Single-cell RNA sequencing uncovers abnormal Sertoli-cell elevation and testicular niche impairment in the transfemales’s testis by Jun Yu, Longfei Hu, Huixia Li, Xiaofeng Li, Chaoye Ma, Ting Jiang, Yongxin Liu, Xue Wang, Xia Li, Liandong Zuo, Haocheng Lin, Wenming Xu, Yiwen Zhou, Yang Liu, Hao Chen

“…However, the testicular impacts of feminising hormones present heterogeneity due to the complexity of testicular regulatory mechanisms. Method In this study, we analyzed approximately 49,385 single-cell transcriptomes from transfemale human testicular tissue, comparing cellular composition with that of cisgender male individuals across a range of ages. …”
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Diabetic distress, low-grade chronic inflammation, and cardiac autonomic neuropathy in internally displaced people (literature review and own observations) by V.A. Serhiyenkо

“…The purpose: using the Ukrainian version of the T2-DDAS validated by us to assess the level of DD among IDP. Materials and methods. Development and application of a validated Ukrainian-language version of the Composite Autonomic Symptom Score 31 demonstrated that this is an acceptable tool for identifying patients with subclinical CAN. …”
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Exploring the concurrent validity of a linguistically responsive pre-reading assessment in bilingual children: the Urdu Phonological Tele-Assessment (U-PASS) tool by Insiya Bhalloo, Insiya Bhalloo, Monika Molnar, Monika Molnar

“…The U-PASS consists of 10 phonological awareness, phonological memory, and rapid automatized naming subtests.MethodsWe tested 115 typically-developing Urdu-English simultaneous bilinguals in Grades 1–2 across Canada and Pakistan on the U-PASS, vocabulary and reading accuracy measures, and background questionnaires.ResultsItem-level analysis, involving point-biserial correlations, accuracy rates, and Cronbach’s alpha, and linear regression, involving subtest- and composite-level analysis, were used to collect evidence for U-PASS’s internal reliability and criterion-based concurrent validity.DiscussionOur linear regression analyses indicated significant phonological processing-reading associations after accounting for background variables, thereby demonstrating U-PASS’s concurrent validity for assessing Urdu word/non-word reading. …”
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Klf9 Loss of Function Protects Against Glucocorticoids Induced Skeletal Muscle Wasting by Yujie Zhang, Jingran Hao, Yueyao Feng, Tongtong Qiu, Jinjin Wu, Xuenan Zhou, Heng Fan, Yongsheng Chang

“…ABSTRACT Background Glucocorticoids (GCs) are the most important and frequently used class of anti‐inflammatory drugs. …”
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ZEB1 transcription factor promotes immune escape in melanoma by Christophe Caux, Stephane Dalle, Arnaud de la Fouchardière, Laurie Tonon, Maud Plaschka, Valentin Benboubker, Maxime Grimont, Justine Berthet, Jonathan Lopez, Myrtille Le-Bouar, Brigitte Balme, Garance Tondeur, Lionel Larue, Alain Puisieux, Yenkel Grinberg-Bleyer, Nathalie Bendriss-Vermare, Bertrand Dubois, Julie Caramel

“…We thus wondered whether ZEB1 signaling in melanoma cells may promote immune evasion and resistance to immunotherapy.Methods We evaluated the putative correlation between ZEB1 expression in melanoma cells and the composition of the immune infiltrate in a cohort of 60 human melanoma samples by combining transcriptomic (RNA-sequencing) and seven-color spatial multi-immunofluorescence analyses. …”
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Intervention effect and mechanism of Dracocephalum moldavica L. extract on bleomycin-induced pulmonary fibrosis in rats by Xiaoyu SUN, Li CHEN, Ruifang GAO, Hui YU, Min JIN

“…ObjectiveTo elucidate the targets and potential mechanism underlying the anti-pulmonary fibrosis efficacy of Dracocephalum moldavica L. extract by employing an amalgamation of network pharmacology and empirical verification. MethodsThe chemical composition of the extract of Dracocephalum moldavica L. was retrieved with the help of China National Knowledge Infrastructure (CNKI) and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). …”
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Metabolome Profiling and Predictive Modeling of Dark Green Leaf Trait in Bunching Onion Varieties by Tetsuya Nakajima, Mari Kobayashi, Masato Fuji, Kouei Fujii, Mostafa Abdelrahman, Yasumasa Matsuoka, Jun’ichi Mano, Muneo Sato, Masami Yokota Hirai, Naoki Yamauchi, Masayoshi Shigyo

