The structure of an amyloid precursor protein/talin complex indicates a mechanical basis of Alzheimer’s disease by Charles Ellis, Natasha L. Ward, Matthew Rice, Neil J. Ball, Pauline Walle, Chloé Najdek, Devrim Kilinc, Jean-Charles Lambert, Julien Chapuis, Benjamin T. Goult

“…Talins are synaptic scaffold proteins that connect the cytoskeletal machinery to the plasma membrane via binding NPxY motifs in the cytoplasmic tail of integrins. …”
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Exploring the Biological Activity of a Humanized Anti-CD99 ScFv and Antibody for Targeting T Cell Malignancies by Nuchjira Takheaw, Thanathat Pamonsupornwichit, Ratthakorn Chaiwut, Kamonporn Kotemul, Kanokporn Sornsuwan, On-anong Juntit, Umpa Yasamut, Passaworn Cheyasawan, Witida Laopajon, Watchara Kasinrerk, Chatchai Tayapiwatana

“…Previous studies have revealed that a mouse monoclonal antibody, mAb MT99/3, selectively binds to CD99, triggering apoptosis in T-ALL/T-LBL cells while preserving the integrity of healthy cells. …”
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Transition metal single-atom catalysts for water splitting: Unravelling coordination strategies and catalytic mechanisms for sustainable hydrogen generation by Yanda Zhu, Jiaqi Su, Jiwen Liao, Hao Peng, Ziyi Wang, Yutong Wang, Wenyu Wang, Ming Luo, Sean Li, Wenxian Li

“…Single-atom catalysts (SACs) lead the field of electrocatalysis water splitting, providing critical benefits like high atomic efficiency, adjustable electronic properties, and metal-support solid binding. These characteristics collectively enhance catalytic performance and minimise metal consumption. …”
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TMEM97 governs partial epithelial-mesenchymal transition of retinal pigment epithelial cells via the CTNND2-ADAM10 axis by Jing Li, Yosuke Nagasaka, Hongtao Shen, Xinyu Zhou, Jianjie Ma, Dilza Trevisan-Silva, Nicholas E. Sherman, Jayakrishna Ambati, Bradley D. Gelfand, Lian-Wang Guo

“…Interestingly, TMEM97 knockout in ARPE19 cells in vitro led to upregulation of cadherin/adhesion-binding pathways, even without oxidant exposure. Integrated proteomic, transcriptomic, segmentation, and immunoblot analyses revealed that TMEM97 ablation induces pEMT, marked by the concurrent expression of epithelial E-cadherin and mesenchymal N-cadherin, a process reversed upon TMEM97 re-expression. …”
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Network pharmacology mechanisms and experimental verification of Hedyotis Diffusae Herba-Scutellariae Barbatae Herba drug pair extract in the treatment of nasopharyngeal carcinoma by Tiantian Li, Haijun Chen, Jing Zhang, Jiaxin Liu, Rundong Tang, Liang Zhang, Tian Feng, Yanchun Xiao, Shiwen Liu, Xiangjun Chen

“…Molecular docking confirmed strong binding between core components and key targets (AKT1, TP53, BCL2). …”
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Implications of the <i>STAT5B</i> and <i>C1QBP</i> Genes of Grain Aphid <i>Sitobion avenae</i> in the Transmission of Barley Yellow Dwarf Virus by Chiping Liu, Manwen Zhang, Chen Luo, Zuqing Hu

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Enhancing mechanical performance and microstructure of reactive powder concrete through optimization of high-temperature curing regimes by Muhammad Abid, Shayan Zeb, Muhammad Kamal Shah, Sheraz Muhammad, Maaz Osman Bashir, Hamad Almujibah, Ali E.A. Elshekh, Kennedy C. Onyelowe

