Multidimensional bioinformatics analysis reveals the potential carcinogenic role of acrylamide in colorectal cancer by Xiaopeng Yu, Junjie Niu, Jinyang Hu

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Phosphatidylserine-targeting bis(zinc-dipicolylamine) farnesol inhibits ATP production in cancer cells to overcome multidrug resistance by Wei Huang, Xuan Nie, Xiao-Hong Zhou, Lei Qiao, Hong-Jie Gao, Jing Zang, Long-Kang Yu, Long-Hai Wang, Ye-Zi You

“…This study introduces an amphiphilic molecule, bis(zinc-dipicolylamine) farnesol (Bis-ZnDPA), which targets phosphatidylserine (PS) – a negatively charged phospholipid prominently displayed on the outer leaflet of cancer cell plasma membranes. Integrating the hydrophobic segment of Bis-ZnDPA into the plasma membrane disrupts its integrity, potentially leading to hole formation and facilitating the uptake of chemotherapeutic drugs. …”
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Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation. by Momoko Horikoshi, Reedik Mӓgi, Martijn van de Bunt, Ida Surakka, Antti-Pekka Sarin, Anubha Mahajan, Letizia Marullo, Gudmar Thorleifsson, Sara Hӓgg, Jouke-Jan Hottenga, Claes Ladenvall, Janina S Ried, Thomas W Winkler, Sara M Willems, Natalia Pervjakova, Tõnu Esko, Marian Beekman, Christopher P Nelson, Christina Willenborg, Steven Wiltshire, Teresa Ferreira, Juan Fernandez, Kyle J Gaulton, Valgerdur Steinthorsdottir, Anders Hamsten, Patrik K E Magnusson, Gonneke Willemsen, Yuri Milaneschi, Neil R Robertson, Christopher J Groves, Amanda J Bennett, Terho Lehtimӓki, Jorma S Viikari, Johan Rung, Valeriya Lyssenko, Markus Perola, Iris M Heid, Christian Herder, Harald Grallert, Martina Müller-Nurasyid, Michael Roden, Elina Hypponen, Aaron Isaacs, Elisabeth M van Leeuwen, Lennart C Karssen, Evelin Mihailov, Jeanine J Houwing-Duistermaat, Anton J M de Craen, Joris Deelen, Aki S Havulinna, Matthew Blades, Christian Hengstenberg, Jeanette Erdmann, Heribert Schunkert, Jaakko Kaprio, Martin D Tobin, Nilesh J Samani, Lars Lind, Veikko Salomaa, Cecilia M Lindgren, P Eline Slagboom, Andres Metspalu, Cornelia M van Duijn, Johan G Eriksson, Annette Peters, Christian Gieger, Antti Jula, Leif Groop, Olli T Raitakari, Chris Power, Brenda W J H Penninx, Eco de Geus, Johannes H Smit, Dorret I Boomsma, Nancy L Pedersen, Erik Ingelsson, Unnur Thorsteinsdottir, Kari Stefansson, Samuli Ripatti, Inga Prokopenko, Mark I McCarthy, Andrew P Morris, ENGAGE Consortium

“…Fine-mapping analyses revealed that the non-coding variants most likely to drive association signals at established and novel loci were enriched for overlap with enhancer elements, which for FG mapped to promoter and transcription factor binding sites in pancreatic islets, in particular. …”
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Optimization of Lipoplexes Functionalized with a Sialic Acid Mimetic (F9-PEG) to Target the C1858T <i>PTPN22</i> Variant for Preclinical Assessment of a Novel Immunotherapy in Endo... by Simona Sennato, Giorgia Paldino, Cecilia Bombelli, Irene Mezzani, Stefania Petrini, Domenico Vittorio Delfino, Francesco Fiorentino, Carlotta Marianecci, Alessia Ciogli, Dante Rotili, Francesca Ceccacci, Alessandra Fierabracci

“…<b>Methods</b>: The effectiveness of siRNA liposome binding was evaluated by varying the relative lipid/siRNA charge ratio and analyzing the stability of the different formulations with respect to the methods of F9-PEG addition and ATTO740 fluorescent labeling by electrophoresis, dynamic and dielectrophoretic light scattering (DLS and DELS), and high-performance liquid chromatography (HPLC). …”
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Evaluation of the Synergistic Activity of Antimicrobial Peptidomimetics or Colistin Sulphate with Conventional Antifungals Against Yeasts of Medical Importance by Shyam Kumar Mishra, Rajesh Kuppusamy, Christina Nguyen, Jennifer Doeur, Harleen Atwal, Samuel Attard, Kristian Sørensen, Jennifer S. Lin, Edgar H. H. Wong, Alex Hui, Annelise E. Barron, Naresh Kumar, Mark Willcox