“…<b>Background:</b> The dark green coloration of bunching onion leaf blades is a key determinant of market value, nutritional quality, and visual appeal. …”
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Distinct Gut Microbiota Profiles in Normal Weight Obesity and Their Association With Cardiometabolic Diseases: Results From Two Independent Cohort Studies by Wenjie Wang, Feijie Wang, Yihan Li, Yuwei Shi, Xiaoyan Wang, Xinyu Chen, Weifang Zheng, Julianna C. Hsing, Ying Lu, Yi‐Shuan Wu, Ann W. Hsing, Juntao Kan, Wei He, Shankuan Zhu

“…ABSTRACT Background Normal weight obesity (NWO) is characterized by excess body fat in individuals with normal body mass index (BMI). …”
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Effects of Different Sources of Selenium on Digestibility, Rumen Parameters, and Carcass Characteristics in Crossbred Zel Fattening Male Lambs by Rademan Bakhtiyari, Yadollah Chashnidel, Asdolah Tymouri Yansari

“…Extended Abstract Background: Generally, most feeds used in livestock nutrition are deficient in some nutrients and require nutritional supplements. …”
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Green Synthesis of Silver Nanoparticles Using <i>Paullinia cupana</i> Kunth Leaf Extract Collected in Different Seasons: Biological Studies and Catalytic Properties by Alan Kelbis Oliveira Lima, Ítalo Rennan Sousa Vieira, Lucas Marcelino dos Santos Souza, Isadora Florêncio, Ingrid Gracielle Martins da Silva, Alberto Gomes Tavares Junior, Yasmin Alves Aires Machado, Lucas Carvalho dos Santos, Paulo Sérgio Taube, Gerson Nakazato, Laila Salmen Espindola, Lorena Carneiro Albernaz, Klinger Antônio da França Rodrigues, Marlus Chorilli, Hugo de Campos Braga, Dayane Batista Tada, Sônia Nair Báo, Luís Alexandre Muehlmann, Mônica Pereira Garcia

“…<b>Background:</b> <i>Paullinia cupana</i> Kunth, popularly known as guarana, a native Amazonian shrub cultivated by the Sateré-Mawé ethnic group, has been used in traditional medicine for various purposes, including stimulant and therapeutic actions, due to its chemical composition, which is rich in bioactive compounds. …”
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Relationship between dietary fiber physicochemical properties and feedstuff fermentation characteristics and their effects on nutrient utilization, energy metabolism, and gut micro... by Feng Yong, Bo Liu, Huijuan Li, Houxu Hao, Yueli Fan, Osmond Datsomor, Rui Han, Hailong Jiang, Dongsheng Che

“…Abstract Background There is a growing focus on using various plant-derived agricultural by-products to increase the benefits of pig farming, but these feedstuffs are fibrous in nature. …”
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Effects of five cannabis oils with different CBD: THC ratios and terpenes on hypertension, dyslipidemia, hepatic steatosis, oxidative stress, and CB1 receptor in an experimental mo... by Valentina Degrave, Michelle Berenice Vega Joubert, Camila Filippa, Paola Ingaramo, Lucía Torregiani, Yamile Soledad Caro, María Mercedes De Zan, María Eugenia D’Alessandro, María Eugenia Oliva

“…Abstract Background Non-alcoholic fatty liver disease (NAFLD) is a common liver disorder caused by oxidative stress and dysregulation of lipid metabolism. …”
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Deciphering cholangiocarcinoma heterogeneity and specific progenitor cell niche of extrahepatic cholangiocarcinoma at single-cell resolution by Chunliang Liu, Xiang Wang, Erdong Liu, Yali Zong, Wenlong Yu, Youhai Jiang, Jianan Chen, Mingye Gu, Zhengyuan Meng, Jingfeng Li, Yang Liu, Yongjie Zhang, Jing Tang, Hongyang Wang, Jing Fu

“…Abstract Background Cholangiocarcinoma (CCA) is a highly heterogeneous malignancy, primarily comprising intrahepatic (iCCA) and extrahepatic (eCCA) subtypes. …”
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Synergic prognostic value of 3D CT scan subcutaneous fat and muscle masses for immunotherapy-treated cancer by Caroline Robert, Aurélien Marabelle, Fabrice Barlesi, Samy Ammari, David Planchard, Siham Farhane, Paul-Henry Cournède, Pierre Decazes, Younes Belkouchi, Léo Mottay, Littisha Lawrance, Antoine de Prévia, Hugues Talbot, Florian Guisier, Tony Ibrahim, Pierre Vera, Nathalie Lassau

