Salvage therapy containing sorafenib and donor lymphocyte infusion is associated with improved outcomes for FLT3 wild-type acute myeloid leukemia relapsing after allogeneic hematop... by Zhonghui Jiang, Ya Zhou, Yuxin Bai, Fang Dai, Menglin Fan, Tian Zhang, Danian Nie, Yunxin Zeng, Yirong Jiang, Ping Zhu, Zhiping Fan, Na Xu, Fen Huang, Ren Lin, Min Dai, Xiaojun Xu, Zhangkun Li, Hua Jin, Jing Sun, Qifa Liu, Li Xuan

“…Abstract Background There is no established standard treatment for acute myeloid leukemia (AML) patients with FLT3 wild-type relapsing after allogeneic hematopoietic stem cell transplantation (allo-HSCT). …”
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BMI-residualized data uncovers a cluster of people with type 2 diabetes and increased serum ferritin protected from cardiovascular disease by Laura Gallardo-Nuell, Jordi Blanch, Yenny Leal, Daniel E Coral, Talita Duarte-Salles, Giuseppe N. Giordano, Paul W. Franks, Ewan R. Pearson, Geltrude Mingrone, Carel W le Roux, Rafael Ramos, José Manuel Fernández-Real

“…Abstract Background Understanding the relationship between serum ferritin levels and cardiovascular outcomes in type 2 diabetes is crucial for improving risk stratification and guiding therapeutic interventions aimed at preventing major adverse cardiovascular events (MACE). …”
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Delivery of care in high mortality hospital settings: a direct observational study examining 1848 h of neonatal nursing in KenyaResearch in context by Abdulazeez Imam, Michuki Maina, Jalemba Aluvaala, Vincent Kagonya, Onesmus Onyango, Fredrick Were, Sebastian Fuller, Kenneth Karumba, Mike English, David Gathara, Peter Mwangi, Lucy Kinyua, Lydia Thuranira, Virginia Njoroge, Ngina Mwangi, Loise Mwangi, Penina Musyoka, Zainab Kioni

“…Summary: Background: In resource-constrained countries, deploying better technologies is expected to improve neonatal care but little attention has been paid to the critical role of nurse staffing. …”
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Impact of awake prone positioning duration on intubation or mortality in COVID-19 patients with acute respiratory failure: secondary analysis of a randomized clinical trial by Qin Sun, Rui Zhang, Junyi Zhang, Jianfeng Xie, Yingzi Huang, Yi Yang, Haibo Qiu, Ling Liu, Hui Chen, the Chi-ARDS Net (Chinese ARDS Research Network)

“…Abstract Background Compared with shorter awake prone positioning (APP), prolonged APP (≥ 12 h daily) reduces the intubation rate in patients with COVID-19-related acute hypoxemic respiratory failure (AHRF). …”
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Elevated monocyte-to-high-density lipoprotein ratio is associated with increased risk of cognitive impairment and severe cerebral small vessel disease burden by Yueshan Zhao, Yueshan Zhao, Yueshan Zhao, Meixi Li, Meixi Li, Meixi Li, Meixi Li, Juan Zhang, Chao Wang, Mengyao Zhao, Qishuo Yang, Tianjun Wang, Peiyuan Lv, Peiyuan Lv, Peiyuan Lv, Peiyuan Lv, Peiyuan Lv

“…BackgroundMonocyte-to-high-density lipoprotein ratio (MHR), as a novel biomarker, has shown potential in predicting the onset and progression of various diseases. …”
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The role of left atrio-ventricular coupling index and left atrial ejection fraction in predicting onset of atrial fibrillation and adverse cardiac events in hypertrophic cardiomyop... by Parisi Francesca, La Franca Eluisa, Pistelli Lorenzo, Gentile Giovanni, Bellavia Diego, Nuzzi Vincenzo, Manca Paolo, Massimiliano Mulè, Zito Concetta, Di Bella Gianluca, Scipione Carerj, Cipriani Manlio, Francesco F. Faletra

