Legal Analysis of the Concept and Provisions of "Unenforceable" Status in Iranian Commercial Law by Ahad Golizadeh Manghutay

“…However, once a ruling is issued, its effects are generally binding on the parties involved but not on third parties who acted in good faith. …”
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Mesenchymal stem cell-secreted KGF ameliorates acute lung injury via the Gab1/ERK/NF-κB signaling axis by Shuning Xin, Yan Ding, Tong Yu, Yunmei Fu, Yong Cui, Hongguang Nie

“…Results In primary mouse AT2 cells, KGF stimulation effectively restored the reduction of growth factor receptor-bound protein 2-associated binding protein 1 (Gab1) and α/γ-ENaC protein levels induced by LPS. …”
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CX-072 (pacmilimab), a Probody PD-L1 inhibitor, in combination with ipilimumab in patients with advanced solid tumors (PROCLAIM-CX-072): a first-in-human, dose-finding study by Omid Hamid, Fiona Thistlethwaite, Johanna Bendell, Ruth Plummer, Patrick A Ott, Rachel E Sanborn, Karen A Autio, Valentina Boni, Elisabeth GE de Vries, Javier Garcia-Corbacho, Daniel C Cho, Mark Stroh, Lawrence Lu

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Microbiota-derived indole acetic acid extends lifespan through the AhR-Sirt2 pathway in Drosophila by Zheng Cao, Cui Zhang, Lijun Liu, Hehua Lei, Huabao Zhang, Yanmeng He, Xinzhi Li, Qingwei Xiang, Yu-Feng Wang, Limin Zhang, Gang Chen

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New soluble CSF-1R-dimeric mutein with enhanced trapping of both CSF-1 and IL-34 reduces suppressive tumor-associated macrophages in pleural mesothelioma by Sophie Deshayes, Christophe Blanquart, Erwan Mortier, Judith Fresquet, Noémie Joalland, Agnès Quéméner, Romain Humeau, Mike Maillasson, Héloïse LeBihan, Apolline Salama, Séverine Remy, Carole Guillonneau, Ignacio Anegon

“…Thus, there is a need for a more specific and yet integrative approach.Methods A human mutated form of the extracellular portion of CSF-1R was in silico modelized to trap both IL-34 and CSF-1 with higher affinity than the wild-type CSF-1R by replacing the methionine residue at position 149 with a Lysine (M149K). …”
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Securing Healthy Circular Material Flows In The Built Environment by Bob Geldermans

“…This cannot be done without binding agreements and multi‑criteria learning loops. …”
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Wuda Granule Alleviates DSS-Induced Colitis in Mice by Inhibiting Inflammation, Protecting Intestinal Barrier and Reducing Oxidative Stress Through Nrf2/Keap1/HO-1 Pathway by Wang T, Ou Y, Xiong W, Luo L, Xu Y, Chen G, Peng Y, Chen Y, Zeng H, Yu Y, Tang H, Yao H, Wang W

“…Molecular docking further revealed one potential active compound, 6,7-Dimethoxy-2-(2-phenylethyl) chromone, which exhibited strong binding affinity with Nrf2/Keap1 complex.Conclusion: WDG alleviates DSS-induced colitis by inhibiting inflammation, enhancing intestinal barrier integrity, and reducing oxidative stress through activation of the Nrf2/Keap1/HO-1 pathway.Keywords: wuda granule, colitis, anti-inflammatory, antioxidant, intestinal barrier protection…”
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Biocontrol potential of newly isolated Streptomyces noursei D337-11 from disease suppressive soil and its metabolites against Fusarium oxysporum f. sp. cubense in banana plants by Dengbo Zhou, Xinxin He, Yufeng Chen, Chunting Li, Wei Wang, Zhiqiang Pan, Yankun Zhao, Yongzan Wei, Junting Feng, Miaoyi Zhang, Dengfeng Qi, Xiaojuan Li, Kai Li, Tao Jing, Jianghui Xie

“…Mechanistic characterization indicated that naringenin exhibits antifungal activity via dual-target inhibition: molecular docking showed strong binding to the trypsin of Foc TR4 (N1RZA7, −6.6 kcal/mol) and nitroalkane oxidase (N1R9V2, −8.4 kcal/mol), which disrupts cellular integrity as evidenced by ultrastructural anomalies. …”
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Clinico-genomic study reveals association of dengue virus genome high frequency mutations with dengue disease severity by Varsha Ravi, Md Imran, Kriti Khare, Pallavi Mishra, Ramakant Mohite, Kanika, Md Abuzar Khan, Aparna Swaminathan, Aanchal Yadav, Sristi Sinha, Richa Shukla, Partha Chattopadhyay, Jyoti Soni, Ranjeet Maurya, Tavpritesh Sethi, Bansidhar Tarai, Sandeep Budhiraja, Rajesh Pandey

“…Present study focuses on integrated analysis of mutation and clinical data accompanied at the onset of dengue fever. …”
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Effect of Hypoxia on Siglec-7 and Siglec-9 Receptors and Sialoglycan Ligands and Impact of Their Targeting on NK Cell Cytotoxicity by Husam Nawafleh, Nagwa Zeinelabdin, Michelle K. Greene, Anitha Krishnan, Linus Ho, Mohamed Genead, Derek Kunimoto, Christopher J. Scott, Michael Tolentino, Salem Chouaib

“…Conclusions: Our findings point to the role of Siglec–sialylated glycan interactions in hypoxic stress-induced NK cell dysfunction and recommend the potential integration of the manipulation of this axis through the targeting of Siglecs in future cancer immunotherapy strategies.…”
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Stabilized diverse HIV-1 envelope trimers for vaccine design by Qian Wang, Bingting Ma, Qingtai Liang, Angqi Zhu, Hua Wang, Lili Fu, Xiaoxu Han, Xuanling Shi, Ye Xiang, Hong Shang, Linqi Zhang

