Urine-based assays for inpatients with HIV-associated tuberculosis in rural South Africa by Mbulelo Mntonintshi, Bianca Sossen, Hloni Bookholane, Aimee Lifson, Lisa Africa, René Goliath, Nicola Wearne, Andy Parrish, Graeme Meintjes

“…Background: Accurate non-sputum-based tuberculosis (TB) diagnostics are urgently needed to improve diagnostic yield and patient outcomes. …”
Get full text

Plasmapheresis, immunosuppressive therapy and anti-GBM disease prognosis: a cohort study of 107 patients by Ying Liu, Yiting Wu, Wei Wei, Letian Yang, Caihong Liu, Jian Li, Yongxiu Huang, Bo Wang, Yingying Yang, Ling Zhang, Ping Fu, Yuliang Zhao

“…Background Anti-glomerular basement membrane (anti-GBM) disease presents with rapidly progressive glomerulonephritis and alveolar hemorrhage, requiring urgent management. …”
Get full text

An expert patient program for people living with multiple sclerosis improves knowledge and empowerment: a pre-test, post-test multicenter implementation study by Miguel Ángel Robles-Sánchez, Miguel Ángel Robles-Sánchez, Miguel Ángel Robles-Sánchez, Paloma Amil-Bujan, Cristina Bosch-Farré, Clàudia Coll-Martínez, Clàudia Coll-Martínez, María Jesús Arévalo, Elisenda Anglada-Clofent, Rebeca Menéndez-Díaz, Montserrat Aroca-Alsina, Montserrat Aroca-Alsina, Miguel Merchan-Ruiz, Miguel Merchan-Ruiz, Santiago Pérez-Hoyos, Santiago Pérez-Hoyos, Ángel Guillermo Arévalo-Bernabé, Ángel Guillermo Arévalo-Bernabé, Xavier Montalban, Ana Hernando, Sara LLufriú, Silvia Peralta-Moncusí, Lluís Brieva, Cristina Ramo-Tello, Mariona Carabí, Nuria Solà-Valls, Maria Cinta Zabay, Maria Alba Mañé-Martínez, Jaume Sastre-Garriga, Lluís Ramió-Torrentà, Lluís Ramió-Torrentà, Lluís Ramió-Torrentà, Carmen Bertran-Noguer

“…BackgroundMultiple sclerosis (MS) is associated with complex needs and demands, which require patient-centered care. …”
Get full text

The HOME (home monitoring of high-risk pregnancies) study: a study protocol for an observational study of a telemedicine-assisted follow-up at home vs. hospitalization by Åsa Henning Waldum, Aase Serine Devold Pay, Aase Serine Devold Pay, Gunvor Aasbø, Vinod Kumar Mishra, Meryam Sugulle, Meryam Sugulle, Anne Cathrine Staff, Anne Cathrine Staff

“…BackgroundPregnancies at high risk for adverse health outcomes for mother and offspring often require long-term antenatal hospitalization and/or frequent outpatient visits. …”
Get full text

A Standardized Validation Framework for Clinically Actionable Healthcare Machine Learning with Knee Osteoarthritis Grading as a Case Study by Daniel Nasef, Demarcus Nasef, Michael Sher, Milan Toma

“…Background: High in-domain accuracy in healthcare machine learning (ML) models does not guarantee reliable clinical performance, especially when training and validation protocols are insufficiently robust. …”
Get full text

Need for Support: Facilitating Early Transfer of Cardiogenic Shock Patients to Advanced Heart Failure Centres by Vicki N. Wang, MD, Darshan H. Brahmbhatt, MB BChir, MD(Res), Julie K.K. Vishram-Nielsen, MD, PhD, Fernando L. Scolari, MD, PhD, Nicole L. Fung, Madison Otsuki, Vesna Mihajlovic, MD, Narmin Ibrahimova, Filio Billia, MD, PhD, Christopher B. Overgaard, MD, Adriana C. Luk, MD, MSc

“…Background: Cardiogenic shock (CS) is a complex, life-threatening condition that requires timely care of patients. …”
Get full text

Impact of Apolipoprotein A-I Infusions on Cardiovascular Events Post-MI by Neutrophil-Lymphocyte Ratio and LDL-Cholesterol Levels by Sem A.O.F. Rikken, MD, C. Michael Gibson, MD, MS, M. Cecilia Bahit, MD, Danielle Duffy, MD, Gerald Chi, MD, Serge Korjian, MD, Niekbachsh Mohammadnia, MD, Harvey White, DSc, Gaya Anschuetz, MS, Bronwyn A. Kingwell, PhD, Ton Oude Ophuis, MD, PhD, Jose C. Nicolau, MD, PhD, Renato D. Lopes, MD, PhD, Basil S. Lewis, MD, Saloua El Messaoudi, MD, PhD, Dragos Vinereanu, MD, PhD, Jurriën M. ten Berg, MD, PhD, Shaun G. Goodman, MD, MSc, Christoph Bode, MD, PhD, P. Gabriel Steg, MD, Peter Libby, MD, Kevin R. Bainey, MD, Arnoud W.J. van 't Hof, MD, PhD, Paul M. Ridker, MD, Kenneth W. Mahaffey, MD, Stephen J. Nicholls, MD, Roxana Mehran, MD, Robert A. Harrington, MD, Jan H. Cornel, MD, PhD