“…The effects of these peptidomimetics on cell membrane integrity were demonstrated in an ergosterol binding assay, supported by SYTOX Green and cellular leakage assays, both indicating a lytic effect. …”
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Long non-coding RNA Malat1 fine-tunes bone homeostasis and repair by orchestrating cellular crosstalk and β-catenin-OPG/Jagged1 pathway by Yongli Qin, Jumpei Shirakawa, Cheng Xu, Ruge Chen, Xu Yang, Courtney Ng, Shinichi Nakano, Mahmoud Elguindy, Zhonghao Deng, Kannanganattu V Prasanth, Moritz F Eissmann, Shinichi Nakagawa, William M Ricci, Baohong Zhao

“…Interestingly, Malat1 does not directly affect osteoclastogenesis but inhibits osteoclastogenesis in a non-autonomous manner in vivo via integrating crosstalk between multiple cell types, including osteoblasts, osteoclasts, and chondrocytes. …”
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CRISPR/Cas9-Mediated Knockout of <i>BmGDAP2</i> in the Silkworm, <i>Bombyx mori</i>: Extended Lifespan and Altered Gene Expression Impacting Developmental Pathways by Chaojun Yuan, Zichong Zhou, Qifeng Guo, Ying Yang, Yue Sun, Yong Liu, Wenyi Jia, Shuoqi Fan, Jinxin Wu, Xiaoting Hua, Ping Lin, Ping Zhao, Qingyou Xia

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Polygonatum sibiricum polysaccharides enhance pancreatic β-cell function in diabetic zebrafish by mitigating mitochondrial oxidative damage via the AMPK-SIRT1 pathway by Fan Lin, Wenjing Yu, Wenjing Yu, Ping Li, Ping Li, Shuyao Tang, Yitong Ouyang, Liya Huang, Di Wu, Shaowu Cheng, Shaowu Cheng, Zhenyan Song, Zhenyan Song

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Piezo1/ITGB1 Synergizes With Ca2+/YAP Signaling to Propel Bladder Carcinoma Progression via a Stiffness‐Dependent Positive Feedback Loop by Minghai Ma, Jianpeng Li, Xing Li, Minxuan Jing, Lu Wang, Yunzhong Jiang, Zezhong Yang, Jiale He, Min Wang, Hang Liu, Yutong Chen, Kaibo Mi, Lei Wang, Jinhai Fan, Hongxia Du

“…The coordinated expression of Piezo1/ITGB1 enhanced ECM interaction, organization, adhesion, and collagen binding. Crucially, Piezo1/ITGB1 overexpression promoted cancer development by suppressing apoptosis and enhancing proliferation. …”
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Exploring the protective mechanisms of the yunpi jiedu tongluo qushi decoction on methotrexate-induced reproductive damage in male rats based on Nrf2/HO-1 signaling pathway by Wu Chen, Wu Chen, Min Chen, Min Chen, Dian-Ming Li, Dian-Ming Li, Wei-Man Shi, Min Zhang, Min Zhang, Zhi-Yu Li, Lin Huang, Lin Huang, Cheng-Ping Wen, Cheng-Ping Wen, Qiao Wang, Qiao Wang

“…Molecular docking results further confirmed the strong binding activity between the core components of YJT and Nrf2, HO-1.ConclusionCollectively, our findings indicate that YJT protects against MTX-induced apoptosis in spermatogenic cells by inhibiting OS and Nrf2/HO-1 signaling pathway. …”
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Synthesis, Antimicrobial Activities, and Model of Action of Indolyl Derivatives Containing Amino-Guanidinium Moieties by Yu-Xi Li, Xiang Geng, Qi Tao, Ruo-Chen Hao, Ya-Jun Yang, Xi-Wang Liu, Jian-Yong Li

“…Compound <b>4P</b> induced the depolarization of the bacterial membrane and disrupted bacterial membrane integrity and was not prone to antibiotic resistance. …”
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Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells by Mélanie Uguen, Devan J. Shell, Madhushika Silva, Yu Deng, Fengling Li, Magdalena M. Szewczyk, Ka Yang, Yani Zhao, Michael A. Stashko, Jacqueline L. Norris-Drouin, Jarod M. Waybright, Serap Beldar, Justin M. Rectenwald, Angie L. Mordant, Thomas S. Webb, Laura E. Herring, Cheryl H. Arrowsmith, Suzanne Ackloo, Steven P. Gygi, Robert K. McGinty, Dalia Barsyte-Lovejoy, Pengda Liu, Levon Halabelian, Lindsey I. James, Kenneth H. Pearce, Stephen V. Frye

