EBV-Derived miR-BART20-3p Influences Proliferation and Migration in EBV-Positive Gastric Cancer Models by Suppressing PPARα by Qiong Wu, Guiying Ye, Xiazhen Xu, Xianchang Zeng, Biyun Wu, Fan Xin, Lu Zhang, Xu Lin, Xinjian Lin, Wannan Chen

“…However, the functional roles of individual EBV-encoded miRNAs in EBVaGC remain poorly defined. In this study, we integrate bioinformatic and experimental analyses to uncover a novel oncogenic axis driven by EBV-encoded miR-BART20-3p. …”
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Exosomal lncRNA Mir100hg from lung cancer stem cells activates H3K14 lactylation to enhance metastatic activity in non-stem lung cancer cells by Lei Shi, Bowen Li, Jiyu Tan, Ling Zhu, Sicheng Zhang, Yuhan Zhang, Meng Xiang, Jie Li, Yan Chen, Xue Han, Jiacheng Xie, Yao Tang, H. Rosie Xing, Jingyu Li, Jianyu Wang

“…Mechanistically, HNRNPF and HNRNPA2B1 directly binds to Mir100hg, facilitating its trafficking via exosomes to non-CSCs. …”
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Ectopic expression of GDF15 in cancer-associated fibroblasts enhances melanoma immunosuppression via the GFRAL/RET cascade by Zhiheng Lin, Li Lin, Yisheng Chen, Yantao Ding, Xiaojing Wang, Zhiwen Luo, Zhenzhen Zhao, Zhijie Zhao, Huabao Cai, Wenyang Nie, Fu Zhao

“…The paracrine secretion of GDF15 was regulated by the transcription factor FOXP1, which subsequently binds to the TGFBR2 receptor on melanoma cells, driving their proliferation and metastatic capacity. …”
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Identification and Functional Validation of the <i>PeDHN</i> Gene Family in Moso Bamboo by Yaqin Ye, Yanting Chang, Wenbo Zhang, Tiankui Chu, Hanchen Tian, Yayun Deng, Zehui Jiang, Yanjun Ma, Tao Hu

“…Yeast one-hybrid assays demonstrated that two <i>PeABF1</i> proteins could bind to the promoter of <i>PeDHN4</i>, suggesting that <i>PeDHN4</i> may regulate stress responses through the ABA signaling pathway. …”
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Knowledge-seeking and knowledge sharing of health services across social networks and communities: a scoping review by Anamitra Bhowmick, Marieke M. van der Zande, Rebecca Harris

“…Abstract Introduction Lay people’s knowledge influences healthcare service utilisation, but the literature on people’s knowledge-seeking and sharing about different healthcare services across social networks is patchy and not well integrated. This scoping review was undertaken to map how different studies report healthcare service -related (healthcare) knowledge-seeking or sharing in social circles and to identify evidence gaps for further research. …”
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Discovery of novel VEGFR2 inhibitors against non-small cell lung cancer based on fingerprint-enhanced graph attention convolutional network by Zixiao Wang, Lili Sun, Yu Xu, Jing Huang, Fang Yang, Yu Chang

“…Employing a multimodal fusion strategy, the model integrates a feature extraction layer that comprises molecular graph feature extraction and molecular fingerprint feature extraction. …”
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Identification of Potential Drug Targets for the Treatment of Severe Burn Wounds from a Multi-Omics Perspective by Zhu G, Li J, Xu J, Guo G, Zhu F

“…Drug prediction indicated that mevastatin binds effectively to the CYP19A1 gene expression protein. …”
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CRISPR-Cas13a-powered electrochemical biosensors for RNA-based disease diagnostic and monitoring by Salma Nur Zakiyyah, Irkham, Karina Salsabiila Putri Sima, Clianta Yudin Kharismasari, Mengzhen Xi, Shabarni Gaffar, Mehmet Ozsoz, Francesco Paolucci, Giovanni Valenti, Yeni Wahyuni Hartati

“…Recent advancements have integrated the CRISPR-Cas13a system with electrochemical biosensors to enhance RNA detection sensitivity and specificity. …”
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RNAi of Neuropeptide CCHamide-1 and Its Receptor Indicates Role in Feeding Behavior in the Pea Aphid, <i>Acyrthosiphon pisum</i> by Sohaib Shahid, Muhammad Bilal Amir, Tian-Bo Ding, Tong-Xian Liu, Guy Smagghe, Yan Shi

“…The docking analysis revealed that the <i>CCHa1</i> peptide binds to its receptor <i>CCHa1R</i> through specific amino acid residues, which are critical for maintaining the structural and functional integrity of the peptide–receptor complex. …”
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High glucose levels promote glycolysis and cholesterol synthesis via ERRα and suppress the autophagy–lysosomal pathway in endometrial cancer by Xiaodan Mao, Lixiang Huang, Xianhua Liu, Xite Lin, Qibin Wu, Xinrui Wang, Yuan Ren, Jincheng Ma, Maotong Zhang, Yao Lin, Damian J. Ralser, Alexander Mustea, Gang Chen, Pengming Sun

