LIN28B promotes the progression of endometrial cancer through upregulating MYC and correlates with immune microenvironment by Yuchao Diao, Xiangkun Li, Chang Wang, Jinwen Jiao, Dongmei Gao, Weifang Mao, Xinping Yu, Hongjuan Yang

“…BackgroundEndometrial cancer (EC), a leading gynecologic malignancy, demonstrates a rising global incidence that imposes significant clinical and socioeconomic burdens. While the RNA-binding protein LIN28B has been reported to promote the progression of EC, its mechanistic role in driving tumor progression and immune modulation remains poorly characterized. …”
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Conservation agricultural practices promoted arbuscular mycorrhizal fungal colonization and glomalin content on sandy clay loam of southern India by Knight Nthebere, Tata Ram Prakash, Padmaja Bhimireddy, Latha P. Chandran, Jayasree Gudapati, Meena Admala, Kavuru Prasad

“…Arbuscular mycorrhizal Fungi (AMF) are essential in agriculture and are often inter-linked with glomalin-related soil protein (GRSP) production which supports binding of aggregates, enhanced SOC and biological attributes. …”
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Natural Bioactive Compounds Promote Cell Apoptosis in Gastric Cancer Treatment: Evidence from Network Pharmacological Study and Experimental Analysis by Yan Wang, Haiyang Wang, Shun Xu

“…The Traditional Chinese Medicine Systems Pharmacology (TCMSP) database and the Traditional Chinese Medicine Integrated Database (TCMID) were widely implemented in selecting the active chemical components of SLCs with an oral bioavailability (OB) ≥ 30% and drug-likeness (DL) ≥ 18%. …”
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Comprehensive Analysis of the Role of Heat Shock Proteins in the Immune Microenvironment and Clinical Significance of Hepatocellular Carcinoma by Xiao H, Wang B, Xiong S, Li C, Ding Y, Chao D, Mei B, Shen N, Luo G

“…Heat shock proteins (HSPs) are a protein class with significant involvement in safeguarding and restoring cellular integrity. They help restore proper protein structure by binding to and refolding denatured proteins. …”
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Evolution of SARS-CoV-2 spike trimers towards optimized heparan sulfate cross-linking and inter-chain mobility by Jurij Froese, Marco Mandalari, Monica Civera, Stefano Elli, Isabel Pagani, Elisa Vicenzi, Itzel Garcia-Monge, Daniele Di Iorio, Saskia Frank, Antonella Bisio, Dominik Lenhart, Rudolf Gruber, Edwin A. Yates, Ralf P. Richter, Marco Guerrini, Seraphine V. Wegner, Kay Grobe

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The Effects of Prebiotic Dietary Fibers, Probiotics, and Synbiotics on Gut Permeability and Immunity: A Systematic Review by Leila Maghsoumi-Norouzabad, Alireza Bagherzadeh-Karimi, Shabnam Aliakbari Majd, Leila Hosseini, Fatemeh Shahi

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Evaluation of dietary vitamin B6 requirement of juvenile largemouth bass (Micropterus salmoides) on the basis of growth performance, transaminase activity, and nutrient metabolism by Leimin Zhang, Dongyu Huang, Jiaze Gu, Hualiang Liang, Mingchun Ren

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Enhanced electrochemical behavior of Ni-doped MoO3 and reduced graphene oxide composite for lithium-ion batteries by Muhammad Talha, Rizwan Akram, Hassan Akhtar, Shumaila Karamat, Shabeya Kanwal, Irfan Sabir

“…Scanning electron microscopy (SEM) shows MoO3 nanosheet integrated with rGO matrix. X-ray Photoelectron Spectroscopy (XPS) confirms the proper substitution of cationic (Ni+2) ions into the MoO3 lattice with reasonable chemical shift in binding energy due to the change of electronic states. …”
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Glycine Supplementation Enhances the Growth of Sow-Reared Piglets with Intrauterine Growth Restriction by Shengdi Hu, David W. Long, Fuller W. Bazer, Robert C. Burghardt, Gregory A. Johnson, Guoyao Wu

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Urinary biomarkers in prediction of subclinical acute kidney injury in pediatric oncology patients treated with nephrotoxic agents by Gordana Miloševski-Lomić, Jelena Kotur-Stevuljević, Dušan Paripović, Srdjan Nikolovski, Jelena Lazić, Predrag Rodić, Goran Milošević, Jadranka Mitrović, Biljana Vukmir, Ana Petrović, Amira Peco-Antić

“…We aimed to assess whether levels of urinary kidney injury molecule-1 (uKIM-1), neutrophil gelatinase-associated lipocalin (uNGAL), liver fatty acid binding protein (uL-FABP) and Vanin-1 (uVNN-1), individually and in combination-integrated could be early markers for cytotoxic treatment induced AKI. …”
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Modulating product selectivity in lignin electroreduction with a robust metallic glass catalyst by Ziqi Zhai, Yumiao Lu, Lufei Ouyang, Junfeng Lu, Wei-Lu Ding, Bobo Cao, Yanlei Wang, Feng Huo, Qiu Zhao, Weihua Wang, Suojiang Zhang, Hongyan He

