A network toxicology and machine learning approach to investigate the mechanism of kidney injury from melamine and cyanuric acid co-exposure by Zhan Wang, Zhaokai Zhou, Zihao Zhao, Junjie Zhang, Shengli Zhang, Luping Li, Yingzhong Fan, Qi Li

“…Molecular docking simulations demonstrated strong binding affinities between MC and the two hub proteins. …”
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EphB2-mediated ephrin-B reverse signaling on microglia drives an anti-viral, but inflammatory and neurotoxic response associated with HIV by Jeffrey Koury, Hina Singh, Samantha N. Sutley-Koury, Dominic Fok, Xinru Qiu, Ricky Maung, Benjamin B. Gelman, Iryna M. Ethell, Marcus Kaul

“…Abstract Background Pathological inflammation with a loss of synaptic integrity and function has been implicated in HIV Associated Neurocognitive Disorders (HAND). …”
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Cryptosporidium parvum infection alters the intestinal mucosa transcriptome in neonatal calves: impacts on epithelial barriers and transcellular transport systems by Arash Veshkini, Christa Kühn, Christa Kühn, Franziska Dengler, Lisa Bachmann, Lisa Bachmann, Wendy Liermann, Christiane Helm, Reiner Ulrich, Cora Delling, Harald M. Hammon

“…ADGRD1 and VCAM1), ATP-binding cassette (ABC, e.g. ABCC2 and ABCD1) and solute carrier (SLC, e.g. …”
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Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [18F]MeTz-PEG2-RM26 for positron emission tomography by Panagiotis Kanellopoulos, Fanny Lundmark, Ayman Abouzayed, Lorenzo Jacopo Ilic Balestri, Esther Olaniran Håkansson, Karim Obeid, Luke R. Odell, Vladimir Tolmachev, Ulrika Rosenström, Jonas Eriksson, Anna Orlova

“…Both in vitro and in vivo studies confirmed the specific binding of [18F]MeTz-PEG2-RM26 to GRPR, with a significant reduction in activity uptake observed upon receptor saturation. …”
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Exploration of the potential neurotransmitter or neuromodulator-like properties of harmine: evidence from synthesis to synaptic modulation by Zhejun Xie, Ning Cao, Manlin Li, Hanxue Wang, Huida Guan, Xuemei Cheng, Changhong Wang

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Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation by Ming‐Yue Wu, Yun‐Jun Ge, Er‐Jin Wang, Qi‐Wen Liao, Zheng‐Yu Ren, Yang Yu, Guoyuan Zhu, Chun‐Ping Liu, Meng‐Ni Zhang, Huanxing Su, Han‐Ming Shen, Ye Chen, Lei Wang, Yi‐Tao Wang, Min Li, Zhaoxiang Bian, Jin Chai, Richard D Ye, Jia‐Hong Lu

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Molecular Assessment of Traditional Mongolian Medicine Tongola-5 in Lactulose Induced Diarrhea: An in vivo Study by Ma C, Buren Q, Eerde M, Qing M, Bao X, Zhao L, Cao L, Zhang X, Bai Q, Chen M, Hong M, Bao Y, Lian H

“…Molecular docking was utilized to assess the binding affinity between key bioactive compounds and their corresponding targets. …”
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A Phase 1 randomized trial of homologous and heterologous filovirus vaccines with a late booster dose by Christina A. Rostad, Inci Yildirim, Carol Kao, Jumi Yi, Satoshi Kamidani, Etza Peters, Kathleen Stephens, Theda Gibson, Hui-Mien Hsiao, Karnail Singh, Paul Spearman, Courtney McCracken, Vivien Agbakoba, Kay M. Tomashek, Johannes B. Goll, Casey E. Gelber, Robert A. Johnson, Sujin Lee, Kristal Maner-Smith, Steven Bosinger, Eric A. Ortlund, Xuemin Chen, Larry J. Anderson, Jens Wrammert, Mehul Suthar, Nadine Rouphael, Evan J. Anderson

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Non-human primate seasonal transcriptome atlas reveals seasonal changes in physiology and diseases by Junfeng Chen, Kousuke Okimura, Liang Ren, Yusuke Nakane, Tomoya Nakayama, Yang Chen, Kai Fukawa, Soutarou Sugiyama, Takayoshi Natsume, Naoko Suda-Hashimoto, Mayumi Morimoto, Takako Miyabe-Nishiwaki, Takao Oishi, Yuma Katada, Manhui Zhang, Kohei Kobayashi, Shoko Matsumoto, Taiki Yamaguchi, Ying-Jey Guh, Issey Takahashi, Taeko Nishiwaki-Ohkawa, Daiki X. Sato, Yoshiharu Murata, Kenta Sumiyama, Atsushi J. Nagano, Hiroo Imai, Takashi Yoshimura