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Denatonium inhibits RANKL-induced osteoclast differentiation and rescues the osteoporotic phenotype by blocking p65 signaling pathway by Sheunghun Lee, Hyerim Lee, You-Jee Jang, Kyubin Lee, Hye-Jung Kim, Jung Yeol Lee, Jin-Man Kim, Sunyou Park, Jin Sook Song, Ji Hoon Lee, Tae Kyung Hyun, Jae-Il Park, Sun-Ju Yi, Kyunghwan Kim

“…Abstract Background Bone remodeling is a critical process that maintains skeletal integrity, orchestrated by the balanced activities of osteoclasts, which resorb bone, and osteoblasts, which form bone. …”
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Transposable Elements Contribute to the Regulation of Long Noncoding RNAs in <i>Drosophila melanogaster</i> by Yuli Gan, Lingyan Wang, Guoxian Liu, Xiruo Guo, Yiming Zhou, Kexin Chang, Zhonghui Zhang, Fang Yan, Qi Liu, Bing Chen

“…Notably, a total of 516 TE-lncRNAs provided transcriptional factor binding sites through transposon insertions. The regulatory network of a key transcription factor was rewired by transposons, potentially recruiting other transcription factors to exert regulatory functions under heavy metal stress. …”
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Study protocol for a phase II, double-blind, randomised controlled trial of cannabidiol (CBD) compared with placebo for reduction of brain neuroinflammation in adults with chronic... by Yi Zhang, Robert Edwards, A Eden Evins, Jodi M Gilman, Chelsea K Pike, Minhae Kim, Kristina Schnitzer, Nathaniel Mercaldo, Vitaly Napadow, Erin Janas Morrissey, Zeynab Alshelh, Marco L Loggia

“…Recently, we used positron emission tomography (PET) to demonstrate increased levels of 18 kDa translocator protein (TSPO) binding, a marker of glial activation, in patients with chronic low back pain (cLBP). …”
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Harnessing AlphaFold to reveal hERG channel conformational state secrets by Khoa Ngo, Pei-Chi Yang, Vladimir Yarov-Yarovoy, Colleen E Clancy, Igor Vorobyov

“…This innovative methodology sets a new benchmark for integrating deep learning-based protein structure prediction with experimental validation. …”
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NAMPT and NNMT released via extracellular vesicles and as soluble mediators are distinguished traits of BRAF inhibitor resistance of melanoma cells impacting on the tumor microenvi... by Beatrice Ghezzi, Irene Fiorilla, Ágata Carreira, Francesco Recco, Leonardo Sorci, Lidia Avalle, Alessia Ponzano, Francesca Mazzola, Alberto Maria Todesco, Nicoletta Tommasi, Massimiliano Gasparrini, Vito Giuseppe D’Agostino, Flavio Mignone, Alessandro Provenzani, Valentina Audrito

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Unveiling the Temporal Dynamics and Molecular Regulation Profiles of Neutrophil Extracellular Traps Following Spinal Cord Injury by Li J, Chang C, Li Y, Cui S, Bai J, Zhang C, Wang X, Li K, Jian F

“…This study aimed to explore the temporal dynamics and key regulatory genes of NET formation in SCI to identify therapeutic targets.Methods: We integrated two transcriptomic datasets from the GEO database to identify differentially expressed NETs-related genes (NRGs) in SCI. …”
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Mucin 18‐targeted humanized monoclonal antibody immune positron emission tomography imaging and patient‐derived tumor xenograft visualization by Qian Zhang, Haizhen Du, Xiuli Ma, Song Liu, Xiangxing Kong, Muye Hu, Jing Shi, Yanfang Tang, ShuHui Liu, Xun Meng, Qian Guo, Yan Kong, Jun Guo, Bin Lian, Zhi Yang, Hua Zhu

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Speciation and biogeochemical behavior of perfluoroalkyl acids in soils and their environmental implications: A review by Chao Guo, Shiwen Hu, Pengfei Cheng, Kuan Cheng, Yang Yang, Guojun Chen, Qi Wang, Ying Wang, Tongxu Liu

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