Neuronal expression of S100B triggered by oligomeric Aβ peptide contributes to protection against cytoskeletal damage and synaptic loss by Joana Saavedra, Joana Saavedra, Joana Saavedra, Mariana Nascimento, Mariana Nascimento, Mariana Nascimento, António J. Figueira, António J. Figueira, Marina I. Oliveira da Silva, Marina I. Oliveira da Silva, Tiago Gião, Tiago Gião, Tiago Gião, João Oliveira, João Oliveira, João Oliveira, Márcia A. Liz, Márcia A. Liz, Márcia A. Liz, Márcia A. Liz, Márcia A. Liz, Cláudio M. Gomes, Cláudio M. Gomes, Isabel Cardoso, Isabel Cardoso, Isabel Cardoso

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Comparison of Serenoa repens, lycopene, and selenium versus dutasteride for the treatment of LUTS/BPH: an Italian multicenter case-control prospective study (COMP study) by Giuseppe Morgia, Arturo Lo Giudice, Sebastiano Cimino, Giulio Reale, Gaetano Larganà, Enza La Manna, Massimo Madonia, Alessandro Tedde, Francesco Santaniello, Giuseppe Vespasiani, Stefano Zaganelli, Salvatore Arnone, Nicola Cruciano, Maurizio Carrino, Francesco Persico, Carlo Terrone, Rafaela Malinaric, Andrea Minervini, Marco Carini, Giorgio Ivan Russo

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Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients by Tzu-Chun Cheng, Mien-Chie Hung, Lu-Hai Wang, Shih-Hsin Tu, Chih-Hsiung Wu, Yun Yen, Chi-Long Chen, Jacqueline Whang-Peng, Wen-Jui Lee, You-Cheng Liao, Yu-Ching Lee, Min-Hsiung Pan, Hui-Kuan Lin, Huey-En Tzeng, Peixuan Guo, Cheng-Ying Chu, Li-Ching Chen, Yuan-Soon Ho

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Multifunctional dietary approach reduces intestinal inflammation in relation with changes in gut microbiota composition in subjects at cardiometabolic risk: the SINFONI project by Hugo Hornero-Ramirez, Arianne Morissette, Bruno Marcotte, Armelle Penhoat, Béryle Lecomte, Baptiste Panthu, Jacob Lessard Lord, Florence Thirion, Laurie Van-Den-Berghe, Emilie Blond, Chantal Simon, Cyrielle Caussy, Nathalie Feugier, Joël Doré, Philippe Sanoner, Alexandra Meynier, Yves Desjardins, Geneviève Pilon, André Marette, Patrice D. Cani, Martine Laville, Sophie Vinoy, Marie-Caroline Michalski, Julie-Anne Nazare

“…Mixed linear models were employed, integrating time (pre/post), treatment (MF/control), and sequence/period. …”
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MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy by Jiabin Liang, Jingxiu Zhao, Lin Yang, Qian Wang, Jing Liao, Jianhao Li, Weizhao Zhuang, Fanghong Li, Jinxian He, Yukuan Tang, Hanwei Chen, Chen Huang

“…Furthermore, ChIP-seq and DLR demonstrated that DSS-Exo affected STAT3 directly binds to SHANK2 promoter regions, forming hydrogen bonds between 5 key amino acids such as GLN-344, HIS-332 and 6 key bases such as DG-258, DG-261. miRNA profiling identified DSS-Exo increased hsa-miR-27a-5p_R-1 to regulated STAT3-SHANK2 and modulating the EMT. …”
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Molecular Diagnosis and Therapy of Dental Caries by Oral Microbiome‐Selective Aggregation‐Induced Photosensitivity by Yandi Zhang, Wenjun Wang, Xiaoru Yang, Xuanmeng An, Xiaoyi Liu, Weiwei Zhao, Lina Zhu, Ting Wang, Ying Wang, Yi Chen, Junkun Feng, Jinlong Shao, Xuedong Zhou, Ben Zhong Tang, Shaohua Ge, Jianhua Li

“…This study presents an integrated strategy for the precise diagnosis and treatment of dental caries at the point of care.…”
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Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value by Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi

“…We interrogated data from 1391 consecutive, newly diagnosed subjects with AML, integrating information on mutation topography, DNA methylation, and transcriptomics. …”
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Alpha-Lipoic Acid-Mediated Inhibition of LTB4 Synthesis Suppresses Epithelial-Mesenchymal Transition, Modulating Functional and Tumorigenic Capacities in Non-Small Cell Lung Cancer... by María José Torres, PhD, Juan Carlos Ríos, PhD, Alexandra Valle, MSc, Sebastián Indo, PhD, Kevin Brockway GV, MSc, Fernanda López-Moncada, PhD, Mario Faúndez, PhD, Enrique A. Castellón, PhD, Héctor R. Contreras, PhD

