Advances in the role of the IGF signaling system in myelodysplastic syndromes and acute myeloid leukemia by Yifan Wang, Yifan Wang, Yifan Wang, Xinyu Dong, Xinyu Dong, Xinyu Dong, Shandong Tao, Shandong Tao, Shandong Tao, Qiuni Chen, Qiuni Chen, Qiuni Chen, Yue Chen, Yue Chen, Yue Chen, Lijuan Zhang, Lijuan Zhang, Lijuan Zhang, Yuye Shi, Yuye Shi, Yuye Shi, Zhengmei He, Zhengmei He, Zhengmei He, Liang Yu, Liang Yu, Liang Yu, Liang Yu, Chunling Wang, Chunling Wang, Chunling Wang, Chunling Wang

“…The insulin-like growth factor (IGF) signaling system comprises functionally specific ligands (IGF-I and IGF-II), receptor (IR), and binding proteins (IGFBP). IGFs are activated by binding to their receptor, IGF-IR, which is a tyrosine kinase receptor. …”
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Insecticidal Activity of Lectin Preparations from <i>Moringa oleifera</i> Lam. (Moringaceae) Seeds Against <i>Alphitobius diaperinus</i> (Panzer) (Coleoptera: Tenebrionidae) by Nataly Diniz de Lima Santos, Patryck Érmerson Monteiro dos Santos, Thiago Lucas da Silva Lira, Aline Rodrigues da Silva Santos, Juliane Nancy de Oliveira Silva, Alícia Natalie Silva dos Santos, Marcus Mello Rego de Amorim, Mércia Rodrigues Barros, Luana Cassandra Breitenbach Barroso Coelho, Patrícia Maria Guedes Paiva, Thâmarah de Albuquerque Lima, Gustavo Ferreira Martins, Thiago Henrique Napoleão, Emmanuel Viana Pontual

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Accompaniment, Silence, or Tolerance of the Islamic Legislator with the Conduct of the Wise by Mahdi Montazerqaem

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Aptamer-Conjugated Magnetic Nanoparticles Integrated with SERS for Multiplex Salmonella Detection by Fan Sun, Kun Pang, Keke Yang, Li Zheng, Mengmeng Wang, Yufeng Wang, Qiang Chen, Zihong Ye, Pei Liang, Xiaoping Yu

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FyTok: An integrated modeling simulator for magnetic confinement fusion Tokamak by Xiaojuan Liu, Zhi Yu

“…FyTok handles each of these separately using data bindings, formula bindings and function bindings. FyTok can be easily configured using configuration files to organise the different module classes, generate the required physical workflows, and track the evolution of physical quantities in the workflows for modeling purposes. …”
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Dbl2 interacts with helicases and an endonuclease to maintain the integrity of repetitive regions by Anetta Bakosova, Lubos Cipak, Nina Mayerova, Kamil Krol, Zsigmond Benko, Alexandra Pitelova, Peter Kolesar, Dominika Piatrova, Maria Smondrkova, Anna Maresova, Lucia Molnarova, Ingrid Cipakova, Veronika Altmannova, Jana Bellova, Peter Barath, Martin Prevorovsky, Jan Palecek, Lumir Krejci, Juraj Gregan, Adrianna Skoneczna, Silvia Bagelova Polakova

“…Therefore, Dbl2 and Fbh1 might be involved in the same molecular pathway, maintaining genome integrity by hindering ectopic recombination at repetitive elements.…”
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Genome-Wide Prediction of Vaccine Candidates for Leishmania major: An Integrated Approach by Satarudra Prakash Singh, Kriti Roopendra, Bhartendu Nath Mishra

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Efficacy and mechanisms of Angelica sinensis in treating endometrial cancer: an integrated study by Zhenyi Li, Congchao Jia, Yiqian Zhou, Qin Wang

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Integration of network pharmacology and experimental validation to explore the pharmacological mechanism of andrographolide against asthma by Qian Yu, LiHong Zhu, XuChun Ding, YaFang Lou

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A Targeted Integration-Based CHO Cell Platform for Simultaneous Antibody Display and Secretion by Jessica P. Z. Ng, Mariati Mariati, Jiawu Bi, Matthew Wook Chang, Yuansheng Yang

