Discovery of amino acid substitutions in penicillin-binding proteins associated with adaptation to D-Ala-D-Lac in vancomycin-resistant Enterococcus faecalis by Nese Caglayan, Banu Sancak, Zeynep Kanlidere, Tanil Kocagoz, Tanil Kocagoz

“…The bacterial cell wall, essential for structural integrity, is synthesized with penicillin-binding proteins (PBPs). …”
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Exploring the role of ATP-binding cassette transporters in tomato (Solanum lycopersicum) under cadmium stress through genome-wide and transcriptomic analysis by Syed Salman Hashmi, Lubna, Saqib Bilal, Rahmatullah Jan, Saleem Asif, Ashraf M. M. Abdelbacki, Kyung-Min Kim, Ahmed Al-Harrasi, Sajjad Asaf

“…ATP-binding cassette (ABC) transporters are integral membrane proteins involved in the active transport of various substrates, including heavy metals, across cellular membrane. …”
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Author Correction: Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src by Zhenxi Li, Xinghai Yang, Ruifeng Fu, Zhipeng Wu, Shengzhao Xu, Jian Jiao, Ming Qian, Long Zhang, Chunbiao Wu, Tianying Xie, Jiqiang Yao, Zhixiang Wu, Wenjun Li, Guoli Ma, Yu You, Yihua Chen, Han-kun Zhang, Yiyun Cheng, Xiaolong Tang, Pengfei Wu, Gewei Lian, Haifeng Wei, Jian Zhao, Jianrong Xu, Lianzhong Ai, Stefan Siwko, Yue Wang, Jin Ding, Gaojie Song, Jian Luo, Mingyao Liu, Jianru Xiao

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INTEGRATION WITH THE SOFTWARE INTERFACE OF THE COM SERVER FOR AUTHORIZED USER by Denis Ratov

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The Union State and Actual Problems of Russian- Byelorussian Integration by A. V. Shurubovich

“…Serious contradictions between the parties on a number of important economic and political issues remain; periodically serious conflicts (“oil”, “gas”, “milk” etc.) accompanied by “information wars” and questioning the prospects of the Russian-Byelorussian integration arise. Recently Russia raises a question of the necessity to accelerate integration in the framework of the US binding it with maintenance of preferences for Byelorussia in mutual economic relations. …”
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Neural correlates of audiovisual integration in schizophrenia – an ERP study by A. Borgolte, C. Sinke, L. Michalke, L. Möde, N. Lepsy, D. Wiswede, S. Bleich, S. Bleich, G. R. Szycik, E. Ghaneirad

“…IntroductionMultisensory integration (MSI) enhances perception by combining information from different sensory modalities. …”
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Participation of host cell proteins in inclusion bodies of non-segmented RNA virus infected cells: a molecular insight by Sharmistha Sarkar, Kriti Kestur Biligiri, Nisha Vats, Shravanti Rampalli, Surajit Ganguly, Naveen Kumar, Debi Prasad Sarkar, Nirmal Kumar Ganguly, Nishi Raj Sharma

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Accurate prediction of protein–ligand interactions by combining physical energy functions and graph-neural networks by Yiyu Hong, Junsu Ha, Jaemin Sim, Chae Jo Lim, Kwang-Seok Oh, Ramakrishnan Chandrasekaran, Bomin Kim, Jieun Choi, Junsu Ko, Woong-Hee Shin, Juyong Lee

“…Scientific contribution Our work introduces a novel training strategy for a protein–ligand binding affinity prediction model by integrating the outputs of three independent sub-models and utilizing expertly crafted decoy sets. …”
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Suveranitatea şi aprofundarea integrării în Uniunea Europeană by Ioan M. Anghel

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Calculating the band structure of 3C-SiC using sp 3 d 5 s* + ∆ model by Murat Onen, Marco Turchetti

“…Abstract We report on a semiempirical tight-binding model for 3C-SiC including the effect of sp 3 d 5 s* orbitals and spin–orbit coupling (∆). …”
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Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator by Snehajyoti Chatterjee, Raphaelle Cassel, Anne Schneider‐Anthony, Karine Merienne, Brigitte Cosquer, Laura Tzeplaeff, Sarmistha Halder Sinha, Manoj Kumar, Piyush Chaturbedy, Muthusamy Eswaramoorthy, Stéphanie Le Gras, Céline Keime, Olivier Bousiges, Patrick Dutar, Petnoi Petsophonsakul, Claire Rampon, Jean‐Christophe Cassel, Luc Buée, David Blum, Tapas K Kundu, Anne‐Laurence Boutillier

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PPI-Graphomer: enhanced protein-protein affinity prediction using pretrained and graph transformer models by Jun Xie, Youli Zhang, Ziyang Wang, Xiaocheng Jin, Xiaoli Lu, Shengxiang Ge, Xiaoping Min

