Structural serology of polyclonal antibody responses to mRNA-1273 and NVX-CoV2373 COVID-19 vaccines by Sandhya Bangaru, Abigail M. Jackson, Jeffrey Copps, Monica L. Fernández-Quintero, Jonathan L. Torres, Sara T. Richey, Bartek Nogal, Leigh M. Sewall, Alba Torrents de la Peña, Asma Rehman, Mimi Guebre-Xabier, Bethany Girard, Rituparna Das, Kizzmekia S. Corbett-Helaire, Robert A. Seder, Barney S. Graham, Darin K. Edwards, Nita Patel, Gale Smith, Andrew B. Ward

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Combined Use of Intranasal Methylprednisolone and Allopregnanolone: Revisiting Anti-inflammatory and Remyelinating Treatment in a Murine Model of Multiple Sclerosis by Iván Nicolás Pérez-Osorio, José Alejandro Espinosa-Cerón, Camila Álvarez-Gutiérrez, Rodrigo Gonzalez-Flores, Hugo Besedovsky, Gladis Fragoso, Mónica A. Torres-Ramos, Edda Sciutto

“…Conclusions: ALLO treatment mainly maintain the integrity of the spinal cord tissue and the presence of myelin without affecting NI and the clinical outcome. …”
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A miR156-SPL module controls shade-induced inhibition of vascular cambium activity through cytokinin pathway in poplar by Hongbin Wei, Xingyue Xiao, Jiao Deng, Yi Li, Mengting Luo, Chengshan Zhang, Jieqiong Li, Jiayi Xu, Keming Luo

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Restriction of Ku translocation protects telomere ends by Stefano Mattarocci, Sonia Baconnais, Florian Roisné-Hamelin, Sabrina Pobiega, Olivier Alibert, Vincent Morin, Alice Deshayes, Xavier Veaute, Virginie Ropars, Maelenn Chevreuil, Johannes Mehringer, Didier Busso, Gerard Mazon, Paloma Fernandez Varela, Éric Le Cam, Jean-Baptiste Charbonnier, Philippe Cuniasse, Stéphane Marcand

“…Abstract Safeguarding chromosome ends against fusions via nonhomologous end joining (NHEJ) is essential for genome integrity. Paradoxically, the conserved NHEJ core factor Ku binds telomere ends. …”
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NAMICA Encapsulation Technology in an Animal Model: MICROscale vs. NANOscale Hyaluronic Acid Particles in Skin Remodeling (Part 2) by Pavel Burko, George Sulamanidze, Dmitriy Nikishin

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Enhancing the confidence of potential targets enriched by similarity-centric models: the crucial role of the similarity threshold by Ling-Fei Tong, You-Jin Ge, Su-Qing Yang

“…Based on the performance under different conditions, multiple influential factors, focusing on the similarity threshold, were investigated.ResultsEvidence showed that the similarity between the query molecule and the reference ligands that bind to the target could serve as a quantitative measure of the target reliability. …”
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Astrocytic NLRP3 cKO mitigates depression-like behaviors induced by mild TBI in mice. by Hui-Tao Miao, Jun Wang, Jing-Jing Shao, Rong-Xin Song, Wen-Guang Li, Jian-Kai Sun, Shi-Yan Jia, Dong-Xue Zhang, Xiao-Ming Li, Jian-Yong Zhao, Li-Min Zhang

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A phase separation-related gene signature for prognosis prediction and immunotherapy response evaluation in gastric cancer with targeted natural compound discovery by Yanjuan Jia, Yuanyuan Ma, Zhenhao Li, Wenze Zhang, Rukun Lu, Wanxia Wang, Chaojun Wei, Chunyan Wei, Yonghong Li, Xiaoling Gao, Tao Qu

“…Moreover, computational screening identified 18 potential therapeutic natural compounds, 13 of which showed high-affinity binding to signature genes (docking scores > 6.0). …”
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NAP1L1 degradation by FBXW7 reduces the deubiquitination of HDGF-p62 signaling to stimulate autophagy and induce primary cisplatin chemosensitivity in nasopharyngeal carcinoma by Bin Gong, Yahui Liu, Weiwei Yan, Chao Cheng, Huiling Yang, Jiyu Huang, Qing Liu, Yuyan Liu, Jiankang Guo, Xiaojie Deng, Beixian Zhou, Dayong Zheng, Xiong Liu, Zhen Liu, Weiyi Fang

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Multimodal Synergistic Strategies for Diabetic Wound Healing Using Glucose Oxidase Nanocomposites: Therapeutic Mechanisms and Nanomaterial Design by Fan Z, Liang C, Zhang J, Li Y, Tan L, Deng H, Wang P, Wang J, Kang J, Zhu Y, Fu H, Tao J

“…Additionally, the abundance of binding sites on the GOx molecular surface enables the construction of multifunctional GOx-based nanocomposites. …”
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MicroRNAs in circulating extracellular vesicles as biomarkers of early colorectal cancer captured using high mannose N-glycan-specific lectin from Oscillatoria Agardhii by Sanae Nakayama, Miyabi Umeda, Kenya Kobayashi, Yukiko Nakano, Kanji Hori, Tsukuru Umemura, Tsukuru Umemura, Hiroshi Kurokawa

