C1Q+ TPP1+ macrophages promote colon cancer progression through SETD8-driven p53 methylation by Veronica Veschi, Francesco Verona, Sebastiano Di Bella, Alice Turdo, Miriam Gaggianesi, Simone Di Franco, Laura Rosa Mangiapane, Chiara Modica, Melania Lo Iacono, Paola Bianca, Ornella Roberta Brancato, Caterina D’Accardo, Gaetana Porcelli, Vincenzo Luca Lentini, Isabella Sperduti, Elisabetta Sciacca, Peter Fitzgerald, David Lopez-Perez, Pierre Martine, Kate Brown, Giuseppe Giannini, Ettore Appella, Giorgio Stassi, Matilde Todaro

“…The direct binding of C1Q present on macrophages and C1Q receptor (C1QR) present on cancer stem cells mediates the cross-talk between the two cell compartments. …”
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Semi-rational engineering of an α-L-fucosidase for regioselective synthesis of fucosyl-N-acetylglucosamine disaccharides by Peng Liu, Xiaodi Chen, Xueting Cao, Yuying Wang, Yafei Gao, Li Xu, Xukai Jiang, Min Xiao

“…Molecular dynamics simulations revealed that the structural flexibility of the loop-4 was substantially reduced in mutant L266H, and the hydrogen bond formation and binding affinity between mutant L266H/M285T and Fuc-α-1,3-GlcNAc was significantly enhanced. …”
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Genomic approach to evaluate the intrinsic antibacterial activity of novel diazabicyclooctanes (zidebactam and nacubactam) against clinical Escherichia coli isolates from diverse c... by Farah Al-Marzooq, Akela Ghazawi, Maitha Alshamsi, Abdulrahman Alzaabi, Omar Aleissaee, Hamad Almansoori, Abdullah Alsaadi, Rauda Aldhaheri, Hafsa Ahli, Lana Daoud, Amna Ahmad, Timothy Collyns, Seema Oommen

“…While the inclusion of DBO therapies in the antibiotic arsenal could significantly impact MDR pathogen treatment, realizing their full potential requires further research, clinical evaluation, and vigilant monitoring of resistance mechanisms through integrated genomic approaches.…”
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C/EBPβ–VCAM1 axis in Kupffer cells promotes hepatic inflammation in MASLD by Shuang-Zhe Lin, Yang Xie, Yu-Qing Cheng, Rui Xue, Yin-Shi Su, Mingxi Liu, Yuan-Wen Chen, Jian-Gao Fan

“…In this study, we investigated the critical role of CCAAT/enhancer binding protein β (C/EBPβ) in Kupffer cells and its implications in MASLD pathogenesis. …”
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Early high nutrition enhances grass-fed beef productivity through epigenetically regulated muscle metabolism, altered early adipogenesis, and rumen fermentation dynamics by D. Nishino, S. Khounsaknalath, K. Saito, A. Saito, T. Abe, E. Kobayashi, F. Ebara, S. Maak, E. Albrecht, M.W. Pfaffl, R. Saneshima, S. Shimamoto, D. Ijiri, S. Koike, S. Yasuo, T. Gotoh

“…Epigenetically mediated metabolism was investigated using integrated multiomics approaches including metabolites, gene expression, and DNA methylation. …”
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Inhibition of FAM19A5 reverses synaptic loss and cognitive decline in mouse models of Alzheimer’s disease by Han-Byul Kim, Sangjin Yoo, Hoyun Kwak, Shi-Xun Ma, Ryunhee Kim, Minhyeok Lee, Nui Ha, Soonil Pyo, Soon-Gu Kwon, Eun-Ho Cho, Sang-Myeong Lee, Juwon Jang, Won Kyum Kim, Hae-Chul Park, Minkyung Baek, Yosub Park, Ji-Young Park, Jin-Woo Park, Sun Wook Hwang, Jong-Ik Hwang, Jae Young Seong

