Single cell RNA-sequencing identified CCR7+/RELB+/IRF1+ T cell responding for juvenile idiopathic arthritis pathogenesis by Lewei He, Xue Gong, Hui Guo, Kaiyu Zhou, Yue Lan, Mingyi Lv, Xiaoliang Liu, Sha Lin, Yimin Hua, Junling Guo, Zhenxin Fan, Yifei Li

“…BackgroundTo further explore the disease heterogeneity of different subtypes of Juvenile idiopathic arthritis (JIA) and analyze their pathogenesis mechanisms.MethodThe single-cell RNA sequencing (scRNA-seq) analysis of peripheral blood mononuclear cells (PBMCs) was carried out to investigate the disease heterogeneity and molecular mechanisms of immune responses in immune cells in JIA.ResultIn our study, we provided a immunological landscape of HLA-B27-positive JIA and HLA-B27-negative JIA immune cells at single cell RNA-Seq resolution. …”
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Selection of In Vivo Relevant Dissolution Test Parameters for the Development of Cannabidiol Formulations with Enhanced Oral Bioavailability by Nathan Koch, Quentin Bourcy, Olivier Jennotte, Patrice Chiap, Anna Lechanteur, Jean-Michel Cardot, Brigitte Evrard

“…<b>Background:</b> Cannabidiol (CBD) shows interesting therapeutic properties but has yet to demonstrate its full potential in clinical trials partly due to its low solubility in physiologic media. …”
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Exploring the association between life’s essential 8 and gallstone disease in the US adult population: a population-based study utilizing NHANES data from 2017-2018 by Yi Xiao, Wenting Zhao, Qiuchan Zhao, Kangfeng Pang, Qiaoping Gao, Xiaoqu Yang, Huadi Chen, Hao Xu

“…Abstract Background and objective Gallstones are a prevalent health issue, with established risk factors such as diet body mass index (BMI) and physical activity. …”
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Prognostic Value of Serum Uric Acid in Patients on the Waiting List before and after Renal Transplantation by Henrique Cotchi Simbo Muela, Jose Jayme Galvão De Lima, Luis Henrique W. Gowdak, Flávio J. de Paula, Luiz Aparecido Bortolotto

“…Background. High serum uric acid (UA) is associated with increased cardiovascular (CV) risk in the general population. …”
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Optimization of Extraction Parameters for Phenolics Recovery from Avocado Peels Using Ultrasound and Microwave Technologies by Lorena Martínez-Zamora, María Carmen Bueso, Mathieu Kessler, Rosa Zapata, Perla A. Gómez, Francisco Artés-Hernández

“…This study optimized the extraction parameters of phenolics using ultrasound- (UAE) and microwave-assisted technologies (MAE) with a Central Composite Design (CCD). Methods: The extraction variables included EtOH concentration (0–100%), temperature (13–47 °C for UAE and 55–95 °C for MAE), and time (3–37 min for UAE and 3–27 min for MAE). …”
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Clopidogrel combined with rivaroxaban in peripheral artery disease after revascularization by Min Lu, Jiaqi Li, Huanyu Ni, Tong Qiao, Baoyan Wang

“…BackgroundTo evaluate the efficacy and safety of clopidogrel-rivaroxaban combination compared to aspirin-rivaroxaban combination in patients with symptomatic peripheral artery disease (PAD).MethodsConsecutive patients with symptomatic PAD patients were analyzed from January, 2018 to June, 2022 at Nanjing Drum Tower Hospital. …”
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Evaluation of a combination adherence strategy to support HIV antiretroviral therapy for pregnancy and breastfeeding in Malawi: A pilot randomized clinical trial. by Wilbroad Mutale, Lauren A Graybill, Friday Saidi, Twambilile Phanga, K Rivet Amico, Kellie Freeborn, Nora E Rosenberg, Lauren M Hill, Twaambo Hamoonga, Brian D Richardson, Katie R Mollan, Benjamin H Chi

“…<h4>Background</h4>There has been tremendous progress in reducing vertical transmission of HIV in the past two decades due to the broad availability of antiretroviral therapy (ART) globally. …”
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Elevated serum amylase concentrations are associated with worse in-hospital outcomes among patients with acute myocardial infarction by Marijana Mikacic, Marko Kumric, Iva Rancic Vidic, Duska Glavas, Tina Ticinovic Kurir, Josko Bozic, Josip Andelo Borovac

“…Blood sample for serum amylase measurement were obtained at the time of admission, using the spectrophotometric method. A composite outcome, comprising death, ventricular tachycardia, 3rd degree atrioventricular block, instances requiring cardiopulmonary resuscitation, and transfer for cardiac surgery, was formulated for the present analysis and was the principal outcome of interest. …”
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Comparing In-Person, Standard Telehealth, and Remote Musculoskeletal Examination With a Novel Augmented Reality Exercise Game System: Pilot Cross-Sectional Comparison Study by Richard Wu, Keerthana Chakka, Sara Belko, Ninad Khargonkar, Kevin Desai, Balakrishnan Prabhakaran, Thiru Annaswamy