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Comparison of genotypes and phenotypes for von Willebrand factor gene variants using Japanese genome database by Takafumi Akimoto, Hiroshi Inaba, Soichi Ogishima, Kazuki Kumada, Ayano Mitsuhashi, Ryui Miyashita, Tomoko Yamaguchi, Masato Bingo, Yushi Chikasawa, Keiko Shinozawa, Takeshi Hagiwara, Kagehiro Amano, Eiichi N. Kodama, Ei Kinai

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Viral Mimetic Bacterial Outer Membrane Vesicles for Targeting Angiotensin-Converting Enzyme 2 by Ahn G, Yoon HW, Jeong JH, Kim YH, Shin WR, Song MS, Ahn JY

“…To apply refined OMVs for human theranostic applications, we developed naturally exposed receptor-binding domain (RBD) OMVs grafted with antigen 43 as a minimal modular system targeting angiotensin-converting enzyme 2 (ACE2).Methods: We constructed E. coli-derived OMVs using the antigen 43 autotransporter system to display RBD referred to as viral mimetic Ag43β 700_RBD OMVs. …”
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A network toxicology approach to decipher paraben-induced molecular dysregulation in breast cancer pathogenesis by Wen Zhang, Rui Xiang, Wang Gu, Qiang Zhang, Lei Liu, Chenglin Wang, Muhu Chen, Yingchun Hu, Guihong Chen

“…Molecular docking showed that paraben had strong binding activities with ESR1, ESR2, and SERPINE1. …”
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RNA G-quadruplexes control mitochondria-localized mRNA translation and energy metabolism by Leïla Dumas, Sauyeun Shin, Quentin Rigaud, Marie Cargnello, Beatriz Hernández-Suárez, Pauline Herviou, Nathalie Saint-Laurent, Marjorie Leduc, Morgane Le Gall, David Monchaud, Erik Dassi, Anne Cammas, Stefania Millevoi

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In-silico proteomic analysis of the role of IL-4 and IL-10 in IVD degeneration: Protein-protein interaction networks for candidate prioritisation by Paola Bermudez-Lekerika, Francesco Gualdi, Christine L. Le Maitre, Janet Piñero, Baldomero Oliva, Benjamin Gantenbein

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Safety Profile of Intravenous Ferulic Acid Nanoparticles: Acute Toxicity and Neurological Effects in Sprague-Dawley Rats by Huang H, Xuan Y, Ma ZC

“…Comprehensive neurotoxicity assessment was performed in three brain regions (striatum, hippocampus, and cerebellum-brain stem) using multiple staining techniques (LFB, GFAP, IBA-1, and Fluoro-Jade) to evaluate myelin integrity, glial activation, and neuronal degeneration. …”
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Toxoplasma gondii virulence in mice is determined by the pseudokinase ROP5B and countered by an IRG-GBP protein interplay by Shishir Singh, Shishir Singh, Shishir Singh, Mateo Murillo-León, Mateo Murillo-León, Mateo Murillo-León, Mateo Murillo-León, Mateo Murillo-León, Aura María Bastidas Quintero, Aura María Bastidas Quintero, Florence Melbert, Florence Melbert, Klaus Pfeffer, Daniel Degrandi, Tobias Steinfeldt, Tobias Steinfeldt

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Elucidating the mechanism of stigmasterol in acute pancreatitis treatment: insights from network pharmacology and in vitro/in vivo experiments by Xuanlin Zhao, Fan Li, Ao Wen, Xiuxian Yu, Xinrui Xu, Chengyu Wan, Yu Cao, Guang Xin, Wen Huang

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LINC01089 governs the miR-1287-5p/HSPA4 axis to negatively regulate osteogenic differentiation of mesenchymal stem cells by Hao Zou, Fei Hu, Xin Wu, Bin Xu, Guifeng Shang, Dong An, Dehao Qin, Xiaolei Zhang, Aofei Yang

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The impact of polyethylene terephthalate microplastics on the pathogenesis of atherosclerosis: Focusing on network toxicology and target gene detection by Lingling Xie, Yan Zhao, Yuqing Pan, Yuxin Shang, Youjin Kong, Yangyang Gu, Tingting Chen, Wei Mao

“…Molecular docking experiments confirmed a strong binding affinity between PET and these targets (<-5.0 kcal/mol). …”
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Mechanisms and network pharmacological analysis of Yangyin Fuzheng Jiedu prescription in the treatment of hepatocellular carcinoma by Yuqing Xie, Fengna Yan, Xinhui Wang, Lihua Yu, Huiwen Yan, Qing Pu, Weihong Li, Zhiyun Yang

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