“…Background: The AEGIS-II (ApoA-I Event Reducing in Ischemic Syndromes-II; NCT03473223) trial evaluated CSL112, a human plasma-derived apolipoprotein A-I therapy, for reducing cardiovascular events after acute myocardial infarction (AMI). …”
Get full text

Planetary health in action: developing a heatwave vulnerability tool for primary care by Karolina Griffiths, Paul Basso-Bert, Mireille Abraham, Elise Chin, Layana Caroupaye-Caroupin, Manal Ahikki, Emilie Agrech, Camille Debrock, Rim Sabri, Grégoire Mercier, François Carbonnel

“…Background: Heatwaves are becoming longer and more frequent. …”
Get full text

Vision-related Quality of Life (VRQOL) and its determinants among the Elderly in rural blocks of Haryana, India by Mona Duggal, Ankita Kankaria, Latika Rohilla, Harashish Jindal, Limalemla Jamir, Parul Chawla Gupta, Debarati Sarkar, Vaibhav Miglani, Akash Kumar, Drishti Sharma, Neha Dahiya, Siddhartha Sharma, Sandeep Grover

“…Background: Vision related quality of life (VRQOL) measures one's satisfaction with their visual ability to perform daily activities. …”
Get full text

Study Design and Protocol for a Randomized Controlled Trial to Assess Long-Term Efficacy and Safety of a Triple Combination of Ezetimibe, Fenofibrate, and Moderate-Intensity Statin... by Nam Hoon Kim, Juneyoung Lee, Suk Chon, Jae Myung Yu, In-Kyung Jeong, Soo Lim, Won Jun Kim, Keeho Song, Ho Chan Cho, Hea Min Yu, Kyoung-Ah Kim, Sang Soo Kim, Soon Hee Lee, Chong Hwa Kim, Soo Heon Kwak, Yong‐ho Lee, Choon Hee Chung, Sihoon Lee, Heung Yong Jin, Jae Hyuk Lee, Gwanpyo Koh, Sang-Yong Kim, Jaetaek Kim, Ju Hee Lee, Tae Nyun Kim, Hyun Jeong Jeon, Ji Hyun Lee, Jae-Han Jeon, Hye Jin Yoo, Hee Kyung Kim, Hyeong-Kyu Park, Il Seong Nam-Goong, Seongbin Hong, Chul Woo Ahn, Ji Hee Yu, Jong Heon Park, Keun-Gyu Park, Chan Ho Park, Kyong Hye Joung, Ohk-Hyun Ryu, Keun Yong Park, Eun-Gyoung Hong, Bong-Soo Cha, Kyu Chang Won, Yoon-Sok Chung, Sin Gon Kim

“…Background Atherogenic dyslipidemia, which is frequently associated with type 2 diabetes (T2D) and insulin resistance, contributes to the development of vascular complications. …”
Get full text

Ultra-fast [18F]florbetapir PET imaging using the uMI Panorama PET/CT system by Xueqian Yang, Meiqi Wu, Menglin Liang, Haiqiong Zhang, Bo Li, Chenhui Mao, Liling Dong, Yuan Wang, Haiqun Xing, Chao Ren, Zhenghai Huang, Qingxiang Wen, Qi Ge, Zhengqing Yu, Feng Feng, Jing Gao, Li Huo

“…Abstract Background There is a need for faster amyloid PET scans to reduce patients’ discomfort, minimize movement artifacts, and increase throughput. …”
Get full text

Prenatal exposure to organophosphate ester flame retardants and behavioral outcomes in early childhood in the Environmental influences on Child Health Outcomes (ECHO) cohort by Jiwon Oh, Lesliam Quirós-Alcalá, Xuan Li, Kurunthachalam Kannan, Wenjie Lyu, Lyndsay A. Avalos, Emily S. Barrett, Theresa M. Bastain, Jessie P. Buckley, Patricia Cintora, Lisa A. Croen, Anne L. Dunlop, Akhgar Ghassabian, Rima Habre, Julie B. Herbstman, Ixel Hernandez-Castro, Irva Hertz-Picciotto, Donghai Liang, Cindy T. McEvoy, Thomas G. O’Connor, Sheela Sathyanarayana, Susan L. Schantz, Rebecca J. Schmidt, Julie B. Schweitzer, Anne P. Starling, Heather E. Volk, Megan L. Woodbury, Tracey J. Woodruff, Qi Zhao, Yeyi Zhu, Deborah H. Bennett

“…Background: Prenatal exposure to organophosphate esters (OPEs) has been linked to neurotoxic effects in children; however, epidemiological evidence remains inconclusive. …”
Get full text

