FMO2+ cancer-associated fibroblasts sensitize anti-PD-1 therapy in patients with hepatocellular carcinoma by Hui Li, Wenxin Xu, Qinghai Ye, Qiang Yu, Jialei Weng, Shaoqing Liu, Minghao Xu, Yinghao Shen, Hui-Chuan Sun, Yufei Zhao, Peiyi Xie, Mincheng Yu, Bugang Liang, Junbo Chen

“…Mechanistically, FMO2 promotes nuclear factor kappa B/p65-mediated CCL19 expression by competitively binding to glycogen synthase 1 (GYS1) with praja ring finger ubiquitin ligase 1 (PJA1), thereby suppressing the PJA1-mediated proteasomal degradation of GYS1. …”
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Designing a multi-epitope vaccine candidate against human rhinovirus C utilizing immunoinformatics approach by Tajul Islam Mamun, Tajul Islam Mamun, Md. Ahad Ali, Md. Nazmul Hosen, Jillur Rahman, Md. Anwarul Islam, Md. Golam Akib, Kamruz Zaman, Md. Masudur Rahman, Md. Masudur Rahman, Ferdaus Mohd Altaf Hossain, Ferdaus Mohd Altaf Hossain, Samir Ibenmoussa, Mohammed Bourhia, Turki M. Dawoud

“…The vaccine candidate was constructed by integrating selected antigens with immunogenic epitopes and adjuvants, employing optimal linkers. …”
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Environmentally Friendly Synthesis of New Mono- and Bis-Pyrazole Derivatives; In Vitro Antimicrobial, Antifungal, and Antioxidant Activity; and In Silico Studies: DFT, ADMETox, and... by Oussama Merzouki, Nadia Arrousse, Elhachmia Ech-chihbi, Ashwag S. Alanazi, El Houssine Mabrouk, Mohamed Hefnawy, Abdelfattah El Moussaoui, Hanane Touijer, Azeddin El Barnossi, Mustapha Taleb

“…These findings highlight the potential of the synthetized compounds for therapeutic development and underscore the value of integrating green synthesis with computational techniques in drug discovery.…”
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First-in-human study of D6-[18F]FP-(+)-DTBZ, a novel VMAT2 tracer: whole-body biodistribution and brain PET comparison with [18F]FP-(+)-DTBZ (AV-133) by Ruiyue Zhao, Jinhua Chen, Ting Ye, Jianmin Chu, Jingwen Li, Yan Zhang, Siran Xu, Shaoyu Liu, Ling Chen, Karl Ploessl, David Alexoff, Hank F. Kung, Lin Zhu, Xinlu Wang

“…These transporters are functionally crucial as they reflect the integrity of monoamine neurons. D6-[18F]FP-(+)-DTBZ, a novel deuterated VMAT2 radioligand, has shown promise as a potential PET tracer for the diagnosis of Parkinson’s disease (PD). …”
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Long-term exercise enhances meningeal lymphatic vessel plasticity and drainage in a mouse model of Alzheimer's disease by Yan Chen, Jiachen Cai, Yuzhu She, Xiaoxin He, Hu Feng, Xuewei Li, Yiran Wei, Yi Fan, Wen-e Zhao, Mengmei Yin, Linjuan Yuan, Yuxi Jin, Fengfei Ding, Chengyu Sheng, Junying Gao, Qian Li, Ming Xiao

“…Results The structural integrity of meningeal lymphatic vessels was compromised in 5 × FAD mice, compared with the wild-type mice. …”
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Metabolomics and proteomics reveal blocking argininosuccinate synthetase 1 alleviates colitis in mice by Shijia Liu, Haijian Sun, Zijing Du, Shuai Lu, Chenwen Wang, Ye Zhang, Zichen Luo, Lu Wang, Zhimin Fan, Peng Wei, Yujiao Yan, Junzhi Zhang, Shusheng Yin, Tongtong Liu, Qiongzi He, Xi Guo, Kang Ding, Jingjie Zhou, Haibing Hua, Chengli Yu, Weichen Xu, Jinjun Shan, Yongming Li, Yi Xu, Xiaotao Shen, Gang Cao, Wei Zhou

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Pharmacological effects and mechanisms of Xuanfei Baidu Decoction in the treatment of viral pneumonia by Jingsheng Zhang, Bo Pang, Qiyue Sun, Jing Sun, Shan Cao, Yingli Xu, Yu Zhang, Xinqi Deng, Shanshan Guo, Lei Bao, Zihan Geng, Shuran Li, Ronghua Zhao, Daohan Wang, Xiaolan Cui, Bin Qu, Yu Wang