“…Abstract Background Several predictors of atrial fibrillation (AF) onset in patients with hypertrophic cardiomyopathy (HCM) have been proposed, however, all of them showed limited accuracy. …”
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A novel therapy targeting the gut–liver axis for chronic hepatitis B: Ursodeoxycholic acid plus Bifidobacterium by Zhen Xun, Xiaobao Yao, Caorui Lin, Xinyao Yang, Yanfang Zhang, Xin Yang, Yujue He, Renquan Jiang, Yanping Lan, Yuchen Ye, Detai Ye, Shanjian Chen, Ke Ma, Wennan Wu, Siyi Xu, Bin Yang, Can Liu, Jing Chen, Qi Zheng, Qishui Ou

“…We aimed to assess the therapeutic efficacy of targeting the gut microbiota-bile acid (BA) axis using ursodeoxycholic acid (UDCA) combined with the probiotic Bifidobacterium to treat chronic hepatitis B (CHB). Methods: BA profiles were characterized by mass spectrometry, and gut microbiota composition was analyzed using 16S rRNA sequencing in patients with CHB and healthy controls (HCs). …”
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Determining optimal timing of birth for women with chronic or gestational hypertension at term: The WILL (When to Induce Labour to Limit risk in pregnancy hypertension) randomised... by Laura A Magee, Katie Kirkham, Sue Tohill, Eleni Gkini, Catherine A Moakes, Jon Dorling, Marcus Green, Jennifer A Hutcheon, Mishal Javed, Jesse Kigozi, Ben W M Mol, Joel Singer, Pollyanna Hardy, Clive Stubbs, James G Thornton, Peter von Dadelszen, WILL Trial Study Group

“…<h4>Background</h4>Chronic or gestational hypertension complicates approximately 7% of pregnancies, half of which reach 37 weeks' gestation. …”
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Impact of Pan-Immune Inflammation Value on Short-Term Outcomes and Long-Term Prognosis in Patients with Type A Aortic Dissection by Cai H, Shourav, Shao Y, Shuangling S, Duan C, Zhang C, Wu QC

“…The Pan-Immune Inflammation Value (PIV), a composite index derived from peripheral blood cell counts, has demonstrated prognostic relevance in multiple clinical conditions. …”
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Elevated triglyceride-glucose index is a risk factor for cardiovascular events in adults with type 1 diabetes: a cohort study by Rosa Oh, Seohyun Kim, Sang Ho Park, Myunghwa Jang, So Hyun Cho, Ji Yoon Kim, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Gyuri Kim, Jae Hyeon Kim

“…Abstract Background The triglyceride-glucose (TyG) index is recognized as an indicator of insulin resistance and is linked to cardiovascular disease (CVD) in patients with type 2 diabetes. …”
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Candida and Bacterial Skin Colonisation of Critically-ill Patients in Two Tertiary Healthcare Facilities in Zambia by Prof Geoffrey Kwenda, Dr John Mwaba, Ms Chalwe Sokoni, Mr Christone Kaile, Ms Faith Kabansa, Mr Darlingtone Mwenya, Ms Tshiama Mirriam Mwamba, Ms Ruth Mpembe, Dr Sabelle Jallow, Ms Rudzani Mashau, Prof Nelesh Govender, Miss Chalwe Sokoni

“…This study aimed to investigate the prevalence of Candida and bacterial colonisation in critically ill patients in Zambia. Methods: In a Point-prevalence survey (PPS) for Candida and bacterial skin colonisation conducted on October 2 and 3, 2023, skin swab samples (composite axilla/groin) were collected from critically-ill patients who were admitted for at least 48 hours to two tertiary hospitals in Zambia. …”
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Candida skin colonization among critically-ill neonates, children and adults admitted to tertiary and district hospitals in Mozambique by Dr Sérgio Massora, Aquino Nhantumbo, Miriam Mwamba, Leocadia Vilanculos, Silondiwe Nzimande, Janeta Machai, Judice Miguel, Milton Kincardett, Corssino Tchavana, Anélsio Cossa, Eládio Alvaro, Sabelle Jallow, Rudzani C Mashau, Inácio Mandomando, Nelesh P Govender

“…Background: Pathogenic fungi are responsible for a largely silent epidemic, often hidden killers causing substantial morbidity and mortality in susceptible individuals. …”
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Effectiveness and risk of ARB and ACEi among different ethnic groups in England: A reference trial (ONTARGET) emulation analysis using UK Clinical Practice Research Datalink Aurum-... by Paris J Baptiste, Angel Y S Wong, Anna Schultze, Catherine M Clase, Clémence Leyrat, Elizabeth Williamson, Emma Powell, Johannes F E Mann, Marianne Cunnington, Koon Teo, Shrikant I Bangdiwala, Peggy Gao, Kevin Wing, Laurie Tomlinson