Effect of Self-reported Physical Activity on Glycaemia and Blood Pressure in Healthy Participants from Bissau: A Cross-sectional Study by Lilica Sanca, Cipriano Có, Nelson Namara, Aladje Lopes, Albino Emanuel, Bárbara Oliveiros, Stine Byberg, Morten Bjerregaard-Andersen, Eugénia Carvalho, Alain Massart, Ana Teixeira

“…Abstract Background Recent data show a dramatic increase in non-communicable diseases in developing countries, including cardiovascular disease, obesity and diabetes. …”
Get full text

Perioperative and Long-Term Outcomes of Acute Stanford Type A Aortic Dissection Repair in Octogenarians by Hannah Masraf, Manoraj Navaratnarajah, Laura Viola, Davorin Sef, Pietro G. Malvindi, Szabolcs Miskolczi, Theodore Velissaris, Suvitesh Luthra

“…Methods: This was a single-centre retrospective study (2007–2021). …”
Get full text

DOAC Score for Predicting Clinical Outcomes After Left Atrial Appendage Closure by Masahiko Asami, MD, Yu Horiuchi, MD, Jun Tanaka, MD, Daiki Yoshiura, MD, Masanori Taniwaki, MD, Kota Komiyama, MD, PhD, Hitomi Yuzawa, MD, PhD, Kengo Tanabe, MD, PhD, Mitsuru Sago, CE, Shuhei Tanaka, MD, PhD, Ryuki Chatani, MD, Toru Naganuma, MD, Yohei Ohno, MD, PhD, Tomoyuki Tani, MD, Hideharu Okamatsu, MD, Kazuki Mizutani, MD, PhD, Yusuke Watanabe, MD, PhD, Masaki Izumo, MD, PhD, Mike Saji, MD, PhD, Shingo Mizuno, MD, Daisuke Hachinohe, MD, Hiroshi Ueno, MD, PhD, Shunsuke Kubo, MD, Shinichi Shirai, MD, Masaki Nakashima, MD, Masanori Yamamoto, MD, PhD, Kentaro Hayashida, MD, PhD

“…Background: The direct-acting oral anticoagulant (DOAC) score has been validated for assessing the bleeding risk in patients with atrial fibrillation (AF). …”
Get full text

Dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy: a systematic review and individual participant data m... by Michelle E. Roh, Julie R. Gutman, Maxwell Murphy, Jenny Hill, Mywayiwawo Madanitsa, Abel Kakuru, Hellen C. Barsosio, Simon Kariuki, John P.A. Lusingu, Frank Mosha, Richard Kajubi, Moses R. Kamya, Don Mathanga, Jobiba Chinkhumba, Miriam K. Laufer, Eulambius Mlugu, Appolinary A.R. Kamuhabwa, Eleni Aklillu, Omary Minzi, Roland Nnaemeka Okoro, Ado Danazumi Geidam, John David Ohieku, Meghna Desai, Prasanna Jagannathan, Grant Dorsey, Feiko O. ter Kuile

“…Summary: Background: High-grade Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in east and southern Africa has prompted trials evaluating intermittent preventive treatment in pregnancy (IPTp) with dihydroartemisinin-piperaquine as an alternative to sulfadoxine-pyrimethamine. …”
Get full text

Adaptation and psychometric properties of the Multigroup Ethnic Identity Inventory in secondary education by S. Suherman, T. Vidákovich

“…Methodology and research methods. The study involved 276 secondary school students (60.1% female; 39.9% male). …”
Get full text

Platelet-bound C4d, low C3 and lupus anticoagulant associate with thrombosis in SLE by John Conklin, Thierry Dervieux, Tyler O'Malley

“…Background Low C3 and lupus anticoagulant (LAC) are known risk factors for thrombosis in SLE. …”
Get full text

Determining optimal strategies for primary prevention of cardiovascular disease: a synopsis of an evidence synthesis study by Olalekan A Uthman, Lena Al-Khudairy, Chidozie Nduka, Rachel Court, Jodie Enderby, Seun Anjorin, Hema Mistry, G J Melendez-Torres, Sian Taylor-Phillips, Aileen Clarke

“…Background Cardiovascular disease remains a leading cause of morbidity and mortality worldwide. …”
Get full text

Single-cell transcriptome analysis revealed a suppressive tumor immune microenvironment in EGFR mutant lung adenocarcinoma by Lei Yang, Qing Zhou, Bo Zhang, Yi-Long Wu, Zhi-Hong Chen, Wen-zhao Zhong, Fen Wang, Yun-Ting He, Song Dong, Xue-Wu Wei, Wei-Dong Chen, Xiao-Rong Yang, Xue-Meng Shang

“…Hence, we initiated this study to describe the specific TME of EGFR-mutant lung adenocarcinoma (LUAD) from cellular compositional and functional perspectives to better understand the immune landscape of this most common subtype of NSCLC.Methods We used single-cell transcriptome sequencing and multiplex immunohistochemistry to investigate the immune microenvironment of EGFR-mutant and EGFR wild-type LUADs and determined the efficacy of immunotherapy. …”
Get full text