Magnetic Microbubbles Combined with ICG-Loaded Liposomes for Synergistic Mild-Photothermal and Ferroptosis-Enhanced Photodynamic Therapy of Melanoma by Xiong K, Luo G, Zeng W, Wen G, Wang C, Ding A, Qi M, Liu Y, Zhang J

“…ICG-Lips enhance targeted delivery through specific binding to the S100B protein on melanoma cells, while MMBs, via ultrasound (US)-induced cavitation effects, shorten the uptake time of ICG-Lips by melanoma cells and improve uptake efficiency. …”
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Efficacy of systemic temozolomide‐activated phage‐targeted gene therapy in human glioblastoma by Justyna Magdalena Przystal, Sajee Waramit, Md Zahidul Islam Pranjol, Wenqing Yan, Grace Chu, Aitthiphon Chongchai, Gargi Samarth, Nagore Gene Olaciregui, Ghazaleh Tabatabai, Angel Montero Carcaboso, Eric Ofori Aboagye, Keittisak Suwan, Amin Hajitou

“…Abstract Glioblastoma multiforme (GBM) is the most lethal primary intracranial malignant neoplasm in adults and most resistant to treatment. Integration of gene therapy and chemotherapy, chemovirotherapy, has the potential to improve treatment. …”
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Revealing electron transport connectivity as an important factor influencing stability of organic solar cells by Haixia Hu, Rui Zhang, Dongcheng Jiang, Xinyu Mu, Jicheng Yi, Han Yu, Lik-Kuen Ma, Bin Li, Lingxin Cao, Mengzhen Sha, Jiangkai Sun, Ruohua Gui, Wei Liu, Shijie Liang, Longlong Li, Shufen Huang, Jianyu Yuan, Chengwang Niu, Cunquan Qu, Jun Yuan, Rongkun Zhou, Chen Zhang, Lin Lu, Xiaoyan Du, Kun Gao, Weiwei Li, Shu Kong So, Yingping Zou, Yanming Sun, Xiaotao Hao, Feng Gao, He Yan, Hang Yin

“…Our findings indicate that PA-integrated devices sustain elevated electron mobilities, even under reduced acceptor ratios (or higher impurity doping) over prolonged device operation. …”
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Impact of nonsynonymous single nucleotide polymorphisms in PROCR gene on protein stability and thrombotic risk: a molecular dynamic approach by Hytham Ahmed Abuagla, Khalid Mohamed Adam, Mohamed E. Elangeeb, Elsadig Mohamed Ahmed, Elshazali W. Ali, Ali M. Edris, Abubakr Ali Elamin MohamedAhmed, Elmoiz Idris Eltieb, Tarig Babikir Algak Khalid, Bahaeldin K. Elamin, Hiba Mahgoub Ali Osman, Ebtehal Salih Idris

“…Protein stability was evaluated using I-Mutant and MUpro, while structural implications were analyzed with Mutation Prediction (MutPred), ConSurf, and Have Our Protein Explained (HOPE). Active binding sites were identified using PyMOL. Finally, 100-nanosecond molecular dynamics (MD) simulations were conducted using GROningen MAchine for Chemical Simulations (GROMACS) to compare structural deviations, flexibility, and solvent interactions between wild-type EPCR and key mutant proteins.ResultsOur integrated analysis identified three high-risk nsSNPs—T174I, N136I, and L168P—that detrimentally affect EPCR function. …”
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Molecular mechanisms and therapeutic targets of acute exacerbations of chronic obstructive pulmonary disease with Pseudomonas aeruginosa infection by Zhiwei Lin, Shuang Liu, Ke Zhang, Tianyu Feng, Yewei Luo, Yu Liu, Baoqing Sun, Luqian Zhou

“…Methods We employed a multi-omics approach, integrating proteomic analyses of bronchoalveolar lavage fluid (BALF) and plasma with transcriptomic analysis of peripheral blood. …”
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Assessment of human leukocyte antigen-based neoantigen presentation to determine pan-cancer response to immunotherapy by Jiefei Han, Yiting Dong, Xiuli Zhu, Alexandre Reuben, Jianjun Zhang, Jiachen Xu, Hua Bai, Jianchun Duan, Rui Wan, Jie Zhao, Jing Bai, Xuefeng Xia, Xin Yi, Chao Cheng, Jie Wang, Zhijie Wang