“…<h4>Background</h4>Guidelines by the National Institute for Health and Care Excellence recommend an angiotensin receptor blocker (ARB) rather than an angiotensin-converting enzyme inhibitor (ACEi) for the treatment of hypertension for people of African and Caribbean descent, due to an increased risk of angioedema associated with ACEi use observed in US trials. …”
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A 5-Year Follow-Up of Patient-Reported Outcome Measures Following External Beam Radiotherapy or Radical Prostatectomy in Localised Prostate Cancer by Rowan V. David, Peter L. Stapleton, Arman A. Kahokehr, Jason Lee, David I. Watson, John Leung, Michael E. O’Callaghan

“…<b>Background/Objectives</b>: Late toxicity following radiotherapy is common and compromises patient quality of life. …”
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Antimicrobial Effects of Thonningianin a (TA)-Loaded Chitosan Nanoparticles Encapsulated by a PF-127&nbsp;hydrogel in Diabetic Wound Healing by Lin Q, Zhu F, Shiye A, Liu R, Wang X, Ye Z, Ding Y, Sun X, Ma Y

“…To promote diabetic wound healing, a composite of thonningianin A (TA)-loaded chitosan nanoparticles (CNPS) encapsulated by a Pluronic F-127 (PF-127) hydrogel (TA-CNPS-PF) was developed in this study.Methods: TA-CNPS was prepared by ionic gelation method and TA-CNPS was thoroughly dispersed into PF-127 hydrogel to prepare TA-CNPS-PF. …”
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Identifying nontuberculous mycobacteria from a mycobacteria growth indicator tube with nuclear magnetic resonance spectroscopy: A laboratory metabolomics analysis case report by Dr Christoffel Opperman, Dr Marwaan Rylands, Dr Sarishna Singh, Ms Aysha Amien, Mr Yonas Ghebrekristos, Prof Rob Warren, Dr Wynand Goosen

“…This method offers potential in discriminating between samples with varied biological compositions, aiding in the identification of diagnostic markers for respiratory tract infections. …”
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Cervical cerclage for prevention of preterm birth and adverse perinatal outcome in twin pregnancies with short cervical length or cervical dilatation: A systematic review and meta-... by Francesco D'Antonio, Nashwa Eltaweel, Smriti Prasad, Maria Elena Flacco, Lamberto Manzoli, Asma Khalil

“…<h4>Background</h4>The optimal approach to prevent preterm birth (PTB) in twins has not been fully established yet. …”
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Equity of National Essential Public Health Services (NEPHS) in Mainland China, 2019: a cross-sectional study based on the NEPHS database by Lu Liu, Jinhong Zhao, Yuxing Wang, Xinyue Chen, Siqi Zhang, Mengyu Li, Lili You, Yuanli Liu

“…Abstract Background China’s National Essential Public Health Service (NEPHS) Program was launched in 2009 to deliver population-based public health and individual health management services to all residents at 800,000 primary health-care centers nationwide. …”
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Pathologic and Oncologic Outcomes of Patients Undergoing Orchiectomy After Chemotherapy for Advanced Testicular Germ Cell Tumors by Viranda H. Jayalath, Fady Baky, Samuel A. Gold, Nicole Liso, Brandon Williams, Samuel A. Funt, Darren R. Feldman, Victor E. Reuter, Joel Sheinfeld, Richard S. Matulewicz

“…Background and objective: Delayed orchiectomy is generally recommended for patients who receive upfront chemotherapy for advanced testicular germ cell tumors (TGCTs). …”
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Impact of differentiated service delivery models on quality of life among people living with HIV in Uganda– a quasi-experimental study by Benson Nasasira, Grace Banturaki, Nelson Kalema, Joseph Musaazi, Aidah Nanvuma, Stephen Okoboi, Nancy Gathoni Kiarie, Joash Ntenga Moitui, Damazo Kadengye, Jonathan Izudi, Barbara Castelnuovo

“…Abstract Background Differentiated service delivery (DSD) models in resource-limited settings reduce strain on health services and improve clinical outcomes such as retention and viral suppression, but little is known about the impact of HIV DSD models on quality of life (QoL), which is essential for optimizing person-centered care. …”
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