“…The synthesis of LTB4 is mediated by leukotriene A4 hydrolase (LTA4H), and it binds to the receptors BLT1 and BLT2. Dysregulation in LTB4 production is linked to the development of various pathologies. …”
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Application of molecular approach in combination with providing treatment and control measures for combating Babesia bovis and Babesia bigemina infections in small scale livestock... by Nutsuda Klinkaew, Pairpailin Jhaiaun, Giang Thi Nguyen, Ruttayaporn Ngasaman, Domechai Keawnoi, Niorn Rattanapob, Pipat Arunvipas, Meyanee Kanjanaphan, Nuttapon Manojai, Suwitcha Panchakhan, Julaluk Jaiboon, Piyavadee Numnual, Prattana Tong-in, Thongphanchang Khanthong, Paween Srirarai, Chutima Chantarakot, Pattarakitti Noenchat, Jaroonwit Napornram, Somtat Yangsuk, Tanakrit Cham-iam, Phuncharat Nilsuwan, Supicha Jindarut, Kanokrat Boonyok, Nipa Thammasonthijarern, Wissanuwat Chimnoi, Tawin Inpankaew, Burin Nimsuphan, Jumnongjit Phasuk, Ketsarin Kamyingkird

“…All the farmers were very satisfied with the integrative approach. This study implemented sensitive and specific nested PCR methods for the detection of Babesia in livestock. …”
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Mechanistic insights into JSS1_004-mediated antagonism of the DndBCDE-FGH restriction system and engineering applications by Yu He, Susu Jiang, Fang Wang, Junwu Bi, Siting Li, Fuliang Yin, Shi Chen, Chao Chen, Lianrong Wang

“…Furthermore, we successfully developed and integrated attenuated-cytotoxicity variants of JSS1_004 into the genome of M13 phages, conferring robust resistance against the DndBCDE-FGH defense system. …”
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Long Noncoding RNA Interleukin 6 Antisense RNA 1 Promotes Inflammatory Effects in Lung Macrophages via Exosomes Through the S100A9/TLR4 Pathway in Chronic Obstructive Pulmonary Dis... by Erkang Yi, Xiaoyu Wang, Yu Liu, Zihui Wang, Ge Bai, Xinyue Mei, Fan Wu, Chengshu Xie, QiYang Li, Weitao Cao, Huahua Xu, Xinyuan Liu, Jieda Cui, Haiqing Li, Ruiting Sun, Xinru Ran, Wei Hong, Zhishan Deng, Bing Li, Yumin Zhou, Pixin Ran

“…The molecular mechanism likely involves exosome‐mediated secretion, with IL6‐AS1 binding to S100A9 protein. These findings suggest that IL6‐AS1 may facilitate crosstalk between fibroblasts and macrophages, contributing to increased pulmonary inflammation, an effect that can be blocked by paquinimod. …”
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Borosilicate bioactive glass synergizing low-dose antibiotic loaded implants to combat bacteria through ATP disruption and oxidative stress to sequentially achieve osseointegration by Mengke Fan, Youliang Ren, Yanbin Zhu, Hao Zhang, Shuaijie Li, Chunyu Liu, Hongzhi Lv, Lei Chu, Zhiyong Hou, Yingze Zhang, Haobo Pan, Xu Cui, Wei Chen

“…Results showed that BSG did not compromises the handling properties of the cement, but actually endowed it with an ionic and alkaline microenvironment, thereby damaging the integrity of bacterial cell walls and membranes, inhibiting ATP synthesis by disrupting the respiratory chain in cell membranes and glycogen metabolism, and elevating reactive oxygen species (ROS) levels by weakening antioxidant components (peroxisomes and carotenoids). …”
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Gain of bipolar disorder-related lncRNA AP1AR-DT in mice induces depressive and anxiety-like behaviors by reducing Negr1-mediated excitatory synaptic transmission by Shufen Li, Hongyu Ni, Yaping Wang, Xiaohui Wu, Jianqiang Bi, Haiyan Ou, Zhongwei Li, Junjiao Ping, Zhongju Wang, Renhao Chen, Qiong Yang, Meijun Jiang, Liping Cao, Tingyun Jiang, Siqiang Ren, Cunyou Zhao

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Adjuvant combination and antigen multimerization shape neutralizing antibody and T cell responses to a SARS-CoV-2 RBD subunit vaccine by João Pedro da Silva Nunes, Mariângela de Oliveira Silva, Juliana de Souza Apostolico, Isabela Pazotti Daher, Rodolfo Ferreira Marques, Marcio Massao Yamamoto, Alexia Adrianne Venceslau Brito Carvalho, Maria Fernanda de Castro-Amarante, Edison Luiz Durigon, Carsten Wrenger, Luiz Mario Ramos Janini, Edmarcia Elisa de Souza, Robert Andreata-Santos, Juliana Terzi Maricato, Edecio Cunha-Neto, Edecio Cunha-Neto, Edecio Cunha-Neto, Jorge Kalil, Jorge Kalil, Silvia Beatriz Boscardin, Silvia Beatriz Boscardin, Daniela Santoro Rosa, Daniela Santoro Rosa

