinming Qin, Jiachen Liu, Shiqi Liu, Ruoyang Lin, Baoyan Meng, Xiaojing Cui, Qian Yang

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Genome-wide DNA methylation analysis of Astragalus on the intervention of ID2 promoter via PI3K/Akt signaling pathway in peritoneal fibrosis by Manshu Yu, Junyi Zhao, Yun Shan, Huibo Dai, Lei Tang, Li Sheng, Lu Zhang, Meixiao Sheng

“…In vivo and in vitro, Astragalus treatment showed a protective effect against PF and Dnmts, characterized by improving pathological manifestation, ameliorating MMT markers, and reducing Dnmt1/3a proteins. Inhibitor of DNA-binding 2 (ID2) was investigated in target gene by integrating the mRNA and methylation profiles involved in PF and Astragalus treatment. …”
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Deep-CABPred: Deep learning model for predicting functional chlorophyll a-b binding proteins in trait-based plant ecology using hybrid embedding with semi-normalized temporal convo... by Farman Ali, Raed Alsini, Tamim Alkhalifah, Fahad Alturise, Wajdi Alghamdi, Majdi Khalid

“…Chlorophyll a-b binding proteins (CABs) are crucial for photosynthesis, directly influencing plant efficiency and environmental adaptation. …”
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