Fragmenstein: predicting protein–ligand structures of compounds derived from known crystallographic fragment hits using a strict conserved-binding–based methodology by Matteo P. Ferla, Rubén Sánchez-García, Rachael E. Skyner, Stefan Gahbauer, Jenny C. Taylor, Frank von Delft, Brian D. Marsden, Charlotte M. Deane

“…This approach works under the assumption of conserved binding: when a larger molecule is designed containing the initial fragment hit, the common substructure between the two will adopt the same binding mode. …”
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The crystal structure of the orphan nuclear receptor NR2E3/PNR ligand binding domain reveals a dimeric auto-repressed conformation. by M H Eileen Tan, X Edward Zhou, Fen-Fen Soon, Xiaodan Li, Jun Li, Eu-Leong Yong, Karsten Melcher, H Eric Xu

“…In this conformation, the putative ligand binding pocket is filled with bulky hydrophobic residues and the activation-function-2 (AF2) helix occupies the canonical cofactor binding site. …”
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GhWRKY75 positively regulates GhPR6-5b via binding to a W-box TTGAC (C/T) to orchestrate cotton resistance to Verticillium dahliae by Qichao Chai, Meina Zheng, Yanli Li, Mingwei Gao, Yongcui Wang, Xiuli Wang, Chao Zhang, Hui Jiang, Ying Chen, Jiabao Wang, Junsheng Zhao

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MERS-CoV spike vaccine-induced N-terminal domain-specific antibodies are more protective than receptor binding domain-specific antibodies by Olubukola M. Abiona, Nianshuang Wang, Sarah R. Leist, Alexandra Schäfer, Adam S. Cockrell, Lingshu Wang, Sandhya Bangaru, Laura Stevens, Rachel L. Graham, Jacob F. Kocher, Yaroslav Tsybovsky, Masaru Kanekiyo, Azad Kumar, Kaitlyn M. Morabito, Osnat Rosen, Wei Shi, Anne Werner, Yi Zhang, Cynthia Ziwawo, Christian K.O. Dzuvor, Charis Palandjian, Connor Eastman, Hannah R. Matthews, Jeswin Joseph, James D. Chappell, Wing-Pui Kong, John R. Mascola, Andrew B. Ward, Mark R. Denison, Ralph Baric, Jason S. McLellan, Barney S. Graham, Kizzmekia S. Corbett-Helaire

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RNA‐Binding Protein Hnrnpa1 Triggers Daughter Cardiomyocyte Formation by Promoting Cardiomyocyte Dedifferentiation and Cell Cycle Activity in a Post‐Transcriptional Manner by Chuling Li, Yijin Chen, Qiqi Chen, Haoxiang Huang, Michael Hesse, Yilin Zhou, Ming Jin, Yu Liu, Yifei Ruan, Xiang He, Guoquan Wei, Hao Zheng, Senlin Huang, Guojun Chen, Wangjun Liao, Yulin Liao, Yanmei Chen, Jianping Bin

“…In addition to transcriptional processes, RNA‐binding proteins (RBPs) are emerging as crucial post‐transcriptional players in regulating CM DACCA. …”
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Gender Equality as Integral to Social Justice – and vice versa by Jane Aeberhard-Hodges

“…While social justice arises from binding and non-binding instruments, and workplace social justice stems from the 1919 ILO Constitution and international labour standards, gender equality springs from a plethora of international treaties negotiated by States to end discrimination based on sex. …”
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Plant tissue-based scaffolds filled with oil function as adipose tissue mimetics by Elyse S. Czapalay, Yasamin Soleimanian, Jarvis A. Stobbs, Alejandro G. Marangoni

“…They maintain their integrity after drying, can serve as a scaffold for incorporating fat, and do not lose integrity upon heating, thus resembling native adipose tissue. …”
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Study of iron in hypothyroidism and Grave's hyperthyroidism as compared to euthyroidism in Northern Andhra Pradesh by Vinayak Ganesh Bhat, Rajkumar Patra, D.S.S.K. Raju, G.V. Mohandas, N. Lakshmana Rao

“…Iron is an important component of the thyroid peroxidase enzyme and 5'deiodinase, which are integral parts of thyroid metabolism. Aim and Objectives: The study evaluates the status of serum iron, ferritin, and Total Iron Binding Capacity (TIBC) in hypothyroidism and Grave's hyperthyroidism with euthyroid subjects as control. …”
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Effects of environmental noise on quantum charge diffusion in DNA sequences by Mirko Rossini, Ole Ammerpohl, Reiner Siebert, Joachim Ankerhold