“…Negative-stain electron microscopy (EM) confirmed the structural integrity of these chimeric UFO trimers with CNE6 gp41ECTO. …”
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Evaluation of the anti-spasmodic activity of essential oils of Ammodaucus leucotrichus fruits and its main chemical component “perillaldehyde” on intestinal smooth muscle contracti... by Ahmed Karim, Mohamed Marghich, Mohamed Marghich, Ouafa Amrani, Abdelhay Addous, Sanae Malek, Leila Beyi, Leila Beyi, Tarik Harit, Dara Aldisi, Mourad A. M. Aboul-Soud, John P. Giesy, John P. Giesy, John P. Giesy, Mohammed Aziz

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Analysis of ABCG2 gene rs2231142 single nucleotide polymorphism and risk factors in hyperuricemia by Meiting Liang, Xingxing Liu, Meng Sun, Jun Zhu, Shanshan Yang, FuRong Jing, Jingyi Shen, Yi He, Wujin Chen, Yuping Sun, Yongsheng Li

“…A predictive model for HUA that integrates the SNP at the ABCG2 gene rs2231142 locus was developed. …”
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Experimental medicine study with stabilised native-like HIV-1 Env immunogens drives long-term antibody responses, but lacks neutralising breadthResearch in context by Katrina M. Pollock, Hannah M. Cheeseman, Leon R. McFarlane, Suzanne Day, Monica Tolazzi, Hannah L. Turner, Jennifer Joypooranachandran, Katsiaryna Shramko, Stefania Dispinseri, Philipp Mundsperger, Ilja Bontjer, Nana-Marie Lemm, Sofia Coelho, Maniola Tanaka, Tom Cole, Bette Korber, Dietmar Katinger, Quentin J. Sattentau, Andrew B. Ward, Gabriella Scarlatti, Rogier W. Sanders, Robin J. Shattock

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Study on the Effect of Phillyrin on <i>Streptococcus suis</i> In Vivo and In Vitro by Fangyan Yuan, Lihan Zheng, Mengzhe Wang, Wei Liu, Xiaoyue Li, Ting Gao, Rui Guo, Zewen Liu, Keli Yang, Chang Li, Qiong Wu, Jiajia Zhu, Yongxiang Tian, Danna Zhou

“…The results showed that phillyrin could disrupt membrane integrity, destroy intracellular structures, and increase the exosmosis of DNA. …”
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Ultrasound-activated carrier-free nanoprodrugs enhanced universality and efficiency of solid tumor-targeting chemotherapy by Xiaodan Xu, Guowei Wang, Yijie Chen, Peile Jin, Jifan Chen, Xia Fang, Dequan Ye, Pintong Huang

“…By screening the OSs library, six small molecules with strong binding ability with PBSN38 and high sonodynamic generation efficiency were identified. …”
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Epstein-Barr virus hijacks histone demethylase machinery to drive epithelial malignancy progression through KDM5B upregulation by Ya-Qing Zhou, Jia-Xin Jiang, Shuai He, Yi-Qi Li, Xi-Xi Cheng, Shu-Qiang Liu, Pan-Pan Wei, Xin-Yuan Guan, Choon Kiat Ong, Vivien Ya-Fan Wang, Chun-Ling Luo, Jin-Xin Bei

“…We demonstrated that EBV stimulates KDM5B expression via interactions of its latent gene EBNA1 with transcription factor CEBPB and through direct binding of its lytic gene BZLF1 to Zta-response elements on the KDM5B promoter. …”
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AI-driven discovery of brain-penetrant Galectin-3 inhibitors for Alzheimer's disease therapy by Xueyan Liu, Jiexin Xu, Shuping Zheng, Yaoyao Yang, Yuchong Xie, Jinyu Liu, Jian Zhong, Huiyao Zhang, Jiajing Chen, Chaoxian Dai, Dingyan Wang, Jiewei Luo, Xiaochun Chen, Feisheng Zhong, Zu-Cheng Ye

“…Following AI-based virtual screening and structure prioritization, FJMU1887 demonstrated direct binding to Gal-3 with an affinity (Kd) of 1.55 μM, determined by microscale thermophoresis (MST). …”
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Genome assembly and characterization of a complex zfBED-NLR gene-containing disease resistance locus in Carolina Gold Select rice with Nanopore sequencing. by Andrew C Read, Matthew J Moscou, Aleksey V Zimin, Geo Pertea, Rachel S Meyer, Michael D Purugganan, Jan E Leach, Lindsay R Triplett, Steven L Salzberg, Adam J Bogdanove

“…In plants, loci containing nucleotide-binding, leucine-rich repeat (NLR) disease resistance genes are an important example of such regions. …”
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Engineering a 3D platform for testis bioengineering: generation and proteomic profiling of decellularized fish testicular scaffolds by Ivana Felipe Rosa, Ivana Felipe Rosa, Ivana Felipe Rosa, Beatriz Marques Souza, Lucas Benites Doretto, Lucas Benites Doretto, Maira da Silva Rodrigues, Caroline Nascimento Barquilha, Matheus Naia Fioretto, Luiz Marcos Frediani Portela, José Carlos Souza Vieira, Luis Antonio Justulin, Pedro de Magalhães Padilha, Changwei Shao, Changwei Shao, Rafael Henrique Nóbrega

“…The efficacy of cellular removal was confirmed by DNA quantification, histological evaluation and DAPI staining, whereas the preservation of ECM integrity was validated through immunofluorescence, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and proteomic profiling. …”
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