-
1
Identification of a comprehensive set of transcriptional regulators involved in the long-term survivability of Escherichia coli in soil
Published 2025-02-01“…These transcription factors are often global regulators and conserved among other pathogenic bacterial species. …”
Get full text
Article -
2
PGC-1α activation to enhance macrophage immune function in mycobacterial infections.
Published 2025-01-01“…NTM infections alter macrophage mitochondrial capacity and decrease ATP production, efficient immune response, and bacterial clearance. Transcription factor peroxisome proliferator activated receptor (PPAR) γ coactivator-1α (PGC-1α) is a master regulator of mitochondrial biogenesis, influencing metabolism, mitochondrial pathways, and antioxidant response. …”
Get full text
Article -
3
CCR2 signaling regulates anti-chlamydia T cell immune responses in the airway.
Published 2025-02-01“…Conversely, ccr2-/- mice exhibit an exaggerated Th2-type immune response, with elevated levels of Th2-promoting cytokines (IL-4), transcription factors (STAT6 and gata3), and il-5, which together lead to more severe lung tissue damage and increased susceptibility to infection. …”
Get full text
Article -
4
Clinical and Pathogenetic Parallels of Nonalcoholic Fatty Liver Disease and Gallstone Disease
Published 2019-03-01“…These include central and peripheral insulin resistance, changes in the expression of transcription factors (liver X-receptor and farnesoid X-receptor) and the bile acid membrane receptors (TGR5). …”
Get full text
Article -
5
Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites
Published 2025-02-01“…Our findings reveal a previously unknown mechanistic impact of PNP on human tumor immunotherapy by modulating gut bacterial metabolic pathways.…”
Get full text
Article -
6
Exometabolomic exploration of culturable airborne microorganisms from an urban atmosphere
Published 2025-02-01“…Bacteria exhibited proficiency in amino acid synthesis, while fungi were actively involved in amino acid metabolism, transcription, and expression processes. Lipid metabolism, amino acid metabolism, and carbohydrate metabolism varied widely among bacterial strains, while fungi exhibited notable differences in carbohydrate metabolism and secondary metabolism. …”
Get full text
Article -
7
Single-cell profiling reveals a reduced epithelial defense system, decreased immune responses and the immune regulatory roles of different fibroblast subpopulations in chronic atro...
Published 2025-02-01“…NichNet analysis was used to analyze the regulatory relationships between CCL11 + APOE + fibroblasts and C1Q + macrophages and between CCL11 + APOE + fibroblasts and CD8 + effector T cells. Transcription factor (TF) analysis was performed to determine the transcription status of different T-cell subtypes in atrophic and normal mucosa. …”
Get full text
Article -
8
Eucalyptus grandis WRKY genes provide insight into the role of arbuscular mycorrhizal symbiosis in defense against Ralstonia solanacearum
Published 2025-02-01“…IntroductionWRKY transcription factors are essential for plant growth, health, and responses to biotic and abiotic stress.MethodsIn this study, we performed a deep in silico characterization of the WRKY gene family in the genome of Eucalyptus grandis. …”
Get full text
Article -
9
Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus
Published 2025-02-01“…Abstract Background The rapid emergence of multiple drug-resistant (MDR) bacterial pathogens and the lack of a novel antibiotic pipeline pose a serious threat to global healthcare. …”
Get full text
Article -
10
In vivo regulation of the monocyte phenotype by Mycobacterium marinum and the ESX-1 type VII secretion system
Published 2025-02-01“…We further show that the transcriptional response of bystander monocytes is influenced by ESX-1-dependent mechanisms, including a reduced responsiveness to IFNγ. …”
Get full text
Article -
11
Differential gene expression profile in Porphyromonas gingivalis treated human gingival keratinocytes and their role in the development of HNSCC
Published 2025-01-01“…Chronic exposure to bacterial components induces changes in the nearby cells. …”
Get full text
Article