Transcription factors, metabolic dysfunction-associated fatty liver disease, and therapeutic implications by Shuwei Hu, Yingjie Ai, Chencheng Hu, Fathima N. Cassim Bawa, Yanyong Xu

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Subtle concentration changes in zinc hold the key to fibrillation of α-synuclein: an updated insight on the micronutrient’s role in prevention of neurodegenerative disorders by Samudra Prosad Banik, Debasis Bagchi, Debasis Bagchi, Debasis Bagchi, Pradipta Banerjee, Sanjoy Chakraborty, Manashi Bagchi, Chaitali Bose, Debasmita De, Sreemoyee Saha, Sreemoyee Saha, Sudipta Chakraborty

“…Zinc is a significant micronutrient of the human body integral to the proper functioning of the nervous system as well as holistic cognitive development. …”
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Lanatoside C activates the E3 ligase STUB1 to inhibit FOXP3 transcriptional activity and promote antitumor immunity by Qian Zhou, Tong Yang, Xixi Yu, Bo Li, Jin Liu, Yongxin Mao, Rongxiang Guo, Zhuo Feng, Li Zhou, Guandi Zeng, Nan Li, Jinxia Liang, Lu Liu, Pengju Feng, Hong-Bing Shu, Liang Chen

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Transcriptional Activation of Pericentromeric Satellite Repeats and Disruption of Centromeric Clustering upon Proteasome Inhibition. by Theona Natisvili, Cihangir Yandim, Raquel Silva, Giulia Emanuelli, Felix Krueger, Sathiji Nageshwaran, Richard Festenstein

“…Our findings suggest that the proteasome plays a role in maintaining heterochromatin integrity of pericentromeres.…”
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Investigation of the inhibitory properties of azo-dyes on chorismate synthase from Paracoccidioides brasiliensis by Katharina Fuchs, Massimo G. Totaro, Marina Toplak, Aleksandar Bijelic, Peter Macheroux

“…Thus, our study is the first to integrate structural and computational methods to guide future efforts towards designing the next generation of CS inhibitors.…”
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Polycyclic aromatic hydrocarbons promote tumorigenesis of gallbladder cancer via aryl hydrocarbon Receptor-HEGBC positive feedback axis by Lei Yuan, Yumeng Zhang, Jianguo Xu, Feng Liu, Yingchao Liang, Beili Wang, Meihong Wu, Zhiyuan Fan, Liang Yang

“…These findings provide the integrative view of a molecular mechanism loop for regulating the malignant progression of GBC centered by PAHs/AhR/HEGBC, which represents a promising strategy for the treatment of GBC.…”
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Bromelain Supplementation in the Management of Otitis Media with Effusion in Children by Francesco Martines, Ginevra Malta, Emanuele Cannizzaro, Theodoridou Kelly, Pietro Salvago, Fulvio Plescia

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Exploring novel roles of lipid droplets and lipid metabolism in regulating inflammation and blood–brain barrier function in neurological diseases by Luo Fu, Luo Fu, Ting Luo, Ting Luo, Zhongnan Hao, Yongli Pan, Yongli Pan, Wenqiang Xin, Lin Zhang, Lin Zhang, Zhuhong Lai, Haitao Zhang, Hua Liu, Wei Wei, Wei Wei

“…These LDs help sustain cellular energy needs and modulate inflammatory responses, which are key factors in maintaining BBB integrity. Surface modifications of liposomes can further enhance their targeting efficiency, enabling them to selectively bind to specific brain cell types, including neurons, astrocytes, and microglia. …”
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Effective Graph Mining for Educational Data Mining and Interest Recommendation by Shasha Xu

“…In order to fully understand and analyze the rules and cognitive characteristics of users’ learning methods and, with the assistance of Internet and artificial acquaintance technology, to emphasize the integrity and degree of personalized education, a personalized graph-learning-based recommendation system including user portraits is proposed. …”
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Pex3 promotes formation of peroxisome-peroxisome and peroxisome-lipid droplet contact sites by Lucía Amado, Louis Percifull, Rico Franzkoch, Vico Flatemersch, Eleni Joana Brüggemann, Olympia Ekaterini Psathaki, Maya Schuldiner, Maria Bohnert, Margret H. Bülow, Ayelén González Montoro

