Design, Synthesis, and In Silico Insights of new 4‐Piperazinylquinolines as Antiproliferative Agents against NCI Renal Cancer Cell Lines by Dr. Gabriele La Monica, Dr. Alessia Bono, Federica Alamia, Prof. Dr. Annamaria Martorana, Prof. Antonino Lauria

“…A particularly interesting approach in medicinal chemistry is molecular hybridization, where different known components are integrated into a single chemical entity, resulting in hybrid molecules with enhanced biological activity. …”
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Comprehensive characterization of multi-omics landscapes between gut microbial metabolites and the druggable genome in sepsis by Jun Liu, Tong Li, Li Xin, Xingyu Li, Jianbo Zhang, Peng Zhu

“…MD simulation and MST further revealed that ILA binds stably to PFKFB2, a pivotal kinase in regulating glycolytic flux and immune activation during sepsis. …”
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A novel ACE inhibitory peptide from Pelodiscus sinensis Wiegmann meat water-soluble protein hydrolysate by Pengying Liao, Huayu Liu, Xueqin Sun, Xinrui Zhang, Miao Zhang, Xianyou Wang, Jun Chen

“…Molecular docking revealed that IEWEF could tightly bind to C-ACE, and N-ACE with energies less than 0 kJ mol−1, and the peptide IEWEF can form hydrogen bonds with C-ACE and N-ACE respectively. …”
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Network toxicology and molecular docking reveal the potential link between acrylamide exposure and breast cancer by Zhaoda Duan, Chunjiao Yu, Wenjie Yang, Wenhui Wang, Qi Zhang, Qiaoling Ruan, Rui Zhang, Yongfang Zhao, Shan Yan

“…Molecular docking results suggested that ACR could bind to key targets including EGFR, FN1, JUN, and COL1A1. …”
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Shear Stress-Dependent Modulation of Endothelin B Receptor: The Role of Endothelial Glycocalyx Heparan Sulfate by Camden Holm, Son Nam Nguyen, Solomon A. Mensah

“…The endothelial glycocalyx (GCX) plays a crucial role in vascular health and integrity and influences many biochemical activities through mechanotransduction, in which heparan sulfate (HS) plays a major role. …”
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OsCBL1 Modulates the Nitrate-Induced Phosphate Response by Altering OsNLP4 Cytoplasmic-Nucleus Shuttling by Zhao Hu, Yunting Tang, Suping Ying, Jiawei Niu, Ting Wang, Huaiyi Zhu, Xiaojue Peng

“…However, the complex mechanisms by which plants integrate complex nutrient signals from nitrogen to phosphorus are not well understood. …”
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Modern Medicines (Assortment) and Trends in the Improvement of Dosage Forms of Hepatoprotective Agents (Review) by D. A. Petrukhina, I. V. Pletneva, B. B. Sysuev

“…The high therapeutic and hepatoprotective effectiveness of modern drugs is largely due to their metabolic effects, as well as their ability to bind free radicals and reactive oxygen species in the cell.Text. …”
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Purification, Characterization and Antibacterial Mechanism of Plantaricin 2-1 by Mengyang LI, Xiaoxue CHE, Qingshen SUN

“…Additionally, P2-1 demonstrated the ability to bind to the genomic DNA of the indicator strains, thereby disrupting their DNA structure. …”
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Identification of an Ara-C resistance-related gene risk score and the role of S100A4 in AML via NR6A1-dependent activation and p53 regulation by Li Wang, Li Wang, Li Wang, Aoshuang Huang, Aoshuang Huang, Aoshuang Huang, Bingqing Cheng, Bingqing Cheng, Xiuying Hu, Xiuying Hu, Jishi Wang, Jishi Wang, Jishi Wang

“…Mechanistically, we identified that the transcription factor NR6A1 directly binds to the S100A4 promoter, enhancing its transcriptional activity. …”
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Research progress on the microbial metabolism and transport of polyamines and their roles in animal gut homeostasis by Chong Zhang, Yongkang Zhen, Yunan Weng, Jiaqi Lin, Xinru Xu, Jianjun Ma, Yuhong Zhong, Mengzhi Wang

