Metabolite profiles associated with disease progression in influenza infection. by Chris H Wendt, Sandra Castro-Pearson, Jennifer Proper, Sarah Pett, Timothy J Griffin, Virginia Kan, Javier Carbone, Nikolaos Koulouris, Cavan Reilly, James D Neaton, INSIGHT FLU003 Plus Study Group

“…<h4>Background</h4>We performed metabolomic profiling to identify metabolites that correlate with disease progression and death.…”
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Response surface optimization for lactose inducible expression of recombinant fructosyl peptide oxidase enzyme in Escherichia coli by Hamid Shahbazmohammadi

“…This research focuses on statistically optimizing lactose-induced expression to produce soluble recombinant FPOX. Methods: A Plackett–Burman design was used to identify key factors influencing enzyme expression, which were further optimized using a central composite design. …”
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Low-grade inflammation in prognosis in patients undergoing coronary artery bypass grafting: The importance of neutrophil-to-lymphocyte ratio and growth differentiation factor 15 by Alla A. Garganeeva, Elena A. Kuzheleva, Olga V. Tukish, Alexey N. Repin

“…Background — Predicting major adverse cardiovascular events (MACE) after coronary interventions is an urgent and important mission. …”
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The Efficacy of Drug-Coated Balloon for Acute Coronary Syndrome by Hirokazu Naganawa, Akira Ito, Shinrou Saiki, Daisuke Nishi, Shinichi Takamatsu, Yoshihisa Ito, Takeshi Suzuki

“…Background. Percutaneous coronary intervention using a drug-eluting stent (DES) is a common therapeutic option for acute coronary syndrome (ACS). …”
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Systematic review on the application of 3D‐bioprinting technology in orthoregeneration: current achievements and open challenges by Rachel L. Pan, Kari Martyniak, Makan Karimzadeh, David G. Gelikman, Jonathan DeVries, Kelly Sutter, Melanie Coathup, Mehdi Razavi, Rajendra Sawh‐Martinez, Thomas J. Kean

“…Abstract Background Joint degeneration and large or complex bone defects are a significant source of morbidity and diminished quality of life worldwide. …”
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Screening Elite Genotypes of Durum Wheat Based on Univariate and Multivariate Stability Models under Unpredictable Environments by Sharyar Sasani, Armin Saed-Moucheshi

“…Moreover, multivariate methods, including the AMMI method, the GGE method, and the heat mapping method, were used to analyze the stability of genotypes. …”
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In Situ Active Contour-Based Segmentation and Dimensional Analysis of Part Features in Additive Manufacturing by Tushar Saini, Panos S. Shiakolas

“…The segmentation performance of the composite method was compared with traditional methods with the results showing the composite method scoring higher in most metrics, including a maximum Jaccard index of 78.34%, effectively segmenting high- and low-contrast features. …”
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Proton Density Fat Fraction Micro-MRI for Non-Invasive Quantification of Bone Marrow Aging and Radiation Effects in Mice by Hemendra Ghimire, Malakeh Malekzadeh, Ji Eun Lim, Srideshikan Sargur Madabushi, Marco Andrea Zampini, Angela Camacho, Weidong Hu, Natalia Baran, Guy Storme, Monzr M. Al Malki, Susanta K. Hui

“…Non-invasive imaging techniques such as Magnetic Resonance Imaging (MRI), Computed Tomography (CT), and Positron Emission Tomography (PET) could provide valuable alternatives for real-time evaluation in both preclinical translational and clinical studies. Methods: We developed a preclinical proton density fat fraction (PDFF) MRI technique for the quantitative assessment of BM composition, focusing on the fat fraction (FF) within mouse femurs. …”
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Inferring flavor mixtures in multijet events by Ezequiel Alvarez, Yuling Yao

“…We have run a toy inferential process with signal $bbbb$ and backgrounds $ccbb$ and $cccc$, and we find that with a few hundred events we can recover the true mixture fractions of the signal and backgrounds, as well as the true $b$-tagging score distribution curves, despite their arbitrariness and nonparametric shapes. …”
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CHANGE: A Multi-Country Cohort Project Exploring Child Malnutrition and Adult Non-Communicable Disease: Generating Evidence on Mechanistic Links to Inform Future Policy/Practice by Kimberley McKenzie, Natasha Lelijveld, Debbie Thompson, Kenneth Anujuo, Mubarek Abera, Marko Kerac

“…Our objectives are as follows: 1. explore different patterns of post-malnutrition weight gain/growth; 2. investigate the associations between weight gain/growth during and after malnutrition and NCD risk profile as assessed by adults/in later life; 3. understand how the following may influence the risk of later-life NCD: a. the timing of the malnutrition, b. the severity of malnutrition, and c. different patient management approaches (NB., Jamaica used inpatient-only management; Malawi was hybrid; Ethiopia used outpatient-only care). Methods: We will use already collected data from three cohorts of survivors of child malnutrition: Jamaica were originally treated for malnutrition in 1960–95; Malawi was originally treated in 2006–7; Ethiopia was originally treated in 2014–15 We will carry out the following steps: 1. pool data from our three cohorts, identifying and grouping common variables; 2. generate new exposure variables of “post-malnutrition growth” (since there is no one standard definition of this, we will use six different alternatives defining growth in slightly different ways); 3. summarise NCD outcome variables already available in the datasets (e.g., BP, body composition, fasting glucose, and other blood markers of NCD risk); 4. use regression analysis to explore the association between early-life post-malnutrition growth and later-life NCD/NCD risk. …”
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A metric to measure long-term well-being of people living with HIV in Spain by María José Fuster-RuizdeApodaca, Trenton M. White, Carlos Prats-Silvestre, Francisco P. Holgado-Tello, Jeffrey V. Lazarus

