The non-metabolic function of 6PGD coordinates CCNA2 and HMGA2 expression to drive colorectal cancer progression and drug response by Mingming Sun, Qi Yan, Xinru Zhai, Xintong Dai, Chenxin Yang, Huifang Zhao, Sizhen Lai, Jiyan Wang, Lian Li, Zhen Li, Yanping Li, Taoyuan Wang, Tao He, Jun Xue, Zhenghu Jia, Chunze Zhang, Shuai Zhang, Changliang Shan

Get full text

Ezetimibe Engineered L14‐8 Suppresses Advanced Prostate Cancer by Activating PLK1/TP53‐SAT1‐Induced Ferroptosis by Yu Zhang, Xiao‐wen Song, Na Zhang, Xue‐hui Li, Fan‐chen Wu, Yu‐ang Wei, Dong‐liang Xu, Ling‐fan Xu, Fu‐wen Yuan

Get full text

The unfolded protein response influences therapy outcome and disease progression in chronic lymphocytic leukaemia by Umair Tahir Khan, Kim Clarke, Gina Eagle, Melanie Oates, Peter Hillmen, Sandrine Jayne, Martin J. S. Dyer, Alex Phipps, Francesco Falciani, Rosalind E. Jenkins, Andrew R Pettitt

Get full text

Epigenetic control of topoisomerase 1 activity presents a cancer vulnerability by Tae-Hee Lee, Colina X. Qiao, Vladislav Kuzin, Yuepeng Shi, Marina Farkas, Zhiyan Zhao, Vijayalalitha Ramanarayanan, Tongyu Wu, Tianyi Guan, Xianzhen Zhou, David Corujo, Marcus Buschbeck, Laura Baranello, Philipp Oberdoerffer

“…Abstract DNA transactions introduce torsional constraints that pose an inherent risk to genome integrity. While topoisomerase 1 (TOP1) activity is essential for DNA supercoil removal, the aberrant stabilization of TOP1:DNA cleavage complexes (TOP1ccs) can result in cytotoxic DNA lesions. …”
Get full text

KLF5 silencing restrains proliferation, invasion, migration and angiogenesis of gallbladder carcinoma cells by transcriptional regulation of PDGFA by Xiaowei Lu, Kui Hu, Dandan Zhang, Xuefeng Yin, Jifeng Nie, Kai Zhao

Get full text

NSUN2 facilitates DICER cleavage of DNA damage-associated R-loops to promote repair by Adele Alagia, Kamal Ajit, Arianna Di Fazio, Qilin Long, Monika Gullerova

“…Abstract DNA integrity is constantly challenged by both endogenous and exogenous damaging agents, resulting in various forms of damage. …”
Get full text

Culture as a Universal Variable Opportunity Flow and Selection Process in Silicon Valley by Olivier Alexandre

“…To do this, they need to manage two processes simultaneously: first, to integrate a growing flow of entrants and possible partners and, secondly, to select limited options between multiple opportunities and potential matches. …”
Get full text

Prolactin Mediates Distinct Time Course Regulation of Tyrosine Hydroxylase Phosphorylation and Gene Expression in Tuberoinfundibular Dopaminergic Neurons of Female Rats by Philip J. Jensik, Lydia A. Arbogast

“…PRL did not alter <i>Th</i> promoter activity in CAD cells, and STAT5B did not bind three putative Gamma Interferon Activation Sites (GAS) elements. …”
Get full text

Structural basis of urate transport by glucose transporter 9 by Daiki Matsushita, Yu Toyoda, Yongchan Lee, Maeda Aoi, Hirotaka Matsuo, Tappei Takada, Tomohiro Nishizawa

Get full text

Design Strategies for Cellular Nanosponges as Medical Countermeasures by Shuyan Wang, Dan Wang, Mingxuan Kai, Wei-Ting Shen, Lei Sun, Weiwei Gao, Liangfang Zhang

“…The interest in using therapeutic nanoparticles to bind with harmful molecules or pathogens and subsequently neutralize their bioactivity has grown tremendously. …”
Get full text