“…Based on a pooled pan-cancer genomic dataset of 885 patients treated with immune checkpoint inhibitors (ICIs), we developed a score integrating the binding affinity of neoantigens to HLA-I, as well as HLA-I allele divergence, termed the HLA tumor-Antigen Presentation Score (HAPS). …”
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Wildlife law and policy by S. Bertouille

“…Gerner & Schraml (2011) suggested the integration of a more cooperative, less 'regulator' and more informative policy style in hunting regulations. …”
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Ternary Inclusion Co‐Crystals for Efficient Photothermal Conversion and Solar‐Driven Water Evaporation by Ruotong Wang, Yi Su, Zhiyu Xiao, Tongtong Wang, Kun Liu, Zhihao Gong, Jiabin Wu, Junyi Chen, Zhixue Liu, Jingjing Li, Yu‐Hui Zhang, Lu Wang, Bin Li, Xiaotao Zhang, Chunju Li

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GPD2 inhibition impairs coagulation function via ROS/NF-κB/P2Y12 pathway by Jiajie Chen, Guifeng Xu, Zhipeng Xie, Shaoxia Xie, Wenwei Luo, Shilong Zhong, Weihua Lai

“…After developing a targeted cellular model using the CRISPR-dCas9-DNMT3A/Tet1CD-U6-sgRNA system and integrating with transcriptomic sequencing data, we conducted mechanistic cellular experiments to elucidate how these methylation sites affect platelet function recovery and bleeding risk. …”
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Modelos de enseñanza del deporte: Un estudio bibliométrico (Teaching models of sport: A bibliometric study) by Sandy Dorian Isla Alcoser, Ana Flávia Backes, Allana Alencar, Juarez Vieira do Nascimento

“… El deporte fomenta un entorno ideal para potenciar el desarrollo integral de las personas por medio de diferentes modelos de enseñanza, estos no se podrían llevar a cabo sin una adecuada metodología y aplicación en niños, adolescentes o adultos. …”
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Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology by Constance Zhou, Evelyn J. Hardin, Till S. Zimmer, Stephanie Jackvony, Daniel Barnett, Noopur Khobrekar, Elisa Giacomelli, Lorenz Studer, Adam L. Orr, Anna G. Orr

“…Alterations in transactivating response region DNA-binding protein 43 (TDP-43) are prevalent in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neurological disorders. …”
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Genome‐wide siRNA library screening identifies human host factors that influence the replication of the highly pathogenic H5N1 influenza virus by Guangwen Wang, Li Jiang, Jinliang Wang, Qibing Li, Jie Zhang, Fandi Kong, Ya Yan, Yuqin Wang, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Liling Liu, Zhigao Bu, Hualan Chen, Chengjun Li

“…Gene Ontology term enrichment analysis revealed that the candidate gene data sets were enriched in gene categories associated with mRNA splicing via spliceosome in the biological process, integral component of membrane in the cellular component, and protein binding in the molecular function. …”
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Regulatory mechanisms of the Hippo/YAP axis by G-protein coupled estrogen receptor in gastric signet-ring cell carcinoma by Yufei Wang, Yuanlin Sun, Weizhu Zhao, Jiazi Zhang, Xiaofeng Wang, Fangqi Hu, Zhifei Han, Longgang Wang, Luguang Liu, Bing Liu, Liqing Liu, Bo Bi, Dong Sun, Bingtian Liu, Jie Chai

“…Moreover, YAP was shown to bind to the GPER promoter, forming a positive feedback loop that reinforced oncogenic signaling. …”
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VarEPS-MPXV: A risk evaluation system for observed and virtual variations in mpox virus genomes by Qinglan Sun, Chang Shu, Yuanbin Liu, Jian Lu, Guomei Fan, Ziquan Lv, Yulin Fu, Yingfeng Luo, Shenghan Gao, Juncai Ma, Songnian Hu, Linhuan Wu