“…In a novel way, we investigate RPC formulations with different ratios of steel fiber, water/binding (w/b) ratios, and slag amount under four different curing conditions: standard room curing, steam curing, hot-temperature curing for 12 h after 3 days of steam curing, and 24 h after 3 days of steam curing. …”
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Expanding automated multiconformer ligand modeling to macrocycles and fragments by Jessica Flowers, Nathaniel Echols, Galen J Correy, Priyadarshini Jaishankar, Takaya Togo, Adam R Renslo, Henry van den Bedem, James S Fraser, Stephanie A Wankowicz

“…Small molecule ligands exhibit a diverse range of conformations in solution. Upon binding to a target protein, this conformational diversity is reduced. …”
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Assessment of the histone mark-based epigenomic landscape in human myometrium at term pregnancy by San Pin Steve Wu, Elvis Quiroz, Tianyuan Wang, Skylar G Montague Redecke, Xin Xu, Lin Lin, Matthew L Anderson, Francesco J DeMayo

“…The myometrium plays a critical role during pregnancy as it is responsible for both the structural integrity of the uterus and force generation at term. …”
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Understanding mechanisms of thrombosis and thrombocytopenia with adenoviral SARS-CoV-2 vaccines: a comprehensive synopsis by Phillip LR Nicolson, Simon T Abrams, Gayatri Amirthalingam, Kevin Brown, Richard J Buka, Mark J Caulfield, Joshua Gardner, David Goldblatt, Charlotte Lovatt, Samantha J Montague, Dean J Naisbitt, Alan Parker, Sue Pavord, Mary E Ramsay, Jonathan AC Sterne, Cathie LM Sudlow, Cheng Hock Toh, Steve P Watson, Guozheng Wang, Angela M Wood, William Whiteley, Munir Pirmohamed

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Dissecting the High Esterase/Lipase Activity and Probiotic Traits in <i>Lactiplantibacillus plantarum</i> B22: A Genome-Guided Functional Characterization by Yunmei Chai, Zhenzhu Li, Wentao Zheng, Xue Yang, Jinze He, Shaomei Hu, Jindou Shi, Yufang Li, Guangqiang Wei, Aixiang Huang

“…Molecular docking studies confirmed strong binding affinity to tributyrin (ΔG ≤ –5.52 kcal/mol) and elucidated the interaction mechanisms, involving hydrogen bonding and hydrophobic interactions between the esterase/lipase enzymes and tributyrin. …”
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Ziziphus spina-christi alleviates paracetamol-induced hepatorenal toxicity in rats through in vivo and computational approaches by Ehsan Kh. M. Khedre, Amany M. M. Hegab, Amira A. El-Mahis, Amina A. S. Abdel Rahman, Sherien H. B. Elwakeel, Ali S. Abdelhameed, Vittorio Calabrese, Ursula M. Jacob, Eman S. G. Hassan

“…This study aimed to evaluate the protective effects of Ziziphus spina-christi (ZSC), a traditional medicinal plant with documented antioxidant and protective properties against PCM-induced hepatorenal toxicity in rats, integrating both in vivo and computational approaches. …”
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Calpain 2 promotes Lenvatinib resistance and cancer stem cell traits via both proteolysis-dependent and independent approach in hepatocellular carcinoma by Xiaolu Ma, Kaixia Zhou, Tianqing Yan, Ling Hu, Suhong Xie, Hui Zheng, Ying Tong, Heng Zhang, Yanchun Wang, Zhiyun Gong, Cuncun Chen, Yanan Tian, Lin Guo, Renquan Lu

“…Herein, we employed integrated bioinformatic analysis to identify calpain-2 (CAPN2) as a novel key regulator for Lenvatinib resistance in HCC, and its expression greatly increased in both Lenvatinib-resistant HCC cell lines and clinical samples. …”
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Explore the potential mechanism of Huachansu injection against osteosarcoma via metabolomics, network pharmacology and bioinformatics by Jingjing Meng, Xiangqi Zhang, Danfeng Xiang, Hanlu Liang, Shuai Zhao, Lingyan Xu, Jiao Yang, JunJun Chen, Jingxian Zhang, Yonglong Han