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From copper homeostasis to cuproptosis: a new perspective on CNS immune regulation and neurodegenerative diseases by Luhao Li, Liangzhen Lv, Zhaodi Wang, Xianbao Liu, Qingyi Wang, Hui Zhu, Bei Jiang, Yapeng Han, Xue Pan, Xueming Zhou, Li Ren, Zhuo Chang

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Positively charged specificity site in cyclin B1 is essential for mitotic fidelity by Christian Heinzle, Anna Höfler, Jun Yu, Peter Heid, Nora Kremer, Rebecca Schunk, Florian Stengel, Tanja Bange, Andreas Boland, Thomas U. Mayer

“…Here, we discover that a positively charged pocket in cyclin B1, which is exclusively conserved within B-type cyclins and binds phosphorylated serine- or threonine-residues, is essential for correct execution of mitosis. …”
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Flavonoid pathway intermediates implicate UVR8 in functions beyond canonical UV-B signaling by Nan Jiang, Tatiana García Navarrete, Yun Sun Lee, Emily G. Pawlowski, Sunyoung Park, Erich Grotewold

“…Abstract Plants integrate light signals to regulate development and produce protective compounds such as flavonoids under excessive light stress. …”
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Lactobacillus acidophilus potentiates oncolytic virotherapy through modulating gut microbiota homeostasis in hepatocellular carcinoma by Jiayu Zhang, Jinneng Yang, Jinyan Luo, Weili Wu, Haidan Luo, Wenxia Wei, Haimei Lyu, Yuzhi Wang, Hairong Yi, Yijing Zhang, Zongmin Fan, Haiwen Lyu, Vishnu Priya Kanakaveti, Baifu Qin, Ping Yuan, Runxiang Yang, Haipeng Zhang, Tao Zuo, Dean W. Felsher, Mong-Hong Lee, Kai Li

“…L. acidophilus supplementation confers sensitivity to VSVΔ51 through restoring gut barrier integrity and microbiota homeostasis destroyed by VSVΔ51. …”
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Mathematical Foundations and Implementation of CONIKS Key Transparency by Elissa Mollakuqe, Hasan Dag, Vesna Dimitrova

“…Through the use of Merkle trees, we verified the integrity of the system, while zero-knowledge proofs were utilized to ensure the confidentiality of key bindings. …”
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Mutational and topological analysis of the Escherichia coli BamA protein. by Douglas F Browning, Sophie A Matthews, Amanda E Rossiter, Yanina R Sevastsyanovich, Mark Jeeves, Jessica L Mason, Timothy J Wells, Catherine A Wardius, Timothy J Knowles, Adam F Cunningham, Vassiliy N Bavro, Michael Overduin, Ian R Henderson

“…The multi-protein β-barrel assembly machine (BAM) of Escherichia coli is responsible for the folding and insertion of β-barrel containing integral outer membrane proteins (OMPs) into the bacterial outer membrane. …”
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Molecular basis of the urate transporter URAT1 inhibition by gout drugs by Yang Suo, Justin G. Fedor, Han Zhang, Kalina Tsolova, Xiaoyu Shi, Kedar Sharma, Shweta Kumari, Mario Borgnia, Peng Zhan, Wonpil Im, Seok-Yong Lee

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Plant DNA Recombinases: A Long Way to Go by Rajani Kant Chittela, Jayashree K. Sainis

“…DNA homologous recombination is fundamental process by which two homologous DNA molecules exchange the genetic information for the generation of genetic diversity and maintain the genomic integrity. DNA recombinases, a special group of proteins bind to single stranded DNA (ssDNA) nonspecifically and search the double stranded DNA (dsDNA) molecule for a stretch of DNA that is homologous with the bound ssDNA. …”
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Endothelial Glycocalyx Injury in SARS-CoV-2 Infection: Molecular Mechanisms and Potential Targeted Therapy by Bingxuan Lv, Shengshi Huang, Hong Huang, Na Niu, Ju Liu

“…When the glycocalyx is incomplete, virus spike protein of SARS-CoV-2 binds with ACE2 and enters ECs for replication. In addition, cytokine storm targets glycocalyx, leading to subsequent coagulation disorder. …”
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Somatic piRNA and PIWI-mediated post-transcriptional gene regulation in stem cells and disease by Mahammed Zaid Patel, Yuguan Jiang, Pavan Kumar Kakumani

“…PIWI-interacting RNAs (piRNAs) are small non-coding RNAs that bind to the PIWI subclass of the Argonaute protein family and are essential for maintaining germline integrity. …”
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