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Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK by Caitlyn E. Bowman, Michael D. Neinast, Ryo Kawakami, Nicholas Forelli, Cholsoon Jang, Jiten Patel, Megan C. Blair, Michael C. Noji, Emily T. Mirek, William O. Jonsson, Qingwei Chu, Lauren Merlo, Laura Mandik-Nayak, Tracy G. Anthony, Joshua D. Rabinowitz, Zolt Arany

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Fibroblast growth factor 16: Molecular mechanisms, signalling crosstalk, and emerging roles in cardiac biology and metabolic regulation by Xiaodan Hui, Qian Lin, Kaiqing Liu, Chunjie Gu, Ahmed Abdelbaset-Ismail, Kupper A. Wintergerst, Zhongbin Deng, Lu Cai, Yi Tan

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Destructive Effects of Pyroptosis on Homeostasis of Neuron Survival Associated with the Dysfunctional BBB-Glymphatic System and Amyloid-Beta Accumulation after Cerebral Ischemia/Re... by Zhongkuan Lyu, Yuanjin Chan, Qiyue Li, Qiang Zhang, Kaili Liu, Jun Xiang, Xiangting Li, Dingfang Cai, Yaming Li, Bing Wang, Zhonghai Yu

“…The results showed that pyroptosis obviously promoted the loss of BBB integrity and AQP-4 polarization, brain edema, Aβ accumulation, and the formation of Aβ1-42 oligomers and thus increased neuronal damage after cerebral I/R. …”
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Investigation of the astringency-masking effect of ι-carrageenan on natural polyphenols and its differential mechanism at various concentrations by Qiang Yu, Yifan Zhang, Jun Liu, Xue Han, Mengqi Li, Junzhi Lin, Taigang Mo, Li Han, Haozhou Huang, Dingkun Zhang

“…Three distinct mechanisms were elucidated: (1) Competitive binding with βCN to inhibit EGCG-induced protein precipitation; (2) Facilitation of βCN aggregation into higher molecular weight coacervates; (3) Formation of ternary EGCG-CA-βCN complexes. …”
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A pathogen effector HaRxL10 hijacks the circadian clock component CHE to perturb both plant development and immunity by Mengyao Fu, Yaoyu Zhou, Xin Zhang, Keyi Yang, Yufeng Xu, Xingwei Wang, Zhaodan Chen, Yu Wang, Yabo Shi, Lin Ma, Hanguang Liu, Yuhua Deng, Shujing Cheng, Jinfang Chu, Jingyi Song, Tongjun Sun, Yuanchao Wang, Wei Wang, Mian Zhou

“…Abstract The intertwining between the life cycle of plants and their pathogens made the plant circadian clock an integral constituent of the plant immune system. Reciprocally, pathogens were also found to perturb the expression pattern of certain clock genes. …”
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Overexpression of the STOX1B isoform of STOX1 triggers preeclampsia-like symptoms through HNF4α-dependent alterations of coagulation cascades in mice by Hélène Collinot, Louise Strubé, Ikram Benouda, Johan Castille, Sandrine Floriot, Nathalie Daniel-Carlier, Bruno Passet, Franck Lager, Isabelle Lagoutte, Gilles Renault, Benjamin Saintpierre, Maryline Favier, Djihane Djeridane, Céline Méhats, Francisco Miralles, Jean-Luc Vilotte, Daniel Vaiman

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Engineering T7 RNA polymerase-cascaded systems controlled by nisin and theophylline for protein overexpression and targeted gene mutagenesis in Lactococcus lactis by Ying Huang, Kang Ma, Yan Li, Qingyan Li, Fuping Lu, Xueli Zhang, Zhe Sun

“…In this study, we enhanced the NICE system by integrating the highly processive T7 RNA polymerase (T7RNAP) to boost protein expression. …”
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Exploring the link between Di-2-ethylhexyl phthalate (DEHP) exposure and muscle mass: A systematic investigation utilizing NHANES data analysis, network toxicology and molecular do... by Jia-qi Hao, Biao Ran, Shu-yue Hu, Zi-xuan Zhuang, Jia-wan Zhang, Meng-rui Xiong, Rui Wang, Wen Zhuang, Mo-jin Wang

“…Molecular docking simulations using CB-dock confirmed the high-affinity binding interactions between DEHP and these key targets. …”
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Advancing macromolecular structure determination with microsecond X-ray pulses at a 4th generation synchrotron by Julien Orlans, Samuel L. Rose, Gavin Ferguson, Marcus Oscarsson, Alejandro Homs Puron, Antonia Beteva, Samuel Debionne, Pascal Theveneau, Nicolas Coquelle, Jerome Kieffer, Paolo Busca, Jeremy Sinoir, Victor Armijo, Marcos Lopez Marrero, Franck Felisaz, Gergely Papp, Herve Gonzalez, Hugo Caserotto, Fabien Dobias, Jonathan Gigmes, Guillaume Lebon, Shibom Basu, Daniele de Sanctis

“…After validating the use of different sample delivery methods with various model systems, we applied SµX to an integral membrane receptor, where only a few thousands diffraction images were sufficient to obtain a fully interpretable electron density map for the antagonist istradefylline-bound A2A receptor conformation, providing access to the antagonist binding mode. …”
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