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Convalescent patient-derived monoclonal antibodies targeting different epitopes of E protein confer protection against Zika virus in a neonatal mouse model by Xuefeng Niu, Lingzhai Zhao, Linbing Qu, Zhipeng Yao, Fan Zhang, Qihong Yan, Shengnan Zhang, Renshan Liang, Peihai Chen, Jia Luo, Wei Xu, Huibin Lv, Xinglong Liu, Hui Lei, Changhua Yi, Pingchao Li, Qian Wang, Yang Wang, Lei Yu, Xiaoyan Zhang, L. Aubrey Bryan, Edgar Davidson, j. Benjamin Doranz, Liqiang Feng, Weiqi Pan, Fuchun Zhang, Ling Chen

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Social Portrait of a Modern Student by O. V. Yarmak, P. P. Deryugin, V. E. Yarmak

“…This fact was assessed as a phenomenon of social gratitude: the young generation, who found in Sevastopol the opportunity to live peacefully and fulfill itself, binds itself to the city, but wants to make it better. …”
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Structural insights into heterohexameric assembly of epilepsy-related ligand–receptor complex LGI1–ADAM22 by Takayuki Yamaguchi, Kei Okatsu, Masato Kubota, Ayuka Mitsumori, Atsushi Yamagata, Yuko Fukata, Masaki Fukata, Mikihiro Shibata, Shuya Fukai

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Comprehensive N-glycosylation profiling of recombinant spike S1 protein from the wild-type SARS-CoV-2 and its variants by Yao Peng, Yao Peng, Yao Peng, Tian-Tian Tong, Qiu-Yu Deng, Lee-Fong Yau, Jia-Qi Qiu, Qing Zhao, Jia-Qi Wu, Zhi-Qiang Xin, Man-Ci Guan, Yue Li, Zhi-Hong Jiang, Hu-Dan Pan, Hu-Dan Pan, Liang Liu, Liang Liu, Liang Liu, Jing-Rong Wang, Jing-Rong Wang

“…The Spike protein forms trimers that bind to the ACE2 receptor on host cells, with the S1 subunit being a primary target for vaccines and antiviral treatments.MethodsHerein, we performed an in-depth analysis of the N-glycosylation of the recombinant Spike S1 protein (S1 protein) across the wild-type (WT) virus and its 5 variants, including Alpha, Beta, Gamma, Delta, and Lambda, by integrating ultrahigh-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF MS) and unique TiO₂-PGC chip-based LC/MS techniques.ResultsA total of 332 glycan structures arising from 180 compositions on the S1 and RBD regions were identified, revealing remarkable glycosylation diversity of the S1 protein. …”
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Clonorchis sinensis-driven hepatocarcinogenesis via E2F1-CD24 transcriptional axis: mechanistic and therapeutic implications by Wen-Min Lu, Jin Yan, Zhao-Ji Liu, Yong Wu, Qian-Ru Cui, Ji Feng, Yu Chen, Guang-Zhi Zhu, Tao Peng, Jing Zhou, Guo-Dong Lu

“…Mechanistically, E2F1 directly binds to CD24 promoter, driving its transcription upon CsESPs exposure. …”
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An association analysis of lipidome and transcriptome highlights the involvement of MmGDPD1 in regulating low phosphorus tolerance in Malus mandshurica by Hong Zhao, Yawei Wu, Luonan Shen, Zhengchun Li, Lin Deng, Xiaopeng Wen

“…Based on expression analysis, a dual-luciferase reporter assay, as well as yeast one-hybrid (Y1H) identification, MmPHR1 was justified to bind with the MmGDPD1 promoter and positively regulate plant tolerance to low-Pi stress. …”
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Impact of c-JUN deficiency on thalamus development in mice and human neural models by Jiantao Shi, Qing Chen, Jianheng Lai, Jieying Zhu, Ran Zhang, Md. Abdul Mazid, Dongwei Li, Huanxing Su, Dajiang Qin

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In vitro Validation of a Novel Disposable Remover to Remove Activated Leukocytes Generated During Cardiopulmonary Bypass: A Pilot Study by Zheng Y, Ran Y, Wu J, Yang P, Liao X, Zhang J, Meng W, Gou D, Li L, Du L, Lin J

“…The device was integrated into a closed extracorporeal circuit containing a blood reservoir, roller pump, and tubes. …”
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PREDICATIVE ARRANGEMENT OF NATIONAL ANTHEM TEXTS IN ENGLISH- AND GERMAN- SPEAKING COMMUNITIES by Anatoliy M. Prykhodko, Nataliia V. Lazebna

“…The category of predicativeness, which correlates linguistic units with reality, binds nominative units into sentences and sentences into cohesive texts. …”
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Disease-Resistance Functional Analysis and Screening of Interacting Proteins of ZmCpn60-3, a Chaperonin 60 Protein from Maize by Bo Su, Lixue Mao, Huiping Wu, Xinru Yu, Chongyu Bian, Shanshan Xie, Temoor Ahmed, Hubiao Jiang, Ting Ding

“…Additionally, yeast two-hybrid assay preliminary data indicated that ZmCpn60-3 might bind to ZmbHLH118 and ZmBURP7, indicating ZmCpn60-3 might be involved in plant abiotic responses. …”
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