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Integrative Bioinformatics Analysis of Proteins Associated with the Cardiorenal Syndrome by Irmgard Mühlberger, Konrad Moenks, Andreas Bernthaler, Christine Jandrasits, Bernd Mayer, Gert Mayer, Rainer Oberbauer, Paul Perco

“…An integrated analysis of identified features pinpointed a protein interaction network involving mediators of hemodynamic change and an accumulation of features associated with the endothelin and VEGF signaling pathway. …”
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Galectin-3: Integrator of Signaling via Hexosamine Flux by Mana Mohan Mukherjee, Devin Biesbrock, John Allan Hanover

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Adenosine Receptor Heteromers and their Integrative Role in Striatal Function by Sergi Ferré, Francisco Ciruela, César Quiroz, Rafael Luján, Patrizia Popoli, Rodrigo A. Cunha, Luigi F. Agnati, Kjell Fuxe, Amina S. Woods, Carme Lluis, Rafael Franco

“…This is exemplified by changes in binding characteristics that are dependent on coactivation of the receptor units of different adenosine receptor heteromers. …”
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Evidence for temporal disintegration of information processing during sensorimotor integration in GTS by Yifan Hao, Paul Wendiggensen, Annet Bluschke, Tina Rawish, Julia Friedrich, Eszter Tóth-Fáber, Zsanett Tárnok, Veit Roessner, Christian Frings, Anne Weissbach, Tobias Bäumer, Alexander Münchau, Christian Beste

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Analysis of the EIAV Rev-responsive element (RRE) reveals a conserved RNA motif required for high affinity Rev binding in both HIV-1 and EIAV. by Jae-Hyung Lee, Gloria Culver, Susan Carpenter, Drena Dobbs

“…The powerful integration of computational and experimental approaches in this study has generated a validated RNA secondary structure for the EIAV RRE and provided provocative evidence that high affinity Rev binding sites of HIV-1 and EIAV share a conserved RNA structural motif. …”
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Lrp4 modulates extracellular integration of cell signaling pathways in development. by Atsushi Ohazama, Eric B Johnson, Masato S Ota, Hong Y Choi, Thantrira Porntaveetus, Shelly Oommen, Nobuyuki Itoh, Kazuhiro Eto, Amel Gritli-Linde, Joachim Herz, Paul T Sharpe

“…We show that a member of the low-density receptor-related protein family, Lrp4 modulates and integrates Bmp and canonical Wnt signalling during tooth morphogenesis by binding the secreted Bmp antagonist protein Wise. …”
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Photoactive integrated microfluidic valves for on-chip fluid control by Christina Schmidleithner, Johannes R. Peham

“…This is, for instance, the case for point-of-care (POC) devices, especially in low resource settings. The integration of photoactive valves into a disposable microfluidic chip is one method of attaining low-power and non-contact fluid control in the blink of an LED. …”
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Expanding the concept of ID conversion in TogoID by introducing multi-semantic and label features by Shuya Ikeda, Kiyoko F. Aoki-Kinoshita, Hirokazu Chiba, Susumu Goto, Masae Hosoda, Shuichi Kawashima, Jin-Dong Kim, Yuki Moriya, Tazro Ohta, Hiromasa Ono, Terue Takatsuki, Yasunori Yamamoto, Toshiaki Katayama

“…This enhancement enables TogoID to distinguish relationships such as "glycans bind to proteins" or "glycans are processed by proteins" between glycans and proteins. …”
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Human immunodeficiency virus-1 induces host genomic R-loops and preferentially integrates its genome near the R-loop regions by Kiwon Park, Dohoon Lee, Jiseok Jeong, Sungwon Lee, Sun Kim, Kwangseog Ahn

“…We also found that HIV-1 integrase proteins physically bind to the host genomic R-loops. These findings provide novel insights into the mechanisms underlying retroviral integration and the new strategies for antiretroviral therapy against HIV-1 latent infection.…”
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Integration of bioinformatics and identification of the role of m6A genes in NAFLD. by Jianguo Ma, Rongyi Xu, Renlin Li, Yangyang Fu, Jing Xu, Lei Zhou, Yan Qi

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An RTLS-Based Approach to Cyber-Physical Systems Integration in Design and Construction by Abiola A. Akanmu, Chimay J. Anumba, John I. Messner

“…A major bottleneck in achieving this integration is the choice of appropriate mechanisms for binding physical components with their virtual representations. …”
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