CULTURE AND THE QUESTION OF IDENTITY IN NORTHERN NIGERIA: AN OVERVIEW OF THE GRAY AREAS IN THE 21ST CENTURY by MARABS JOSHUA ANTHONY, SOJA ZAKKA, JOEL JOSEPH GAJERE

“… The history of human existence revealed that, culture is an integral part of human endeavor. To every community/group of people, there is a cultural identity that binds them together at different levels of cultural practices. …”
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Base-excision repair pathway shapes 5-methylcytosine deamination signatures in pan-cancer genomes by André Bortolini Silveira, Alexandre Houy, Olivier Ganier, Begüm Özemek, Sandra Vanhuele, Anne Vincent-Salomon, Nathalie Cassoux, Pascale Mariani, Gaelle Pierron, Serge Leyvraz, Damian Rieke, Alberto Picca, Franck Bielle, Marie-Laure Yaspo, Manuel Rodrigues, Marc-Henri Stern

“…We demonstrate that the BER glycosylase MBD4 preferentially binds to active chromatin and early replicating DNA, which correlates with lower mutational burden in these domains. …”
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The virulence regulator CovR boosts CRISPR-Cas9 immunity in Group B Streptococcus by Adeline Pastuszka, Maria-Vittoria Mazzuoli, Chiara Crestani, Léonie Deborde, Odile Sismeiro, Coralie Lemaire, Vanessa Rong, Myriam Gominet, Elise Jacquemet, Rachel Legendre, Philippe Lanotte, Arnaud Firon

“…Here, we show that the master regulator of virulence, CovR, regulates CRISPR-Cas9 immunity against mobile genetic elements in Streptococcus agalactiae, a pathobiont responsible for invasive neonatal infections. We show that CovR binds to and represses a distal promoter of the cas operon, integrating immunity within the virulence regulatory network. …”
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N-methyl-D-aspartate Receptors and Depression: Linking Psychopharmacology, Pathology and Physiology in a Unifying Hypothesis for the Epigenetic Code of Neural Plasticity by Stefano Comai, Sara De Martin, Andrea Mattarei, Clotilde Guidetti, Marco Pappagallo, Franco Folli, Andrea Alimonti, Paolo L. Manfredi

“…This NMDAR Ca²⁺ quantal hypothesis for the epigenetic code of neural plasticity integrates recent psychopharmacology findings into established physiological and pathological mechanisms of brain function.…”
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A single transcription factor regulates evolutionarily diverse but functionally linked metabolic pathways in response to nutrient availability by Amy K Schmid, David J Reiss, Min Pan, Tie Koide, Nitin S Baliga

“…Specifically, during nutritional limitation, TrmB binds a cis‐regulatory element to activate or repress 113 promoters of genes encoding enzymes in diverse metabolic pathways. …”
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A novel NFKB1 agonist remodels tumor microenvironment and activates dendritic cells to promote anti-tumor immunity in colorectal cancer by Ying Chen, Qiaoming Li, Zixiang Wang, Ling V. Sun, Steven X. Hou

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Geranyl hydroquinone alleviates rheumatoid arthritis-associated pain by suppressing neutrophil accumulation, N1 polarization and ROS production in mice by Sen Huang, Yuxin Xie, Zhaochun Zhan, Fengdong Liu, Peiyang Liu, Fei Xu, Tingting Xu, Zhenning Fang, Zhiqiang Chen, Qingjian Han, Ligang Jie, Rougang Xie, Hongfei Zhang, Shiyuan Xu, Yiwen Zhang, Kai Mo, Xin Luo

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Molecular identification of a malaria merozoite surface sheddase. by Philippa K Harris, Sharon Yeoh, Anton R Dluzewski, Rebecca A O'Donnell, Chrislaine Withers-Martinez, Fiona Hackett, Lawrence H Bannister, Graham H Mitchell, Michael J Blackman

“…Here we identify it as PfSUB2, an integral membrane subtilisin-like protease (subtilase). …”
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A Novel Identified Long Intergenic Noncoding RNA, LINC01574, Contributes to Breast Cancer Deterioration via the Regulation of miR-6745/TTYH3 Axis by Liang Zhang, Lingyuan Wu, Mengjiao Wei, Peikai Ding, Xingsong Tian, Kunbing Zhu

“…The expression and prognosis of LINC01574 in BC were detected by integrating analysis of data mining, bioinformatics, and RT-qPCR. …”
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Allosteric communication occurs via networks of tertiary and quaternary motions in proteins. by Michael D Daily, Jeffrey J Gray

“…Allosteric proteins bind an effector molecule at one site resulting in a functional change at a second site. …”
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Growth-inhibiting effects of the unconventional plant APYRASE 7 of Arabidopsis thaliana influences the LRX/RALF/FER growth regulatory module. by Shibu Gupta, Amandine Guérin, Aline Herger, Xiaoyu Hou, Myriam Schaufelberger, Romain Roulard, Anouck Diet, Stefan Roffler, Valérie Lefebvre, Thomas Wicker, Jérôme Pelloux, Christoph Ringli