“…Positively charged polyamines bind to negatively charged macromolecules, such as nucleic acids and acidic phospholipids, and are involved in physiological activities including cell proliferation, differentiation, apoptosis and gene regulation. …”
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Role of Cathelicidins in Atherosclerosis and Associated Cardiovascular Diseases by Siarhei A. Dabravolski, Nikolay A. Orekhov, Alexey V. Churov, Irina A. Starodubtseva, Dmitry F. Beloyartsev, Tatiana I. Kovyanova, Vasily N. Sukhorukov, Alexander N. Orekhov

“…In atherosclerosis, LL-37 interacts with scavenger receptors to modulate lipid metabolism and binds with mitochondrial DNA and lipoproteins. In acute coronary syndrome, LL-37 influences T cell responses and mitigates calcification within atherosclerotic plaques. …”
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Hypoxic stimulation of DCLK1 transcription and alternative-promoter switching fuels tumor malignancy in clear cell renal cell carcinoma by Jiannan Yao, Xuying Huang, Qianqian Sun, Wenjing Zhao, Nathaniel Weygant, Xiaona Fan, Heshu Liu, Zeru Xiao, Rui Yan, Yang Ge, Guangyu An, Jian Liu

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Over-expressed Phospholamban in Cancer-associated Fibroblasts Is a Driver for CMS4 Subtype Colorectal Cancer FormationSummary by Tao Li, Yuxiang Fei, Xu Sun, Jun Zhu, Xin Fang, Fanjun Meng, Danyi Wang, Xu Zhang, Chao Liu, Qianming Du

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Non-canonical activation of MAPK signaling by the lncRNA ASH1L-AS1-encoded microprotein APPLE through inhibition of PP1/PP2A-mediated ERK1/2 dephosphorylation in hepatocellular car... by Lei Zhao, Ke Si, Shenjian Luo, Lantian Zhang, Shuai Mao, Wenliang Zhang

“…Methods Translatable lncRNAs associated with HCC were identified by integrating data from the TCGA-LIHC cohort and the TransLnc database. …”
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RNF213 Acts as a Molecular Switch for Cav-1 Ubiquitination and Phosphorylation in Human Cells by Jungmi Choi, Ryoichi Inoue, Yuki Masuo, Yukiko Shimizu, Kazuhiro Sonomura, Minsoo Kim, Hatasu Kobayashi, Kouji H. Harada, Yohei Mineharu, Akio Koizumi, Tohru Tezuka, Shohab Youssefian

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Quaking–cZFP609 Axis Remedies Aberrant Plasticity of Vascular Smooth Muscle Cells via Mediating Platelet‐Derived Growth Factor Receptor β Degradation by Yong‐Qing Dou, Xiao‐Yun Zhang, Rui‐Juan Guo, Xiao‐Fu Huang, Yu Song, Xin‐Long Liu, Jie Shi, Fan‐Qin Li, Dan‐Dan Zhang, Peng Kong, Lei Nie, Han Li, Fan Zhang, Mei Han

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Cancer Accumulation and Anticancer Activity of “CROX (Cluster Regulation of RUNX)” PIP in HER2‐Positive Gastric Cancer Evaluated by Chicken Egg Cancer Model by Tatsuya Masuda, Takayoshi Watanabe, Yasutoshi Tatsumi, Jason Lin, Kazuhiro Okumura, Toshinori Ozaki, Hiroshi Sugiyama, Yasuhiko Kamikubo

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The TEAD4-DYNLL1 axis accelerates cell cycle progression and augments malignant properties of lung adenocarcinoma cells by Dapeng Li, An Wang, Xuan Wang, Mengkun Shi, Xiaofeng Chen, Yubao Lyu, Dayu Huang

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Characteristics of Chips From Scales of Carp, Tilapia and Gourami Fish Using Various Coating Flours by Decky Sapuan Ramadhani, Reza Widyasaputra, Ngatirah Ngatirah

“…Coating can help to bind processed fish scales together, adding structural support and preventing the chips from crumbling or breaking apart during handling and consumption. …”
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Whispers of the Earth: Decolonizing Energy for a Just Energy Transformation by Ahmad Fauzi, Cintya Faliana

“…Instead, the paper advocates for a decolonial approach that integrates Indigenous values and&nbsp;</span><span style="font-size: 1rem;">ecological stewardship. …”
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