“…Current deep learning methods trained on large-scale data can characterize proteins to a certain extent, but they often struggle to adequately capture information about protein binding interfaces. To address this limitation, we propose the PPI-Graphomer module, which integrates pretrained features from large-scale language models and inverse folding models. …”
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Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells. by Karsten Jürchott, Ralf-Jürgen Kuban, Till Krech, Nils Blüthgen, Ulrike Stein, Wolfgang Walther, Christian Friese, Szymon M Kiełbasa, Ute Ungethüm, Per Lund, Thomas Knösel, Wolfgang Kemmner, Markus Morkel, Johannes Fritzmann, Peter M Schlag, Walter Birchmeier, Tammo Krueger, Silke Sperling, Christine Sers, Hans-Dieter Royer, Hanspeter Herzel, Reinhold Schäfer

“…We recognized E2F and NFY transcription factor binding sites as prevalent motifs in those pathway-responsive genes and confirmed the predicted regulatory role of Y-box binding protein 1 (YBX1) by reporter gene, gel shift, and chromatin immunoprecipitation assays. …”
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The SARS-CoV-2 envelope PDZ binding motif acts as a virulence factor disrupting host’s epithelial cell–cell junctions by Flavio Alvarez, Guilherme Dias de Melo, Florence Larrous, Lauriane Kergoat, Batiste Boëda, Vincent Michel, Danielle Seilhean, Magali Tichit, David Hing, David Hardy, Etienne Kornobis, Hervé Bourhy, Nicolas Wolff, Célia Caillet-Saguy

“…The Envelope (E) protein is key to virulence, notably through its PDZ-binding motif (PBM), which interacts with host PDZ proteins, affecting signaling pathways and pathogenicity. …”
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Genome-wide identification and expression profiling reveal the diverse role of Methyl-CpG-binding domain proteins in tea plant Camellia sinensis by Yao Chen, Yuteng Li, Hengze Ren, Jianrong Zhou, Lu Wang, Yajun Yang, Xinyuan Hao, Xinchao Wang

“…Methyl-CpG-binding domain (MBD) proteins are important DNA methylation readers that recognise methylated CpG sites and recruit histone deacetylase (HDAC) complexes and chromatin remodelling factors, leading to chromatin compaction, gene transcription, and genome integrity. …”
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The allelic rice immune receptor Pikh confers extended resistance to strains of the blast fungus through a single polymorphism in the effector binding interface. by Juan Carlos De la Concepcion, Josephine H R Maidment, Apinya Longya, Gui Xiao, Marina Franceschetti, Mark J Banfield

“…Allelic variation in a heavy metal associated (HMA) domain integrated in the receptor Pik-1 confers differential binding to AVR-Pik variants, determining resistance specificity. …”
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Association between serum levels of insulin-like growth factor-binding proteins at admission and outcomes at 3 months after acute ischemic stroke by Yuyi Zhu, Huan Wang, Ting Cui, Mingxi Chen, Yaqi Chen, Simiao Wu, Zilong Hao, Shihong Zhang, Xinyi Leng, Deren Wang

“…Background Insulin-like growth factor-binding proteins (IGFBPs) contribute to central nervous system development and may influence recovery after stroke. …”
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Identification of natural compound inhibitors for substrate-binding site of MTHFD2 enzyme: Insights from structure-based drug design and biomolecular simulations by Nisarg Rana, Priyanka Solanki, Rukmankesh Mehra, Anu Manhas

“…These findings demonstrated that compounds C3, C5, and C6 exhibit high stability, and strong binding interactions towards the MTHFD2 enzyme. By integrating multicomplex pharmacophore modeling, molecular dynamics, protein-ligand interaction energy analysis, and free energy calculations, this study offers a framework for identifying novel anticancer agents.…”
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Remboîtage of a Binding: Authenticity and Conservation of "Fifty-two Plates Engraved from Portraits by Van Dyck and Others, 16th - 17th Century" by Malina Belcheva

“…The present study of the album Fifty-two Plates Engraved from Portraits by Van Dyck and Others, 16th - 17th Century, includes commentaries on the conservation research, the album provenance, bibliographical information, acquisition; details of the conservation treatment: the binding, text block, and graphic works consolidation; and it underlines the conservation integration of the historical repairs through contemporary conservation materials applied for stabilization of the album condition and enhancement of the binding flexibility and solidity.…”
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MD simulation of the Tat/Cyclin T1/CDK9 complex revealing the hidden catalytic cavity within the CDK9 molecule upon Tat binding. by Kaori Asamitsu, Takatsugu Hirokawa, Takashi Okamoto

“…Interestingly, Tat addition significantly reduced the structural variability of the T-loop, thus consolidating the structural integrity of P-TEFb. Finally, we deciphered the formation of the hidden catalytic cavity of CDK9 upon Tat binding. …”
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