“…Variations in the OPG190 gene may alter antibody affinity, while the mutation at site 127 in the OPG038 gene may influence immune protein binding stability. The VarEPS-MPXV offers vital support for managing MPXV outbreaks and other viral diseases, contributing to global public health research and practice. …”
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Single‐Cell and Spatial Transcriptomics Reveals a Stereoscopic Response of Rice Leaf Cells to Magnaporthe oryzae Infection by Wei Wang, Xianyu Zhang, Yong Zhang, Zhe Zhang, Chang Yang, Wen Cao, Yuqin Liang, Qinzheng Zhou, Qian Hu, Yimai Zhang, Yu Wang, Yingying Xing, Wenfeng Qian, Nan Yao, Ning Xu, Jun Liu

“…Abstract Infection by the fungal pathogen Magnaporthe oryzae elicits dynamic responses in rice. Utilizing an integrated approach of single‐cell and spatial transcriptomics, a 3D response is uncovered within rice leaf cells to M. oryzae infection. …”
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Cadmium induced ferroptosis and inflammation in sheep via targeting ACSL4/NF-κB axis by Zimeng Ma, Zimeng Ma, Shuo Yan, Shuo Yan, Huimin Zhang, Huimin Zhang, Ruilin Du, Ruilin Du, Xinyue Cheng, Xinyue Cheng, Siqin Bao, Siqin Bao, Xihe Li, Xihe Li, Xihe Li, Yongli Song, Yongli Song

“…Elucidating its pathogenic mechanisms is crucial for developing therapeutic interventions.MethodsThis study employed multi-omics approaches to systematically investigated cadmium-induced ileal dysfunction in Hu sheep and the intervention mechanisms of sodium octanoate.ResultsPhenotypic assessment revealed cadmium exposure caused intestinal barrier impairment and histopathological changes. Integrated transcriptomic-proteomic analysis revealed cadmium disrupted mitochondrial dysfunction via oxidative phosphorylation pathway inhibition. …”
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Genome-Wide Identification of <i>G3BP</i> Family in U’s Triangle <i>Brassica</i> Species and Analysis of Its Expression in <i>B. napus</i> by Alain Tseke Inkabanga, Qiheng Zhang, Shanshan Wang, Yanni Li, Jingyi Chen, Li Huang, Xiang Li, Zihan Deng, Xiao Yang, Mengxin Luo, Lingxia Peng, Keran Ren, Yourong Chai, Yufei Xue

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Regulation of cortical neurogenesis by MED13L via transcriptional priming and its implications for MED13L syndrome by Jia Li, Yu-zhu Hao, Jia Cui, Xiao-xiao Cao, Nan Wu, Ji Ma, Shuang-yi Xie, Yi-Hsuan Pan, Xue-lian He, Yu-lan Zhao, Xiao-Bing Yuan

“…This priming effect is mediated by MED13L binding to the core mediator complex, which facilitates the complex’s association with RNA Pol II and subsequent dissociation from MED13L. …”
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Evaluation of Olive Oil-Based Formulations Loaded with Baricitinib for Topical Treatment of Alopecia Areata by Negar Beirampour, Mireia Mallandrich, Paola Bustos-Salgado, Valeri Domínguez-Villegas, Núria Garrós, Roya Mohammadi-Meyabadi, Beatriz Clares-Naveros, Maria Nuria Romero-Olid, Francisco J. Pérez-Cano, Marina Girbal, Maria José Rodríguez-Lagunas, Joaquim Suñer-Carbó, Ana Cristina Calpena

“…Skin integrity remained intact during the experiments, with no signs of irritation or alterations observed. …”
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Tcf21 modulates fibroblast activation and promotes cardiac fibrosis after injury via Pdgfrb signaling by Yusuke Baba, Yoshiro Maezawa, Naomichi Kondo, Takuya Minamizuka, Haruhide Udagawa, Shintaro Ide, Kana Ide, Naoya Teramoto, Ayano Yamaguchi, Hiyori Kaneko, Shinichiro Funayama, Hisaya Kato, Mayumi Shoji, Kazuto Aono, Makoto Miyabayashi, Tetta Sato, Takumi Kitamoto, Yusuke Yagyu, Ryoichi Ishibashi, Masaya Koshizaka, Yusuke Endo, Masato Kanda, Minoru Takemoto, Naoya Takayama, Kazuki Yasuda, Yoshio Kobayashi, Koutaro Yokote

“…Chromatin immunoprecipitation-sequencing assay demonstrated the direct binding of Tcf21 to COL1A1, COL3A1, IL6, and PDGFRB loci. …”
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