“…Conclusions This study demonstrated that inhibiting FAM19A5 function with an anti-FAM19A5 antibody restores synaptic integrity and enhances cognitive function in AD, suggesting a novel therapeutic strategy for AD. …”
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Emu-miR-10a-5p in Echinococcus multilocularis-derived-extracellular vesicles alleviates airway inflammation in mice with allergic asthma by inhibiting macrophage M2a polarization t... by Yunzhuo Xin, Yunzhuo Xin, Rou Wen, Rou Wen, Rou Wen, Dong Song, Jing Xiao, Jing Xiao, Xiaoping Gao, Mei Yin, Yanli Bai, Jie Wang, Jie Wang, Xiangyu Zhou, Jiaqing Zhao, Jiaqing Zhao, Jiaqing Zhao

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Investigating the Effect of Chicken Manure and Potassium Sulfate on the Physiological Properties of Fenugreek )Trigonella foenum-graecum L.( Medicinal Plant by Mohammad hossein Aminifard, Sajjad Nadafa, Hassan Hassan, Mehdi Jahani

“…The planting depth of fenugreek seeds was considered to be 1.5 cm. To prevent the binding of seeds, the seeds were covered with fine sand mixed with animal manure. …”
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14-3-3 proteins inhibit autophagy by regulating SINAT-mediated proteolysis of ATG6 in Arabidopsis by Ting Liu, Yuping Zheng, Shunkang Zhou, Yao Wang, Xue Lei, Lijuan Xie, Qingqi Lin, Changqing Chang, Shi Xiao, Rongliang Qiu, Hua Qi

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Targeted hematopoietic stem cell depletion through SCF-blockade by Yan Yi Chan, Pui Yan Ho, Carla Dib, Leah Swartzrock, Maire Rayburn, Hana Willner, Ethan Ko, Katie Ho, Julian D. Down, Adam C. Wilkinson, Hiro Nakauchi, Morgane Denis, Taylor Cool, Agnieszka Czechowicz

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Radiosensitizing properties of dual-functionalized carbon nanostructures loaded with temozolomide by Radmila Milenkovska, Nikola Geskovski, Dushko Shalabalija, Ljubica Mihailova, Petre Makreski, Dushko Lukarski, Igor Stojkovski, Maja Simonoska Crcarevska, Kristina Mladenovska

“…Cytotoxicity and effects on cell membrane integrity of the blank and TMZ-loaded dual-functionalized carbon nanostructures (CNs) were evaluated in vitro on a GBM cell line (U87MG), as well as their radiosensitizing properties after exposure of the pre-treated GBM cells to gamma radiation with a standard clinical dose for patients with GBM. …”
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Identification of osteoarthritis-associated chondrocyte subpopulations and key gene-regulating drugs based on multi-omics analysis by Ting Hao, Zhiwei Pei, Sile Hu, Zhenqun Zhao, Wanxiong He, Jing Wang, Liuchang Jiang, jirigala Ariben, Lina Wu, Xiaolong Yang, Leipeng Wang, Yonggang Wu, Xiaofeng Chen, Qiang Li, Haobo Yang, Siqin Li, Xing Wang, Mingqi Sun, Baoxin Zhang

“…Molecular docking results reveal that CAY10603, Tenulin, T0901317, and Nonactin exhibit high binding activity to CHI3L1, suggesting their potential as therapeutic drugs for OA. …”
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Green-Synthesized Nanomaterials for Aflatoxin Mitigation: A Review by Gelaye Y, Luo H

“…Green nanoparticles reduce aflatoxin load primarily through their antioxidant properties, which neutralize oxidative stress, and their high adsorption capacity, which binds aflatoxins and reduces their bioavailability. …”
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Smart bactericidal textile enabling in-situ visual assessment of antimicrobial activity by Amparo Ferrer-Vilanova, Josune Jimenez Ezenarro, Kristina Ivanova, Óscar Calvo, Ilana Perelshtein, Giulio Gorni, Ana Cristina Reguera, Rosalía Rodríguez-Rodríguez, Maria Blanes, Núria Vigués, Jordi Mas, Aharon Gedanken, Tzanko Tzanov, Gonzalo Guirado, Xavier Muñoz-Berbel