“…This study aimed to reveal the underlying mechanisms of HCSI against osteosarcoma by integrating metabolomics, network pharmacology and bioinformatics. …”
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Genome-wide identification and comprehensive characterization of the ADF gene family in Triticum monococcum L. subsp. aegilopoides with insights into structure, evolution and cold... by Xin Liu, Xin Liu, Minghu Zhang, Jian Su, Lei Wu, Mang Shen, Qi Wang, Yamei Zhuang, Lianquan Zhang, Haosheng Li, Gang Chen

“…Furthermore, co-expression and gene ontology enrichment analyses of the upregulated genes identified key biological pathways involved in membrane integrity, phosphorylation, ribosome maturation, and lipid signaling. …”
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Dynamic distribution and temporal transcriptome adaptations elucidate lithium accumulation pattern in Cardamine violifolia by Lulu Chen, Mingwei Yue, Xiaomeng Liu, Xin Cong, Shuiyuan Cheng, Shen Rao

“…This study systematically revealed the unique distribution patterns of Li in C. violifolia. By integrating physiological, biochemical, and transcriptomic analyses, we identified multiple gene families associated with Li transport in plants. …”
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Gross Antioxidant Capacity and Anti-Inflammatory Potential of Flavonol Oxidation Products: A Combined Experimental and Theoretical Study by Karen Acosta-Quiroga, Esteban Rocha-Valderrama, Matías Zúñiga-Bustos, Raúl Mera-Adasme, Gustavo Cabrera-Barjas, Claudio Olea-Azar, Mauricio Moncada-Basualto

“…This led to the proposal of the Gross Antioxidant Capacity (GAC) concept to integrate the contribution of all generated species. …”
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LAMA4+ CD90+ eCAFs provide immunosuppressive microenvironment for liver cancer through induction of CD8+ T cell senescence by Jianlei Zhang, Zhihui Li, Qiong Zhang, Wen Ma, Weina Fan, Jing Dong, Jingjie Tian, Hongfan Liao, Junzhe Guo, Yabing Cao, Jiang Yin, Guopei Zheng, Nan Li

“…LAMA4 induced DNA damage signaling and senescence in CD8+ T cells via binding ITGA6.…”
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Comparative Transcriptomic Analysis Between High- and Low-Growth-Rate Meat-Type Rabbits Reveals Key Pathways Associated with Muscle Development by Chao Yang, Lingxi Zhu, Li Tang, Xiangyu Zhang, Min Lei, Xiaohong Xie, Cuixia Zhang, Dingsheng Yuan, Congyan Li, Ming Zhang

“…GO (Gene Ontology) analysis of DEGs indicated DEGs in the thigh muscle were enriched in these terms related to biological processes of muscle cell migration and smooth muscle cell migration, cellular components of sarcomere, myofibril, and actin filament bundle, while DEGs in <i>longissimus dorsi</i> muscle were enriched in these terms associated with biological processes of muscle cell migration, smooth muscle cell migration and muscle structure development, cellular component of actin cytoskeleton, contractile fiber, myofibril, myosin complex and molecular function of actin filament binding. Integrated GO, KEGG and PPI analyses of co-expressive DEGs implicated the HIF-1 signaling pathway and Glycolysis/Gluconeogenesis in muscular development. …”
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Virtual Screening Approaches to Identify Promising Multitarget-Directed Ligands for the Treatment of Autism Spectrum Disorder by Jakub Jończyk, Klaudia Przybylska, Marek Staszewski, Justyna Godyń, Tobias Werner, Monika Stefaniak-Napieralska, Holger Stark, Krzysztof Walczyński, Marek Bajda

“…Among the selected ligands, compounds <b>25</b> and <b>30</b> blocked radioligand binding to the D₂ receptor at over 50% at a screening concentration of 1 µM. …”
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