“…Background Our aim was to explore the prognostic value of anthropometric parameters in a large population of patients treated with immunotherapy.Methods We retrospectively included 623 patients with advanced non-small cell lung cancer (NSCLC) (n=318) or melanoma (n=305) treated by an immune-checkpoint-inhibitor having a pretreatment (thorax-)abdomen-pelvis CT scan. …”
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Double Burden of Malnutrition and Validity of Overweight/Obesity Indicators Among Students in the Democratic Republic of Congo: A Cross Sectional Study From the University of Kinsh... by Makulo JR, Tshiswaka Mutombo T, Kamitalu Kabongo R, Tunda AK, Sumaili EK, Kisoka Lusunsi C, Beni Kasangwala B, Mulundu Lakwon C, Boluta B, Lubamba Mubiala G, Niangi Mawana T, Mbau Modju Jnr D, Betela CK, Mbala Kintoki F, Kasiam Lasi On'Kin JB, Bayauli Mwasa P, Ekolo Adiaka J, Lokangaka Odiko C, Mangani Nseka N, Ntumba Kayembe JM

“…Using bioimpedance to assess body composition, BMI correlates better with FM in women; the usual thresholds defining overweight and obesity were not valid in men.Keywords: obesity, fat mass, bioimpedance, correlation, students, DR Congo…”
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Conserving biodiversity, carbon, and community values in a fragmented landscape by A. Susilowati, Y. Lisnawati, H.H. Rachmat, H. Kurniawan, W.C. Adinugroho, R. Imanuddin, D.J. Sudrajat, I.W.S. Dharmawan, M. Iqbal, S. Fahmi, L.M. Nugraha, E. Novriyanti, E. Sutrisno, A.B. Siswanto

“…BACKGROUND AND OBJECTIVES: Fragmenting forests into small and isolated areas due to deforestation increases the risk of species loss. …”
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Temporal trends in the planetary health diet index and its association with cardiovascular, kidney, and metabolic diseases: A comprehensive analysis from global and individual pers... by Haoxian Tang, Xuan Zhang, Nan Luo, Jingtao Huang, Qinglong Yang, Hanyuan Lin, Mengyue Lin, Shiwan Wu, Jiasheng Wen, Jianan Hong, Pan Chen, Liwen Jiang, Yequn Chen, Xuerui Tan

“…Background: Diet plays a critical role in human health and environmental sustainability, particularly in cardiovascular, kidney, and metabolic (CKM) diseases. …”
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SLIT3-mediated intratumoral crosstalk induces neuroblastoma differentiation via a spontaneous regression-like program by Meiling Liu, Dekang Lv, Wenjing Yan, Yi Wu, Shulan Wang, Luoxuan Wang, Jie Lei, Deshun Zeng, Zifeng Wang, Fang Liu, Bing Deng, Quentin Liu, Bin He, Min Yan

“…Spontaneous regression is often accompanied by tumor differentiation, but the mechanisms underlying this process remain largely unclear. Methods Single-nucleus transcriptomics (snRNA-seq) data of neuroblastoma samples were obtained from the Synapse repository to investigate the composition of heterogeneous tumor cell clusters. …”
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Interplay between the gut microbiome and typhoid fever: insights from endemic countries and a controlled human infection model by Philip M. Ashton, Leonardos Mageiros, James E. Meiring, Angeziwa Chunga-Chirambo, Farhana Khanam, Sabina Dongol, Happy Banda, Abhilasha Karkey, Lorena Preciado-Llanes, Helena Thomaides-Brears, Malick Gibani, Nazmul Hasan Rajib, Nazia Rahman, Prasanta Kumar Biswas, Md Amirul Islam Bhuiyan, Sally Kay, Kate Auger, Olivier Seret, Nicholas R. Thomson, Andrew J. Pollard, Stephen Baker, Buddha Basnyat, John D. Clemens, Christiane Dolecek, Sarah J. Dunstan, Gordon Dougan, Robert S. Heyderman, Virginia E. Pitzer, Firdausi Qadri, Melita A. Gordon, Kathryn E. Holt, Thomas C. Darton, STRATAA Study Group

“…Abstract Background Typhoid fever is a systemic infection caused by Salmonella enterica serovar Typhi (S. …”
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Traditional Mongolian Medicine Qiqirigan-8 alleviates non-alcoholic fatty liver disease via restoring gut microbiota and metabolism by Dandan Yang, Dandan Yang, Wuyunsiqin, Wuyunsiqin, YanNiu, Hashentuya, Tana, Anna, Mingxing Ma, Wenhui Zhao, Menggenduxi, Minjie Wang, Minjie Wang

“…However, the material basis and in vivo metabolic process of the therapeutic effect of MMQ-8 on non-alcoholic fatty liver disease (NAFLD) remain unclear.MethodsThe chemical composition of MMQ-8 was determined using Ultra-high-performance liquid chromatography-quadrupole Exactive Mass spectrometry analysis (UHPLC-QE-MS). …”
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