Impact of intrarenal arterial lesions on prognosis of IgA nephropathy: insights from a retrospective cohort study by Jingying Tu, Xiaoqian Chen, Haichun Yang, Yiqin Zuo, Fanfan Li, Ji Zhang, Bo Chen, Yinqiu Lv, Chaosheng Chen, Zhen Su, Duo Li

“…Background IgA nephropathy (IgAN) presents a challenging spectrum of outcomes, often complicated by intrarenal arterial/arteriolar lesions (IALs) in affected individuals. …”
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RETRACTED: Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification by J. Marvin Herndon

“…BackgroundU.S. military perception of nuclear warfare led to countless unethical nuclear experiments performed on unsuspecting individuals without their informed consent. …”
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Influence of high-definition transcranial direct current stimulation to the parietal cortex on postural control: a single-blind randomized crossover study by Fan Yang, Fan Yang, Yang Liu, Yang Liu, Xianglin Lv, Yaqi He, Jinpeng Gao, Pei Zhang, Qing Li, Zhongmei Peng, Jinghua Qian, Jinghua Qian

“…BackgroundThe parietal lobe is an important cerebral cortex area for sensory information processing to maintain postural control. …”
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Ability of soluble TREM2 and PRO-C3 as biomarkers to predict changes in MASLD activity by Charlotte Wilhelmina Wernberg, Vineesh Indira Chandran, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Camilla Dalby Hansen, Johanne Kragh Hansen, Lea Ladegaard Grønkjær, Birgitte Gade Jacobsen, Tina Di Caterino, Sönke Detlefsen, Maja Thiele, Alejandro Mayorca Guiliani, Ida Falk Villesen, Diana Julie Leeming, Morten Karsdal, Jonas Heilskov Graversen, Aleksander Krag

“…Background & Aims: Diet and weight loss remain the primary treatment for most patients with metabolic dysfunction-associated fatty liver disease (MASLD), with one recent drug therapy approved for severe cases. …”
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Immune-neuroendocrine crosstalk in mood and psychotic disorders: A meta-analysis and systematic review by Minne Van Den Noortgate, Filip Van Den Eede, Violette Coppens, Erik J. Giltay, Livia De Picker, Manuel Morrens

“…Background: Bidirectional interactions between immune and neuroendocrine mechanisms are involved in mood and psychotic disorders, although individual studies report inconsistent and even contradictory findings on the nature of this crosstalk. …”
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Pathophysiological and Prognostic Importance of an ExtraCardiac Comorbidity Burden in Patients with Heart Failure with Preserved Ejection Fraction by Yuki Saito, MD, PhD, Tomonari Harada, MD, PhD, Naoki Yuasa, MD, Kazuki Kagami, MD, PhD, Yuta Tani, MSc, Ayami Naito, MD, Fumitaka Murakami, MD, Tomoaki Ishii, RS, Toshimitsu Kato, MD, PhD, Naoki Wada, MD, PhD, Yasuo Okumura, MD, PhD, Hideki Ishii, MD, PhD, Masaru Obokata, MD, PhD

“…Background: Extracardiac comorbidities are highly prevalent in patients with heart failure with preserved ejection fraction (HFpEF). …”
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First-line vs Second-Line Catheter Ablation Therapy for Patients with Atrial Fibrillation—Data from a National Multicentre Registry by Ranin Hilu, MD, Mahmoud Suleiman, MD, Adi Elias, MD, MPH, Ibrahim Marai, MD, Roy Beinart, MD, Eyal Nof, MD, Yoav Michowitz, MD, Michael Glikson, MD, Yuval Konstantino, MD, Moti Haim, MD, David Luria, MD, David Pereg, MD, Avishag Laish-Farkash, MD, PhD, Alexander Omelchenko, MD

“…Background: An early catheter ablation treatment strategy is effective for rhythm control in patients with atrial fibrillation (AF). …”
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Comparative genomic insights into adaptation, selection signatures, and population dynamics in indigenous Indian sheep and foreign breeds by Malarmathi Muthusamy, Oludayo Michael Akinsola, Oludayo Michael Akinsola, Pritam Pal, Chitra Ramasamy, Saravanan Ramasamy, Abdulraheem Arome Musa, Aranganoor Kannan Thiruvenkadan

“…BackgroundIndia’s indigenous sheep breeds have evolved under extreme and diverse agro‐ecological pressures, yet the genomic basis of their resilience and local adaptation remains poorly understood.MethodThis study combines genomic inbreeding estimates, runs of homozygosity (ROH), population structure analyses, and composite selection scans to investigate three native Indian breeds—Changthangi, Deccani, and Garole—within a panel of nine breeds that also includes populations from Africa (Ethiopian Menz), East and South Asia (Tibetan, Chinese Merino, Bangladesh Garole, Bangladesh East), and Europe (Suffolk).ResultsROH and heterozygosity estimates revealed strong contrasts: Bangladesh East sheep exhibited high genomic inbreeding (FROH≈14.4%) and low observed heterozygosity (∼30.6%), whereas Deccani sheep showed low inbreeding (FROH≈1.1%) and high observed heterozygosity (∼35.6%), consistent with broader gene flow and larger flock sizes. …”
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Carotid plaque thickness predicts cardiovascular events and death in patients with chronic kidney disease by Sasha S. Bjergfelt, Ida M. H. Sørensen, Laerke Urbak, Klaus F. Kofoed, Theis Lange, Bo Feldt-Rasmussen, Henrik Sillesen, Christina Christoffersen, Susanne Bro

