The Diagnostic and Prognostic Value of the 12-Lead ECG in Arrhythmogenic Left Ventricular Cardiomyopathy by Leonardo Calò, MD, Cinzia Crescenzi, MD, Andrea Di Marco, MD, PhD, Francesca Fanisio, MD, Fabiana Romeo, MD, Alessio Gargaro, MSc, Annamaria Martino, MD, PhD, Chiara Cappelletto, MD, Marco Merlo, MD, Mattia Targetti, MD, Elisabetta Toso, MD, Federica Toto, MD, Maria Beatrice Musumeci, MD, Giacomo Tini, MD, Michele Ciabatti, MD, Matteo Stefanini, MD, Stefano Canestrelli, MD, Elisa Fedele, MD, Chiara Lanzillo, MD, PhD, Armando Fusco, MD, PhD, Federica Carla Sangiuolo, MD, PhD, Cinzia Radesich, MD, Maria Perotto, MD, Maurizio Pieroni, MD, Ruggiero Mango, MD, PhD, Alessio Gasperetti, MD, PhD, Camillo Autore, MD, Michela Casella, MD, PhD, Antonio Dello Russo, MD, PhD, Davide Stolfo, MD, PhD, Mikael Laredo, MD, PhD, Estelle Gandjbakhch, MD, PhD, Maddalena Graziosi, MD, PhD, Elena Biagini, MD, PhD, Costantina Catalano, MD, Ludovica Barile, MD, Fabrizio Drago, MD, Marianna Cicenia, MD, Anwar Baban, MD, PhD, Gemma Pelargonio, MD, PhD, Maria Lucia Narducci, MD, Federica Re, MD, Giovanni Peretto, MD, Elena Paiotti, MD, Carles Diez Lopez, MD, Iacopo Olivotto, MD, Fiorenzo Gaita, MD, Gianfranco Sinagra, MD, Giuseppe Novelli, MD, PhD

“…Background: Electrocardiographic findings in arrhythmogenic left ventricular cardiomyopathy (ALVC) have been limited to small studies. …”
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Prevalence, Characteristics, and Outcomes of Children With Congenital Heart Disease Undergoing Noncardiac Surgery in the Presence or Absence of COVID‐19 Infection During the Pandem... by David Faraoni, James A. DiNardo, Viviane G. Nasr

“…Background Children with congenital heart disease undergoing noncardiac surgery are at increased risk of perioperative complications. …”
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Hyperkalemia and the Risks of Adverse Cardiovascular Outcomes in Patients With Chronic Kidney Disease by Abiy Agiro, Fan Mu, Erin Cook, Alexandra Greatsinger, Jingyi Chen, Angela Zhao, Elaine Louden, Ellen Colman, Pooja Desai, Glenn M. Chertow

“…Background This real‐world evidence study compared risks of cardiovascular events in hospital settings among patients with chronic kidney disease (CKD) with and without hyperkalemia. …”
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Effect of early tranexamic acid treatment on fatigue in patients with mild traumatic brain injury: data from the CRASH-3 clinical trial [version 3; peer review: 2 approved, 1 not a... by Temitayo Shokunbi, Haleema Shakur-Still, Raoul Mansukhani, Antonio Belli, Rizwana Chaudhri, Sabariah Faizah Jamaluddin, Amy Brenner, Lauren Frimley, Rashid Jooma, Ian Roberts

“…Background Each year world-wide about 65 million people sustain a mild traumatic brain injury (mTBI). …”
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Experiences of symptom burden among young children born with esophageal atresia–tracheoesophageal fistula: a US focus group study by Michaela Dellenmark-Blom, John Bennett, Rosella Micalizzi, Lianne Cole, Kaylee Woods, Lauren Cardoni, Leah Frain, Abdimajid Mohamed, Jessica Yasuda, Peter Ngo, Anke Widenmann, Graham Slater, Benjamin Zendejas

“…Abstract Background Children born with esophageal atresia–tracheoesophageal fistula (EA–TEF) can suffer from aerodigestive morbidity that impairs their quality of life and can persist into adulthood. …”
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Thromboembolic Events in the Hemodialysis Setting: Understanding Risk Profiles and Cumulative Incidences to Inform Clinical Trial Design by Angelo Karaboyas, Junhui Zhao, Laszlo B. Tanko, Kristian Tore Joergensen, Akos F. Pap, Indranil Dasgupta, Masaomi Nangaku, Michel Jadoul, Roberto Pecoits‐Filho

“…Background People with kidney failure have a high risk of cardiovascular morbidity/death, including thromboembolic events. …”
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Transcatheter Aortic Valve Replacement and Surgical Aortic Valve Replacement Outcomes in Left Ventricular Assist Device Patients with Aortic Insufficiency by Aniket S Rali, Siva S Taduru, Lena E Tran, Sagar Ranka, Kelly H Schlendorf, Colin M Barker, Ashish S Shah, JoAnn Lindenfeld, Sandip K Zalawadiya

