An expanded cell wall damage signaling network is comprised of the transcription factors Rlm1 and Sko1 in Candida albicans. by Marienela Y Heredia, Mélanie A C Ikeh, Deepika Gunasekaran, Karen A Conrad, Sviatlana Filimonava, Dawn H Marotta, Clarissa J Nobile, Jason M Rauceo

“…Notable targets include genes involved in cell wall integrity, osmolarity, and cellular aggregation, as well as several uncharacterized genes. …”
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Correlating disordered activation domain ensembles with gene expression levels by Eduardo Flores, Aleah R. Camacho, Estefania Cuevas-Zepeda, Mary B. McCoy, Feng Yu, Max V. Staller, Shahar Sukenik

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Multi-level evidence reveals PANK2 as a potential target of PFOA/PFOS-induced bone metabolism disruption: From network toxicology to in vitro validation by Yiming Shao, Wenhao Fan

“…In this study, we systematically investigated the toxicological mechanisms of PFOA and PFOS on bone metabolism by integrating network toxicology, molecular docking and molecular dynamics simulations, and in vitro cellular experiments. …”
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HOXC8 impacts lung tumorigenesis by preventing pyroptotic cell death through the suppression of caspase-1 expression by Ravi Padia, Lei Sun, Ya-Fang Liao, Ozlem Calbay, Cheng Chi, Mahmuda Akter, Lizi Wu, Zheng Fu, Dan-Dan Zhang, Shuang Huang

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PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2 by Marwah Karim, Manjari Mishra, Chieh-Wen Lo, Sirle Saul, Halise Busra Cagirici, Manon Gourdelier, Luca Ghita, Amrita Ojha, Do Hoang Nhu Tran, Aditi Agrawal, Connor McGraw, Michael P. East, Karen Anbro Gammeltoft, Malaya Kumar Sahoo, Nancie A. Mooney, Gary L. Johnson, Soumita Das, Pieter Leyssen, Johan Neyts, Winston Chiu, Courtney A. Cohen, Jens Bukh, Judith Gottwein, John M. Dye, Norma Neff, Peter K. Jackson, Benjamin A. Pinsky, Tuomo Laitinen, Tatu Pantsar, Antti Poso, Fabio Zanini, Steven De Jonghe, Christopher R. M. Asquith, Shirit Einav

“…We identify PIP4K2C’s roles in SARS-CoV-2 entry, RNA replication, and assembly/egress, validating it as a druggable antiviral target. Integrating proteomics, single-cell transcriptomics, and functional assays, reveals that PIP4K2C binds SARS-CoV-2 nonstructural protein 6 and regulates virus-induced autophagic flux impairment. …”
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A hidden cysteine in Fis1 targeted to prevent excessive mitochondrial fission and dysfunction under oxidative stress by Suman Pokhrel, Gwangbeom Heo, Irimpan Mathews, Shun Yokoi, Tsutomu Matsui, Ayori Mitsutake, Soichi Wakatsuki, Daria Mochly-Rosen

“…Importantly, SP11 preserves mitochondrial integrity and function in cells during oxidative stress and thus may serve as a candidate molecule for the development of treatment for diseases with underlying Fis1-mediated mitochondrial fragmentation and dysfunction.…”
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Galectin-3 in Cardiovascular Health: A Narrative Review Based on Life’s Essential 8 and Life’s Simple 7 Frameworks by Adrian Martuszewski, Patrycja Paluszkiewicz, Rafał Poręba, Paweł Gać

“…Gal-3, also known as galectin-3, a lectin that binds β-galactosides, has gained attention as a novel biomarker and pathophysiological mediator in cardiovascular disease, where it contributes to inflammation, fibrosis, metabolic dysregulation and cardiac remodeling. …”
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Citronellol inhibits the activity of AtSRT1 to increase IAA content and signal transduction, promoting the growth of A. thaliana by Jin-Rui Wen, Hong-Yan Nie, Hong-Xin Liao, Fu-Rong Xu, Xiao-Yun Liu, Xian Dong

“…Enzyme activity assays, molecular docking, and molecular dynamics simulations showed that Citronellol binds to specific residues (PHE:64, ARG:65, MET:1, and ILE:214) of the histone deacetylase AtSRT1 in Arabidopsis, inhibiting its activity and elevating H3K9ac levels. …”
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Novel nitroxoline derivative combating resistant bacterial infections through outer membrane disruption and competitive NDM-1 inhibition by Peng He, Sijing Huang, Rui Wang, Yunkai Yang, Shangye Yang, Yue Wang, Mengya Qi, Jiyang Li, Xiaofen Liu, Xuyao Zhang, Meiqing Feng

“…ASN-1733 can effectively compete for Ca2+ on the bacterial surface, causing the detachment of lipopolysaccharides (LPS), thereby compromising the outer membrane integrity and permeability and exhibiting broad-spectrum bactericidal activity. …”
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Antibody conjugates in neuroblastoma: a step forward in precision medicine by Jihane Balla, Carlotta Siddi, Maria Scherma, Paola Fadda, Paola Fadda, Simona Dedoni