Genome and transcriptome analysis of Chinese wheat powdery mildew isolate 21–2 for discovery of important virulence determinants by Fansong Zeng, Bo Zhang, Bin Yuan, Minfeng Xue, Wenqi Shi, Shuangjun Gong, Tom Hsiang, Dazhao Yu, Lijun Yang

“…Here, we constructed a chromosome-level genome assembly (136.19 Mb) of Chinese isolate 21–2, with repetitive element expansion (predominantly retrotransposons), by integrating Illumina, PacBio, Nanopore, and Hi-C sequencing technologies. …”
Get full text

Sperm acrosome overgrowth and infertility in mice lacking chromosome 18 pachytene piRNA. by Heejin Choi, Zhengpin Wang, Jurrien Dean

“…piRNAs are small non-coding RNAs required to maintain genome integrity and preserve RNA homeostasis during male gametogenesis. …”
Get full text

Harnessing the potential of recombinant human BMP2: regulating scleral changes in myopic guinea pigs by Yijie Liu, Qi Hao, Xuemei Pan, Pubo Wang, Dadong Guo, Qingmei Tian, Xiuyan Zhang, Xiuzhen Lu, Qiuxin Wu, Hongsheng Bi

Get full text

Novel type II toxin-antitoxin systems with VapD-like proteins by Konstantin Gilep, Dmitry Bikmetov, Aleksandr Popov, Anastasiia Rusanova, Shunsuke Tagami, Svetlana Dubiley, Konstantin Severinov

“…The crystal structure of the VapD-VapW complex reveals that VapW lacks the dimerization interface essential for the catalytic activity of VapD but retains the second interaction interface that enables VapD hexamerization. This allows VapW to bind VapD in the same manner that VapD dimers bind to each other in hexamers. …”
Get full text

RpoN1 (sigma factor 54) contributes to the virulence of Paracidovorax citrulli by regulating the expression of type IV pili PilA by Minghui Sun, Yuqiang Zhao, Liuyang Zhao, Jun Wang, Yanli Tian, Baishi Hu

Get full text

Computational biology approach to predict molecular mechanism in cancer by Ansari Vikhar Danish Ahmad, Subur W. Khan, Qazi Yasar, Mohd Sayeed Shaikh, Mohd Mukhtar Khan

“…This methodical strategy enables the evaluation of potential medications by assessing their capacity to bind effectively to cancer causing targets for enhanced treatment accuracy.'' …”
Get full text

Securing top-k query processing in two-tiered sensor networks by Xiaoyan Kui, Jiannan Feng, Xinran Zhou, Huakun Du, Xia Deng, Ping Zhong, Xingpo Ma

“…Integrity and privacy are two important secure matrices in cyber security. …”
Get full text

Texture Properties, Water Activity, Emulsion Stability, and Microstructure of Beef Sausage with the Addition of Papaya Peel Flour by Herly Evanuarini, Agus Susilo, Premy Puspitawati Rahayu

“…Emulsion stability was improved with the addition of papaya peel flour, due to its capacity to bind water and retain fat. SEM analysis showed a well-integrated fiber distribution at 0.3%, which contributed to the structural integrity. …”
Get full text

Primary cilia prevent activation of the cGAS-STING pathway during mouse decidualization by Bo Li, Yu-Ying He, Wen-Xu Yao, Dan-Dan Jin, Hui-Na Luo, Meng-Yuan Li, Ying Wu, Zeng-Ming Yang

“…Within these micronuclei, double-stranded DNA (dsDNA) can directly bind to cyclic GMP-AMP synthase (cGAS) in situ, initiating downstream signaling. …”
Get full text

Optimized Protocol for High-Quality RNA Extraction from Grape Berry Skins Using Sorbitol Pre-Wash by Annalisa Prencipe, Antonella Salerno, Margherita D’Amico, Antonio Domenico Marsico, Mario Ventura, Riccardo Velasco, Maria Francesca Cardone, Carlo Bergamini, Flavia Angela Maria Maggiolini

“…Our results show that it significantly improves the RNA yield and quality from grape berry skins, increasing the RNA purity and integrity, as evidenced by higher RIN (RNA Integrity Number) values and better Qubit and Nanodrop measurements. …”
Get full text