“…Background: Worsening aortic insufficiency (AI) is a known sequela of prolonged continuous-flow left ventricular assist device (LVAD) support with a significant impact on patient outcomes. …”
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Educational Attainment and the Effect of Intensive Blood Pressure Reduction: A Post Hoc Analysis of the SPRINT Study by Joshua Garfein, Akira Sekikawa, Andrew Mrkva, Djhenne Dalmacy, Jarett D. Berry, Yordanos M. Tiruneh, Jared W. Magnani

“…Background Hypertension is a major risk factor for cardiovascular disease (CVD). …”
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A study on the design of a universal signage system for the Ruijin Soviet cultural heritage site by Lu Shizhu, Huang Qiuyu, Min Ziyi, Jia Pengjiang

“…Through surveys, in-depth interviews, and a “structure-humanity” composite evaluation method, we thoroughly explores the relationships between perception, comprehensibility, visual cognition, and the design of universal signage systems. …”
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Estimation of Genetic Parameters for Growth and Acute Hepatopancreatic Necrosis Resistance in Different Strains of Penaeus vannamei by Guixian HUANG, Xupeng LI, Jiteng TIAN, Sheng LUAN, Jie KONG, Baoxiang CAO, Ning LIU, Kun LUO, Jian TAN, Jiawang CAO, Ping DAI, Baolong CHEN, Guangfeng QIANG, Mianyu LIU, Yang LIU, Hongjie WANG, Xuehui LIU, Juan SUI, Xianhong MENG

“…Due to the complex genetic background of existing P. vannamei germplasm resources in China, genetic parameters are influenced considerably by the tested population, infection methods, and other factors. …”
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Registry for Evaluating Healthy Life Expectancy and Long-Term Outcomes after Catheter Ablation of Atrial Fibrillation in the Very Elderly (REHEALTH AF) study: rationale and design... by Kengo Kusano, Ayako Okada, Koji Miyamoto, Eizo Tachibana, Wataru Shimizu, Masato Murakami, Tomoo Harada, Kojiro Tanimoto, Takeshi Kato, Satoru Sakagami, Katsuhito Fujiu, Tatsuya Hayashi, Yasuo Okumura, Kazuhiro Satomi, Tomoyuki Shiozawa, Hideki Kobayashi, Michifumi Tokuda, Teiichi Yamane, Ryohsuke Narui, Seigo Yamashita, Satoru Miyanaga, Ikutaro Nakajima, Hidehira Fukaya, Hajime Kihara, Shiro Nakahara, Koichi Nagashima, Kenta Murotani, Shinya Suzuki, Ryuta Watanabe, Katsuaki Yokoyama, Hidemori Hayashi, Yu-ki Iwasaki, Yuhi Fujimoto, Yasushi Mukai, Koichiro Ejima, Takayuki Otsuka, Masaomi Kimura, Masahide Harada, Junjiroh Koyama, Hideharu Okamatsu, Mitsuru Takami, Morio Shoda, Kenichi Hiroshima, Tadashi Fujino, Keijiro Nakamura, Koji Kumagai, Yuji Watari, Mina Hatsuno, Kazuki Iso, Kazumasa Sonoda, Yoshiyasu Aizawa, Akio Chikata, Masaru Inoue, Hitoshi Minamiguchi, Nobuhiko Makino, Yoshinao Yazaki, Hideshi Aoyagi, Makoto Ichikawa, Hironori Haruta, Takafumi Hiro, Kimie Okubo, Ken Arima, Taiki Tojo, Yoshiaki Fukuda, Koji Oiwa, Tamami Fujiishi, Masashi Akabane, Norikazu Ishikawa, Haruna Tabuchi, Kenjiro Miyamoto, Hiroshi Mase

“…The primary endpoint will be the composite incidence of stroke/transient ischaemic attack (TIA) or systemic embolism (SE), another cardiovascular event, major bleeding and/or death from any cause. …”
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A Novel Phantom for Standardized Microcalcification Detection Developed Using a Crystalline Growth System by Dee H. Wu, Caroline Preskitt, Natalie Stratemeier, Hunter Lau, Sreeja Ponnam, Supriya Koya

“…Background/Objectives: The accurate detection of microcalcifications in mammograms is critical for the early detection of breast cancer. …”
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Validation of the International Trauma Interview (ITI) among treatment-seeking people with adverse childhood experiences in South Korea by Hyunjung Choi, Hae Seong Lee, Neil P. Roberts