“…Plant cell growth involves coordination of numerous processes and signaling cascades among the different cellular compartments to concomitantly enlarge the protoplast and the surrounding cell wall. The cell wall integrity-sensing process involves the extracellular LRX (LRR-Extensin) proteins that bind RALF (Rapid ALkalinization Factor) peptide hormones and, in vegetative tissues, interact with the transmembrane receptor kinase FERONIA (FER). …”
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Cryo-EM structures of the E. coli Ton and Tol motor complexes by Herve Celia, Istvan Botos, Rodolfo Ghirlando, Denis Duché, Bridgette M. Beach, Roland Lloubes, Susan K. Buchanan

“…The generated force is transmitted through the periplasmic space to protein components associated with the outer membrane, either to maintain the outer membrane integrity for the Tol system, or to allow essential nutrients to enter the cell for Ton. …”
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Aptamer-functionalized graphene quantum dots combined with artificial intelligence detect bacteria for urinary tract infections by Kun Li, Shiqiang Fang, Tangwei Wu, Chao Zheng, Yi Zeng, Jinrong He, Yingmiao Zhang, Yingmiao Zhang, Zhongxin Lu, Zhongxin Lu

“…In this study, we propose a novel approach utilizing aptamer-functionalized graphene quantum dots integrated with an artificial intelligence detection system (AG-AI detection system) for rapid and highly sensitive detection of Escherichia coli (E. coli).MethodsFirstly, graphene quantum dots were modified with the aptamer that can specifically recognize and bind to E. coli. …”
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Hydrocolloids in Rice Noodle Production: Enhancing Texture, Cooking Quality, and Sustainability in Gluten-Free Formulations: A Review by Muhammad Lubowa, Yeoh Shin Yong, Mubajje Muhamad Shaban

“…Their ability to bind water, form gels, and interact with starches and proteins contributes to enhanced noodle elasticity, chewiness, and overall quality. …”
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Shared molecular mechanisms of bisphenol A and phthalates in endometriosis: A bioinformatics and molecular docking study by Zhixiang Fan, Reyilanmu Maisaidi, Yibanuer Reheman, Yang Li, Penglai Zhou, Lili Han

“…Methods: Bioinformatics and molecular docking analyses were integrated to characterize the chemical-pathway interactions in endometriosis development. …”
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CCDC113 stabilizes sperm axoneme and head-tail coupling apparatus to ensure male fertility by Bingbing Wu, Chenghong Long, Yuzhuo Yang, Zhe Zhang, Shuang Ma, Yanjie Ma, Huafang Wei, Jinghe Li, Hui Jiang, Wei Li, Chao Liu

“…The structural integrity of the sperm is crucial for male fertility, defects in sperm head-tail linkage and flagellar axoneme are associated with acephalic spermatozoa syndrome (ASS) and the multiple morphological abnormalities of the sperm flagella (MMAF). …”
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Tetrandrine regulates NAADP-mediated calcium signaling through a LIMP-2-dependent and sphingosine-mediated mechanism by Wing-Cheung Chan, Qian Zhao, Koon Ho Wong, Hok-Him Tang, Daniel Kam-Wah Mok, Lakhansing Pardeshi, Ye Chun Ruan, Yang Yang, Chi-Ming Wong, Clarence T. T. Wong, Yong-Juan Zhao, Ka Ying Chan, Zengsheng Yin, Howard Ho-Wai Leung, Xiyang Ma, Mary P. Chau, Franco King-Chi Leung, Ying-Ying Lui, Shannon Wing-Ngor Au, Kailei Sun, Chin Yu Mok, Fang Wang, Cong Ma, Yu-Hin Ho, Xiang-Yang Ye, Man Lung Yeung, Yajing Zhang, Yan Xiang Zhao, Jiang Liu, Ka-Hing Wong, Larry M. C. Chow, Xiang David Li, Gary M. Tse, Man-Kin Wong, Xiao Shen, Pauline Chiu, Ben C. B. Ko

“…Tet binds LIMP-2’s ectodomain, inhibiting lysosomal cholesterol and sphingosine transport, which alters lipid metabolism. …”
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LINC02163 promotes colorectal cancer progression via miR-511-3p/AKT3 axis by Junwen Ma, Lihai Zhang, Anquan Shang, Hu Song, Jiege Huo, Mingjian Zhang, Liuqin Jiang

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Evolution of PqsE as a Pseudomonas aeruginosa-specific regulator of LuxR-type receptors: insights from Pseudomonas and Burkholderia by Caleb P. Mallery, Kayla A. Simanek, Autumn N. Pope, Jon E. Paczkowski

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The social dimension of language. A review of the literature by Michał Bergier, Izabela Karpiszuk

“…It is one of the most important elements of culture, directly related to the traditions of individual societies, as well as to everyday life and social relations. Language can both integrate and divide a society. Sociolect, jargon, or slang can be what distinguishes individual social groups, binds the people belonging to them together, and sets values that sometimes oppose the commonly held ones. …”
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