“…Abstract Background Classical risk scoring systems underestimate the risk of cardiovascular disease in chronic kidney disease (CKD). …”
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Enhancing Patient Safety Education: Cross-Cultural Validation of the APSQ-III in Brazilian Healthcare Students by João Daniel de Souza Menezes, Matheus Querino da Silva, Emerson Roberto dos Santos, Rodrigo Soares Ribeiro, Natália Almeida de Arnaldo Silva Rodriguez Castro, Isabela Amaral de Almeida Bistafa, Alex Bertolazzo Quitério, Eliana Fazuoli Chubaci, Sônia Maria Maciel Lopes, Flávia Cristina Custódio, Stela Regina Pedroso Vilela Torres de Carvalho, Gustavo Schiavinato, Thalissa Catricala, José Nathan Fernandes Rocha, Vânia Maria Sabadoto Brienze, Josimerci Ittavo Lamana Faria, Denise Cristina Mós Vaz Oliani, Antônio Hélio Oliani, Vânia Zaqueu Brandão, Júlio Cesar André, Rita de Cassia Helú Mendonça Ribeiro

“…<b>Background:</b> This study aimed to adapt and validate the Attitudes to Patient Safety Questionnaire (APSQ-III) for Brazilian Portuguese and to compare patient safety attitudes between medical and nursing students. …”
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Area-level socioeconomic inequalities in hypertension care cascade in China: a nationwide population-based study based on the ChinaHEART projectResearch in context by Wenyao Peng, Siqi Lin, Xuan Liu, Bowang Chen, Xueke Bai, Chaoqun Wu, Xiaoyan Zhang, Yang Yang, Jianlan Cui, Wei Xu, Lijuan Song, Hao Yang, Wenyan He, Yan Zhang, Xi Li, Jiapeng Lu

“…Summary: Background: Socioeconomic status (SES) is one of key social determinants of health. …”
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Interpreting the clinical significance of multiple large-scale mitochondrial DNA deletions (MLSMD) in skeletal muscle tissue in the diagnostic evaluation of primary mitochondrial d... by Jing Wang, Jing Wang, James T. Peterson, Joaquim Diego D. Santos, Ada J. S. Chan, Maria Alejandra Diaz-Miranda, Imon Rahaman, Jean Flickinger, Amy Goldstein, Amy Goldstein, Emily Bogush, Elizabeth M. McCormick, Colleen C. Muraresku, Vernon E. Anderson, Matthew C. Dulik, Matthew C. Dulik, Douglas C. Wallace, Douglas C. Wallace, Rui Xiao, Marni J. Falk, Marni J. Falk, Angela N. Viaene, Angela N. Viaene, Zarazuela Zolkipli-Cunningham, Zarazuela Zolkipli-Cunningham, Zarazuela Zolkipli-Cunningham

“…We sought to evaluate clinical, biochemical, and histopathological phenotypes of a large clinical cohort harboring MLSMD in muscle to better understand their significance across a range of clinical phenotypes.MethodsA single-site retrospective study was performed of 212 diagnostic muscle biopsies obtained from patients referred for Primary Mitochondrial Disease (PMD) evaluation with muscle mitochondrial (mt)DNA sequencing performed at our institution, including electronic medical record (EMR) review of symptoms, biochemical results, and Mitochondrial Myopathy Composite Assessment Tool (MM-COAST) scores.ResultsMLSMD were identified in 50 of 212 (24%) diagnostic tissue biopsies, and were universally present. in subjects ≥50 years (n = 18/18). …”
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Neurodevelopmental outcomes of very low birth weight preterm infants during the COVID-19 pandemic by Yen-Chen Lin, Hung-Yang Chang, Chia-Huei Chen, Jui-Hsing Chang, Wai-Tim Jim, Chyong-Hsin Hsu, Chia-Ying Lin, Yu-Xiang Song, Cheng-Wei Chen, Tzu-Yu Liu, Mary Hsin-Ju Ko

“…Background: During the COVID-19 pandemic, parental involvement in NICU and post-discharge follow-up for preterm infants in Taiwan were limited. …”
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Characterization of Malnutrition in Atrial Functional Mitral Regurgitation by Tsukasa Murakami, MD, PhD, Nobuyuki Kagiyama, MD, PhD, Tomohiro Kaneko, MD, PhD, Kazuki Kagami, MD, PhD, Masashi Amano, MD, PhD, Taiji Okada, MD, PhD, Yukio Sato, MD, PhD, Yohei Ohno, MD, PhD, Kimi Sato, MD, PhD, Kojiro Morita, MPH, PhD, RN, PHN, Tomoko Machino-Ohtsuka, MD, PhD, Yukio Abe, MD, PhD, Hideki Ishii, MD, PhD, Masaru Obokata, MD, PhD

