Treatment of hypothyroidism with levothyroxine plus slow-release liothyronine: a study protocol for a randomized controlled double-blinded clinical trial by F. Azizi, A. Amouzegar, H. Abdi, M. Tohidi, S. Masoumi, D. Khalili, Y. Mehrabi, A. Zadehvakili, M. Hedayati, A. A. Momenan, L. Mehran

“…Abstract Background There are emerging controversies regarding the priority of T4 + T3 combination therapy over standard care with levothyroxine (LT4) monotherapy in the management of hypothyroid subjects. …”
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Comparative Analysis of Infusions and Ethanolic Extracts of <i>Annona muricata</i> Leaves from Colima, Mexico: Phytochemical Profile and Antioxidant Activity by Gustavo A. Hernandez-Fuentes, Osiris G. Delgado-Enciso, Edgar G. Larios-Cedeño, Juan M. Sánchez-Galindo, Silvia G. Ceballos-Magaña, Kayim Pineda-Urbina, Mario A. Alcalá-Pérez, Nancy E. Magaña-Vergara, Josuel Delgado-Enciso, Uriel Díaz-Llerenas, Janet Diaz-Martinez, Idalia Garza-Veloz, Margarita L. Martinez-Fierro, Iram P. Rodriguez-Sanchez, Ivan Delgado-Enciso

“…Background: <i>Annona muricata</i> L. (guanabana) leaves are rich in bioactive compounds with potential antioxidant properties. …”
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In-vitro immune-modulation of triple-negative breast cancer through targeting miR-30a-5p/MALAT1 axis using nano-PDT combinational approach by Asmaa Ramzy, Mohammad Abdel-Halim, Tamer Manie, Noha M. Elemam, Samar Mansour, Rana A. Youness, Aya Sebak

“…Background: Triple negative breast cancer (TNBC) is an immunogenic tumor; however, its tumor immune microenvironment (TIME) is densely packed with immune suppressive cytokines and immune checkpoints. …”
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Combination of Essential Oils and Extracts Enriched with Tocopherols in Diet of Holstein Steers and Its Effect on Ruminal Fermentation, Antioxidant and Anti-Inflammatory Response,... by João Gustavo Weschenfelder Wandscheer, Natalia Turcatto, Guilherme Luiz Deolindo, Mateus Henrique Signor, Alexandro Fritzen, Marcelo Vedovatto, Camila Ten Kathen Jung, Gilberto Vilmar Kozloski, Ana Carolina Hadlich Xavier, Roger Wagner, Bianca Fagan Bissacotti, Priscila Marquezan Copetti, Aleksandro Schafer da Silva

“…Background: This experiment evaluated whether the combination of essential oils (thyme, rosemary, orange) with extracts of <i>Cinnamomum</i> and <i>Quillaja saponaria</i> (enriched with tocopherols) in steers’ diet has positive effects on the health, digestibility, growth, oxidative stress, and fatty acid profile of meat. …”
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Examining the social distributions in neighbourhood black carbon and ultrafine particles in Montreal and Toronto, Canada by Emmanuelle Batisse, Marshall Lloyd, Alicia Cavanaugh, Arman Ganji, Junshi Xu, Marianne Hatzopoulou, Jill Baumgartner, Scott Weichenthal

“…Methods: We collected vulnerability indicators, including social, economic, household composition, and immigration status, at the dissemination area level for Montreal and Toronto using data from the 2006 and 2021 Canadian Census of Population. …”
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Discovering biomarkers associated with infiltration of CD8+ T cells and tumor-associated fibrosis in colon adenocarcinoma using single-cell RNA sequencing and gene co-expression ne... by Jinning Zhang, Jinning Zhang, Ziquan Sun, Ziquan Sun, Guodong Li, Guodong Li, Lixian Ding, Zitong Wang, Ming Liu, Ming Liu

“…BackgroundColorectal adenocarcinoma (COAD) is a prevalent malignant tumor associated with a high mortality rate. …”
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Conjugated bile acids promote metabolic dysfunction-associated steatotic liver disease through inducing nuclear translocation of sphingosine-1-phosphate receptor 2 to disrupt perox... by Rong-Rong Miao, Ming-Yong Tan, Han-Bing Shao, Zhi-Meng Sun, Sheng Zhan, Wei-Shi Liang, Xiao-Hui Liu, Ke-Qin Li, Yu-Yao Cheng, Xin-Feng Wu, Rui Xu, Shu-Xiang Cui, Yong Hai, Xian-Jun Qu

“…Abstract Background Conjugated bile acids (CBAs) induced metabolic dysfunction-associated steatotic liver disease (MASLD) through activating sphingosine-1-phosphate receptor 2 (S1PR2). …”
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Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals. by Robert F Hillary, Daniel L McCartney, Hannah M Smith, Elena Bernabeu, Danni A Gadd, Aleksandra D Chybowska, Yipeng Cheng, Lee Murphy, Nicola Wrobel, Archie Campbell, Rosie M Walker, Caroline Hayward, Kathryn L Evans, Andrew M McIntosh, Riccardo E Marioni

“…<h4>Background</h4>DNA methylation is a dynamic epigenetic mechanism that occurs at cytosine-phosphate-guanine dinucleotide (CpG) sites. …”
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Characterizing Nonculprit Lesions and Perivascular Adipose Tissue of Patients Following Acute Myocardial Infarction Using Coronary Computed Tomography Angiography: A Comparative St... by Xiaomeng Wang, Ching H. Sia, Philip D. Adamson, Charlotte E. Greer, Weimin Huang, Hwee K. Lee, Shuang Leng, Yan T. Loong, Nur A. S. Raffiee, Swee Y. Tan, Sock H. Tan, Lynette L. S. Teo, Sung L. Wong, Xiaoxun Yang, Min S. Yew, Thon H. Yong, Liang Zhong, Leslee J. Shaw, Mark Y. Y. Chan, Derek J. Hausenloy, Lohendran Baskaran