“…ObjectiveThis pilot study evaluated the feasibility of the VIRTEPEX system as a supplement to telehealth musculoskeletal strength assessments. MethodsIn this cross-sectional pilot study, 12 study participants with upper extremity pain and/or weakness underwent strength evaluations for four upper extremity movements using in-person, telehealth, VIRTEPEX, and composite (telehealth plus VIRTEPEX) assessments. …”
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Effect of proximal box elevation on fracture resistance and microleakage of premolars restored with ceramic endocrowns. by Hong Zhang, He Li, Qian Cong, Zhimin Zhang, Aobo Du, Ying Wang

“…<h4>Background</h4>Restoration of endodontically treated premolar is in high risk for biomechanical failure, and often presents with subgingival margins. …”
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Association between use of sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide 1 agonists, and dipeptidyl peptidase 4 inhibitors with kidney outcomes in patients with... by Shuo Yang, Wei He, Lu Zhao, Yaochuan Mi

“…<h4>Methods</h4>PubMed, EMBASE, and CENTRAL were searched for studies published up to September 28, 2020. …”
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Prognostic value of carbohydrate antigen 125 combined with N-terminal pro B-type natriuretic peptide in patients with acute heart failure: a prospective cohort study in Vietnam by Chau Minh Truong, Nguyen Hoang Nguyen Do, Hoa Ngoc Chau, Truc Thanh Thai

“…Abstract Background Carbohydrate antigen 125 (CA125) is an emerging prognostic biomarker for acute heart failure (AHF). …”
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Lower-Quarter Y-Balance Test Differs by Age: Younger Athletes May Not Be Generalized to High School-Aged Counterparts by James J McGinley, Ben Randoing, Laura Saleem, Caroline Podvin, Henry B Ellis, Philip L Wilson, Sophia Ulman

“…# Background Given rising youth sport participation, 8 to 10-year-olds increasingly display comparable lower-extremity injury incidence to 11 to 17-year-olds and require effective return to sport criteria. …”
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Comparative effectiveness and tolerance of immunosuppressive treatments for idiopathic membranous nephropathy: A network meta-analysis. by Song Ren, Ying Wang, Ying Wang, Li Xian, Tadashi Toyama, Meg Jardine, Guisen Li, Vlado Perkovic, Daqing Hong

“…<h4>Background</h4>Immunosuppressive agents in general are shown to prevent renal progression and all-cause mortality in idiopathic membranous nephropathy (IMN) patients with nephrotic syndrome. …”
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A Numerical Investigation of the Deformation Mechanism of a Large Metro Station Foundation Pit under the Influence of Hydromechanical Processes by Yan Wang, Yongjun Zhang, Mingfei Li, Yi Qi, Tianhui Ma

“…Considering the unique conditions of deep and large subway foundation pit excavation affected by heavy rainfall in soil-rock composite strata, this paper employs finite element numerical simulation methods to study foundation pit instability under the influence of heavy rainfall. …”
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HOMOCYSTEINE-LOWERING THERAPY AND LONG-TERM PROGNOSIS AFTER ELECTIVE PERCUTANEOUS CORONARY INTERVENTION by O. O. Shakhmatova, A. L. Komarov, A. N. Samko, T. I. Kotkina, D. V. Rebrikov, A. D. Deev, E. P. Panchenko

“…Background. Vitamins В6 В12 and folic acid (FA) therapy to reduce cardiovascular risk appears to be unreasonable. …”
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Comparing weight loss rates between males and females: a preliminary analysis by Valentina Rodriguez Da Silva, Ryan Singh, Valeria V. Silva Ramirez, Daniel Arevalo, Eric T. Trexler, Landon Shannahan, John Solis, Samuel Blanke, Samuel Evers, Talon Westervelt, John Holtje, Bill I. Campbell

“…Background Biological differences between males and females include variations in fat-free mass, resting metabolic rate, and hormone profiles. …”
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Early Cardiovascular Events in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation by Nazanin Aghel, MD, MSc, Vincent Wang, BHSc, Darryl Leong, MD, PhD, Michelle Lui, PharmD, MSc, Livia Fu, BNSc, MN, RN(EC), Jasmine Kang, MD, Dina Khalaf, MD, Irwin Walker, MD, Christopher Hillis, MD, MSc, Brian Leber, MD, Harry Klimis, MD, PhD, Anne Holbrook, MD, PharmD, MSc, Catherine Demers, MD, MSc, Philip Joseph, MD, MSc, Kylie Lepic, MD, Alejandro Garcia-Horton, MD, Tobias Berg, MD, PhD, Jeffrey Howard Lipton, MD, PhD, Mylinh Duong, MD, MSc, Jane Turner, MD, Jinhui Ma, PhD

“…Background: Allogeneic hematopoietic stem cell transplantation (HSCT) is associated with organ toxicities, including cardiovascular (CV) complications. …”
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Geochemical nature of the geothermal water from Lanzhou Basin: Implications for the genesis of shallow helium-bearing fluids by Jianzhou TANG, Shuangming WANG, Zhicheng ZHANG, Ke LI, Changpeng LI

“…Objective and Methods Investigations on the geochemical nature of geothermal water are vital to the comprehension of the origin of helium-rich fluids in shallow basins. …”
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Outcomes and Risk Factors Associated with Clostridium difficile Diarrhea in Hospitalized Adult Patients by Daniela Zilio Larentis, Regis Goulart Rosa, Rodrigo Pires dos Santos, Luciano Zubaran Goldani

“…Background. The epidemiology of Clostridium difficile infection has changed over time. …”
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