“…Prussian blue, a chromogenic bacterial-sensing probe, is integrated onto hospital-grade antibacterial fabrics containing copper oxide nanoparticles. …”
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Neuroprotective effects and mechanisms of the YiQiWenYangSanHan formula on Parkinson's disease mice by Jinling Liu, Dong Di, Suping Sun, Yan Sun, Shihan Zhou, Jing Liu, Zizhen Qin, Xinyu Yang, Xiao Wang, Zheng Xu, Boran Zhu, Haoxin Wu

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Galectin-8 drives ERK-dependent mitochondrial fragmentation, perinuclear relocation and mitophagy, with metabolic adaptations for cell proliferation by Adely de la Peña, Claudio Retamal, Francisca Pérez-Molina, Nicole Díaz-Valdivia, Francisco Veloso-Bahamondes, Diego Tapia, Jorge Cancino, Felix Randow, Alfonso González, Claudia Oyanadel, Andrea Soza

“…Galectin-8 (Gal-8), a carbohydrate-binding protein that promotes cell proliferation by transactivating the EGFR-ERK signaling pathway, is overexpressed in several cancers. …”
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Helicobacter pylori infection induces DNA double-strand breaks through the ACVR1/IRF3/POLD1 signaling axis to drive gastric tumorigenesis by Xinbo Xu, Xiao Fei, Huan Wang, Xidong Wu, Yuan Zhan, Xin Li, Yan’an Zhou, Chunxi Shu, Cong He, Yi Hu, Jianping Liu, Nonghua Lv, Nianshuang Li, Yin Zhu

“…We conducted a comprehensive analysis of the clinical relevance of ACVR1 by integrating data from public databases and our local collection of human gastric tissues. …”
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Antibacterial Activity and Molecular Docking of Lignans Isolated from <i>Artemisia cina</i> Against Multidrug-Resistant Bacteria by Leslie Cynthia García Hernández, Rosa Isabel Higuera-Piedrahita, Nallely Rivero-Perez, Ana Lizet Morales-Ubaldo, Benjamín Valladares-Carranza, Héctor Alejandro de la Cruz-Cruz, Jorge Alfredo Cuéllar-Ordaz, Cynthia González-Ruiz, María Inés Nicolás-Vázquez, Adrian Zaragoza-Bastida

“…The antibacterial activity was determined by calculating the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC), the time-kill kinetics assay, and the cell membrane integrity and DNA release assay. Molecular docking studies of lignans demonstrated the binding mode involved in the active site of DNA gyrase B. …”
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CHIT1 and DDAH1 levels relate to amyloid-related imaging abnormalities risk profile in Alzheimer’s disease patients by Marlies Oosthoek, Everard G.B. Vijverberg, Elena R. Blujdea, Sjors G.J.G. In’t Veld, Martín Pucheu Avilés, Sára E. Zsadanyi, Yanaika S. Hok-A-Hin, Allerdien Visser, Wiesje M. van der Flier, Frederik Barkhof, Marta del Campo, Martijn C. Schut, Alexandre Bejanin, Daniel Alcolea, Charlotte E. Teunissen, Lisa Vermunt

“…DDAH1 levels had the highest co-expression with synaptic process, energy utilization and RNA-binding cell signaling related proteins (R > 0.8). …”
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Hemoglobin state-flux: A finite-state model representation of the hemoglobin signal for evaluation of the resting state and the influence of disease. by Randall L Barbour, Harry L Graber, San-Lian S Barbour

“…The developed methodology integrates concepts from stochastic network theory with known modulatory features of the vascular bed, and in doing so provides access to a previously unrecognized dense feature space that is shown to have promising diagnostic potential. …”
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