PCI-DB: a novel primary tissue immunopeptidome database to guide next-generation peptide-based immunotherapy development by Sven Nahnsen, Hans-Georg Rammensee, Cécile Gouttefangeas, Jonas S Heitmann, Juliane S Walz, Jens Bauer, Marcel Wacker, Annika Nelde, Jonas Scheid, Steffen Lemke, Marissa L Dubbelaar, Patrick Zimmermann, Naomi Hoenisch Gravel, Susanne Jung, Anna Dengler, Yacine Maringer, Sven Fillinger, Tatjana Bilich

“…Background Various cancer immunotherapies rely on the T cell-mediated recognition of peptide antigens presented on human leukocyte antigens (HLA). …”
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Combined microbiome and metabolomics analysis of yupingfeng san fermented by Bacillus coagulans: insights into probiotic and herbal interactions by Yu Kang, Yanting Sun, Jinzhong Cui, Yuzhen Song, Zilong Sun, Huan Li, Ruiyan Niu, Hongxing Qiao

“…Background Yupingfeng san is a traditional Chinese medicine formula composed of siler, atractylodes, and astragalus. …”
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Evaluation of the state of small intestinal microbiota, pro- and anti-inflammatory cytokines, short-chain fatty acids in metabolic dysfunction-associated steatotic liver disease in... by Yu.M. Stepanov, V.I. Didenko, I.A. Klenina, O.M. Tatarchuk, O.P. Petishko, R.M. Kyslova

“…Background. The intestinal microbiota and its metabolites have a significant impact on the pathophy­siology of liver diseases, it plays an important role in human metabolism, supports the intestinal mucosal barrier and interacts with the immune system. …”
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Environmentally friendly synthesis of nanoporous silica materials using quercetin as a morphogenetic agent by A.R. Zare Hoseinabadi, E. Rafiei Taqanaki, S. Hafez Ghoran, A.M. Amani, H. Kamyab, A. Razmfarsa, E. Khalili, M. Yusuf, S. Rajendran

“…BACKGROUND AND OBJECTIVES: The synthesis of mesoporous silica nanoparticles using non-surfactant agents is gaining popularity owing to the easier purification and lower toxicity of this method compared to traditional surfactant-based ones. …”
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TGF-β3 promotes vascular normalization of prostate cancer to potentiate immunotherapy and chemotherapy by Qiliang Teng, Niu Wang, Hanqi Lei, Tongyu Tong, Yupeng Guan, Mengjun Huang, Fei Cao, Bin Xu, Jia Yang, Yimian Huo, Wenping Chen, Ran Bi, Xuanqi Wang, Zhenyu Wang, Fu-Ying Tian, Bo Zhao, Jun Pang

“…Abstract Background Prostate cancer (PCa) has previously been established as a cold tumor with highly complex tumor environment. …”
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Microbial Patterns in Newly Diagnosed Inflammatory Bowel Disease Revealed by Presence and Transcriptional Activity - Relationship to Diagnosis and Outcome by Vatn SS, Hansen SH, Tannæs TM, Brackmann S, Olbjørn C, Bergemalm D, Keita ÅV, Gomollon F, Detlie TE, Kalla R, Satsangi J, Jahnsen J, Vatn MH, Halfvarson J, Hov JR, Ricanek P, Moen AEF

“…Simen Svendsen Vatn,1– 3,* Simen Hyll Hansen,1,4,* Tone Møller Tannæs,5 Stephan Brackmann,1,2 Christine Olbjørn,1,6 Daniel Bergemalm,7 Åsa V Keita,8 Fernando Gomollon,9 Trond Espen Detlie,1,2 Rahul Kalla,10 Jack Satsangi,10,11 Jørgen Jahnsen,1,2 Morten Harald Vatn,1 Jonas Halfvarson,7 Johannes Roksund Hov,1,4,12 Petr Ricanek,2,13 Aina EF Moen1,5,14 On behalf of the IBD-Character Consortium1Institute of Clinical Medicine, University of Oslo, Oslo, Norway; 2Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway; 3Innlandet Hospital Trust, Gjøvik, Norway; 4Norwegian PSC Research Center and Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Oslo, Norway; 5Section for Clinical Molecular Biology (Epigen), Akershus University Hospital, Lørenskog, Norway; 6Department of Pediatric and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway; 7Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; 8Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; 9Digestive Diseases Unit, IIS Aragón, Zaragoza, Spain; 10Gastrointestinal Unit, Centre for Genomics and Molecular Medicine, Division of Medical and Radiological Sciences, University of Edinburgh, Edinburgh, UK; 11Translational Gastroenterology Unit, Medical Sciences/ Experimental Medicine Division, University of Oxford, Oxford, UK; 12Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway; 13Department of Gastroenterology, lovisenberg Diaconal Hospital, Oslo, Norway; 14Department of Virology, Norwegian Institute of Public Health, Oslo, Norway*These authors contributed equally to this workCorrespondence: Simen Svendsen Vatn, Innlandet Hospital Trust, Gjøvik, Norway, Tel +47 94277594, Email bikkjas@hotmail.comBackground: As part of the IBD Character initiative, we examined an inception cohort and investigated mucosal microbiota composition and transcriptional activity in relation to clinical outcomes.Methods: A cohort of 237 individuals were included from five countries: Crohn’s disease (CD, n = 72), ulcerative colitis (UC, n = 57), symptomatic non-IBD controls (SC, n = 78) and healthy controls (HC, n = 30). …”
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Impact of Long‐Term Fasting on Skeletal Muscle: Structure, Energy Metabolism and Function Using 31P/1H MRS and MRI by Antoine Naëgel, Magalie Viallon, Hélène Ratiney, Thu Nguyen, Benjamin Leporq, Djahid Kennouche, Thomas Grenier, Franziska Grundler, Robin Mesnage, Jean‐Michel Guy, Robin Schultze, Françoise Wilhelmi de Toledo, Pierre Croisille