“…Objective: We developed a targeted integration-based CHO cell platform for simultaneous antibody display and secretion, enabling a streamlined transition from antibody library screening to production without requiring the re-cloning of antibody genes. …”
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GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss by Hui Cheng, Xuegang Wang, Mingjun Zhong, Jia Geng, Wenjian Li, Kanglu Pei, Jing Wang, Lanchen Wang, Yu Lu, Jing Cheng, Fengxiao Bu, Huijun Yuan

“…Abstract Effective research and clinical application in audiology and hearing loss (HL) require the integration of diverse data, yet the absence of a dedicated database impedes understanding and insight extraction in HL. …”
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The murine ATP-binding cassette transporter C5 (Abcc5/MRP5/cMOAT) plays a role in memory consolidation, circadian rhythm regulation and glutamatergic signalling by Gareth Banks, Malgorzata Cyranka, Natascia Vedovato, Charlotte Meller, Alex Rawnsley, Edward O. Mann, Michelle Stewart, Heidi de Wet

“…Abstract ATP-Binding cassette (ABC) transporters are a family of integral membrane ATPases that transport a large number of structurally unrelated compounds. …”
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Galectin 3‐binding protein (LGALS3BP) depletion attenuates hepatic fibrosis by reducing transforming growth factor‐β1 (TGF‐β1) availability and inhibits hepatocarcinogenesis... by Dae‐Hwan Kim, Minjeong Sung, Myong‐Suk Park, Eun‐Gene Sun, Sumin Yoon, Kyung Hyun Yoo, Kamalakannan Radhakrishnan, Sung Yun Jung, Woo‐Kyun Bae, Sang‐Hee Cho, Ik‐Joo Chung

“…Abstract Background Increased Galectin 3‐binding protein (LGALS3BP) serum levels have been used to assess hepatic fibrosis stages and the severity of hepatocellular carcinoma (HCC). …”
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CCDC68 Maintains Mitotic Checkpoint Activation by Promoting CDC20 Integration into the MCC by Qi Li, Qingzhou Chen, Tao Zheng, Fulin Wang, Junlin Teng, Haining Zhou, Jianguo Chen

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FKBP51 is Involved in Epileptic Seizure by Regulating PSD95 in a PTZ-Induced Epileptic Mouse Model by Ling Chen, Wenxiu Cui, Jiyao Qin, Manmin Zhu, Haiqing Zhang, Juan Yang, Zucai Xu, Hao Huang

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Integrating Surface Plasmon Resonance and Docking Analysis for Mechanistic Insights of Tryptase Inhibitors by Alessia Porta, Candida Manelfi, Carmine Talarico, Andrea Rosario Beccari, Margherita Brindisi, Vincenzo Summa, Daniela Iaconis, Marco Gobbi, Marten Beeg

“…Here, we explored an integrated approach to characterize tryptase ligands, combining novel experimental binding studies using Surface Plasmon Resonance, with in silico analysis through the Exscalate platform. …”
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Evolutionary rewiring of bacterial regulatory networks by Tiffany B. Taylor, Geraldine Mulley, Liam J. McGuffin, Louise J. Johnson, Michael A. Brockhurst, Tanya Arseneault, Mark W. Silby, Robert W. Jackson

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Exploring the combined diagnostic role of serum MBL in association with renal resistive index and renal shear wave elastography in diabetic kidney disease patients by Enas Ahmed Osman, Khaled Mabrouk, Ahmed Abdelsamie Mahmoud, Medhat Madbouly, Mohamed Moharam Mohamed Hussin, Osama Mosbah, Nevine Sherif, Mohammed Ghanem Gaber, Farida M. Khanany

“…Result The average serum MBL levels, mean RI and SWE of both kidneys were significantly higher in DKD patients compared to T2DM patients without nephropathy. The integration of the aforementioned methodologies significantly enhanced diagnostic performance, achieving a sensitivity of 96.89% and a specificity of 95.11%. …”
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Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators by Zeynep Madak‐Erdogan, Tze‐Howe Charn, Yan Jiang, Edison T Liu, John A Katzenellenbogen, Benita S Katzenellenbogen

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Integrative systems biology and in-vitro analysis of cryptolepine’s therapeutic role in breast cancer by Hina Qayoom, Pankaj Keshari, Manzoor A. Mir

“…Target prediction was performed using SWISS-TARGET-PREDICTION and Integrative Pharmacology for BC. Identified targets were cross-referenced with BC-related genes from Gene Atlas, TCGA, and OMIM. …”
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