“…We further optimized our vaccine formulation by combining the adjuvants AddaS03 and Poly I:C, which demonstrated a synergistic effect, integrating the potent humoral response induced by AddaS03 with the cellular Th1 skewing capacity of Poly I:C. …”
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Identification and expression analysis of ACBPs family members of Hippophae rhamnoides subsp. sinensis Rousi in response to lead stress by CHEN Ke, LI Xinjuan, ZHANG Tian, REN Qiandan, SUN Jing, ZHOU Wu

“…The ACBPs gene family is integral to plant biology, playing a critical role in normal plant growth and development. …”
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Potential asthma biomarkers identified by nontargeted proteomics of extracellular vesicles in exhaled breath condensate by Reina Hara, MD, Yoshito Takeda, MD, PhD, Takatoshi Enomoto, MD, Hanako Yoshimura, MD, PhD, Makoto Yamamoto, MD, Satoshi Tanizaki, MD, Yuya Shirai, MD, PhD, Takahiro Kawasaki, MD, PhD, Mana Nakayama, Saori Amiya, MD, Yuichi Adachi, MD, Yoshimi Noda, MD, Takayuki Niitsu, MD, Ryuya Edahiro, MD, PhD, Moto Yaga, MD, PhD, Yuki Hosono, MD, PhD, Maiko Naito, MD, PhD, Kentaro Masuhiro, MD, PhD, Yujiro Naito, MD, PhD, Takayuki Shiroyama, MD, PhD, Kotaro Miyake, MD, PhD, Kiyoharu Fukushima, MD, PhD, Shohei Koyama, MD, PhD, Kota Iwahori, MD, PhD, Haruhiko Hirata, MD, Izumi Nagatomo, MD, PhD, Yusuke Kawashima, PhD, Mari Nogami-Itoh, PhD, Atsushi Kumanogoh, MD, PhD

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Research advances on reisistance to kiwifruit bacterial canker by ZHANG Min, SUN Leiming, FU Rong, LIN Miaomiao, WANG Ran, QI Xiujuan

“…When Psa toxic effector factors are injected into the host plant, it triggers the immune defense response of plant, PTI (PAMP-triggered-immunity) and ETI (effector-triggered-immunity). Nucleotide binding and leucine rich repeat receptors (NLRs) are the largest family of immune receptors in plants. …”
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Multi-omics landscape of alternative splicing in diffuse midline glioma reveals immune- and neural-driven subtypes with implications for spliceosome-targeted therapy by Chaxian Liu, Chaxian Liu, Chaxian Liu, Chaxian Liu, Chaxian Liu, Yue Liu, Yue Liu, Yue Liu, Yue Liu, Yue Liu, Hao Lin, Hao Lin, Hao Lin, Hao Lin, Hao Lin, Chufan Zhang, Chufan Zhang, Chufan Zhang, Bilong Zhang, Bilong Zhang, Bilong Zhang, Haikun Song, Haikun Song, Haikun Song, Xiaomin Fan, Yi Lyu, Hui Yang, Hui Yang, Hui Yang, Hui Yang, Hui Yang, Ying Mao, Ying Mao, Ying Mao, Ying Mao

“…Additionally, our study identified an RNA-binding protein-based classification of DMG and characterized RALYL as a potential regulatory factor, highlighting its potential as a novel therapeutic target.…”
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Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift by Ge Song, Meng Yuan, Hejun Liu, Tazio Capozzola, Ryan N. Lin, Jonathan L. Torres, Wan-ting He, Rami Musharrafieh, Katharina Dueker, Panpan Zhou, Sean Callaghan, Nitesh Mishra, Peter Yong, Fabio Anzanello, Gabriel Avillion, Anh Lina Vo, Xuduo Li, Yuexiu Zhang, Muzamil Makhdoomi, Ziqi Feng, Xueyong Zhu, Linghang Peng, David Nemazee, Yana Safonova, Bryan Briney, Andrew B. Ward, Dennis R. Burton, Ian A. Wilson, Raiees Andrabi

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Brg1 and RUNX1 synergy in regulating TRPM4 channel in mouse cardiomyocytes by Tao Ban, Tao Ban, Tao Ban, Xianhui Dong, Ziyue Ma, Jing Jin, Jing Li, Yunfeng Cui, Yuyang Fu, Yongzhen Wang, Yadong Xue, Tingting Tong, Kai Zhang, Yuxuan Han, Meimei Shen, Yu Zhao, Ling Zhao, Lingzhao Xiong, Hongzhao Lv, Yang Liu, Rong Huo

“…Several binding sites of RUNX1 with the TRPM4 promoter region were predicted by the JASPAR database, and empirical validation substantiated Brg1 modulated TRPM4 promoter activity via RUNX1 engagement. …”
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