“…Molecular docking and surface plasmon resonance (SPR) experiments confirmed the strong binding affinity between key XFBD components and PKA. …”
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Modulation of dopaminergic transmission and brain activity by frontotemporal tDCS: A multimodal PET-MR imaging study by Clara Fonteneau, Inés Merida, Jérome Redoute, Frédéric Haesebaert, Sophie Lancelot, Nicolas Costes, Marine Mondino, Jerome Brunelin

“…Results: PET [11C]raclopride analysis revealed a significant reduction in Non-Displaceable Binding Potential in the left executive striatal subregion 15 min after tDCS in the active group, compared to both baseline and the sham group. …”
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Self-assembled epitope-based nanoparticles targeting the SARS-CoV-2 spike protein enhanced the immune response and induced potential broad neutralizing activity by Yue Liu, Yue Liu, Chenxi Li, Zirui Wu, Yu Zhao, Tieyan Yin, Xiaopan Liu, Jiaru Hui, Qingyu Wang, Yi Pan, Yaming Shan, Yaming Shan, Xinglong Qu

“…We aimed to evaluate the potential of epitope-based nanoparticles (NPs) to induce broad cross-protection and durable immune responses against SARS-CoV-2.MethodsFour conserved epitopes derived from the receptor-binding domain (RBD) and S2 subunit of the spike protein were integrated into Helicobacter pylori ferritin to create epitope-based NPs named S18-F, RBM-F, UH-F, and HR2-F. …”
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Genome-Wide Analyses and Expression Profiling of <i>PME</i>/<i>PMEI</i> Gene Families Reveal Their Relevance to Chilling Stress Response and Grafted Healing Efficiency in Cucumber/... by Huangfang Lin, Huilan Ye, Qingqing Shao, Saichuan Cheng, Ge Bi, Biying Lin, Honghui Lin, Lei He, Baoying Shen, Haisheng Zhu, Qingfang Wen, Shuang Liu, Qingqing Chen

“…Pectin methylesterases (PMEs) and their inhibitors (PMEIs) serve as pivotal enzymes in pectin methylation modifications, playing crucial roles in plant morphogenesis, cell adhesion, and maintenance of the cell wall integrity. However, there have been limited studies exploring the functions of the <i>PME</i>/<i>PMEI</i> gene families in the healing process of grafted-cucumber seedlings and their responses to stress conditions. …”
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Exploring advanced genomic and immunoinformatics techniques for identifying drug and vaccine targets against SARS-CoV-2 by Syed Luqman Ali, Awais Ali, Waseef Ullah, Abdulaziz Alamri, Elham Mohammed Khatrawi, Gulzira Sagimova, Aigul Almabayeva, Farida Rakhimzhanova, Gulsum Askarova, Fatima Suleimenova, Nabras Al-Mahrami, Prasanta Kumar Parida

“…Molecular docking and immunological simulation analyses were then employed to develop and characterize a multi-epitope vaccine, integrating findings from the aforementioned evaluations. …”
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dyphAI dynamic pharmacophore modeling with AI: a tool for efficient screening of new acetylcholinesterase inhibitors by Yasser Hayek-Orduz, Dorian Armando Acevedo-Castro, Dorian Armando Acevedo-Castro, Juan Sebastián Saldarriaga Escobar, Brandon Eli Ortiz-Domínguez, María Francisca Villegas-Torres, Paola A. Caicedo, Álvaro Barrera-Ocampo, Natalie Cortes, Edison H. Osorio, Andrés Fernando González Barrios

“…The protocol identified 18 novel molecules from the ZINC database with binding energy values ranging from −62 to −115 kJ/mol, suggesting their strong potential as AChE inhibitors. …”
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Functional Analysis of CPSF30 in <i>Nilaparvata lugens</i> Using RNA Interference Reveals Its Essential Role in Development and Survival by Shengli Jing, Jing Yang, Yali Liu, Feifei Wang, Fang Zheng, Aobo Ren, Bingbing Yu, Yue Zhao, Bing Jia, Ruixian Chen, Bin Yu, Qingsong Liu, Jingang Xu

“…These results suggest that <i>NlCPSF30</i> is integral to critical physiological processes, with its disruption leading to increased mortality. …”
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RBM15 recruits myeloid-derived suppressor cells via the m6A-IGF2BP3/CBR3-AS1/miR-409-3p/CXCL1 axis, facilitating radioresistance in non-small-cell lung cancer by Songliu Hu, Ning Zhan, Jian Li, Liqun Wang, Yiyan Liu, Ke Jin, Yixuan Wang, Juxuan Zhang, Yiyang Chen, Yang Bai, Yichong Wang, Lishuang Qi, Shilong Liu