“…Background The comparison of coronary computed tomography angiography plaques and perivascular adipose tissue (PVAT) between patients with acute myocardial infarction (AMI) posttreatment and patients with stable coronary artery disease is poorly understood. …”
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Ranges, temporal trend, and determinants of novel obesity indices in middle-aged and older Chinese population: insights from a nationally representative and longitudinal study by Liufang Huang, Yifan Zhou, Kaiweisa Abuduxukuer, Kaiweisa Abuduxukuer, Chuchu Wang, Chuchu Wang, Chuchu Wang, Ya’nan Hou, Wenming Shi, Jianfeng Luo, Jianfeng Luo, Jianfeng Luo, Jin Wei, Yuhang Yue

“…BackgroundTraditional obesity assessment using body mass index (BMI) fails to adequately capture fat distribution, particularly central obesity, which is closely linked to metabolic dysfunction and obesity-related complications. …”
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Improving Diet Quality of People Living With Obesity by Building Effective Dietetic Service Delivery Using Technology in a Primary Health Care Setting: Protocol for a Randomized Co... by Deborah A Kerr, Clare E Collins, Andrea Begley, Barbara Mullan, Satvinder S Dhaliwal, Claire E Pulker, Fengqing Zhu, Marie Fialkowski, Richard L Prince, Richard Norman, Anthony P James, Paul Aveyard, Helen Mitchell, Jacquie Garton-Smith, Megan E Rollo, Chloe Maxwell-Smith, Amira Hassan, Hayley Breare, Lucy M Butcher, Christina M Pollard

“… BackgroundAlmost a third of Australian adults are living with obesity, yet most cannot access medical nutrition therapy from dietitians, that is, the health professionals trained in dietary weight management services. …”
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Gradual changes within long-lived influenza virus-specific CD8+ T cells are associated with the loss of public TCR clonotypes in older adultsResearch in context by Carolien E. van de Sandt, Hayley A. McQuilten, Malet Aban, Thi H.O. Nguyen, Sophie A. Valkenburg, Emma J. Grant, Sneha Sant, Jamie Rossjohn, Stephanie Gras, Jane Crowe, Katherine Kedzierska

“…Summary: Background: Susceptibility to life-threatening influenza increases with age, partly due to declining immunity. …”
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Differential item functioning of material deprivation assessment in households with or without children. by Maria Eugénia Ferrão, Marcel Toledo Vieira

“…<h4>Background</h4>Composite multidimensional indices are broadly used to measure child poverty and social exclusion. …”
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Metagenome-validated combined amplicon sequencing and text mining-based annotations for simultaneous profiling of bacteria and fungi: vaginal microbiota and mycobiota in healthy wo... by Seppo Virtanen, Schahzad Saqib, Tinja Kanerva, Rebecka Ventin-Holmberg, Pekka Nieminen, Tiina Holster, Ilkka Kalliala, Anne Salonen

“…Abstract Background Amplicon sequencing of kingdom-specific tags such as 16S rRNA gene for bacteria and internal transcribed spacer (ITS) region for fungi are widely used for investigating microbial communities. …”
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Role of immunostimulatory deoxycytidylate-phosphate-deoxyguanylate (CpG) motifs in oral bacteria associated with oral diseases by Pisit Charoenwongwatthana, Oslovenya S. Caroline, Halah Ahmed, Jamie Coulter, Chien-Yi Chang

“…Background CpG oligodeoxynucleotide motifs in bacterial DNA with composition variations exhibit potent immunostimulation. …”
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Effect of a feed supplement containing probiotics on fecal score and clinical parameters in dogs with chronic kidney disease and intestinal disorders: A pilot study by Francesca Perondi, Ilaria Lippi, Natascia Bruni, Nicolò Lonigro, Elisa Martello

“…Background: Chronic kidney disease (CKD) in dogs is often accompanied by dysbiosis and abnormal gut microbiota composition, leading to gastrointestinal issues. …”
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The Rotating Bulge and Halo in the Milky Way: Evidence of Angular Momentum Transferred from the Decelerating Bar by Zhuohan Li, Chengdong Li, Gang Zhao, Ruizhi Zhang, Xiang-Xiang Xue

“…In this study, we identified a component consisting of 1,175,737 stars with net rotation through the application of a neural network (NN) method. To investigate the composition of this rotating sample and the origin of its rotation, we conducted a test particle simulation incorporating an equilibrium axisymmetric background potential together with a central decelerating bar. …”
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The Design and Cell-Free Protein Synthesis of a Pembrolizumab Single-Chain Variable Fragment by Landon E. Ebbert, Tyler J. Free, Mehran Soltani, Bradley C. Bundy

“…Background/Objectives: Cancer is a leading cause of death. …”
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Artificial intelligence driven malnutrition diagnostic model for patients with acute abdomen based on GLIM criteria: a cross-sectional research protocol by Yu Wang, Lu Wang, Hua Jiang, Wei Ma, Bin Cai, Ming-Wei Sun, Charles Damien Lu

“…Background Patients with acute abdomen often experience reduced voluntary intake and a hypermetabolic process, leading to a high occurrence of malnutrition. …”
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Comprehensive characterization of volatile compounds in Iranian black teas using chemometric analysis of GC-MS fingerprints by Adineh Aminianfar, Mohammad Hossein Fatemi, Fatemeh Azimi

“…Black tea, a widely popular non-alcoholic beverage, is renowned for its unique aroma and has attracted significant attention due to its complex composition. However, the chemical profile of Iranian tea remains largely unexplored. …”
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