“…This work opens versatile pathways for lignin upgrading through integrated tandem reactions and expands the scope of catalyst design with amorphous structures.…”
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Unveiling genetic signatures of immune response in immune-related diseases through single-cell eQTL analysis across diverse conditions by Zhenhua Zhang, Wenchao Li, Qiuyao Zhan, Michelle Aillaud, Javier Botey-Bataller, Martijn Zoodsma, Rob ter Horst, Leo A. B. Joosten, Christoph Bock, Leon N. Schulte, Cheng-Jian Xu, Mihai G. Netea, Marc Jan Bonder, Yang Li

“…Our study provides a paradigm to decipher genetic underpinnings of complex traits by integrating single-cell eQTLs with multi-omics data from patients and public databases.…”
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Targeting the FOXA1/BMI1 axis to overcome chemoresistance and suppress tumor progression in nasopharyngeal carcinoma by Yaping Qin, Mingqing Yang, Yunzhu Cao, Yue Fu, Fan Yang, Xiaoling Zhang, Shengjun Xiao

“…The current study explores the intricate relationship between Forkhead Box A1 (FOXA1) and B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1) in the cancer progression and chemoresistance of NPC. …”
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Targeting the splicing factor SNRPB inhibits endometrial cancer progression by retaining the POLD1 intron by Yingwei Li, Zhongshao Chen, Huimin Xiao, Yanling Liu, Chen Zhao, Ning Yang, Cunzhong Yuan, Shi Yan, Peng Li

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New design of an intelligent electromagnetic torque controller based on neural network and fractional calculus: Variable-speed wind energy systems application by Yattou El Fadili, Ismail Boumhidi

“…This proposed controller binds the sliding mode (SM) with the fractional calculus (FC) and the neural network (NN) to exploit the benefits of each technique. …”
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TFE3 fusion oncoprotein condensates drive transcriptional reprogramming and cancer progression in translocation renal cell carcinoma by Choon Leng So, Ye Jin Lee, Bujamin H. Vokshi, Wanlu Chen, Binglin Huang, Emily De Sousa, Yangzhenyu Gao, Marie Elena Portuallo, Sumaiya Begum, Kasturee Jagirdar, W. Marston Linehan, Vito W. Rebecca, Hongkai Ji, Eneda Toska, Danfeng Cai

“…The coiled-coil domains (CCDs) of NONO and SFPQ are essential for condensate formation, prolonging TFE3 FOs’ chromatin binding time and enhancing transcription. Compared with wild-type TFE3, TFE3 FOs bind to new chromatin regions, alter chromatin accessibility, and form new enhancers and super-enhancers at pro-growth gene loci. …”
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Network pharmacology-based approach to research the effects and mechanisms of Salvia Miltiorrhiza injection against idiopathic pulmonary fibrosis by Liangyu Chen, Liangyu Chen, Haobo Lin, Haobo Lin, Haobo Lin, Linmang Qin, Linmang Qin, Linmang Qin, Guangfeng Zhang, Guangfeng Zhang, Guangfeng Zhang, Peisheng Chen, Zebo Jiang, Pan Xu, Donghui Huang, Xiao Zhang, Xiao Zhang

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ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages by Timothy A Bates, Mila Trank-Greene, Xammy Huu Wrynla, Aidan Anastas, Sintayehu K Gurmessa, Ilaria R Merutka, Shandee D Dixon, Anthony Shumate, Abigail R Groncki, Matthew AH Parson, Jessica R Ingram, Eric Barklis, John E Burke, Ujwal Shinde, Hidde L Ploegh, Fikadu G Tafesse

“…Mycobacterium tuberculosis (Mtb) is known to survive within macrophages by compromising the integrity of the phagosomal compartment in which it resides. …”
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Identification and validation of synergistic drug strategies targeting macrophage polarization in triple-negative breast cancer via single-cell transcriptomics and deep learning by Qi Qi, Wenhao Yang, Liang Li, Yuheng Tang, Yongzhi Chen, Hui Wang, Sun Yingjie, Jialin Shi, Samina Gul, Wenru Tang, Jianyu Pang, Xiaoli Xie

“…Computational pharmacology identified finasteride as a ZBTB20 modulator (binding energy:7.7 kcal/mol) capable of reversing tumor-induced M2 macrophage polarization. …”
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Effective Mixed-Type Tissue Crusher and Simultaneous Isolation of RNA, DNA, and Protein from Solid Tissues Using a TRIzol-Based Method by Kelly Karoline dos Santos, Isabelle Watanabe Daniel, Letícia Carani Delabio, Manoella Abrão da Costa, Júlia de Paula Dutra, Bruna Estelita Ruginsk, Jeanine Marie Nardin, Louryana Padilha Campos, Fabiane Gomes de Moraes Rego, Geraldo Picheth, Glaucio Valdameri, Vivian Rotuno Moure

“…The isolated macromolecule validation included the detection of mRNA levels of ATP-binding cassette (ABC) transporters through RT-qPCR, genotyping of <i>TNFR1</i> (rs767455), and protein visualization through SDS-PAGE following Coomassie blue staining and Western blot. …”
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