“…Background: The International Trauma Interview (ITI) is a clinician-administered assessment that has been newly developed for the International Classification of Diseases (ICD-11) diagnoses of posttraumatic stress disorder (PTSD) and complex PTSD (CPTSD).Objective: The current study evaluated the psychometric properties of the ITI for treatment-seeking people with adverse childhood experiences (ACE) in South Korea, with the aims of verifying the validity and reliability of ITI as well as examining the differentiation of ICD-11 CPTSD and borderline personality disorder (BPD).Methods: In total, data of 103 people were analysed. …”
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Pharmacist Use of a Population Management Dashboard for Safe Anticoagulant Prescribing: Evaluation of a Nationwide Implementation Effort by Geoffrey D. Barnes, Charity Chen, Rob Holleman, Joshua Errickson, F. Jacob Seagull, Michael P. Dorsch, Arthur L. Allen, Patrick Spoutz, Jeremy B. Sussman

“…Background Direct oral anticoagulants (DOACs) have complex dosing regimens and are often incorrectly prescribed. …”
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Prognostic Value of Hospital Frailty Risk Score and Clinical Outcomes in Critical Limb‐Threatening Ischemia and End‐Stage Kidney Disease by Monil Majmundar, Wan‐Chi Chan, Vivek Bhat, Kunal N. Patel, Kirk A. Hance, Georges Hajj, Axel Thors, Kamal Gupta

“…Background End‐stage kidney disease (ESKD) is commonly associated with critical limb‐threatening ischemia (CLTI) and frailty. …”
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Pain and Sleep Disturbances are Associated with Post-stroke Anger Proneness and Emotional Incontinence by Adekola B. Ademoyegun, Wasiu A. Rasaq, Omotola I. Adelowokan, Victor A. Afolabi, Adebukola G. Ibitoye, Taofeek O. Awotidebe, Chidozie E. Mbada

“…We investigated the influence of composite and different components of post-stroke pain(PSP) as well as post-stroke sleep disorders (PSSD) on PSAP and PSEI.Methods: Cross-sectional data on PSAP, PSEI, PSP and PSSD were evaluated through validated instruments and structured interviewsfor a total of 185 community-dwelling stroke survivors attending two Nigerian tertiary health facilities. …”
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Descriptive analysis of total elbow arthroplasty for distal humerus fractures: 30-day complications by Dany El-Najjar, Apoorva Mehta, Caroline Taber, Puneet Gupta, Joel R. Peterson, Brandon Rogalski, Charles M. Jobin, David P. Trofa

“…Background Although functional outcomes of total elbow arthroplasty (TEA) for distal humerus fractures are satisfactory, there is a high rate of complications. …”
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Effectiveness of the GRACE risk score according to troponin elevation in patients admitted with non-ST elevation acute coronary syndrome: a post hoc analysis of the UKGRIS parallel... by Chris P Gale, Derek P Chew, Andrew T Yan, David B Brieger, Ramesh Nadarajah, Catherine Reynolds, Catherine Fernandez, Linda Sharples, Kathryn Carruthers, Keith A A Fox, Rachael Gilberts, Shaun Goodman, Deborah Stocken, Suleman Aktaa

“…Background The effectiveness of risk stratification using the Global Registry of Acute Coronary Events (GRACE) Risk Score (GRS) for patients presenting to hospital with suspected non-ST elevation acute coronary syndrome (NSTEACS) according to troponin elevation is unknown.Methods Post hoc analysis of a phase 3 parallel group cluster randomised controlled trial (UK GRACE Risk Score, UKGRIS) of adult patients presenting with suspected NSTEACS to 42 hospitals in England between 9 March 2017 and 30 December 2019, with hospitals randomised (1:1) to standard care or according to the GRS and associated guidelines. …”
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Outcomes in quality improvement and patient safety training: moving from in-person to synchronous distance education by Chenwei Wu, Anders Chen, Natasha Kwendakwema, Lisa K Vande Vusse, Maya Narayanan, Lindee Strizich, Tyler Albert

“…Background The COVID-19 pandemic necessitated increased synchronous distance education (SDE) in graduate medical education, presenting challenges for Quality Improvement and Patient Safety (QIPS) best practices, which call for integration with daily clinical care and investigation of real patient safety events.Objective To evaluate educational outcomes for QIPS training after conversion of a mature, in-person curriculum to SDE.Methods 68 postgraduate year (PGY)-1 residents were surveyed before and after the SDE Culture of Patient Safety training in June 2020, and 59 PGY-2s were administered the Quality Improvement Knowledge Application Tool-Revised (QIKAT-R) before and after the SDE QIPS seminar series in July–August 2020. …”
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Acute Declines in Estimated Glomerular Filtration Rate in Patients Treated With Benazepril and Hydrochlorothiazide Versus Amlodipine and Risk of Cardiovascular Outcomes by Elaine Ku, Kenneth Jamerson, Timothy P. Copeland, Charles E. McCulloch, Hocine Tighiouart, Mark J. Sarnak

“…Background Acute declines in estimated glomerular filtration rate (eGFR) occur commonly after starting angiotensin‐converting enzyme inhibitors. …”
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