“…Methods This study employs a Delphi consensus process with composite score analysis of cross-sectional survey data from 500 PLHIV in Spain. …”
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Impact of Central Event Adjudication on the PLATO Trial Results by Victor L. Serebruany, Wendy Ziai, Hector A. Cabrera-Fuentes, Brendon Pokov, Isabella Hwang, Thomas Marciniak

“…Background: This study aimed to determine the impact of central adjudication of site-reported events in patients with acute coronary syndromes treated with ticagrelor or clopidogrel in addition to aspirin within the frame of indication-seeking The PLATelet Inhibition and Clinical Outcomes (PLATO) trial. …”
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Review of Clinical Studies of the Treatment of Ulcerative Colitis Using Acupuncture and Moxibustion by Jun Ji, Yan Huang, Xia-Fei Wang, Zhe Ma, Huan-Gan Wu, Hyoyoung Im, Hui-Rong Liu, Lu-Yi Wu, Jing Li

“…Background. Clinical studies suggest that acupuncture and moxibustion therapy in ulcerative colitis (UC) can regulate bowel inflammation, and these treatments have the advantages of low rates of adverse reactions and recurrence as well as good long-term efficacy. …”
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Efficacy of a gelatin-based hemostatic sponge and hydroxyapatite-chitosan nanocomposites (nHAp/CS) on regeneration of radial bone defects in rabbits by Taher Naser Elmeshreghi, Fathy D. El-Seddawy, Mohamed Gomaa, Shimaa A. Ezzeldein, Mustafa Abd El Raouf

“…Background: Bone-graft substitutes are a frequently employed method for the clinical reconstruction of osseous bone defects, and research on synthetic biomaterials is currently ongoing. …”
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The NLRP3 Genetic Variant (rs10754555) Reduces the Risk of Adverse Outcome in Middle-Aged Patients with Chronic Coronary Syndrome by Trine B. Opstad, Jostein Nordeng, Alf-Aage R. Pettersen, Sissel Åkra, Vibeke Bratseth, Hani Zaidi, Ragnhild Helseth, Svein Solheim, Ingebjørg Seljeflot

“…Background. Inflammation is central in development of cardiovascular disease (CVD). …”
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Assessing Risk in Patients with Stable Coronary Disease: When Should We Intensify Care and Follow-Up? Results from a Meta-Analysis of Observational Studies of the COURAGE and FAME... by Umberto Barbero, Fabrizio D’Ascenzo, Freek Nijhoff, Claudio Moretti, Giuseppe Biondi-Zoccai, Marco Mennuni, Davide Capodanno, Marco Lococo, Michael J. Lipinski, Fiorenzo Gaita

“…Therefore, we performed a meta-analysis of studies in patients with stable angina to assess which variables predict prognosis. Methods. MEDLINE and PubMed were searched for eligible studies published up to 2015, reporting multivariate predictors of major adverse cardiac events (MACE, a composite endpoint of death, myocardial infarction, and revascularization) in patients with stable angina. …”
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Suppress or Not to Suppress … CRAFT It: A Targeted Metabolomics Case Study Extracting Essential Biomarker Signals Directly from the Full ¹H NMR Spectra of Horse Serum Sa... by James Chen, Ayelet Yablon, Christina Metaxas, Matheus Guedin, Joseph Hu, Kenith Conover, Merrill Simpson, Sarah L. Ralston, Krish Krishnamurthy, István Pelczer

“…<b>Background</b>: There are a few very specific inflammation biomarkers in blood, namely lipoprotein NMe⁺ signals of protein clusters (GlycA and GlycB) and a composite resonance of phospholipids (SPC). …”
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Comparative effect of different types of artificial teeth and the effect of different surface treatments on the shear bond strength to CAD/CAM denture base by Hajar M. Saleh, Ammar Kh. Al-Noori

“…Methods: Milled CAD/CAM denture base resin was used to test three types of denture teeth: acrylic, composite, and milled CAD/CAM. …”
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The independent and joint role of socioeconomic status and family relationships on mortality risk in China: cultural differences and health inequalities in the context of intergene... by Zhixi Zhu, Yiying Wang, Xin Wang, Fuyan Zhang, Lisha Yu, Tao Liu

“…Abstract Background Socioeconomic status (SES) and family relationships are critical social determinants of health disparities. …”
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Agreement between CES-D and CIDI-SF scales of depression among older adults: a cross-sectional comparative study based on the longitudinal aging study in India, 2017-19 by T. Muhammad, Soomi Lee, Manish Kumar, T. V. Sekher, Mathew Varghese

“…Abstract Background Understanding the differences between various instruments for assessing depression will help researchers and health practitioners to choose a more appropriate tool and develop a framework to enhance resilience to mental health problems in the older population. …”
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