“…Background: In this study we sought to characterize the prevalence, clinical characteristics, and outcomes of malnutrition in patients with atrial functional mitral regurgitation (AFMR). …”
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Machine learning applied to wearable fitness tracker data and the risk of hospitalizations and cardiovascular events by John Kundrick, Aditi Naniwadekar, Virginia Singla, Krishna Kancharla, Aditya Bhonsale, Andrew Voigt, Alaa Shalaby, N.A. Mark Estes, Sandeep K Jain, Samir Saba

“…Background: Wearable fitness trackers generate extensive physiological and activity data, offering potential to monitor health and predict outcomes. …”
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Adjuvant rituximab and elevated intratumoural CD8 expression are associated with sustained disease control after radiotherapy in a randomised trial of systemic therapy in early-sta... by Michael P. MacManus, John F. Seymour, Hennes Tsang, Richard Fisher, Colm Keane, Muhammed B. Sabdia, Soi C. Law, Jay Gunawardana, Karthik Nath, Stephen H. Kazakoff, Mario L. Marques-Piubelli, Daniela E. Duenas, Michael R. Green, Daniel Roos, Peter O'Brien, Andrew McCann, Richard Tsang, Sidney Davis, David Christie, Chan Cheah, Benhur Amanuel, Tara Cochrane, Jason Butler, Anna Johnston, Mohamed Shanavas, Li Li, Claire Vajdic, Robert Kridel, Victoria Shelton, Samantha Hershenfield, Tara Baetz, David Lebrun, Nathalie Johnson, Marianne Brodtkorb, Maja Ludvigsen, Francesco d’Amore, Ella R. Thompson, Piers Blombery, Maher K. Gandhi, Joshua W.D. Tobin

“…Summary: Background: We report extended follow-up of TROG99.03, a randomised phase III trial in early-stage follicular lymphoma (ESFL) including new information on the role of adjuvant rituximab and translational studies. …”
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Global landscape and trends in lifetime risks of haematologic malignancies in 185 countries: population-based estimates from GLOBOCAN 2022Research in context by Kexin Sun, Hongliang Wu, Qian Zhu, Kai Gu, Hui Wei, Shaoming Wang, Li Li, Chunxiao Wu, Ru Chen, Yi Pang, Bingfeng Han, Hongmei Zeng, Meicen Liu, Rongshou Zheng, Wenqiang Wei

“…Summary: Background: Haematologic malignancies accounted for 6.6% of total cancer cases and 7.2% of total cancer-related deaths worldwide in 2022. …”
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Application of a deep learning algorithm for the diagnosis of HCC by Philip Leung Ho Yu, Keith Wan-Hang Chiu, Jianliang Lu, Gilbert C.S. Lui, Jian Zhou, Ho-Ming Cheng, Xianhua Mao, Juan Wu, Xin-Ping Shen, King Ming Kwok, Wai Kuen Kan, Y.C. Ho, Hung Tat Chan, Peng Xiao, Lung-Yi Mak, Vivien W.M. Tsui, Cynthia Hui, Pui Mei Lam, Zijie Deng, Jiaqi Guo, Li Ni, Jinhua Huang, Sarah Yu, Chengzhi Peng, Wai Keung Li, Man-Fung Yuen, Wai-Kay Seto

“…Background &amp; Aims: Hepatocellular carcinoma (HCC) is characterized by a high mortality rate. …”
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Assessing Diagnostic Precision: Adaptations of the Hopkins Symptom Checklist (HSCL-5/10/25) Among Tertiary-Level Students in Norway by Børge Sivertsen, Jens C. Skogen, Anne Reneflot, Marit Knapstad, Otto Robert Frans Smith, Leif Edvard Aarø, Benedicte Kirkøen, Bengt Oscar Lagerstrøm, Ann Kristin Skrindo Knudsen

“…[Background] Universities worldwide are witnessing a surge in mental health problems among students, particularly in anxiety and depression. …”
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The sodium-glutamate antagonist riluzole improves outcome after acute spinal cord injury: results from the RISCIS randomised controlled trial analysed using a global statistical an... by Michael G. Fehlings, Karlo M. Pedro, Mohammed Ali Alvi, Ali Moghaddamjou, James S. Harrop, Ralph Stanford, Jonathon Ball, Bizhan Aarabi, Paul M. Arnold, James D. Guest, Shekar N. Kurpad, James M. Schuster, Ahmad N. Nassr, Karl M. Schmitt, Jefferson R. Wilson, Darrel S. Brodke, Faiz U. Ahmad, Albert Yee, Wilson Z. Ray, Nathaniel P. Brooks, Jason Wilson, Diana S-L. Chow, Elizabeth G. Toups, Kevin E. Thorpe, Jiaxin Huang, Peng Huang

“…Summary: Background: Spinal cord injury (SCI) clinical trials typically rely on a single primary endpoint to assess drug efficacy. …”
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