“…Results The methyltransferase RNA binding motif protein 15 (RBM15) was identified as it was significantly positively correlated with CBR3-AS1 expression and overall survival of NSCLC patients receiving radiotherapy. …”
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m6A methylation profiling as a prognostic marker in nasopharyngeal carcinoma: insights from MeRIP-Seq and RNA-Seq by Xiaochuan Chen, Wenqian Xu, Junping Pan, Hanxuan Yang, Yi Li, Xin Chen, Yingming Sun, Qinying Liu, Sufang Qiu

“…N6-methyladenosine (m6A) modification significantly contributes to tumorigenesis and progression by altering RNA secondary structure and influencing RNA-protein binding at the transcriptome level. However, the mechanism and role of abnormal m6A modification in nasopharyngeal carcinoma remain unclear.MethodsNasopharyngeal Carcinoma tissues from 3 patients and non-cancerous nasopharyngeal tissues from 3 individuals, all from Fujian Cancer Hospital, were sequenced for m6A methylation. …”
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N terminus and C terminus of Arabidopsis P4-ATPase AtALA1 facilitate the detoxification of the mycotoxin deoxynivalenol in wheat by Fanlong Wang, Mingliang Qiu, Lei Hou, Xianbi Li, Hui Ren, Jingxin Zhuo, Haoru Liu, Yujie Li, Yang Yang, Xingying Yan, Mi Zhang, Dan Jin, Ting Lan, Jianyan Zeng, Yanhua Fan, Yang Yuan, Zhengqiang Ma, Yan Pei

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IGF2BP3 As a Prognostic Biomarker and Regulator of Metastasis in Merkel Cell Carcinoma by Yajie Yang, Jiwei Gao, Hao Shi, Harri Sihto, Sami Kilpinen, François Vilcot, Libuse Janská, Jakob Jeschonneck, Todor Cvetanovic, Anders Höög, Jan Siarov, John Paoli, C. Christofer Juhlin, Lisa Villabona, Catharina Larsson, Weng-Onn Lui

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Interference of a phytoconstituent from Nymphaea lotus-derived ligand N-acetyl glucosamine with signaling receptors in diabetes mellitus development: A targeted computational analy... by Sunday Amos Onikanni, Tran Nhat-Phong Dao, Adewale Oluwaseun Fadaka, Halliru Zailani, Oluwafemi Shittu Bakare, Omolola Esther Amos, Ashwil Klein, Valens Munyembaraga, Morenike Grace Ajayi, Adebola Iyabode Akinjokun, Babatunji Emmanuel Oyinloye, Leandro Miranda-Alves

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Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD. by Wei Sun, Katerina Kechris, Sean Jacobson, M Bradley Drummond, Gregory A Hawkins, Jenny Yang, Ting-Huei Chen, Pedro Miguel Quibrera, Wayne Anderson, R Graham Barr, Patricia V Basta, Eugene R Bleecker, Terri Beaty, Richard Casaburi, Peter Castaldi, Michael H Cho, Alejandro Comellas, James D Crapo, Gerard Criner, Dawn Demeo, Stephanie A Christenson, David J Couper, Jeffrey L Curtis, Claire M Doerschuk, Christine M Freeman, Natalia A Gouskova, MeiLan K Han, Nicola A Hanania, Nadia N Hansel, Craig P Hersh, Eric A Hoffman, Robert J Kaner, Richard E Kanner, Eric C Kleerup, Sharon Lutz, Fernando J Martinez, Deborah A Meyers, Stephen P Peters, Elizabeth A Regan, Stephen I Rennard, Mary Beth Scholand, Edwin K Silverman, Prescott G Woodruff, Wanda K O'Neal, Russell P Bowler, SPIROMICS Research Group, COPDGene Investigators

“…The pQTL SNPs explained >10% of measured variation in 13 protein biomarkers, with a single SNP (rs7041; p = 10-392) explaining 71%-75% of the measured variation in vitamin D binding protein (gene = GC). Some of these pQTLs [e.g., pQTLs for VDBP, sRAGE (gene = AGER), surfactant protein D (gene = SFTPD), and TNFRSF10C] have been previously associated with COPD phenotypes. …”
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A multimodal approach for establishing ACTL6A and ERCC1 as chemoresistance genes in locally advanced head and neck cancer by Raushan Kumar Chaudhary, Prakash Patil, Vijith Vittal Shetty, Uday Venkat Mateti, Praveenkumar Shetty, Praveenkumar Shetty

“…Furthermore, FDA-approved drugs like gemcitabine and panobinostat were found to be the best candidates for downregulating ERCC1 and ACTL6A expressions based on binding affinities of −3.707 and −4.198 kcal/mol, respectively.ConclusionThe increased expressions of ACTL6A and ERCC1 during/after cisplatin-based CRT are expected to mediate DNA repair leading to chemoresistance, which could result in poor overall survival in HNC patients. …”
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