“…We explored the impact of long‐term fasting (12 days, 250 kcal/day) on muscle structure, metabolism and performance. Methods We prospectively assessed muscle volume, composition, relaxometry data and lipid metabolism in 32 subjects (16 men; 50% over 50 years old) before fasting, at the end of fasting and 1 month post‐fasting. …”
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Large MAF transcription factors reawaken evolutionarily dormant fast-glycolytic type IIb myofibers in human skeletal muscle by Shunya Sadaki, Ryosuke Tsuji, Takuto Hayashi, Masato Watanabe, Ryoto Iwai, Gu Wenchao, Ekaterina A. Semenova, Rinat I. Sultanov, Andrey V. Zhelankin, Edward V. Generozov, Ildus I. Ahmetov, Iori Sakakibara, Koichi Ojima, Hidetoshi Sakurai, Masafumi Muratani, Takashi Kudo, Satoru Takahashi, Ryo Fujita

“…Abstract Background Small mammals such as mice rely on type IIb myofibers, which express the fast-contracting myosin heavy chain isoform Myh4, to achieve rapid movements. …”
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The Role of the Bone Marrow Microenvironment in Physical Function and Quality of Life in Patients with Multiple Myeloma After First-Line Treatment with Novel Agents and Autologous... by Polyxeni Spiliopoulou, Pantelis Rousakis, Chrysanthi Panteli, Evangelos Eleutherakis-Papaiakovou, Magdalini Migkou, Nikolaos Kanellias, Ioannis Ntanasis-Stathopoulos, Panagiotis Malandrakis, Foteini Theodorakakou, Despina Fotiou, Evangelos Terpos, Vassilios Myrianthopoulos, Maria Gavriatopoulou, Ourania E. Tsitsilonis, Efstathios Kastritis, Meletios Athanasios Dimopoulos, Gerasimos Terzis

“…Background/Objectives: Multiple myeloma is a malignancy of plasma cells detected in the bone marrow, inducing symptoms like anemia, hypercalcemia, renal problems, and bone fractures in multiple myeloma patients, affecting their quality of life. …”
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Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM by Jiaxuan Li, Zhenyu Tian, Tongxue Zhang, Jiajia Jin, Xinjie Zhang, Panpan Xie, Haiyan Lin, Junfei Gu, Yingjie Wu, Xiaowei Wang, Shucui Zhang, Xuefang Yan, Dong Guo, Zhe Wang, Qunye Zhang

“…Abstract Background Vasculopathy underlies diabetic complications, with perivascular adipose tissue (PVAT) playing crucial roles in its development. …”
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Nutritional quality and on-package marketing of pre-packaged foods and non-alcoholic beverages for sale in Senegalese supermarkets by Yassarath Onifade, Adama Diouf, Mane Hélène Faye, Fatou Fall, Gary Sacks, Nicole Idohou-Dossou, Boyd Swinburn, Stefanie Vandevijvere

“…Abstract Background The high availability and marketing of unhealthy foods has contributed to unhealthy diets. …”
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Influence of Different Cationic Polymer-Based Micelles on the Corneal Behavior and Anti-Cataract Effect of Diosmetin by Jing Zhang, Min Zha, Anping Wan, Satya Siva Kishan Yalamarty, Nina Filipczak, Xiang Li

“…<b>Background</b> Despite many studies on polymer-incorporated nanocarriers for ophthalmic drug delivery, few have thoroughly explored the relationship between coating composition and performance. …”
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Effects of 8-week Theracurmin Super (TS-P1; curcumin) supplementation on exercise-induced oxidative stress: A randomized double-blind, placebo-controlled parallel clinical trial by Xinxing Li, Dae Young Kim, Yunho Sung, Donghyun Kim, Seohyun Ahn, Hyejung Shin, Nur Afiqah Binti Zulkifli, Ji-won Seo, Shu Jiang, Parivash Jamrasi, SoYoung Ahn, Jun Hyun Bae, HeeKyung Yeo, Hayoung Park, Wook Song