“…Future research should also prioritize refining and integrating these technologies into multimodal treatment protocols to improve outcomes for pediatric NB patients.…”
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Functional aptamer evolution-enabled elucidation of a melanoma migration-related bioactive epitope by Hong Xuan, Siqi Bian, Qinguo Liu, Jun Li, Shaojin Li, Sharpkate Shaker, Haiyan Cao, Tongxuan Wei, Panzhu Yao, Yifan Chen, Xiyang Liu, Ruidong Xue, Youbo Zhang, Liqin Zhang

“…Additionally, XH3C is an affinity and functional molecule that selectively binds to a unique epitope on CSPG4, enabling the development of innovative therapeutic strategies.…”
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Keratin-72 restricts HIV-1 infection in resting CD4+ T cells by sequestering capsids in intermediate filaments by Yang He, Meng Xu, Jiayue Ouyang, Li Zhao, Tiankui Ma, Xiaowei Zhang, Ruolin Wang, Hong Shang, Guoxin Liang

“…In contrast, without KRT72, HIV-1 capsids are transported to the nucleus, leading to high levels of integrated HIV-1 DNA. Thus, KRT72 is a Vpx-counteracted antiviral factor that binds the incoming capsids to cytoplasmic IFs, restricting HIV-1 infection in resting CD4+ T cells.…”
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Human eIF2A has a minimal role in translation initiation and in uORF-mediated translational control in HeLa cells by Mykola Roiuk, Marilena Neff, Aurelio A Teleman

“…Nonetheless, eIF2A is still considered a translation initiation factor because it binds the ribosome and shows genetic interactions with other initiation factors such as eIF4E. …”
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MMDH2-mediated hydroxyproline accumulation regulates iron-deficiency stress response in Arabidopsis by Xi Wu, Mengfan Wu, Qian Ma, Zhen Zhang, Junjia Sheng, Yifan Zhu, Jiena Xu, Guangna Chen, Hui Song, Shuqing Cao

“…This study positions MMDH2 as a central hub integrating metabolic and transcriptional pathways essential for maintaining Fe homeostasis. …”
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NHE7 drives endometrial cancer progression by delaying senescence through cAMP/CREB/GRIN2B axis-mediated Ca²⁺ influx by Shizhou Yang, Tao Shen, Minghua Yu, Tingting Wu, Linhua Qian, Wu Liu, Ting Wang, Xiufeng Huang

“…Mechanistically, NHE7 binds to a cAMP-related transcription factor, thereby increasing GRIN2B expression to elevate intracellular Ca²⁺ levels influx, which delays cell senescence and promotes cancer progression in vitro and in vivo. …”
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Wag31, a membrane tether, is crucial for lipid homeostasis in mycobacteria by Yogita Kapoor, Himani Khurana, Debatri Dutta, Arnab Chakraborty, Anshu Priya, Archana Singh, Siddhesh S Kamat, Neeraj Dhar, Thomas John Pucadyil, Vinay Kumar Nandicoori

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Balance equations for physics-informed machine learning by Sandor M. Molnar, Joseph Godfrey, Binyang Song

“…We show that all of these equations can be derived from a single equation known as the generic balance equation, in conjunction with specific constitutive relations that bind the balance equation to a particular domain. …”
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MODERN ASPECTS OF HUMAN PAPILLOMAVIRUS VACCINATION by O. S. Alyautdina, M. A. Darmostukova

“…These three  vaccines effectively prevent HPV infections, causing the production of neutralizing antibodies that bind to viral particles and block their  entry into host cells. …”
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Staphylococcal phenotypes induced by naturally occurring and synthetic membrane-interactive polyphenolic β-lactam resistance modifiers. by Lucia Palacios, Helena Rosado, Vicente Micol, Adriana E Rosato, Patricia Bernal, Raquel Arroyo, Helen Grounds, James C Anderson, Richard A Stabler, Peter W Taylor

“…We have endeavoured to potentiate the capacity of ECg to modify the MRSA phenotype by stepwise removal of hydroxyl groups from the B-ring pharmacophore and the A:C fused ring system of the naturally occurring molecule. ECg binds rapidly to the membrane, inducing up-regulation of genes responsible for protection against cell wall stress and maintenance of membrane integrity and function. …”
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Stimulation of gross chromosomal rearrangements by the human CEB1 and CEB25 minisatellites in Saccharomyces cerevisiae depends on G-quadruplexes or Cdc13. by Aurèle Piazza, Alexandre Serero, Jean-Baptiste Boulé, Patricia Legoix-Né, Judith Lopes, Alain Nicolas

“…Genomes contain tandem repeats that are at risk of internal rearrangements and a threat to genome integrity. Here, we investigated the behavior of the human subtelomeric minisatellites HRAS1, CEB1, and CEB25 in Saccharomyces cerevisiae. …”
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