“…Background: Given the antioxidant properties of curcumin, this study aimed to determine the effectiveness and safety of Theracurmin Super supplementation in mitigating exercise-induced oxidative stress in healthy adults. …”
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Legume-based green concentrate alleviates negative energy balance and enhances performance, metabolic health, and profitability in postpartum Holstein Friesian cows by Renny Fatmyah Utamy, Ambo Ako, Zyahrul Ramadan, Yasuyuki Ishii, Mohammad Mijanur Rahman, Kannika Umpuch, Azisah Nurfadilah, Gemal Umar Akmal Alkatiry, Muhammad Akram, Jiant Muthahra Maharani

“…Background and Aim: Negative energy balance (NEB) is a common metabolic disorder in postpartum dairy cows that compromises milk yield, metabolic health, and reproductive function. …”
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Tailored Magnetic Fe₃O₄-Based Core–Shell Nanoparticles Coated with TiO₂ and SiO₂ via Co-Precipitation: Structure–Property Correlation fo... by Elena Emanuela Herbei, Daniela Laura Buruiana, Alina Crina Muresan, Viorica Ghisman, Nicoleta Lucica Bogatu, Vasile Basliu, Claudiu-Ionut Vasile, Lucian Barbu-Tudoran

“…<b>Methods:</b> Fe₃O₄, Fe₃O₄@TiO₂, and Fe₃O₄@SiO₂ nanoparticles were synthesized via co-precipitation at varying temperatures from iron salt precursors. …”
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Enhancing the nutritional profile of purple sweet potato flour through fermentation with Lactiplantibacillus plantarum InaCC B157: A functional food perspective by Tiurma Pasaribu, Yati Sudaryati Soeka, Novik Nurhidayat, Suciatmih Suciatmih, Titin Yulinery, Evi Triana, Tri Ratna Sulistiyani, Ninik Setyowati, Desty Dwi Sulistyowati, Dwi Ningsih Susilowati

“…This study aimed to evaluate the ability of Lactiplantibacillus plantarum InaCC B157 to enhance the biochemical and functional composition of purple sweet potato flour. Materials and Methods: Six L. plantarum strains were screened for enzymatic activities. …”
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Plasma Fatty Acid Profiling and Mathematical Estimation of the Omega-3 Index: Toward Diagnostic Tools in Atherosclerosis and Statin Therapy Monitoring by Nikolay Eroshchenko, Elena Danilova, Anastasiia Lomonosova, Alexey Antonik, Svetlana Lebedeva, Daria Gognieva, Dmitry Shchekochikhin, Tatiana Demura, Marina Krot, Nana Gogiberidze, Abram Syrkin, Philipp Kopylov

“…<b>Background/Objectives:</b> Omega-3 highly unsaturated fatty acids (HUFAs), particularly EPA and DHA, have anti-inflammatory and lipid-modulating properties for treating atherosclerosis. …”
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Immunohistochemical analysis of PD-L1, CD4, CD8, CD20, and PU.1 expression in a dedifferentiated chondrosarcoma: the clinical and prognostic value by Olga V. Kovaleva, Irena V. Boulytcheva, Dmitrii V. Rogozhin, Alexei N. Gratchev, Polina L. Prishchep, Nikolay E. Kushlinskii

“…Background: Dedifferentiated chondrosarcoma (DDCS) is a rare and extremely aggressive variant of mesenchymal bone tumors, with a biphasic structure represented by the classical chondrosarcoma elements, usually of low or intermediate grade, combined with a sharp transition to a highly malignant (high grade) non-cartilaginous sarcoma. …”
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Exploring the efficacy and safety of Yu-Ping-Feng powder with variation against allergic rhinitis: a randomized, double-blind, placebo-controlled trial by Zhi-Xiu Lin, Tin Muk Ho, Yan-Fang Xian, Kam Leung Chan, Qing-Qing Xu, Cho Wing Lo, Justin Che Yuen Wu, Kam Lun Hon, Sin Bond Leung, Chon Pin Chia, Chi Him Sum, Tak Yee Chow, Pui Kuan Cheong, Jessica Yuet Ling Ching, Hongwei Zhang, Ka Chun Leung, Wai Ling Lin

“…Abstract Background Allergic rhinitis (AR) is a common allergic condition characterized by frequent sneezing, nasal congestion, nasal itching and rhinorrhea. …”
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Handgrip strength and menopause are associated with cardiovascular risk in women with obesity: a cross-sectional study by Jaqueline de Paula Chaves Freitas, Joyce Noelly Vitor Santos, Daniela Barreto de Moraes, Gabriele Teixeira Gonçalves, Leonardo Augusto da Costa Teixeira, Maria Thereza Otoni Figueiró, Tamara Cunha, Vanessa Kelly da Silva Lage, Ana Lúcia Danielewicz, Pedro Henrique Scheidt Figueiredo, Henrique Silveira Costa, Alessandro Sartorio, Thyago José Silva, Fidelis Antônio da Silva Júnior, Cheyenne Alves Fonseca, Elizabethe Adriana Esteves, Ana Cristina Rodrigues Lacerda, Vanessa Amaral Mendonça

“…Abstract Background While physical performance is closely linked to cardiovascular health, further research is essential to elucidate the association of physical tests in the early screening for cardiovascular risk (CVR), underscoring the potential for these assessments to enhance preventive healthcare strategies. …”
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